TWAS hub - SENP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0550	0.0190	5.5e-05	0.024	0.038	0.032	0.036	0.031	5.1e-04	1.7e-05	8.5e-05	2.6e-05	9.2e-05
2	GTEx	Testis	0.2030	0.0690	5.3e-05	0.128	NA	0.096	NA	0.103	2.7e-06	NA	4.9e-05	NA	2.7e-05
3	TCGA	Bladder Urothelial Carcinoma	0.0970	0.0490	1.3e-04	0.046	0.041	0.029	NA	0.037	8.3e-05	2.2e-04	1.7e-03	NA	3.7e-04
4	TCGA	Breast Invasive Carcinoma	0.0144	0.0088	4.7e-03	0.004	0.006	0.001	NA	0.003	5.3e-02	1.8e-02	2.0e-01	NA	7.5e-02
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0682	0.0391	6.9e-04	0.009	0.021	0.016	NA	0.019	3.1e-02	1.9e-03	5.2e-03	NA	2.9e-03
6	TCGA	Brain Lower Grade Glioma	0.0358	0.0271	9.6e-03	0.015	0.013	0.022	NA	0.020	7.5e-03	1.1e-02	1.4e-03	NA	2.0e-03
7	TCGA	Lung Adenocarcinoma	0.0566	0.0365	5.1e-04	0.034	0.029	0.031	NA	0.036	6.9e-05	2.0e-04	1.2e-04	NA	4.6e-05
8	TCGA	Lung Squamous Cell Carcinoma	0.0393	0.0220	2.0e-04	0.029	0.027	0.024	NA	0.027	2.4e-04	4.4e-04	8.1e-04	NA	4.7e-04
9	TCGA	Ovarian Serous Cystadenocarcinoma	0.0860	0.0460	2.2e-04	0.020	0.051	0.057	NA	0.035	1.5e-02	2.3e-04	1.1e-04	NA	2.1e-03
10	TCGA	Prostate Adenocarcinoma	0.0616	0.0396	2.8e-03	0.004	0.007	0.004	NA	0.004	1.0e-01	5.7e-02	1.0e-01	NA	1.1e-01
11	TCGA	Stomach Adenocarcinoma	0.0870	0.0400	1.6e-04	0.026	0.023	0.026	NA	0.027	5.4e-03	8.6e-03	5.6e-03	NA	4.8e-03
12	TCGA	Thyroid Carcinoma	0.0450	0.0270	8.1e-03	0.014	0.003	-0.001	NA	0.004	1.6e-02	1.6e-01	4.2e-01	NA	1.3e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Blood Red Count	9.4	90.7	166.8	10.2	-12.9	6.8	11.4	6.3	8.5	9.5	12.0	11.2	7.4	6.6	8.4
Bipolar Disorder (2011)	8.7	8.4	12.7	2.0	-2.3	2.6	3.2	2.5	3.2	3.2	2.7	3.6	2.5	3.2	3.3
Medication: Simvastatin	8.3	12.2	18.1	-3.8	3.7	-2.7	-4.2	-1.9	-2.9	-3.8	-3.9	-4.1	-1.8	-3.7	-4.2
HbA1C	8.1	9.0	18.4	-1.4	2.2	-2.8	-3.2	-3.7	-2.8	-3.1	-2.7	-3.1	-4.3	-2.6	-3.2
High cholesterol (Self-reported)	7.4	13.2	18.2	-3.4	3.9	-3.1	-4.2	-2.3	-3.5	-4.1	-4.0	-4.1	-2.1	-3.7	-4.3
Medication: Cholesterol lowering	6.5	10.1	14.7	-3.8	3.6	-2.6	-3.7	-1.9	-2.9	-3.4	-3.7	-3.7	-1.7	-2.9	-3.4
Basal cell carcinoma (self-reported)	6.5	7.7	11.5	1.1	-2.5	3.4	2.8	2.3	2.6	3.3	3.1	3.1	1.7	3.1	3.3
Knee pain experienced in last month	6.3	9.8	14.5	-2.8	3.4	-2.9	-3.8	-2.2	-2.8	-3.6	-3.5	-3.4	-2.2	-3.1	-3.2
Impedance of leg (right)	5.2	25.4	67.6	-4.7	5.5	-1.9	-7.3	-3.3	-4.5	-4.8	-4.8	-8.2	-3.5	-4.1	-4.5
Medication: Metformin	4.7	6.7	9.6	-1.3	1.7	-3.0	-2.5	-2.9	-2.7	-2.9	-2.4	-1.9	-3.0	-3.1	-2.9
Hand grip strength (right)	4.7	12.7	23.5	4.0	-4.2	2.0	4.8	2.2	3.3	3.5	3.9	4.8	2.2	3.0	3.4
Impedance of leg (left)	4.6	22.3	54.8	-3.5	4.6	-2.6	-6.6	-3.7	-4.5	-4.8	-4.2	-7.4	-3.8	-4.2	-4.6
Loud music exposure frequency	4.2	4.5	7.6	-0.8	1.0	-2.1	-2.8	-2.4	-1.6	-2.7	-1.3	-2.0	-2.5	-2.6	-2.5
Eye problems/disorders: None of the above	4.2	4.9	9.7	-1.2	0.6	2.6	2.6	3.0	0.7	2.8	-0.1	0.5	2.9	3.1	2.7
Tinnitus: Yes, now most or all of the time	4.2	4.9	12.5	3.5	-3.0	0.3	2.9	0.3	2.0	1.7	2.9	2.8	1.0	1.4	1.6
Townsend deprivation index at recruitment	3.8	5.4	8.6	-2.4	2.6	-2.0	-2.6	-1.2	-2.8	-2.7	-2.9	-2.4	-1.0	-2.1	-2.4
High blood pressure (mother)	3.7	5.2	20.2	-4.5	3.9	0.7	-2.1	1.0	-1.0	-0.5	-3.2	-3.0	0.7	0.4	-0.3
Commuting to job workplace: Car/motor vehicle	3.5	4.0	6.4	1.2	-2.1	1.7	2.3	2.0	2.2	2.1	2.0	2.5	1.9	1.6	2.1
Medication for cholesterol	3.5	5.3	20.1	4.5	-3.7	0.2	2.7	-0.3	1.0	1.5	3.2	2.5	-0.1	0.6	1.5
Age started oral contraceptive pill	3.5	4.4	14.5	-0.6	1.0	2.3	1.4	3.7	0.5	1.8	-0.8	1.3	3.8	2.6	2.0
Impedance of whole body	3.5	18.1	50.1	-4.5	5.4	-0.3	-6.6	-1.8	-3.3	-3.5	-4.6	-7.1	-2.6	-2.8	-3.3
Smoking Status	3.4	8.2	17.7	0.0	1.3	-4.2	-2.3	-3.0	-3.4	-3.7	-2.1	-1.8	-2.5	-3.9	-3.2
Cardiovascular Disease	3.4	11.3	41.6	-6.4	4.8	-0.5	-4.5	-0.2	-1.6	-2.6	-4.2	-3.7	-0.8	-1.6	-2.4
Medication for cholesterol, blood pressure or diabetes	3.4	5.7	18.1	4.3	-3.3	1.0	3.1	0.5	1.4	2.2	3.0	2.5	0.6	1.3	2.1
Diabetes (self-reported)	3.3	5.2	7.0	-1.2	2.2	-2.3	-2.5	-2.1	-2.2	-2.6	-2.5	-1.8	-2.5	-2.6	-2.4
Cholesterol lowering medication	3.3	4.8	8.8	-2.8	2.4	-1.3	-3.0	-0.8	-1.8	-2.4	-2.4	-2.6	-0.6	-2.3	-2.5
Type 2 Diabetes (T2D) (2018)	3.2	6.1	8.6	-2.6	2.7	-1.9	-2.9	-1.9	-1.9	-2.5	-2.8	-2.2	-2.6	-2.7	-2.6
Neck or shoulder pain in last month	3.2	4.5	7.8	-1.8	2.1	-1.7	-2.5	-2.1	-2.3	-2.1	-2.1	-2.8	-2.5	-1.9	-1.4
Medication: Amlodipine	3.1	4.4	18.3	-4.3	3.2	-0.0	-2.3	0.3	-0.8	-1.2	-2.6	-2.8	-0.3	-0.5	-1.1
Diabetes diagnosed by doctor	3.1	5.1	7.4	-1.7	2.2	-2.1	-2.7	-2.0	-2.1	-2.5	-2.5	-1.8	-2.3	-2.7	-2.4
Heart disease (mother)	2.9	3.5	10.8	-3.3	3.1	-0.5	-1.7	0.8	-1.1	-1.3	-2.9	-1.9	1.0	-0.8	-1.3
Illnesses of siblings: Diabetes	2.9	3.6	6.3	-1.8	2.4	-2.1	-1.6	-1.3	-2.3	-2.0	-2.5	-1.8	-1.0	-1.3	-1.8
Neuroticism	2.8	6.7	11.8	-1.8	2.0	-1.9	-3.4	-2.1	-2.4	-3.0	-2.2	-3.3	-2.4	-3.2	-2.7
Impedance of arm (right)	2.8	13.3	34.9	-5.1	5.4	1.6	-5.9	0.6	-1.7	-2.0	-4.4	-5.9	-0.5	-1.4	-1.8
Vitamin and mineral supplements	2.7	3.6	6.9	-0.1	0.2	-2.4	-1.7	-2.5	-1.9	-2.3	-0.8	-1.2	-1.9	-2.6	-2.6
Loneliness, isolation	2.7	3.7	9.9	0.1	0.4	-2.3	-1.2	-3.1	-2.0	-1.8	-0.7	-2.3	-3.0	-1.7	-1.8
Ever taken oral contraceptive pill	2.7	3.0	5.6	0.2	-1.3	2.2	1.3	2.3	2.1	1.8	1.6	1.5	2.4	1.5	1.6
Alzheimer’s Disease (in father)	2.6	2.8	5.2	1.1	-1.2	1.4	2.2	1.2	1.2	2.1	1.3	1.6	1.5	2.3	2.3
Systolic Blood Pressure	2.6	13.1	57.8	-7.6	5.3	0.0	-4.4	1.1	-0.9	-2.2	-4.7	-3.9	0.7	-1.4	-2.3
Multivitamins +/- minerals	2.6	3.3	6.1	0.7	-0.2	1.9	2.1	2.2	1.6	2.3	0.6	1.3	2.0	2.5	2.5
Suffer from ‘nerves’	2.6	4.2	6.6	-1.9	2.5	-1.6	-2.6	-1.3	-1.5	-2.1	-2.6	-2.3	-1.6	-2.2	-1.8
Smoking status: Previous	2.6	4.0	5.6	-1.6	2.3	-2.1	-2.1	-1.3	-2.2	-2.3	-2.4	-2.3	-1.0	-1.9	-1.9
Hand grip strength (left)	2.5	6.6	15.8	4.0	-3.3	0.3	3.8	0.9	1.8	2.0	2.8	3.9	1.4	1.5	1.6
Medication: Blood pressure	2.5	4.4	21.5	-4.6	3.2	0.4	-2.4	1.0	-0.6	-1.1	-2.8	-1.7	0.7	-0.4	-0.9
Guilty feelings	2.5	3.7	8.5	-1.0	1.5	-1.8	-2.9	-1.8	-1.0	-2.5	-1.7	-1.6	-2.1	-2.3	-2.0
Hearing difficulty/problems with background noise	2.4	3.9	6.2	1.0	-0.4	2.4	1.7	2.4	2.1	2.1	0.9	2.4	2.0	2.5	2.5
Impedance of arm (left)	2.4	11.2	31.2	-4.2	5.0	1.1	-5.4	0.0	-1.8	-2.0	-4.1	-5.6	-1.0	-1.4	-1.8
Happiness	2.3	2.8	6.4	1.1	-1.0	1.7	1.8	0.9	2.5	2.1	1.5	1.9	0.2	2.1	1.9
Noisy workplace	2.3	2.9	4.8	-0.9	1.4	-1.8	-2.0	-1.4	-2.2	-2.0	-1.9	-1.6	-1.4	-2.0	-1.5
Schizophrenia vs Biploar Disorder	2.2	3.0	6.8	-0.6	1.6	-2.6	-1.0	-1.6	-2.3	-2.3	-1.8	-0.9	-1.4	-1.5	-1.9
Primary Biliary Cirrhosis	2.2	3.1	7.9	-1.7	2.7	-1.6	-1.8	-0.5	-1.8	-1.8	-2.8	-1.3	-0.6	-1.6	-1.5
Trunk fat percentage	2.2	8.7	18.4	-3.5	3.9	-1.3	-4.3	-1.1	-1.8	-2.9	-3.9	-3.2	-2.1	-2.6	-2.9
Past tobacco smoking	2.2	4.0	6.5	1.6	-2.1	1.9	2.6	1.1	2.0	2.4	2.4	1.8	1.2	2.4	1.9
Number of live births	2.2	3.1	8.5	2.0	-2.9	0.9	1.8	0.6	1.7	1.5	2.7	2.3	0.8	0.5	1.3
Osteoarthritis (self-reported)	2.2	2.9	4.8	-1.2	1.7	-2.1	-1.3	-0.9	-2.2	-2.0	-2.0	-2.0	0.3	-1.6	-1.8
Supplements: Zinc	2.1	2.3	5.4	-0.1	0.4	2.0	1.1	1.8	1.6	1.9	0.2	1.1	1.1	2.3	2.1
Chronic bronchitis/emphysema (father)	2.1	2.4	4.8	1.2	-2.2	0.9	2.1	1.1	1.3	1.5	1.9	2.2	1.5	1.0	1.1
Illnesses of mother	2.1	2.7	12.9	3.6	-2.6	-0.3	1.5	-0.8	0.6	0.6	2.3	1.6	-0.8	-0.1	0.6
Leg pain on walking	2.1	2.7	6.1	-2.0	2.5	-1.0	-2.4	-0.7	-0.4	-1.7	-2.1	-1.9	-0.9	-1.2	-1.2
Commuting to job workplace: Public transport	2.1	2.5	5.5	-2.0	1.3	-1.1	-2.3	-1.3	-0.7	-1.9	-1.2	-1.7	-1.3	-1.6	-2.0
Medication for hormone replacement therapy	2.0	2.3	5.2	-2.0	2.2	-0.9	-1.5	0.1	-1.7	-1.3	-2.3	-1.8	0.4	-1.1	-1.1
Overall health rating	2.0	4.2	9.0	-2.3	2.3	-1.2	-3.0	-1.8	-0.5	-2.0	-1.9	-2.3	-2.5	-1.7	-2.0
Supplements: Fish oil (including cod liver oil)	2.0	2.7	5.1	2.3	-1.3	0.9	2.2	0.8	1.8	1.7	1.7	1.8	0.8	1.7	1.7
Neuroticism (Nagel 2018)	1.9	4.4	8.0	-2.0	2.6	-1.0	-2.8	-0.9	-2.0	-2.0	-2.5	-2.8	-1.5	-2.4	-1.6
Blood White Count	1.9	14.0	23.0	-2.5	3.3	-3.7	-3.7	-2.8	-4.6	-4.3	-4.0	-3.9	-2.3	-4.0	-4.8
Glaucoma (self-reported)	1.9	2.3	4.2	-0.1	1.1	-1.3	-1.8	-2.0	-1.7	-1.7	-1.0	-1.7	-2.0	-1.1	-1.4
Leg fat percentage (right)	1.9	7.0	10.2	-1.6	2.1	-2.5	-3.2	-2.5	-2.3	-3.0	-2.4	-2.7	-2.5	-3.2	-3.1
Blood Eosinophil Count	1.8	14.1	25.1	-1.6	2.6	-4.5	-3.3	-3.9	-4.2	-4.4	-3.2	-3.9	-3.0	-4.2	-5.0
Blood Platelet Count	1.8	21.2	69.9	-5.1	8.4	-1.2	-5.0	0.1	-4.5	-3.3	-7.6	-5.8	-0.8	-1.4	-2.5
Waist Hip Ratio (WHR)	1.8	8.0	14.4	1.0	1.1	-3.1	-2.9	-3.8	-3.4	-3.3	-1.3	-3.3	-3.0	-3.1	-2.9
Diabetes (mother)	1.8	2.3	5.8	-2.4	1.6	-0.7	-1.7	-0.3	-1.1	-1.5	-1.7	-1.9	-0.2	-1.3	-2.2
Average weekly fortified wine intake	1.8	2.1	4.6	0.7	-1.1	1.3	1.6	1.4	2.1	1.6	1.4	1.3	1.8	1.5	1.2
Alcohol intake versus 10 years previously	1.8	2.7	9.9	-3.1	1.4	2.3	0.2	2.3	0.4	1.3	-1.0	-0.5	1.9	1.7	0.7
Body fat percentage	1.8	7.3	14.0	-2.6	3.1	-1.8	-3.7	-1.5	-1.9	-3.0	-3.2	-2.7	-2.2	-2.8	-3.0
Health satisfaction	1.8	2.3	5.5	-1.3	1.0	-1.2	-2.3	-1.7	0.3	-1.7	-0.9	-1.0	-2.3	-1.7	-1.4
Mean time to correctly identify matches	1.8	3.4	6.3	0.0	-1.2	2.4	1.2	2.5	2.2	1.9	1.5	1.7	2.5	1.8	1.7
Mineral and other dietary supplements	1.8	2.4	4.2	-1.2	0.6	-1.1	-2.0	-1.4	-1.8	-1.8	-1.0	-1.7	-1.3	-2.0	-1.9
Bipolar Disorder (2018)	1.7	2.7	6.5	1.3	-1.7	1.7	1.2	1.0	2.6	1.7	2.0	2.0	0.8	1.5	1.5
Heel T-Score	1.7	13.9	31.7	3.2	-5.6	0.1	5.5	1.6	3.6	2.7	4.9	5.5	3.3	1.6	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	3.5	-0.3	1.2	-1.9	-1.2	-1.7	-1.5	-1.7	-1.4	-1.9	-1.5	-1.5	-1.7
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	3.6	0.5	-0.9	1.8	1.0	1.1	1.8	1.6	1.2	1.4	0.6	1.7	1.9
Medication: Atenolol	1.7	2.1	4.6	-2.0	2.1	2.0	-0.7	2.1	0.4	0.7	-1.4	-0.7	1.6	1.5	0.5
Father’s age at death	1.7	2.3	5.1	2.3	-1.3	0.9	1.9	0.5	1.6	1.6	1.7	1.8	0.2	1.3	1.8
Number of children fathered	1.7	1.9	6.1	1.9	-2.5	0.0	1.3	-1.1	0.8	0.8	2.3	1.2	-1.2	0.0	0.8
Hypertension (Self-reported)	1.7	4.7	29.3	-5.4	3.0	0.6	-2.7	0.6	0.3	-1.0	-2.3	-1.8	0.1	0.0	-0.8
Medication: Gliclazide	1.7	1.9	4.8	-0.5	0.5	-1.5	-1.3	-2.0	-1.3	-1.4	-0.8	-1.0	-2.2	-1.5	-1.3
Leg fat percentage (left)	1.7	6.1	9.9	-0.9	1.6	-2.9	-2.6	-2.6	-2.2	-3.0	-2.0	-2.1	-2.5	-3.1	-3.1
Depressed Affect (Nagel 2018)	1.6	3.4	7.0	-2.3	2.6	-0.9	-1.9	-0.6	-2.0	-1.4	-2.6	-2.6	-1.0	-1.5	-1.3
High blood pressure	1.6	4.6	30.0	-5.5	2.9	0.8	-2.3	0.9	0.4	-0.7	-2.2	-1.7	0.5	0.3	-0.6
Pulse wave reflection index	1.6	2.0	4.5	1.6	-2.1	1.0	1.5	1.0	1.1	1.2	2.0	1.7	1.1	0.5	1.1
Myopia	1.6	2.3	5.3	-2.1	2.3	-0.7	-1.8	-0.6	-1.2	-1.2	-2.1	-1.9	-0.8	-0.6	-1.2
Average weekly spirits intake	1.5	1.9	3.6	-1.7	1.3	-0.9	-1.2	0.3	-1.5	-1.4	-1.6	-1.9	1.3	-1.1	-1.3
Length of working week for main job	1.5	1.6	3.9	-1.3	1.2	-0.5	-1.9	-1.0	-0.5	-1.1	-1.0	-2.0	-1.2	-1.3	-1.4
Birth weight of first child	1.5	2.6	5.0	-0.9	1.1	-1.5	-2.2	-2.0	-0.9	-1.8	-1.1	-1.6	-2.2	-1.4	-1.9
Hypothyroidism/myxoedema (self-reported)	1.5	3.0	6.3	-1.7	1.4	-1.3	-2.5	-1.2	-1.2	-2.2	-1.7	-1.4	-1.4	-2.0	-2.3
Number of self-reported non-cancer illnesses	1.5	2.7	9.5	-3.1	2.5	-0.3	-2.1	-0.1	-0.9	-1.1	-2.2	-2.1	-0.4	-0.6	-0.6
Eye problems/disorders: Glaucoma	1.5	1.7	3.8	0.5	0.6	-1.2	-1.5	-1.8	-1.2	-1.5	-0.6	-1.4	-2.0	-1.3	-1.4
Illnesses of father: High blood pressure	1.5	1.9	6.4	-2.5	2.3	0.9	-1.6	0.7	-0.2	-0.1	-1.8	-2.0	0.2	0.2	-0.1
Vascular/heart problems diagnosed by doctor	1.5	4.1	27.7	5.3	-2.7	-0.6	2.2	-0.6	-0.3	0.7	2.0	1.9	-0.2	-0.5	0.6
Intelligence (Savage-Jansen 2018)	1.4	4.2	6.9	1.4	-1.8	2.1	2.2	1.8	2.6	2.4	2.0	2.5	1.3	2.0	2.1
Trunk fat mass	1.4	5.9	11.1	-2.7	3.1	-1.5	-3.3	-1.5	-1.4	-2.4	-3.1	-2.4	-2.3	-2.1	-2.5
Qualifications: A levels/AS levels or equivalent	1.4	3.0	5.7	1.5	-1.6	1.6	1.8	0.1	2.2	2.0	2.2	1.6	-0.4	2.4	1.8
Chronic bronchitis/emphysema (mother)	1.4	1.6	3.7	-0.7	0.7	-1.9	-1.3	-1.5	-0.9	-1.8	-0.8	-0.8	-1.1	-1.4	-1.5
Angina (self-reported)	1.4	1.8	4.9	-2.1	2.2	-0.2	-1.5	-0.1	-0.7	-0.8	-1.9	-2.2	-0.0	-0.3	-1.0
Average weekly red wine intake	1.4	2.1	5.2	0.7	-0.1	-2.2	-0.3	-2.3	-1.9	-1.3	-0.4	-0.7	-2.1	-1.6	-1.1
Medication: Paracetamol	1.4	2.2	4.6	-0.8	0.6	2.1	0.5	2.1	1.5	1.7	0.1	0.1	1.7	2.0	2.1
Worry (Nagel 2018)	1.3	2.7	5.7	-1.3	2.0	-0.9	-2.4	-0.8	-1.4	-1.8	-2.0	-2.1	-1.1	-1.7	-1.4
LDL Cholesterol	1.3	2.1	3.4	-1.3	1.4	-1.3	-1.5	-1.0	-1.3	-1.4	-1.6	-1.9	-0.8	-1.7	-1.6
Rheumatoid Arthritis	1.3	1.8	6.2	1.0	-0.6	-2.1	-0.2	-2.5	-1.3	-1.3	0.4	-1.0	-1.9	-1.1	-1.0
Qualifications: CSEs or equivalent	1.3	1.7	5.1	-1.3	1.7	-0.7	-1.1	-0.5	-1.8	-1.0	-1.5	-2.2	-0.7	-1.1	-0.9
Illnesses of siblings	1.3	1.8	7.6	2.2	-2.8	0.0	0.8	-0.6	0.9	0.4	2.4	1.2	-0.3	-0.3	0.2
Qualifications: College or University degree	1.3	4.2	7.7	1.8	-1.4	2.4	2.0	0.7	2.7	2.7	2.0	1.7	-0.1	2.8	2.4
Leg fat mass (right)	1.3	5.1	7.1	-1.6	2.0	-2.4	-2.6	-2.2	-1.7	-2.5	-2.3	-1.9	-2.4	-2.6	-2.7
Illnesses of father: Heart disease	1.3	1.7	3.3	-0.4	1.7	-1.5	-0.9	-1.2	-1.4	-1.4	-1.6	-0.7	-1.4	-0.9	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.6	5.3	-2.3	0.3	-0.9	-1.6	-0.8	-1.2	-1.5	-0.7	-0.8	-0.8	-1.5	-1.2
Medication: Lisinopril	1.3	1.6	5.0	-2.2	1.8	1.4	-0.4	1.9	0.9	0.7	-1.4	0.2	1.3	0.7	0.9
Leg fat mass (left)	1.3	5.2	7.5	-1.2	1.8	-2.7	-2.4	-2.4	-1.9	-2.7	-2.2	-1.7	-2.6	-2.6	-2.7
Angina	1.2	1.6	4.4	-2.0	2.1	-0.0	-1.3	0.1	-0.6	-0.7	-1.7	-2.0	0.1	-0.1	-0.9
Maternal smoking around birth	1.2	1.8	3.0	-1.2	1.5	-0.9	-1.6	-0.4	-1.7	-1.5	-1.7	-1.5	-0.5	-1.4	-1.4
Fed-up feelings	1.2	2.3	3.9	-0.8	1.9	-1.4	-1.5	-1.3	-1.4	-1.4	-2.0	-1.6	-1.5	-1.4	-1.5
Stomach or abdominal pain in last month	1.2	1.6	2.8	-0.2	0.4	-1.5	-1.4	-1.6	-0.6	-1.6	-0.8	-0.8	-1.5	-1.7	-1.5
Waist circumference	1.2	4.3	7.8	0.1	0.9	-2.8	-1.8	-2.8	-1.9	-2.4	-1.4	-1.2	-2.8	-2.4	-2.5
Qualifications: None of the above	1.2	2.6	6.2	-1.5	0.6	-1.7	-1.9	-0.3	-1.5	-2.2	-1.3	-1.2	0.6	-2.5	-2.2
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.0	-0.1	-0.7	1.7	0.6	1.5	1.7	1.3	1.0	1.0	1.5	1.3	1.3
Whole body fat mass	1.2	4.9	8.0	-2.2	2.6	-1.8	-2.8	-1.6	-1.4	-2.4	-2.8	-1.9	-2.2	-2.1	-2.4
Eye problems/disorders: Cataract	1.2	1.4	4.5	2.1	-1.4	-1.0	-0.3	-1.7	0.4	-0.7	1.2	0.7	-1.6	-1.0	-0.9
Current tobacco smoking	1.1	1.8	4.9	0.7	-0.2	-1.8	-1.1	-1.6	-1.3	-1.7	-0.4	-0.2	-1.6	-2.2	-1.3
Supplements: Glucosamine	1.1	1.5	3.4	-0.2	1.1	-1.9	-0.8	-1.7	-1.1	-1.3	-1.1	-0.8	-1.7	-1.0	-0.9
Headache pain in last month	1.1	1.9	5.6	-0.9	0.7	2.3	0.1	1.0	1.2	1.7	0.2	-0.5	0.3	2.4	2.3
Mood swings	1.1	2.0	5.0	-2.1	2.2	-0.1	-1.4	0.3	-1.3	-0.6	-2.2	-2.0	0.2	-0.7	-0.4
Ever had bowel cancer screening	1.1	1.3	5.1	-2.2	1.3	1.2	-0.7	1.7	0.4	0.2	-1.1	0.1	1.4	0.6	0.3
Qualifications: nursing, teaching	1.1	1.8	5.3	-0.3	0.6	2.0	0.9	1.3	1.1	1.8	0.1	0.9	0.6	2.3	1.9
Smoking status: Current	1.1	1.8	4.8	0.9	-0.4	-1.9	-1.0	-1.6	-1.1	-1.6	-0.3	0.1	-1.7	-2.2	-1.2
Pain experienced in last month	1.1	1.8	4.7	1.1	-1.7	0.8	1.7	1.0	1.4	1.2	1.6	2.2	1.2	1.0	0.5
Major Depression (MDD)	1.0	1.2	3.8	1.9	-1.4	0.3	0.9	0.4	1.6	0.7	1.3	1.5	0.4	0.2	0.5
HDL Cholesterol	1.0	1.6	3.8	0.2	0.7	-1.3	-1.5	-1.8	-1.3	-1.2	-0.8	-1.0	-1.9	-1.3	-0.9
Lung FVC	1.0	4.9	14.9	2.5	-2.3	-0.0	3.9	2.0	0.3	1.6	1.3	3.1	3.2	1.3	1.4
Medication: Co-codamol	1.0	1.1	3.5	-1.6	1.9	0.8	-0.7	1.0	-0.7	0.2	-1.7	-1.0	0.8	0.3	0.4
Relative age voice broke	1.0	1.5	4.6	-0.2	-0.5	2.1	0.6	1.4	1.0	1.5	0.8	0.8	1.2	1.7	1.2
Alcohol usually taken with meals	1.0	1.6	5.4	2.3	-2.0	-0.8	1.0	-1.5	0.0	0.2	1.6	0.9	-1.3	-0.2	0.2
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	3.9	0.1	0.4	-1.4	-1.2	-1.8	-0.9	-1.3	-0.7	-1.2	-2.0	-1.4	-1.4
Fluid intelligence score	1.0	2.2	3.5	1.5	-1.8	1.6	1.3	1.1	1.7	1.6	1.9	1.4	0.8	1.1	1.4
Tense / ‘highly strung’	1.0	1.7	3.7	0.2	1.1	-1.0	-1.6	-1.5	-1.0	-1.3	-1.2	-1.5	-1.9	-1.2	-1.1
Ever highly irritable/argumentative for 2 days	1.0	1.2	4.4	-0.2	0.4	-1.3	-0.9	-1.7	-0.5	-1.2	-0.5	-0.2	-2.1	-1.2	-1.1
Comparative height size at age 10	1.0	5.4	14.9	-1.1	1.4	-2.8	-1.6	-3.9	-1.9	-2.2	-1.2	-3.0	-3.4	-0.7	-2.2
Medication: Aspirin	1.0	1.3	4.1	-2.0	1.9	0.4	-0.8	0.8	-0.7	-0.2	-1.6	-1.3	0.8	-0.1	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	1.7	1.2	-1.2	0.7	1.3	0.5	0.8	1.2	1.1	1.1	0.2	1.1	1.3
Ever smoked	1.0	1.7	2.9	-0.5	1.1	-1.6	-1.5	-1.1	-1.6	-1.6	-1.5	-0.7	-1.3	-1.7	-1.0
Depression (Nagel 2018)	0.9	1.4	3.0	-1.0	1.4	-1.0	-0.9	-0.6	-1.7	-1.1	-1.7	-1.6	-0.3	-1.0	-1.1
Chronotype (morning person)	0.9	2.0	5.2	-1.9	2.3	-0.0	-0.9	0.8	-1.7	-0.6	-2.3	-2.1	1.0	-0.1	-0.5
Systolic blood pressure, automated reading	0.9	2.6	14.6	-3.8	2.3	1.0	-1.6	1.5	0.7	-0.2	-1.8	-0.9	1.0	0.3	-0.3
Time employed in main current job	0.9	1.1	3.7	-1.9	1.2	1.3	-0.3	1.3	0.2	0.6	-0.6	-0.4	1.0	1.0	1.0
Medication: Paracetamol	0.9	1.5	4.0	-1.0	1.1	2.0	-0.2	1.7	1.2	1.3	-0.3	-0.5	1.0	1.5	1.6
Pulse wave peak to peak time	0.9	1.1	3.0	-1.3	1.7	-0.7	-1.1	-0.5	-0.5	-0.8	-1.7	-0.8	-1.1	-0.7	-0.8
Friendships satisfaction	0.9	1.1	3.4	-0.3	-0.0	1.3	0.5	1.1	1.8	1.3	0.3	0.7	0.7	1.1	1.4
Osteoporosis (self-reported)	0.9	1.1	2.8	1.7	-0.7	-1.3	-0.1	-1.5	-0.8	-0.7	0.4	-0.6	-1.4	-1.4	-0.7
Pain type(s) experienced in last month: Hip pain	0.9	1.2	4.3	0.7	0.1	-2.1	-0.1	-1.3	-1.8	-1.4	-0.5	-0.3	-0.5	-1.1	-0.7
Lung FEV1/FVC ratio	0.8	4.2	11.7	3.4	-3.2	0.1	2.4	-0.1	1.8	1.3	2.7	2.8	0.1	1.0	1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	5.5	0.8	-2.2	-0.1	2.3	0.4	0.9	1.4	1.7	1.6	1.2	0.4	1.4
Sitting height	0.8	5.7	16.2	-3.7	2.1	4.0	-0.9	2.5	2.6	2.3	-1.0	-0.9	0.6	2.9	2.2
Neuroticism score	0.8	1.7	3.8	-1.0	1.6	-0.7	-1.8	-0.8	-1.0	-1.3	-1.6	-2.0	-1.1	-1.3	-0.9
Arm fat percentage (right)	0.8	3.1	6.4	-2.0	2.2	-1.0	-2.5	-0.4	-0.9	-1.9	-2.5	-1.3	-1.0	-2.1	-1.9
Lung cancer (father)	0.8	0.9	2.5	-1.3	0.9	1.6	-0.2	1.5	0.8	0.7	-0.3	-0.2	1.1	0.9	0.6
High blood pressure (siblings)	0.8	1.2	4.8	-1.9	2.2	0.5	-0.2	1.0	0.0	0.3	-1.8	-0.2	0.6	0.9	0.4
Worry too long after embarrassment	0.8	1.3	4.7	-1.6	1.8	0.5	-2.2	0.3	0.2	-0.8	-1.4	-1.5	-0.3	-0.6	-0.6
Shortness of breath walking on level ground	0.8	0.9	2.8	-0.7	-0.2	-0.1	-1.7	-1.3	0.1	-0.9	0.3	-0.9	-1.7	-0.9	-0.8
Medication: Blood pressure	0.8	1.6	7.0	-2.7	1.2	1.5	-0.3	1.3	1.3	0.7	-0.5	0.0	0.9	1.5	0.7
Medication: Bendroflumethiazide	0.8	1.2	2.2	-1.4	0.7	1.1	0.5	1.5	0.9	1.0	-0.4	0.9	1.3	1.4	1.1
Ovarian Cancer	0.7	0.9	2.9	-0.4	-0.3	1.6	0.2	1.1	1.7	1.1	0.7	0.8	0.2	0.8	1.0
Diabetes (father)	0.7	0.8	2.9	0.9	0.9	-0.7	-0.8	-1.1	-0.6	-0.8	-0.7	-0.4	-1.7	-0.8	-0.7
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.0	-0.2	-0.1	1.4	0.8	1.3	1.0	1.1	0.3	0.4	1.4	1.0	0.4
Medication: Levothyroxine sodium	0.7	1.2	6.2	-2.5	1.4	0.0	-1.3	0.1	-0.1	-0.8	-1.3	-0.7	-0.2	-0.5	-1.1
Financial difficulties in last 2 years	0.7	1.0	1.3	-0.6	1.1	-0.9	-1.0	-0.8	-1.1	-1.1	-1.2	-1.0	-0.9	-1.2	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.3	-1.3	0.7	1.4	0.0	0.9	0.7	1.1	-0.2	-0.1	0.4	1.3	1.5
Depression (self-reported)	0.7	0.9	2.7	-1.2	1.6	0.1	-1.1	0.2	-0.6	-0.5	-1.3	-1.5	-0.3	-0.3	-0.3
Medication: Lansoprazole	0.7	0.8	2.0	-1.3	1.3	0.0	-1.2	0.5	-0.6	-0.6	-1.4	-0.9	0.3	-0.7	-0.4
Peak expiratory flow (PEF)	0.7	1.6	6.1	2.5	-1.9	-1.3	2.2	-0.8	-0.2	0.3	1.2	1.3	-0.4	0.1	0.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	2.3	1.1	-1.2	0.6	1.0	-0.5	0.9	1.0	1.5	1.0	-1.1	0.8	1.1
Comparative body size at age 10	0.7	1.8	4.7	2.1	-2.2	-1.1	1.9	0.2	0.5	0.2	1.5	1.9	1.2	-0.0	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.4	0.8	-1.0	1.1	0.5	0.7	1.6	0.9	1.4	0.8	0.3	0.8	1.0
Medication for pain relief, constipation, heartburn	0.7	1.1	4.2	2.0	-1.6	-1.3	0.9	-1.0	-0.3	-0.4	1.0	1.1	-0.5	-0.6	-0.5
Medication: Seretide 50 evohaler	0.7	0.8	1.4	-0.2	0.6	-1.2	-1.1	-1.0	-0.9	-1.2	-0.8	-0.7	-1.0	-0.7	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	3.5	-0.5	1.0	-0.9	-1.1	-1.7	-1.2	-1.0	-0.9	-1.8	-1.9	-0.5	-0.8
Medication: Aspirin	0.7	0.9	2.5	-1.6	1.6	-0.1	-0.5	0.4	-1.0	-0.4	-1.4	-1.2	0.6	-0.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	4.0	1.5	-0.7	0.3	2.0	1.1	0.4	1.2	0.6	1.1	1.7	1.1	1.3
Verbal and Numeric Reasoning (VNR)	0.6	1.5	2.4	0.2	-0.7	1.6	1.1	1.5	1.4	1.5	0.8	1.0	1.3	1.4	1.2
Coronary Artery Disease (CAD)	0.6	0.7	1.6	-0.8	0.9	-0.7	-0.9	-0.7	-0.7	-0.8	-0.8	-1.3	-0.5	-0.7	-0.8
Allergy or Eczema	0.6	1.5	3.3	1.2	-1.5	0.9	1.3	0.5	1.1	1.1	1.5	1.8	0.3	1.2	1.2
Hypothyroidism (self reported)	0.6	1.4	3.4	-0.7	0.5	-0.9	-1.8	-1.1	-0.3	-1.5	-0.8	-0.7	-1.5	-1.6	-1.6
Number of treatments/medications taken	0.6	1.1	6.0	-2.4	1.4	1.0	-0.9	1.1	0.8	0.3	-0.8	-0.2	0.8	0.5	0.7
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.5	1.1	-0.9	0.8	0.5	0.0	1.6	0.9	1.1	0.8	-0.5	0.5	0.8
Falls in the last year	0.6	0.9	3.2	0.1	0.3	-0.4	-1.5	-1.1	0.5	-0.9	-0.1	-0.6	-1.8	-1.1	-0.7
Mouth/teeth dental problems: Dentures	0.6	0.9	1.9	1.1	-1.4	-0.9	-0.5	-1.3	0.3	-0.8	1.0	0.3	-1.0	-1.2	-1.0
Exposure to tobacco smoke at home	0.6	0.7	1.6	-1.0	0.1	-0.6	-1.3	-0.7	0.1	-1.1	-0.1	-0.4	-0.6	-1.1	-1.1
Breastfed as a baby	0.6	0.7	2.0	1.1	-0.3	-1.4	0.1	-1.4	-0.8	-0.7	0.1	-0.2	-1.0	-0.8	-0.6
Number of full brothers	0.6	0.8	2.1	-0.6	0.2	-0.4	-1.3	-0.7	-0.9	-0.9	-0.4	-1.0	-0.7	-1.4	-1.1
Age at first live birth	0.6	1.0	4.2	0.6	0.5	0.9	1.2	0.5	0.5	1.3	-0.1	0.7	0.0	2.0	1.6
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.3	-1.1	0.6	-1.0	-0.8	-0.7	-0.5	-0.9	-0.9	-0.1	-1.0	-1.0	-0.5
Medication: Allopurinol	0.6	0.9	3.2	-1.4	0.9	0.7	0.5	1.6	0.6	0.5	-0.6	-0.0	1.8	0.4	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.8	-0.4	0.4	-0.9	-0.6	-0.4	-1.4	-0.9	-0.8	-0.8	-0.1	-1.3	-1.1
Number of full sisters	0.6	0.7	3.2	0.2	-1.0	0.5	0.7	1.0	0.9	0.7	0.7	0.7	1.8	0.4	0.5
Chest pain or discomfort	0.6	0.8	2.8	-1.7	1.6	1.0	-0.9	0.3	1.0	0.2	-0.7	-0.9	-0.6	0.5	0.3
Had major operations	0.6	0.7	2.1	-0.2	1.4	-0.4	-0.8	0.6	-1.1	-0.7	-1.5	-0.8	0.7	-0.4	-0.1
Family relationship satisfaction	0.6	0.7	2.7	0.5	-0.5	-1.1	-0.2	-1.6	-0.8	-0.6	0.2	-0.3	-1.6	-0.7	-0.4
Arm fat percentage (left)	0.6	2.3	4.4	-1.4	1.9	-1.0	-2.1	-0.5	-0.7	-1.6	-2.1	-0.9	-1.1	-1.8	-1.7
Long-standing illness, disability or infirmity	0.6	0.9	2.9	-1.7	1.4	-0.9	-1.0	-0.4	-0.5	-1.0	-1.3	-0.5	-0.4	-0.8	-0.8
Breast cancer (self-reported)	0.6	0.7	2.0	0.4	-0.6	0.2	1.1	0.9	0.5	0.7	0.6	1.1	1.4	0.7	0.8
Alcohol drinker status: Never	0.6	0.7	2.3	0.8	-1.4	-0.2	1.4	-0.2	0.1	0.5	1.5	0.3	0.5	0.4	0.7
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.8	0.2	-0.7	0.8	0.9	0.8	0.9	0.9	0.7	0.8	0.7	1.0	1.3
Unable to work because of sickness or disability	0.6	0.8	2.7	0.8	-0.6	-1.6	0.1	-1.7	-0.5	-0.9	0.4	0.1	-1.0	-0.5	-0.7
Bipolar Disorder or Schizophrenia	0.5	1.1	3.7	1.9	-1.1	-0.1	1.2	-0.1	1.3	0.5	1.2	1.8	-0.3	0.5	0.5
Alzheimer’s Disease (in mother)	0.5	0.6	2.1	0.5	-1.4	0.3	0.5	0.3	0.9	0.3	1.2	1.4	0.6	0.0	0.2
Alzheimer’s Disease (including proxy)	0.5	0.7	1.9	0.6	-1.4	0.4	0.8	0.3	1.0	0.6	1.3	1.3	0.6	0.5	0.4
Reaction Time	0.5	0.9	3.7	-1.0	0.1	1.3	0.2	1.7	0.7	0.7	0.1	0.2	1.9	0.6	0.4
Body Mass Index (BMI) (2010)	0.5	0.7	1.7	0.8	-0.7	0.7	0.9	0.6	1.1	0.9	0.6	1.3	0.4	0.9	0.5
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.1	-0.6	0.5	0.3	-1.4	-0.7	-0.1	0.1	-0.8	-0.9	-1.3	-0.5	-0.0
Sensitivity / hurt feelings	0.5	0.9	2.2	-0.1	0.6	-0.4	-1.3	-0.8	-0.9	-0.9	-0.8	-1.5	-1.2	-1.2	-0.8
Ever had hysterectomy (womb removed)	0.5	0.6	3.3	-1.8	0.9	0.5	-0.0	0.8	0.5	0.3	-0.7	-0.5	0.6	0.8	0.5
Number of incorrect matches in round	0.5	0.8	2.2	1.5	-1.3	0.5	0.4	0.1	1.4	0.3	1.4	1.0	-0.5	-0.3	0.1
Had other major operations	0.5	0.6	1.2	1.0	-0.1	0.4	1.0	0.7	0.2	0.8	0.4	0.8	0.9	1.1	0.9
Pulse rate	0.5	0.8	2.8	1.4	-1.6	-0.1	0.5	-0.8	0.7	0.2	1.7	0.7	-0.5	0.3	0.1
Pulse wave Arterial Stiffness index	0.5	0.6	1.8	0.8	-1.4	0.7	0.7	0.2	0.3	0.6	1.3	0.3	0.7	0.6	0.6
Arm fat mass (right)	0.5	2.2	4.0	-1.5	1.7	-1.3	-1.8	-0.8	-0.8	-1.6	-2.0	-0.7	-1.3	-1.7	-1.8
Wheeze or whistling in the chest in last year	0.5	0.9	2.7	-0.6	0.4	-0.2	-1.6	-1.0	0.0	-0.8	-0.1	-1.1	-1.6	-1.2	-0.6
Emphysema/chronic bronchitis	0.5	0.6	1.8	-1.2	0.7	-0.2	-1.3	-0.5	0.1	-0.7	-0.6	-0.9	-0.9	-0.7	-0.7
Pulse rate, automated reading	0.5	1.6	4.1	0.6	-2.0	1.4	0.4	0.8	1.7	1.0	1.9	1.6	0.9	0.7	0.8
Age at last live birth	0.5	0.8	2.2	0.7	-0.4	0.8	1.2	0.6	0.6	1.2	0.6	0.8	0.3	1.2	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.0	1.1	-1.4	-0.1	1.1	0.1	-0.2	0.4	1.1	0.5	1.0	0.3	0.6
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.2	-0.2	-0.6	1.5	0.2	1.4	1.1	0.8	0.7	1.0	1.0	0.6	0.8
Leg predicted mass (right)	0.5	2.5	8.3	1.1	-1.2	0.4	2.5	0.5	1.6	1.7	0.9	2.9	-0.0	1.9	1.6
Miserableness	0.5	0.8	2.9	-1.4	1.7	-0.0	-0.6	-0.1	-0.5	-0.2	-1.2	-1.7	-0.2	0.1	-0.0
Medication: Atorvastatin	0.5	0.7	1.4	0.3	0.8	-0.5	-1.0	-0.9	-1.2	-0.8	-0.9	-0.7	-1.2	-0.4	-0.5
Average weekly beer plus cider intake	0.5	0.7	1.5	-1.2	1.0	0.6	-1.0	1.0	-0.4	-0.3	-0.9	-1.0	0.9	-0.4	-0.3
Irritability	0.5	0.8	1.8	0.4	0.3	-1.2	-0.4	-1.0	-1.3	-0.9	-0.6	-1.0	-0.6	-1.4	-1.0
Heart disease (siblings)	0.5	0.6	2.2	-1.5	1.3	0.5	-0.6	0.6	-0.1	-0.0	-0.9	-0.8	0.4	0.3	-0.0
Alcohol drinker status: Previous	0.5	0.6	2.1	-1.0	0.5	0.5	0.8	1.1	0.2	0.5	-0.4	0.3	1.4	1.0	0.3
Schizophrenia (2018)	0.4	0.7	2.2	1.5	0.0	-1.5	0.6	-1.0	-0.4	-0.7	-0.1	0.8	-1.1	-0.6	-0.6
Crohns Disease (2012)	0.4	0.7	1.6	-0.8	0.6	-0.7	-1.1	-0.2	-0.8	-0.9	-0.8	-1.0	0.3	-1.3	-0.6
Schizophrenia (2014)	0.4	0.9	3.6	1.9	-0.3	-1.3	1.4	-0.7	-0.3	-0.1	0.3	1.5	-0.8	0.0	0.2
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.3	-0.2	0.7	-0.9	-0.5	-0.8	-0.9	-0.8	-0.9	-1.2	-0.6	-0.8	-0.9
Relative age of first facial hair	0.4	0.7	2.4	-0.4	-0.2	1.5	0.2	1.5	0.1	0.7	0.2	0.7	1.5	0.7	0.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.4	-0.7	0.7	-0.4	-0.4	-0.2	-1.2	-0.4	-1.0	-0.2	-0.2	-0.7	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.6	0.4	-1.5	-0.4	1.6	0.2	0.7	0.9	1.2	1.2	1.2	-0.1	0.7
Trunk fat-free mass	0.4	2.2	5.9	1.3	-1.7	-0.4	2.4	-0.7	1.0	1.3	1.4	2.4	-0.6	1.6	1.3
Hip circumference	0.4	1.7	3.4	-1.4	1.6	-1.1	-1.4	-1.0	-0.4	-1.2	-1.8	-0.5	-1.8	-0.9	-1.4
Trunk predicted mass	0.4	2.1	5.9	1.3	-1.6	-0.3	2.4	-0.6	1.0	1.3	1.3	2.4	-0.6	1.7	1.3
Standing height	0.4	4.2	10.8	-2.5	2.6	-0.0	-2.5	-2.1	-0.9	-0.7	-2.1	-3.3	-3.1	0.6	-0.6
Hair/balding pattern: Pattern 4	0.4	0.9	2.0	-1.2	1.4	1.0	-1.2	1.0	-0.5	-0.1	-1.2	-1.3	0.6	0.5	0.4
Blood clot in the leg (DVT)	0.4	0.5	1.2	-0.9	0.7	-0.3	-1.1	-0.4	-0.4	-0.7	-0.7	-0.9	-0.9	-0.5	-0.3
Gout (self-reported)	0.4	0.6	2.9	-0.9	1.7	0.2	-0.1	0.9	0.1	-0.0	-1.3	-0.4	0.6	0.0	-0.2
Migraine (self-reported)	0.4	0.5	1.8	-1.0	1.0	0.7	-1.4	-0.0	-0.1	-0.1	-0.8	-0.7	-0.5	0.0	0.7
Medication: Ibuprofen	0.4	0.4	1.4	-0.7	0.5	0.9	0.1	0.4	0.4	0.9	-0.2	-0.1	0.1	0.9	1.2
Leg fat-free mass (right)	0.4	2.4	8.2	1.0	-1.1	0.4	2.4	0.5	1.6	1.7	0.8	2.9	0.0	1.9	1.6
Illnesses of father: None of the above (group 1)	0.4	0.5	1.7	0.3	-1.3	0.3	0.8	0.6	0.1	0.4	1.0	0.5	0.9	0.1	0.6
Arm fat mass (left)	0.4	1.7	3.8	-1.4	1.7	-1.1	-1.5	-0.6	-0.6	-1.4	-1.9	-0.5	-1.2	-1.4	-1.5
Number of operations (self-reported)	0.4	0.6	1.7	0.1	0.6	0.4	0.7	1.1	0.3	0.7	-0.3	0.6	1.2	1.0	1.3
Risk taking	0.4	0.6	2.1	1.2	-1.5	0.2	1.2	-0.2	0.3	0.8	1.1	0.8	-0.2	-0.1	0.4
Ever depressed for a whole week	0.4	0.5	3.2	0.9	0.2	-0.7	-0.4	-1.2	-0.0	-0.3	-0.2	-0.0	-1.8	-0.3	0.1
Commuting to job workplace: Cycle	0.4	0.5	1.4	-0.0	-0.2	0.7	0.4	0.8	1.2	0.8	0.4	0.3	1.1	0.7	0.7
Pack years of smoking	0.4	0.6	1.8	0.8	-1.3	0.0	0.9	-0.4	0.5	0.4	1.3	0.9	0.2	0.7	-0.0
Crohns Disease (2017)	0.3	0.7	1.4	-0.9	0.4	-0.2	-1.0	0.2	-1.1	-0.9	-0.5	-1.2	0.9	-1.0	-0.8
Fasting Glucose	0.3	0.4	1.5	-0.4	0.3	0.5	-1.2	0.3	-0.2	-0.3	-0.4	-0.7	0.1	-0.9	-0.7
Lupus	0.3	0.4	1.1	1.0	-0.8	-0.1	0.9	0.1	0.8	0.3	1.0	0.7	0.2	0.2	0.3
Neuroticism (2016)	0.3	0.4	1.0	-0.6	1.0	-0.5	-0.8	-0.4	-0.5	-0.6	-1.0	-0.4	-0.9	-0.5	0.0
Ulcerative Colitis	0.3	0.4	1.2	-0.8	1.0	-0.3	-0.5	0.2	-0.4	-0.3	-1.1	-0.9	0.8	-0.1	-0.2
Height	0.3	5.5	15.1	-2.8	2.8	0.3	-2.5	-2.8	-0.7	-0.4	-1.9	-3.9	-3.9	1.2	-0.3
Respiratory disease	0.3	0.6	1.9	-1.4	1.0	-0.4	-0.9	-0.1	-0.1	-0.7	-0.8	-1.0	0.2	-0.3	-0.9
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	2.1	1.0	-0.1	-1.4	0.7	-0.7	-0.6	-0.5	-0.0	0.5	-0.2	-0.2	-0.1
Severe depression (siblings)	0.3	0.3	1.0	-1.0	0.7	0.6	-0.7	0.6	0.5	0.0	-0.4	-0.3	0.3	-0.0	0.4
Taking other prescription medications	0.3	0.5	1.2	-1.1	0.8	-0.8	-0.7	-0.4	-0.6	-0.7	-0.7	-0.6	0.2	-0.6	-0.2
Hair/balding pattern: Pattern 2	0.3	0.4	1.9	0.7	-1.4	-0.3	0.3	-0.7	0.2	-0.0	1.2	0.2	-0.3	-0.4	-0.3
Had menopause	0.3	0.4	1.3	-1.2	0.8	-0.0	-0.6	0.8	-0.2	-0.6	-0.5	-0.3	0.8	-0.2	-0.0
Mouth/teeth dental problems	0.3	0.5	1.8	-0.4	1.4	-0.4	0.9	0.3	-0.7	0.4	-1.2	-0.3	0.6	0.8	0.3
Allergy	0.3	0.6	2.4	-0.7	0.3	0.6	0.5	1.3	0.9	0.6	-0.2	0.1	1.5	0.6	0.4
Medication: Ramipril	0.3	0.4	2.5	-1.6	0.3	0.3	-0.6	-0.5	0.3	-0.0	0.2	-0.6	-0.7	0.3	-0.3
Weight	0.3	1.3	3.9	-0.8	0.9	-1.5	-0.8	-1.6	-0.6	-1.1	-1.2	-0.3	-2.0	-0.9	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.9	-0.8	0.3	1.4	-0.1	0.8	0.6	0.7	-0.1	-0.2	0.6	0.7	0.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.5	1.8	-1.4	0.2	1.1	-1.2	0.4	0.4	-0.1	0.1	-0.5	-0.5	0.0	0.3
Birth weight	0.3	0.6	2.1	0.1	0.8	-0.7	-1.0	-1.1	-0.4	-0.7	-0.9	-0.6	-1.4	-0.1	-0.4
Arm fat-free mass (right)	0.3	1.5	3.6	1.3	-1.3	-1.3	1.7	-1.4	0.4	0.4	0.9	1.9	-1.5	0.7	0.3
Exposure to tobacco smoke outside home	0.3	0.4	1.7	-1.3	1.1	-0.1	-0.4	0.6	-0.1	-0.5	-1.0	0.2	0.5	-0.1	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.1	0.6	0.7	-0.4	1.0	-0.1	-0.3	0.5	-0.5	0.5	-0.3	0.8	0.6
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.0	-0.4	0.5	0.9	0.1	1.0	0.8	0.6	-0.2	0.0	0.8	0.8	0.2
Whole body fat-free mass	0.3	1.9	6.1	1.0	-1.3	-0.2	2.2	-0.3	1.1	1.3	1.0	2.5	-0.5	1.6	1.3
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.1	1.1	-0.9	-0.3	0.3	-0.5	0.2	-0.0	0.6	0.6	-0.4	-0.7	-0.4
Whole body water mass	0.3	1.9	6.0	0.9	-1.3	-0.1	2.3	-0.1	1.1	1.4	1.0	2.5	-0.4	1.7	1.3
Wears glasses or contact lenses	0.3	0.3	1.4	-0.2	0.0	0.7	0.3	0.8	0.1	0.6	0.1	-0.3	1.2	0.5	0.6
Hearing aid user	0.3	0.3	0.9	0.2	0.2	-0.8	-0.2	-1.0	-0.5	-0.5	-0.2	-0.2	-0.9	-0.5	-0.4
Fractured/broken bones in last 5 years	0.3	0.4	1.7	0.5	0.0	-0.0	-1.1	-0.4	-0.3	-0.6	-0.2	-0.3	-1.3	-0.9	0.0
Diastolic blood pressure, automated reading	0.3	1.0	4.3	-0.5	-1.2	1.1	0.0	0.6	2.1	0.7	1.3	1.2	0.3	0.3	0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.3	0.5	-0.7	0.0	1.1	0.4	-0.1	0.4	0.7	0.9	0.7	0.5	0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.0	-0.7	0.6	-0.3	-1.0	-0.4	-0.5	-0.7	-0.6	-0.9	-0.8	-0.5	-0.3
Ulcerative Colitis (UC)	0.2	0.4	1.4	0.5	-0.2	0.7	0.4	0.8	0.8	0.5	0.3	0.2	1.2	0.6	0.3
Age at First Birth	0.2	0.3	0.9	0.7	-1.0	0.1	0.8	0.1	-0.1	0.5	0.7	0.4	0.6	0.3	0.4
Mean Putamen Volume	0.2	0.2	0.7	0.2	-0.4	0.8	0.2	0.3	0.5	0.5	0.5	0.1	0.1	0.7	0.5
Hearing difficulty/problems: Yes	0.2	0.4	1.1	0.2	0.5	-0.4	-0.5	-0.7	-1.0	-0.7	-0.5	-0.7	-0.8	0.0	-0.3
Pack years adult smoking proportion	0.2	0.3	0.9	0.5	-0.9	-0.4	0.4	-0.8	0.1	-0.1	0.9	0.2	-0.2	0.2	-0.6
Leg fat-free mass (left)	0.2	1.1	3.9	0.2	-0.4	0.3	1.5	0.3	1.2	1.2	0.2	2.0	-0.3	1.4	1.1
Age when periods started (menarche)	0.2	0.6	2.9	-1.7	0.5	0.9	-1.3	0.8	0.6	-0.1	-0.5	-0.2	0.4	-0.0	0.0
Serious illness, injury or assault to yourself	0.2	0.2	0.5	-0.3	-0.2	0.3	0.3	-0.2	0.7	0.4	0.5	0.5	-0.5	0.7	0.6
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.5	1.2	-0.9	-0.1	0.3	-0.9	-0.3	0.2	0.7	0.5	-1.1	0.0	0.2
Body mass index (BMI)	0.2	0.7	2.5	0.4	-0.3	-1.6	0.3	-0.6	-0.2	-0.8	-0.3	1.3	-0.6	-1.2	-1.0
Leg predicted mass (left)	0.2	1.0	3.8	0.1	-0.3	0.3	1.4	0.3	1.2	1.1	0.1	2.0	-0.3	1.4	1.1
Heart attack	0.2	0.3	0.9	0.3	-0.5	0.1	0.9	0.4	-0.1	0.3	0.5	0.6	0.8	0.5	0.4
Pain all over the body in last month	0.2	0.2	0.4	0.1	0.5	0.1	0.6	0.6	0.2	0.4	-0.4	0.5	0.6	0.7	0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.0	0.8	-0.5	0.3	0.5	-0.2	-0.0	0.6	0.7	0.3	-0.1	0.6	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.6	-0.1	0.7	-0.5	-0.5	-0.4	-0.4	-0.5	-0.7	-0.4	-0.7	-0.6	0.2
Prospective memory result	0.2	0.2	0.9	-0.1	0.1	0.5	0.0	0.9	0.6	0.2	-0.2	0.6	0.9	0.0	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.9	-0.2	0.4	-0.8	-0.4	-0.5	-1.0	-0.9	-0.4	-0.9	-0.2	-0.5	-0.4
Medication: Omeprazole	0.2	0.3	1.3	0.5	-0.6	-0.7	0.5	-0.2	-0.2	-0.2	0.4	-0.2	1.1	0.1	-0.3
Arm predicted mass (right)	0.2	1.1	3.0	0.8	-1.0	-1.2	1.6	-1.3	0.3	0.3	0.6	1.7	-1.4	0.7	0.2
Supplements: Vitamin C	0.2	0.2	0.5	0.7	-0.5	0.2	0.5	-0.3	-0.2	0.4	0.7	0.4	-0.5	0.5	0.6
Commuting to job workplace: Walk	0.2	0.2	0.6	-0.5	0.7	0.1	-0.8	-0.2	0.5	-0.4	-0.2	-0.6	-0.2	0.1	-0.5
Average weekly champagne plus white wine intake	0.2	0.3	0.9	0.1	-0.6	1.0	0.3	0.6	0.3	0.5	0.7	-0.3	0.7	0.7	0.1
Mother’s age at death	0.2	0.2	0.4	0.2	-0.6	0.4	0.4	0.4	0.3	0.4	0.5	0.3	0.7	0.5	0.4
Financial situation satisfaction	0.2	0.3	1.3	-0.2	0.0	-0.1	-0.6	-0.8	0.4	-0.2	0.2	-0.6	-1.2	-0.6	-0.5
Basal metabolic rate	0.2	0.8	3.3	0.5	-0.7	-0.5	1.5	-0.6	0.7	0.7	0.3	1.8	-0.9	1.0	0.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.8	0.5	-0.7	-0.5	0.4	-0.1	0.1	-0.1	0.6	-0.0	0.9	-0.0	-0.3
Supplements: Calcium	0.2	0.3	1.0	-0.9	1.0	-0.2	-0.1	0.2	-0.4	-0.2	-0.8	-0.4	0.1	-0.0	-0.2
Irritable Bowel Disease (IBD)	0.1	0.3	2.2	0.1	-0.0	0.5	-0.0	0.9	0.1	0.1	0.1	-0.3	1.5	-0.0	0.0
Triglycerides	0.1	0.2	0.8	-0.9	0.2	0.5	-0.0	0.8	0.3	0.1	-0.2	-0.4	0.9	0.0	-0.2
BMI	0.1	0.5	2.2	0.1	-0.4	-0.7	0.3	0.4	0.7	-0.3	-0.2	1.5	0.4	-1.1	-0.7
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.4	0.6	0.5	0.1	-0.6	0.2	-0.2	-0.4	-0.4	0.3	-0.3	-0.4	-0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	0.4	0.6	-0.3	0.1	-0.2	-0.6	-0.2	-0.3	-0.1	-0.2	-0.2	-0.1
Nervous feelings	0.1	0.2	0.7	-0.3	0.6	0.2	-0.9	0.1	-0.1	-0.4	-0.4	-0.8	0.0	-0.4	-0.2
Forced vital capacity (FVC)	0.1	0.3	1.0	-0.1	0.7	-0.6	0.6	0.2	-0.9	-0.0	-1.0	-0.3	0.4	0.3	-0.1
Worrier / anxious feelings	0.1	0.2	0.7	-0.2	0.3	0.6	-0.9	0.4	0.3	-0.3	-0.1	-0.4	0.1	0.0	0.5
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	-0.4	0.7	0.2	0.2	0.2	0.3	0.3	-0.6	0.3	-0.1	0.5	0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.5	1.0	0.0	-1.0	1.2	-0.3	-0.9	0.0	-0.5	0.1	0.2	0.3	-0.1
Asthma	0.1	0.2	0.7	0.0	0.3	-0.8	-0.3	-0.6	-0.3	-0.6	-0.1	-0.4	-0.3	-0.5	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.7	0.5	0.4	-0.8	0.6	-0.1	-0.6	-0.1	-0.8	-0.2	-0.0	0.0	-0.2
Forced vital capacity (FVC), Best measure	0.1	0.3	1.2	-0.2	0.9	-0.4	0.3	0.1	-0.7	-0.1	-1.1	-0.6	0.1	0.3	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.4	-0.1	-0.4	-0.1	-0.6	-0.4	0.1	-0.4	0.4	-0.5	-0.1	-0.2	-0.2
Alcohol intake frequency.	0.1	0.1	0.6	-0.6	0.1	0.0	0.8	-0.0	-0.3	0.5	-0.0	-0.1	0.1	0.5	0.1
Back pain experienced in last month	0.1	0.2	0.7	0.3	0.0	-0.7	0.2	-0.3	-0.9	-0.2	-0.3	-0.5	0.3	-0.3	0.4
Asthma (self-reported)	0.1	0.1	0.4	-0.3	0.3	-0.6	-0.2	-0.5	-0.0	-0.4	-0.1	-0.3	-0.2	-0.3	-0.3
Arm fat-free mass (left)	0.1	0.7	2.6	0.3	-0.7	-0.9	1.3	-0.9	0.3	0.3	0.3	1.6	-1.2	0.6	0.2
Arm predicted mass (left)	0.1	0.8	2.6	0.4	-0.8	-0.8	1.4	-0.9	0.3	0.4	0.4	1.6	-1.1	0.7	0.4
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.0	3.7	0.8	-0.7	0.5	1.9	0.9	0.3	1.1	1.1	0.1	1.3	1.1	0.7
Tanning	0.0	0.2	0.6	-0.7	0.2	0.4	-0.6	0.2	0.6	-0.3	0.1	0.1	-0.5	-0.3	-0.4

Hub : Genes

SENP1

Models

Trait associations