TWAS
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Traits
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High blood pressure
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chr12:89,116,708-90,799,212
Best TWAS P=5.33e-16 · Best GWAS P=3.81e-25 conditioned to 2.55e-13
89.2M
89.4M
89.6M
89.8M
90M
90.2M
90.4M
90.6M
90.8M
0
5
10
15
20
25
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Artery Tibial
ATP2B1
0.08
0.01
enet
10
0.03
0.0035
-9.5
-8.1
5.3e-16
0.37
0.12
0.55
TRUE
3
The Cancer Genome Atlas
Cervical Squamous Cell Carcinoma
LOC338758
0.14
0.00
enet
6
0.01
0.0619
2.1
-6.2
5.3e-10
0.31
0.00
0.18
TRUE
2
GTEx
Prostate
POC1B
0.25
0.00
enet
37
0.01
0.1640
-9.9
5.8
7.6e-09
-0.54
0.03
0.58
FALSE