Best TWAS P=1.51e-09 · Best GWAS P=4.94e-10 conditioned to 0.00589
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | SPPL3 | 0.19 | 0.19 | lasso | 8 | 0.19 | 3.7e-15 | -5.7 | -5.5 | 2.8e-08 | -0.75 | 0.03 | 0.97 | FALSE |
| 2 | GTEx | Artery Aorta | SPPL3 | 0.18 | 0.15 | enet | 13 | 0.17 | 1.4e-09 | -6.0 | -5.2 | 1.9e-07 | -0.69 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Brain Cerebellum | SPPL3 | 0.29 | 0.22 | enet | 9 | 0.24 | 8.6e-08 | -5.7 | -5.8 | 6.7e-09 | -0.80 | 0.05 | 0.95 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | SPPL3 | 0.24 | 0.14 | enet | 7 | 0.03 | 5.1e-02 | -6.0 | -5.7 | 1.6e-08 | -0.77 | 0.04 | 0.87 | FALSE |
| 5 | GTEx | Esophagus Muscularis | SPPL3 | 0.16 | 0.14 | lasso | 2 | 0.16 | 3.8e-10 | -5.7 | -6.0 | 2.1e-09 | -0.73 | 0.05 | 0.95 | FALSE |
| 6 | GTEx | Nerve Tibial | SPPL3 | 0.24 | 0.16 | enet | 33 | 0.21 | 4.8e-15 | -5.7 | -6.0 | 1.5e-09 | -0.71 | 0.03 | 0.97 | TRUE |
| 7 | GTEx | Pancreas | SPPL3 | 0.14 | 0.10 | lasso | 3 | 0.09 | 9.3e-05 | -6.0 | -5.7 | 1.5e-08 | -0.76 | 0.04 | 0.89 | FALSE |
| 8 | GTEx | Testis | SPPL3 | 0.31 | 0.30 | lasso | 3 | 0.27 | 2.0e-12 | -5.7 | -5.9 | 3.9e-09 | -0.77 | 0.03 | 0.97 | FALSE |
| 9 | METSIM | Adipose | SPPL3 | 0.12 | 0.15 | lasso | 8 | 0.16 | 1.6e-22 | -6.0 | -5.5 | 3.7e-08 | -0.77 | 0.01 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SPPL3 | 0.11 | 0.01 | lasso | 1 | 0.01 | 1.0e-01 | -6.0 | -6.0 | 2.0e-09 | -0.81 | 0.02 | 0.65 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SPPL3 | 0.07 | 0.09 | lasso | 3 | 0.09 | 9.9e-11 | -5.7 | -5.7 | 9.8e-09 | -0.76 | 0.05 | 0.95 | FALSE |
| 12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SPPL3 | 0.04 | 0.04 | blup | 95 | 0.04 | 3.7e-05 | -6.0 | -5.5 | 3.4e-08 | -0.76 | 0.03 | 0.97 | FALSE |