Best TWAS P=1.7e-15 · Best GWAS P=3.1e-15 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue (Female) | KDM2B | 0.13 | 0.00 | lasso | 3 | 0.01 | 1.2e-01 | -7.77 | 8.0 | 1.7e-15 | -0.91 | 0.03 | 0.36 | TRUE |
| 2 | GTEx | Lung | KDM2B | 0.10 | 0.06 | lasso | 3 | 0.05 | 1.4e-04 | -7.69 | 7.7 | 1.1e-14 | -0.97 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Nerve Tibial | KDM2B | 0.08 | 0.04 | enet | 16 | 0.05 | 1.6e-04 | -7.77 | 5.5 | 2.8e-08 | -0.81 | 0.02 | 0.96 | FALSE |
| 4 | GTEx | Testis | RNF34 | 0.18 | 0.20 | lasso | 3 | 0.17 | 5.2e-08 | -7.77 | 7.7 | 1.9e-14 | -0.97 | 0.01 | 0.99 | TRUE |
| 5 | GTEx | Thyroid | KDM2B | 0.13 | 0.05 | enet | 20 | 0.05 | 8.1e-05 | -5.17 | 7.0 | 2.3e-12 | -0.91 | 0.02 | 0.98 | FALSE |
| 6 | METSIM | Adipose | WDR66 | 0.04 | 0.00 | blup | 341 | 0.01 | 1.4e-02 | -0.73 | -5.7 | 1.2e-08 | 0.18 | 0.05 | 0.04 | TRUE |