Best TWAS P=1.45e-09 · Best GWAS P=1.48e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Muscularis | CTB-31O20.6 | 0.16 | 0.07 | lasso | 5 | 0.05 | 7.8e-04 | -6.0 | -5.9 | 4.5e-09 | 0.99 | 0.01 | 0.99 | TRUE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | KLF16 | 0.12 | 0.08 | bslmm | 372 | 0.08 | 1.0e-10 | -5.6 | -6.0 | 1.4e-09 | 0.43 | 0.03 | 0.97 | TRUE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ATP8B3 | 0.06 | 0.00 | blup | 49 | 0.03 | 2.7e-04 | -3.7 | -5.3 | 1.4e-07 | 0.69 | 0.02 | 0.71 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ATP8B3 | 0.04 | 0.01 | blup | 49 | 0.02 | 2.2e-03 | -5.6 | -5.6 | 2.2e-08 | 0.55 | 0.01 | 0.27 | FALSE |