[Hub]/) : Traits : High blood pressure :

chr12:111,102,574-113,517,494

Best TWAS P=3.83e-21 · Best GWAS P=7.32e-29 conditioned to 3.51e-11

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ALDH2 0.05 0.11 blup 223 0.10 1.8e-12 -5.9 6.8 9.4e-12 0.42 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex ATXN2 0.02 0.03 enet 8 0.02 4.8e-04 -6.5 8.6 1.0e-17 0.56 0.27 0.63 FALSE
3 CommonMind Brain Pre-frontal Cortex NAA25 0.03 0.02 blup 213 0.03 1.1e-04 -4.8 -5.5 5.0e-08 -0.33 0.74 0.02 FALSE
4 GTEx Adipose Subcutaneous HECTD4 0.06 0.00 enet 15 0.02 1.0e-02 -6.0 7.1 1.0e-12 0.65 0.07 0.82 FALSE
5 GTEx Adipose Subcutaneous MAPKAPK5-AS1 0.08 0.01 enet 26 0.03 2.1e-03 -7.1 -6.9 4.3e-12 -0.44 0.98 0.02 FALSE
6 GTEx Adipose Subcutaneous AC003029.1 0.08 0.07 enet 30 0.05 1.2e-04 -6.0 -7.3 3.9e-13 -0.47 1.00 0.00 FALSE
7 GTEx Adipose Visceral Omentum TMEM116 0.21 0.14 lasso 11 0.14 1.1e-07 -4.8 -5.2 1.9e-07 -0.29 1.00 0.00 FALSE
8 GTEx Adipose Visceral Omentum RP3-462E2.5 0.15 0.07 enet 8 0.07 1.0e-04 -5.4 6.0 2.0e-09 0.28 0.62 0.12 FALSE
9 GTEx Adrenal Gland MAPKAPK5-AS1 0.10 0.08 lasso 12 0.03 3.0e-02 -6.0 -6.1 9.8e-10 -0.39 0.56 0.06 FALSE
10 GTEx Adrenal Gland AC003029.1 0.12 0.10 lasso 13 0.07 2.0e-03 -6.0 -6.1 1.2e-09 -0.39 0.80 0.04 FALSE
11 GTEx Artery Aorta ALDH2 0.05 0.04 enet 33 0.05 1.3e-03 -3.4 5.3 1.1e-07 0.38 0.59 0.09 FALSE
12 GTEx Artery Aorta TMEM116 0.27 0.21 lasso 16 0.20 1.9e-11 -4.8 -5.1 2.9e-07 -0.26 1.00 0.00 FALSE
13 GTEx Artery Aorta AC003029.1 0.07 0.01 lasso 7 0.01 5.4e-02 -7.1 -6.3 3.0e-10 -0.43 0.21 0.24 FALSE
14 GTEx Artery Coronary MAPKAPK5-AS1 0.16 0.10 lasso 13 0.06 5.7e-03 -6.0 -5.7 1.5e-08 -0.38 0.38 0.07 FALSE
15 GTEx Artery Tibial ALDH2 0.08 0.09 lasso 2 0.07 2.7e-06 -6.0 6.1 1.1e-09 0.41 0.94 0.02 FALSE
16 GTEx Artery Tibial HECTD4 0.05 0.02 lasso 3 0.01 3.1e-02 8.3 7.9 2.1e-15 0.78 0.02 0.92 FALSE
17 GTEx Artery Tibial MAPKAPK5-AS1 0.07 0.05 lasso 11 0.05 9.7e-05 -4.9 -5.6 2.2e-08 -0.33 0.76 0.02 FALSE
18 GTEx Artery Tibial AC003029.1 0.05 0.04 lasso 12 0.03 3.6e-03 -6.1 -6.0 1.7e-09 -0.38 0.58 0.04 FALSE
19 GTEx Brain Cerebellum NAA25 0.12 -0.01 lasso 12 0.00 3.0e-01 -4.7 -5.7 1.1e-08 -0.34 0.12 0.07 FALSE
20 GTEx Brain Frontal Cortex BA9 ALDH2 0.33 0.04 enet 24 0.09 2.0e-03 -7.1 6.2 7.1e-10 0.33 0.09 0.08 FALSE
21 GTEx Brain Frontal Cortex BA9 TMEM116 0.10 0.09 lasso 7 0.18 1.9e-05 -6.0 -6.2 6.1e-10 -0.36 0.38 0.04 FALSE
22 GTEx Brain Putamen basal ganglia ALDH2 0.12 0.00 lasso 14 0.02 1.3e-01 -7.1 6.7 2.5e-11 0.39 0.16 0.15 FALSE
23 GTEx Breast Mammary Tissue HECTD4 0.06 0.08 lasso 1 0.07 1.6e-04 -6.0 6.0 2.5e-09 0.38 0.31 0.19 FALSE
24 GTEx Cells Transformed fibroblasts HECTD4 0.04 0.01 lasso 5 0.00 4.5e-01 -4.9 6.0 2.0e-09 0.35 0.22 0.04 FALSE
25 GTEx Cells Transformed fibroblasts MAPKAPK5-AS1 0.06 0.04 lasso 12 0.02 9.5e-03 -6.0 -6.0 1.9e-09 -0.38 0.53 0.03 FALSE
26 GTEx Cells Transformed fibroblasts AC003029.1 0.06 0.05 lasso 1 0.03 2.1e-03 -6.0 -6.0 2.5e-09 -0.38 0.66 0.02 FALSE
27 GTEx Colon Sigmoid MAPKAPK5-AS1 0.17 0.05 lasso 15 0.07 1.5e-03 -6.0 -6.1 1.3e-09 -0.37 0.51 0.06 FALSE
28 GTEx Colon Sigmoid AC003029.1 0.17 0.08 lasso 14 0.09 3.8e-04 -6.0 -5.9 3.2e-09 -0.35 0.60 0.07 FALSE
29 GTEx Colon Transverse FAM109A 0.21 0.00 lasso 4 0.01 1.3e-01 -6.8 6.2 4.8e-10 0.41 0.06 0.06 FALSE
30 GTEx Colon Transverse MAPKAPK5-AS1 0.16 0.09 lasso 13 0.06 7.1e-04 -6.0 -5.8 8.7e-09 -0.39 0.82 0.02 FALSE
31 GTEx Colon Transverse AC003029.1 0.15 0.09 lasso 12 0.07 2.1e-04 -6.1 -5.8 5.7e-09 -0.39 0.81 0.02 FALSE
32 GTEx Esophagus Gastroesophageal Junction TMEM116 0.37 0.36 lasso 7 0.33 8.0e-13 -4.8 -5.3 1.2e-07 -0.30 1.00 0.00 FALSE
33 GTEx Esophagus Gastroesophageal Junction AC003029.1 0.06 0.03 lasso 3 0.04 1.9e-02 -5.2 -5.5 4.3e-08 -0.38 0.15 0.09 FALSE
34 GTEx Esophagus Gastroesophageal Junction RP3-462E2.5 0.12 0.09 lasso 5 0.09 3.5e-04 -4.8 5.2 2.3e-07 0.28 0.20 0.05 FALSE
35 GTEx Esophagus Mucosa ALDH2 0.05 0.06 lasso 6 0.07 1.7e-05 -6.0 6.2 6.2e-10 0.43 0.93 0.04 FALSE
36 GTEx Esophagus Muscularis HECTD4 0.06 0.03 lasso 4 0.02 1.8e-02 -6.0 6.1 1.0e-09 0.41 0.57 0.08 FALSE
37 GTEx Esophagus Muscularis MAPKAPK5-AS1 0.04 0.02 enet 7 0.02 2.7e-02 -5.9 -6.0 2.6e-09 -0.39 0.35 0.03 FALSE
38 GTEx Esophagus Muscularis AC003029.1 0.07 0.01 enet 14 0.02 1.4e-02 -5.9 -5.5 3.4e-08 -0.23 0.73 0.01 FALSE
39 GTEx Esophagus Muscularis RP3-462E2.5 0.06 0.04 lasso 14 0.03 4.6e-03 -4.8 5.8 8.4e-09 0.32 0.75 0.02 FALSE
40 GTEx Lung ALDH2 0.07 0.01 lasso 10 0.02 5.9e-03 -6.0 5.9 4.3e-09 0.39 0.38 0.03 FALSE
41 GTEx Nerve Tibial ALDH2 0.05 0.04 lasso 3 0.05 2.4e-04 -6.0 6.0 2.2e-09 0.39 0.76 0.02 FALSE
42 GTEx Nerve Tibial HECTD4 0.05 0.01 enet 6 0.01 3.6e-02 -5.5 5.4 6.9e-08 0.41 0.24 0.41 FALSE
43 GTEx Nerve Tibial FAM109A 0.26 0.06 lasso 4 0.07 9.5e-06 -7.1 6.4 1.9e-10 0.25 0.31 0.03 FALSE
44 GTEx Nerve Tibial MAPKAPK5-AS1 0.05 0.00 lasso 19 0.00 1.4e-01 -4.8 -5.3 1.1e-07 -0.30 0.18 0.05 FALSE
45 GTEx Nerve Tibial AC003029.1 0.04 0.00 lasso 23 0.00 4.2e-01 -4.8 -6.0 1.4e-09 -0.38 0.18 0.06 FALSE
46 GTEx Nerve Tibial RP3-462E2.5 0.06 0.04 lasso 5 0.05 3.3e-04 -4.7 5.2 2.2e-07 0.26 0.46 0.04 FALSE
47 GTEx Pituitary ADAM1A 0.18 0.22 enet 42 0.20 9.6e-06 -4.8 6.3 3.5e-10 0.35 0.81 0.03 FALSE
48 GTEx Pituitary RP3-462E2.5 0.15 0.12 lasso 3 0.14 2.3e-04 -6.0 6.8 8.7e-12 0.43 0.23 0.05 FALSE
49 GTEx Prostate ADAM1A 0.30 0.11 lasso 16 0.12 5.4e-04 -4.8 5.6 1.8e-08 0.34 0.49 0.23 FALSE
50 GTEx Prostate RP3-462E2.5 0.22 0.10 lasso 4 0.13 4.4e-04 -4.7 5.3 1.4e-07 0.23 0.08 0.05 FALSE
51 GTEx Skin Not Sun Exposed Suprapubic ALDH2 0.13 0.18 lasso 9 0.16 5.0e-09 -6.0 6.4 1.9e-10 0.40 1.00 0.00 FALSE
52 GTEx Skin Not Sun Exposed Suprapubic MAPKAPK5-AS1 0.04 0.00 enet 30 0.00 7.0e-01 -6.1 -7.1 1.3e-12 -0.53 0.21 0.16 FALSE
53 GTEx Skin Sun Exposed Lower leg ALDH2 0.10 0.09 enet 13 0.13 6.7e-11 -5.9 7.7 1.2e-14 0.62 0.98 0.02 FALSE
54 GTEx Skin Sun Exposed Lower leg MAPKAPK5-AS1 0.09 0.10 lasso 4 0.10 1.1e-08 -6.0 -6.1 1.1e-09 -0.39 1.00 0.00 FALSE
55 GTEx Skin Sun Exposed Lower leg AC003029.1 0.09 0.10 lasso 2 0.10 8.8e-09 -6.0 -6.1 1.1e-09 -0.39 1.00 0.00 FALSE
56 GTEx Stomach TMEM116 0.13 0.03 lasso 7 0.03 1.6e-02 -4.7 -7.0 2.1e-12 -0.46 0.07 0.15 FALSE
57 GTEx Testis MAPKAPK5 0.23 0.12 lasso 5 0.15 3.1e-07 -3.4 5.2 2.5e-07 0.41 0.73 0.21 FALSE
58 GTEx Testis BRAP 0.06 0.03 enet 13 0.01 8.7e-02 -6.0 -6.3 3.8e-10 -0.41 0.43 0.08 FALSE
59 GTEx Testis MAPKAPK5-AS1 0.07 0.04 lasso 1 0.03 1.3e-02 -6.1 -6.1 1.3e-09 -0.38 0.19 0.14 FALSE
60 GTEx Testis AC003029.1 0.10 0.10 lasso 14 0.09 5.8e-05 -6.1 -6.1 1.2e-09 -0.38 0.64 0.12 FALSE
61 GTEx Thyroid BRAP 0.07 0.02 lasso 7 0.03 1.1e-03 -7.1 -6.8 7.6e-12 -0.54 0.35 0.44 FALSE
62 GTEx Thyroid ALDH2 0.06 0.04 lasso 4 0.05 9.7e-05 -7.1 7.6 3.2e-14 0.47 0.88 0.07 FALSE
63 GTEx Thyroid MAPKAPK5-AS1 0.04 0.04 lasso 2 0.03 1.5e-03 -6.0 -6.0 2.4e-09 -0.38 0.62 0.02 FALSE
64 GTEx Thyroid AC003029.1 0.04 0.05 lasso 3 0.04 8.3e-04 -6.0 -6.0 1.4e-09 -0.39 0.81 0.04 FALSE
65 GTEx Whole Blood ADAM1A 0.08 0.02 lasso 10 0.01 2.7e-02 -4.8 5.3 1.2e-07 0.31 0.36 0.31 FALSE
66 NTR Blood TMEM116 0.01 0.00 blup 199 0.00 9.3e-03 -6.1 -5.1 2.8e-07 -0.27 0.64 0.01 FALSE
67 YFS Blood ATXN2 0.05 0.02 blup 257 0.04 2.8e-12 -5.4 -6.4 1.6e-10 -0.28 1.00 0.00 FALSE
68 YFS Blood SH2B3 0.05 0.01 enet 22 0.02 3.3e-07 -7.1 9.4 3.8e-21 0.64 0.68 0.32 TRUE
69 The Cancer Genome Atlas Breast Invasive Carcinoma C12orf47 0.01 0.01 blup 31 0.01 7.3e-03 -6.0 -5.8 6.2e-09 -0.38 0.02 0.81 FALSE
70 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ALDH2 0.10 0.00 enet 6 0.00 2.6e-01 4.9 5.9 4.5e-09 0.22 0.01 0.23 FALSE
71 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C12orf47 0.07 0.04 lasso 2 0.03 1.0e-04 -6.2 -6.2 4.7e-10 -0.36 0.01 0.99 FALSE
72 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ALDH2 0.10 0.08 blup 30 0.09 4.5e-06 -5.8 5.3 1.3e-07 0.36 0.02 0.97 FALSE
73 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma TMEM116 0.04 0.04 enet 13 0.04 2.7e-03 -4.7 -5.6 2.6e-08 -0.31 0.05 0.12 FALSE
74 The Cancer Genome Atlas Brain Lower Grade Glioma ACAD10 0.02 0.02 lasso 3 0.01 7.0e-03 -5.1 -5.2 1.8e-07 -0.50 0.03 0.64 FALSE
75 The Cancer Genome Atlas Brain Lower Grade Glioma ALDH2 0.03 0.03 lasso 1 0.03 3.1e-04 -5.9 5.9 3.2e-09 0.38 0.02 0.77 FALSE
76 The Cancer Genome Atlas Brain Lower Grade Glioma MAPKAPK5 0.03 0.01 blup 42 0.01 2.5e-02 -3.4 5.4 6.8e-08 0.37 0.04 0.63 FALSE
77 The Cancer Genome Atlas Brain Lower Grade Glioma TMEM116 0.03 0.03 blup 43 0.03 8.0e-05 -4.8 -6.5 1.1e-10 -0.43 0.52 0.21 FALSE
78 The Cancer Genome Atlas Liver Hepatocellular Carcinoma TMEM116 0.04 0.02 blup 43 0.02 3.5e-02 -4.8 -6.2 6.3e-10 -0.39 0.03 0.12 FALSE
79 The Cancer Genome Atlas Lung Adenocarcinoma C12orf47 0.02 0.01 blup 31 0.02 1.7e-03 -6.0 -5.6 2.7e-08 -0.36 0.02 0.86 FALSE
80 The Cancer Genome Atlas Pancreatic Adenocarcinoma TMEM116 0.12 0.07 blup 43 0.10 7.6e-05 -4.8 -5.7 1.6e-08 -0.37 0.36 0.21 FALSE
81 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma ALDH2 0.08 0.08 blup 32 0.09 2.3e-04 -6.0 5.9 3.4e-09 0.37 0.02 0.94 FALSE
82 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma ERP29 0.11 0.03 blup 25 0.05 5.0e-03 -6.0 -7.7 1.4e-14 -0.60 0.01 0.75 FALSE
83 The Cancer Genome Atlas Prostate Adenocarcinoma ALDH2 0.02 0.02 blup 31 0.01 1.2e-02 -6.0 5.8 5.8e-09 0.35 0.01 0.76 FALSE
84 The Cancer Genome Atlas Prostate Adenocarcinoma C12orf47 0.04 0.03 blup 31 0.02 2.8e-03 -6.0 -5.5 4.8e-08 -0.30 0.02 0.86 FALSE
85 The Cancer Genome Atlas Thyroid Carcinoma ALDH2 0.03 0.02 blup 31 0.02 6.4e-03 -6.0 5.3 1.3e-07 0.32 0.02 0.82 FALSE