TWAS hub - HDAC7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Head and Neck Squamous Cell Carcinoma	0.0516	0.0245	0.0015	0.015	0.015	0.001	NA	0.008	0.0069	0.0075	0.2300	NA	0.036
2	TCGA	Brain Lower Grade Glioma	0.0604	0.0270	0.0031	0.004	0.014	0.014	NA	0.016	0.0980	0.0088	0.0087	NA	0.005

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Allergy	7.9	18.1	24.4	4.9	3.4
Asthma (self-reported)	7.2	14.4	18.8	-4.3	-3.2
High blood pressure	7.1	19.8	33.8	-5.8	-2.4
Blood Platelet Count	7.0	80.9	161.3	12.7	0.8
Respiratory disease	7.0	15.6	18.8	-4.3	-3.5
Asthma	6.9	13.6	17.0	-4.1	-3.2
Medication: Ventolin 100micrograms inhaler	6.6	8.4	10.4	-2.6	-3.2
Loneliness, isolation	6.2	8.6	10.8	-3.3	-2.5
Hypertension (Self-reported)	6.0	16.6	29.7	-5.4	-1.9
Mouth/teeth dental problems: Loose teeth	5.9	7.0	12.1	-3.5	-1.4
Number of self-reported non-cancer illnesses	5.8	10.0	18.8	-4.3	-1.1
Systolic Blood Pressure	5.6	27.9	55.5	-7.5	-0.6
Taking other prescription medications	5.3	8.2	10.8	-3.3	-2.4
Fractured/broken bones in last 5 years	5.2	6.7	12.9	3.6	0.6
Commuting to job workplace: Car/motor vehicle	5.1	5.8	11.0	0.8	3.3
Hayfever/allergic rhinitis (self-reported)	4.8	6.4	9.8	-3.1	-1.7
Systolic blood pressure, automated reading	4.7	13.8	27.5	-5.2	0.3
Allergy or Eczema	4.6	12.0	18.6	-4.3	-2.4
Average weekly spirits intake	4.5	5.5	6.9	2.6	2.0
Vascular/heart problems diagnosed by doctor	4.5	12.3	21.8	4.7	1.7
Hayfever, allergic rhinitis or eczema	4.2	9.1	13.6	-3.7	-2.1
Exposure to tobacco smoke at home	3.9	4.4	6.7	1.4	2.6
Diastolic blood pressure, automated reading	3.8	11.7	22.8	-4.8	0.8
Commuting to job workplace: Cycle	3.7	4.4	8.8	0.2	-3.0
Medication: Aspirin	3.4	4.5	4.9	2.2	2.0
Medication: Blood pressure	3.3	6.3	12.6	-3.6	0.0
Medication: Aspirin	3.2	4.2	4.7	2.2	1.9
Bipolar Disorder (2018)	3.1	4.9	8.1	2.8	1.3
Medication: Levothyroxine sodium	3.1	5.3	6.1	-2.5	-2.1
Mean Putamen Volume	3.0	3.4	5.1	-1.3	-2.3
Ever highly irritable/argumentative for 2 days	2.9	3.5	6.6	-2.6	-0.6
Illnesses of father: High blood pressure	2.9	3.6	6.4	-2.5	-0.9
Number of treatments/medications taken	2.8	5.1	6.4	-2.5	-1.9
Shortness of breath walking on level ground	2.8	3.4	4.0	-2.0	-1.7
Basal cell carcinoma (self-reported)	2.8	3.3	4.2	2.1	1.5
Bipolar Disorder or Schizophrenia	2.7	6.6	8.2	2.2	2.9
Alzheimer’s Disease (in mother)	2.6	3.1	5.3	-2.3	0.9
Cardiovascular Disease	2.6	8.4	15.2	-3.9	-1.3
Age at first live birth	2.6	4.7	8.7	3.0	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.6	5.5	10.2	3.2	0.9
Medication: Atorvastatin	2.6	3.2	6.4	2.5	-0.3
Schizophrenia vs Biploar Disorder	2.5	3.3	5.8	-2.4	-0.8
Lung FEV1/FVC ratio	2.5	12.6	17.6	4.2	2.8
Medication: Co-codamol	2.5	2.9	5.3	-2.3	-0.7
Alcohol drinker status: Previous	2.5	2.8	3.7	-1.4	-1.9
Illnesses of mother	2.4	2.9	4.8	2.2	1.0
Prospective memory result	2.3	2.8	5.4	0.4	2.3
Health satisfaction	2.3	3.0	5.5	-2.3	-0.8
Alcohol intake frequency.	2.3	5.3	10.4	-3.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	2.3	3.7	3.9	1.9	2.0
Diabetes (mother)	2.2	2.8	5.3	-2.3	0.6
Supplements: Vitamin C	2.2	2.6	3.6	-1.3	1.9
Supplements: Zinc	2.1	2.3	4.6	-0.1	-2.1
Pulse rate	2.1	3.5	4.0	1.7	2.0
Wheeze or whistling in the chest in last year	2.1	3.8	5.1	-2.3	-1.5
Alzheimer’s Disease (in father)	2.0	2.1	3.3	1.8	1.0
Loud music exposure frequency	2.0	2.1	3.4	0.9	1.8
Medication: Ibuprofen	2.0	2.3	3.9	2.0	-0.9
Handedness (chirality/laterality): Left-handed	2.0	2.4	4.3	0.7	2.1
Ulcerative Colitis (UC)	1.9	3.6	6.9	2.6	-0.5
Schizophrenia (2014)	1.9	4.1	8.1	0.3	2.8
Average weekly fortified wine intake	1.8	2.1	2.6	1.2	-1.6
Alcohol usually taken with meals	1.8	2.9	3.8	-1.9	-1.4
Medication: Blood pressure	1.8	3.2	4.6	-2.1	-1.3
Schizophrenia (2018)	1.7	3.5	6.8	0.5	2.6
Severe depression (siblings)	1.7	1.9	3.1	-1.8	-0.8
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	3.1	-1.8	-1.6
Breastfed as a baby	1.7	2.0	2.1	1.4	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	3.9	-2.0	-0.2
Alzheimer’s Disease (including proxy)	1.6	2.4	4.1	-0.8	2.0
Ovarian Cancer	1.6	2.1	3.0	1.1	1.7
High blood pressure (mother)	1.6	2.3	3.1	-1.2	-1.8
Medication: Amlodipine	1.6	2.2	3.4	-1.8	-1.0
Qualifications: College or University degree	1.6	4.9	9.2	3.0	0.8
Wears glasses or contact lenses	1.6	1.9	3.7	-1.9	0.1
Medication: Bendroflumethiazide	1.6	2.4	4.1	-0.8	-2.0
Medication: Lisinopril	1.6	2.1	2.8	-1.7	-1.2
Heart disease (siblings)	1.6	1.9	3.1	-0.9	1.7
Type 2 Diabetes (T2D) (2012)	1.5	1.8	3.4	1.8	-0.4
Ulcerative Colitis	1.5	2.1	2.8	1.7	-1.2
Happiness	1.5	1.8	3.6	0.2	-1.9
Gout (self-reported)	1.5	2.0	3.7	-1.9	-0.5
Number of full brothers	1.5	1.9	2.1	1.5	1.3
Overall health rating	1.5	3.3	6.0	-2.4	-0.7
Long-standing illness, disability or infirmity	1.5	2.2	4.3	-2.1	0.4
Osteoarthritis (self-reported)	1.5	2.0	2.9	-1.7	-1.0
Fed-up feelings	1.4	2.6	3.5	-1.9	-1.3
Chronic bronchitis/emphysema (father)	1.4	1.7	3.3	-1.8	0.1
Qualifications: None of the above	1.4	3.1	6.0	-2.5	0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	3.3	1.8	-0.2
Heart disease (mother)	1.4	1.7	2.0	-1.2	1.4
Pack years of smoking	1.4	2.1	3.2	-1.8	1.0
Pack years adult smoking proportion	1.3	2.0	3.1	-1.8	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	2.3	-1.5	-1.0
Multivitamins +/- minerals	1.3	1.7	2.0	1.4	1.2
Past tobacco smoking	1.3	2.4	2.6	-1.6	-1.5
Glaucoma (self-reported)	1.3	1.5	3.0	0.2	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	1.7	-1.3	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.8	5.3	-0.5	-2.3
Commuting to job workplace: Public transport	1.3	1.6	3.0	0.5	-1.7
Risk taking	1.3	1.9	3.3	0.7	1.8
Ever had hysterectomy (womb removed)	1.2	1.3	2.7	-1.6	-0.1
Medication: Metformin	1.2	1.7	3.3	-1.8	-0.2
Number of children fathered	1.2	1.4	2.0	1.4	0.9
Medication: Allopurinol	1.2	1.6	2.3	-1.5	0.9
Illnesses of father: Heart disease	1.2	1.7	2.9	-1.7	-0.7
Mother’s age at death	1.2	1.5	2.5	-0.7	-1.6
Supplements: Fish oil (including cod liver oil)	1.2	1.5	1.6	1.3	1.2
Depressed Affect (Nagel 2018)	1.1	2.4	4.5	-2.1	-0.6
Vitamin and mineral supplements	1.1	1.5	2.6	-0.7	-1.6
Maternal smoking around birth	1.1	1.5	2.8	-0.6	1.7
Supplements: Glucosamine	1.1	1.4	2.6	-0.5	-1.6
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	2.2	1.5	-0.6
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	2.6	-1.6	-0.6
Pulse rate, automated reading	1.1	3.7	6.1	1.1	2.5
Age at last live birth	1.1	1.5	3.1	1.8	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.7	0.1	1.6
Osteoporosis (self-reported)	1.1	1.3	2.7	1.6	0.0
Heart attack/myocardial infarction (self-reported)	1.1	1.4	1.5	1.2	1.1
Depression (Nagel 2018)	1.0	1.5	2.9	-1.7	-0.1
Townsend deprivation index at recruitment	1.0	1.4	1.6	-1.1	-1.3
Heart attack	1.0	1.2	1.4	1.2	1.1
Impedance of arm (right)	1.0	4.7	8.6	2.9	0.9
Time employed in main current job	1.0	1.2	2.3	-1.5	-0.1
Mouth/teeth dental problems: Dentures	1.0	1.7	1.8	-1.3	1.3
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	2.1	1.5	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.2	-1.5	0.9
Eye problems/disorders: None of the above	1.0	1.2	2.0	1.4	0.6
Smoking status: Previous	1.0	1.5	1.7	1.3	1.1
Mood swings	1.0	1.8	3.5	-1.9	0.1
Medication: Gliclazide	1.0	1.1	1.7	-1.3	-0.6
Ever smoked	1.0	1.8	2.7	1.6	0.9
Pain experienced in last month	1.0	1.6	2.9	-0.6	-1.7
Reaction Time	0.9	1.7	1.7	-1.3	1.3
Height	0.9	17.9	22.3	-3.7	-4.7
Hearing difficulty/problems: Yes	0.9	1.3	2.0	1.4	0.8
Age when periods started (menarche)	0.9	2.1	3.8	2.0	-0.6
Stomach or abdominal pain in last month	0.9	1.1	1.2	-1.1	-1.0
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	5.7	2.4	-0.7
Arm fat-free mass (right)	0.9	4.4	5.8	-2.4	-1.7
Comparative body size at age 10	0.9	2.4	4.7	0.4	2.2
Arm predicted mass (right)	0.9	4.8	6.2	-2.5	-1.9
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.0	1.4	-0.4
Major Depression (MDD)	0.8	1.0	1.9	1.4	0.0
Verbal and Numeric Reasoning (VNR)	0.8	1.8	2.7	1.6	-1.0
Relative age voice broke	0.8	1.2	2.3	-1.5	-0.4
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.8	1.4	0.2
Trunk fat-free mass	0.8	4.3	6.9	-2.6	-1.3
Medication: Lansoprazole	0.8	0.9	1.0	-1.0	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	4.9	2.2	-0.5
Impedance of arm (left)	0.8	3.6	7.0	2.6	0.4
Trunk predicted mass	0.8	4.7	7.4	-2.7	-1.4
Tense / ‘highly strung’	0.8	1.2	1.5	-1.0	1.2
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.4	-1.2	-0.6
Migraine (self-reported)	0.8	1.0	1.8	-0.5	-1.4
Ever had bowel cancer screening	0.8	1.0	1.7	-0.4	1.3
Illnesses of father: None of the above (group 1)	0.8	0.9	1.8	1.3	0.3
Eye problems/disorders: Glaucoma	0.8	1.0	2.0	0.1	-1.4
Arm fat-free mass (left)	0.8	4.0	6.2	-2.5	-1.4
Average weekly beer plus cider intake	0.8	1.2	2.4	1.6	0.1
Supplements: Calcium	0.8	0.8	1.7	-0.1	1.3
Waist Hip Ratio (WHR)	0.7	3.1	4.4	1.4	-2.1
Type 2 Diabetes (T2D) (2018)	0.7	1.4	1.6	-1.1	1.3
Lung FVC	0.7	3.7	7.3	2.7	0.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.3	-1.1	0.6
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.3	-0.4	1.1
Sitting height	0.7	4.6	5.8	-1.9	-2.4
Hearing difficulty/problems with background noise	0.7	1.1	1.8	1.4	0.7
Falls in the last year	0.7	0.9	1.0	1.0	0.9
Qualifications: A levels/AS levels or equivalent	0.7	1.5	3.0	1.7	-0.0
Pulse wave reflection index	0.7	0.9	1.1	-0.8	-1.0
High blood pressure (siblings)	0.7	1.0	1.2	-1.1	0.9
Family relationship satisfaction	0.7	0.8	1.5	-1.2	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.5	-1.2	-0.2
Friendships satisfaction	0.7	0.8	1.4	0.4	-1.2
Commuting to job workplace: Walk	0.7	0.8	1.5	1.2	-0.0
Financial situation satisfaction	0.7	0.8	1.5	-1.2	-0.4
Arm predicted mass (left)	0.7	3.7	4.9	-2.2	-1.6
Coronary Artery Disease (CAD)	0.6	0.7	0.9	0.7	-1.0
Fasting Glucose	0.6	0.7	1.4	-1.2	-0.1
Rheumatoid Arthritis	0.6	0.8	1.3	0.6	-1.1
Triglycerides	0.6	1.0	1.9	-1.4	-0.3
Smoking Status	0.6	1.4	1.5	1.2	1.1
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.2	-1.1	-0.7
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.2	1.1	-0.6
Current tobacco smoking	0.6	1.0	1.9	-1.4	-0.4
Serious illness, injury or assault to yourself	0.6	0.7	0.8	-0.9	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.3	-0.8	-1.1
Mouth/teeth dental problems	0.6	0.9	1.5	1.2	-0.6
Medication: Ramipril	0.6	0.8	1.1	-1.0	-0.7
Father’s age at death	0.6	0.8	1.3	0.5	-1.2
Peak expiratory flow (PEF)	0.6	1.5	2.4	-0.8	-1.5
Worry too long after embarrassment	0.6	1.1	1.1	1.0	-1.1
Neck or shoulder pain in last month	0.6	0.9	1.7	-1.3	-0.3
Mean time to correctly identify matches	0.6	1.1	2.2	-1.5	-0.2
Mineral and other dietary supplements	0.6	0.8	1.2	-1.1	-0.6
Whole body water mass	0.6	3.6	4.7	-2.2	-1.6
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.1	-1.1	-0.5
Neuroticism (Nagel 2018)	0.5	1.1	2.1	-1.5	-0.2
Irritable Bowel Disease (IBD)	0.5	1.3	1.8	1.4	-0.8
Age at First Birth	0.5	0.7	1.4	0.1	-1.2
Crohns Disease (2012)	0.5	0.9	1.4	1.2	0.6
HbA1C	0.5	0.5	1.0	1.0	0.2
Chronotype (morning person)	0.5	1.1	2.0	-1.4	-0.4
Medication for hormone replacement therapy	0.5	0.6	0.9	0.9	-0.5
Qualifications: CSEs or equivalent	0.5	0.6	0.7	0.9	0.8
Nervous feelings	0.5	0.9	1.7	1.3	0.2
Forced vital capacity (FVC)	0.5	1.8	1.9	1.4	-1.3
Fluid intelligence score	0.5	1.1	2.1	1.5	-0.4
Hair/balding pattern: Pattern 3	0.5	0.7	1.2	-0.4	1.1
Standing height	0.5	5.3	9.1	-1.2	-3.0
Medication for pain relief, constipation, heartburn	0.5	0.8	1.3	-1.1	-0.6
Medication: Seretide 50 evohaler	0.5	0.5	0.8	-0.9	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	0.9	-0.9	0.5
Comparative height size at age 10	0.5	2.9	4.2	-2.0	-1.3
Suffer from ‘nerves’	0.5	0.8	1.0	-1.0	-0.8
Had major operations	0.5	0.5	1.1	1.0	-0.1
Whole body fat-free mass	0.5	3.0	4.1	-2.0	-1.4
Diabetes diagnosed by doctor	0.5	0.7	1.3	-1.1	0.5
Smoking status: Current	0.5	0.7	1.2	-1.1	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.8	-0.9	-0.7
Intelligence (Savage-Jansen 2018)	0.4	1.1	1.8	1.4	-0.6
LDL Cholesterol	0.4	0.6	0.6	0.8	-0.8
Blood White Count	0.4	3.3	4.6	-2.1	1.4
Hypothyroidism (self reported)	0.4	0.8	1.6	0.1	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.2	-0.8	1.1
Medication: Atenolol	0.4	0.5	0.6	-0.6	-0.8
Hair/balding pattern: Pattern 2	0.4	0.5	0.9	-1.0	0.1
Diabetes (self-reported)	0.4	0.5	0.9	-0.9	0.5
Arm fat percentage (right)	0.4	1.5	2.3	0.9	1.5
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.1	-0.2	-1.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	0.8	0.9	0.7
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.4	-0.3	-1.2
Pulse wave peak to peak time	0.4	0.4	0.9	0.1	-0.9
Emphysema/chronic bronchitis	0.4	0.5	0.7	0.5	0.8
Chest pain or discomfort	0.4	0.6	1.1	-1.1	-0.2
Illnesses of siblings: Diabetes	0.4	0.5	0.7	-0.8	0.5
Medication for cholesterol	0.4	0.7	1.1	1.1	0.5
Average weekly champagne plus white wine intake	0.4	0.5	0.7	0.6	-0.8
Guilty feelings	0.4	0.6	1.1	-0.3	-1.0
Basal metabolic rate	0.4	2.2	3.0	-1.7	-1.2
Worry (Nagel 2018)	0.3	0.7	1.3	-1.1	0.2
Blood Eosinophil Count	0.3	2.0	2.4	1.6	1.3
Heel T-Score	0.3	2.1	3.2	1.0	1.8
Neuroticism	0.3	0.8	1.6	-1.3	-0.3
Angina	0.3	0.4	0.5	-0.4	0.7
Number of incorrect matches in round	0.3	0.5	0.6	0.6	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	0.9	-1.0	0.6
Medication: Simvastatin	0.3	0.5	1.0	0.1	1.0
Alcohol intake versus 10 years previously	0.3	0.4	0.7	-0.3	0.9
Noisy workplace	0.3	0.3	0.6	-0.8	0.1
Pulse wave Arterial Stiffness index	0.3	0.3	0.6	-0.2	0.8
Hair/balding pattern: Pattern 4	0.3	0.6	1.2	1.1	-0.3
Birth weight	0.3	0.6	1.1	0.0	-1.1
Leg fat percentage (right)	0.3	1.0	1.2	-0.8	1.1
Exposure to tobacco smoke outside home	0.3	0.4	0.6	-0.8	0.5
Arm fat percentage (left)	0.3	1.0	1.6	0.7	1.3
Breast cancer (self-reported)	0.3	0.3	0.5	0.7	-0.3
Leg predicted mass (right)	0.3	1.3	2.0	-0.9	-1.4
Number of operations (self-reported)	0.3	0.5	0.7	0.5	0.8
Ever depressed for a whole week	0.3	0.3	0.7	0.8	0.1
Myopia	0.3	0.4	0.6	0.8	-0.4
Impedance of whole body	0.3	1.6	3.1	1.8	0.4
Crohns Disease (2017)	0.2	0.5	0.8	-0.5	-0.9
HDL Cholesterol	0.2	0.4	0.6	0.8	-0.4
Blood Red Count	0.2	1.6	3.0	-1.7	-0.5
BMI	0.2	1.0	1.5	0.6	1.2
Leg fat-free mass (left)	0.2	1.3	1.5	-1.0	-1.2
Leg predicted mass (left)	0.2	1.2	1.5	-0.9	-1.2
Waist circumference	0.2	0.5	1.1	-0.2	-1.0
Had menopause	0.2	0.3	0.6	-0.1	-0.8
Had other major operations	0.2	0.2	0.5	-0.7	-0.1
Financial difficulties in last 2 years	0.2	0.2	0.4	0.2	0.6
Worrier / anxious feelings	0.2	0.3	0.6	-0.3	0.7
Birth weight of first child	0.2	0.3	0.6	-0.0	-0.8
Headache pain in last month	0.2	0.3	0.6	-0.8	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.8	0.8	0.9	-0.8
Medication: Omeprazole	0.2	0.3	0.5	-0.7	-0.3
Knee pain experienced in last month	0.2	0.3	0.4	-0.5	-0.7
Leg fat-free mass (right)	0.2	1.1	1.8	-0.7	-1.3
Qualifications: nursing, teaching	0.2	0.3	0.6	0.8	0.3
Back pain experienced in last month	0.2	0.3	0.5	0.7	0.3
Alcohol drinker status: Never	0.2	0.3	0.4	-0.3	0.7
Leg fat percentage (left)	0.2	0.8	0.9	-0.9	1.0
Age started oral contraceptive pill	0.2	0.3	0.5	0.0	-0.7
Neuroticism (2016)	0.1	0.1	0.1	-0.3	-0.3
Primary Biliary Cirrhosis	0.1	0.1	0.1	0.3	-0.3
Hair Pigment	0.1	1.7	2.4	-1.0	-1.6
Hand grip strength (left)	0.1	0.2	0.2	-0.4	0.5
Relative age of first facial hair	0.1	0.2	0.3	-0.2	-0.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.3	-0.6	0.1
Impedance of leg (right)	0.1	0.4	0.7	0.3	0.8
Trunk fat percentage	0.1	0.5	0.8	0.9	0.5
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	0.5	-0.2
Body mass index (BMI)	0.1	0.6	0.9	-0.5	1.0
Impedance of leg (left)	0.1	0.3	0.3	0.4	0.6
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.3	0.5	-0.2
Pain all over the body in last month	0.1	0.2	0.2	-0.3	-0.4
Illnesses of siblings	0.1	0.2	0.2	0.3	-0.5
Neuroticism score	0.1	0.2	0.3	-0.4	-0.5
Weight	0.1	0.5	0.8	-0.9	-0.4
Hip circumference	0.1	0.5	0.7	-0.9	-0.5
Number of live births	0.1	0.1	0.3	0.1	0.5
Depression (self-reported)	0.1	0.1	0.1	-0.3	-0.3
Blood clot in the leg (DVT)	0.1	0.2	0.2	0.4	0.4
Body fat percentage	0.1	0.5	0.6	0.6	0.8
Angina (self-reported)	0.1	0.2	0.2	-0.4	0.4
Leg fat mass (right)	0.1	0.4	0.5	-0.7	0.5
Number of full sisters	0.1	0.2	0.3	-0.5	0.3
Leg pain on walking	0.1	0.1	0.1	-0.3	-0.3
Average weekly red wine intake	0.1	0.1	0.2	-0.4	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	-0.2	0.3
Arm fat mass (left)	0.1	0.2	0.5	-0.1	0.7
Miserableness	0.1	0.2	0.2	0.5	-0.4
Ever taken oral contraceptive pill	0.1	0.1	0.1	0.2	-0.4
Hearing aid user	0.1	0.1	0.2	0.5	0.1
High cholesterol (Self-reported)	0.1	0.1	0.2	-0.1	0.4
Irritability	0.1	0.1	0.2	0.5	0.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	-0.4	-0.1
Unable to work because of sickness or disability	0.1	0.1	0.1	-0.2	0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.2	0.4	0.4
Leg fat mass (left)	0.1	0.4	0.6	-0.8	0.3
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	0.0	0.2
Lupus	0.0	0.0	0.1	-0.1	0.2
Tanning	0.0	0.5	0.9	-0.2	0.9
Sensitivity / hurt feelings	0.0	0.0	0.1	0.0	-0.3
Diabetes (father)	0.0	0.0	0.0	0.1	-0.1
Hand grip strength (right)	0.0	0.0	0.0	-0.1	0.1
Trunk fat mass	0.0	0.0	0.0	0.1	0.1
Medication: Cholesterol lowering	0.0	0.1	0.1	0.4	0.1
Lung cancer (father)	0.0	0.0	0.0	-0.2	-0.2
Arm fat mass (right)	0.0	0.2	0.3	-0.2	0.5
Length of working week for main job	0.0	0.0	0.0	-0.1	-0.0
Medication: Paracetamol	0.0	0.1	0.1	-0.0	-0.4
Whole body fat mass	0.0	0.2	0.3	-0.0	0.6
Eye problems/disorders: Cataract	0.0	0.0	0.1	0.1	0.2
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.1	0.3	0.1
Medication: Paracetamol	0.0	0.0	0.1	0.3	-0.0
Cholesterol lowering medication	0.0	0.1	0.1	-0.3	-0.0

Hub : Genes

HDAC7

Models

Trait associations