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chr12:122,713,991-124,591,385

Best TWAS P=2.86e-11 · Best GWAS P=5.17e-10 conditioned to 0.818

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	CDK2AP1	0.20	0.18	lasso	11	0.19	1.0e-15	5.9	-5.3	9.2e-08	-0.92	0.04	0.96	FALSE
2	GTEx	Adipose Subcutaneous	RP11-282O18.3	0.15	0.14	lasso	7	0.15	2.0e-12	5.4	-5.7	1.2e-08	-0.92	0.04	0.96	FALSE
3	GTEx	Adipose Visceral Omentum	MPHOSPH9	0.07	0.02	lasso	4	0.00	3.5e-01	5.8	5.4	8.3e-08	0.90	0.04	0.72	FALSE
4	GTEx	Adipose Visceral Omentum	CDK2AP1	0.14	0.14	lasso	4	0.11	2.7e-06	5.8	-5.3	1.0e-07	-0.91	0.03	0.97	FALSE
5	GTEx	Adipose Visceral Omentum	ARL6IP4	0.08	0.02	lasso	5	0.06	3.7e-04	-3.0	-5.2	1.7e-07	-0.79	0.05	0.80	FALSE
6	GTEx	Adipose Visceral Omentum	RP11-282O18.3	0.14	0.11	enet	12	0.10	6.7e-06	5.8	-5.5	4.3e-08	-0.93	0.03	0.97	FALSE
7	GTEx	Artery Aorta	MPHOSPH9	0.08	0.01	lasso	4	0.04	4.6e-03	-3.7	5.2	1.9e-07	0.77	0.09	0.73	FALSE
8	GTEx	Artery Aorta	CDK2AP1	0.17	0.19	lasso	2	0.15	8.0e-09	5.9	-5.9	3.4e-09	-0.92	0.02	0.98	FALSE
9	GTEx	Artery Aorta	RP11-282O18.3	0.18	0.19	lasso	9	0.16	4.3e-09	5.9	-5.9	3.2e-09	-0.95	0.03	0.97	FALSE
10	GTEx	Artery Tibial	MPHOSPH9	0.05	0.03	lasso	3	0.03	2.2e-03	4.5	5.4	5.7e-08	0.96	0.04	0.94	FALSE
11	GTEx	Artery Tibial	ABCB9	0.04	0.02	lasso	2	0.01	3.0e-02	4.7	5.7	1.6e-08	0.92	0.06	0.89	FALSE
12	GTEx	Artery Tibial	SETD8	0.07	0.03	lasso	7	0.03	2.2e-03	5.4	5.3	1.4e-07	0.90	0.06	0.89	FALSE
13	GTEx	Brain Hypothalamus	OGFOD2	0.24	0.14	lasso	4	0.14	4.0e-04	5.8	5.9	3.1e-09	0.87	0.04	0.91	FALSE
14	GTEx	Breast Mammary Tissue	CDK2AP1	0.08	0.06	lasso	3	0.07	1.2e-04	5.2	-5.7	9.5e-09	-0.93	0.05	0.92	FALSE
15	GTEx	Breast Mammary Tissue	RP11-282O18.3	0.10	0.06	lasso	6	0.08	5.4e-05	5.2	-5.7	1.0e-08	-0.93	0.06	0.93	FALSE
16	GTEx	Breast Mammary Tissue (Female)	CDK2AP1	0.08	0.03	lasso	3	0.02	6.4e-02	5.9	-5.8	5.7e-09	-0.93	0.06	0.56	FALSE
17	GTEx	Breast Mammary Tissue (Female)	RP11-282O18.3	0.09	0.07	enet	8	0.08	2.8e-03	5.6	-5.5	3.5e-08	-0.94	0.08	0.78	FALSE
18	GTEx	Cells Transformed fibroblasts	OGFOD2	0.10	0.07	lasso	7	0.07	3.1e-06	4.9	5.7	1.1e-08	0.91	0.22	0.77	FALSE
19	GTEx	Cells Transformed fibroblasts	CDK2AP1	0.31	0.32	lasso	8	0.35	8.5e-27	5.9	-5.8	5.6e-09	-0.92	0.03	0.97	FALSE
20	GTEx	Cells Transformed fibroblasts	C12orf65	0.07	0.05	lasso	4	0.04	5.8e-04	4.3	-5.3	1.3e-07	-0.91	0.12	0.80	FALSE
21	GTEx	Cells Transformed fibroblasts	ABCB9	0.08	0.12	enet	7	0.12	4.3e-09	5.0	5.3	1.2e-07	0.89	0.09	0.91	FALSE
22	GTEx	Cells Transformed fibroblasts	SETD8	0.10	0.12	enet	9	0.09	1.4e-07	5.0	5.8	8.2e-09	0.83	0.06	0.94	FALSE
23	GTEx	Cells Transformed fibroblasts	RP11-282O18.3	0.25	0.29	enet	16	0.28	2.2e-21	5.9	-5.9	4.7e-09	-0.93	0.03	0.97	FALSE
24	GTEx	Colon Sigmoid	ABCB9	0.18	0.16	lasso	6	0.15	4.8e-06	6.2	6.2	6.0e-10	0.96	0.03	0.97	FALSE
25	GTEx	Colon Transverse	CDK2AP1	0.17	0.19	enet	7	0.22	1.4e-10	5.9	-6.0	2.7e-09	-0.96	0.03	0.97	FALSE
26	GTEx	Colon Transverse	ABCB9	0.08	0.07	enet	5	0.09	5.3e-05	5.3	5.7	1.3e-08	0.88	0.10	0.86	FALSE
27	GTEx	Colon Transverse	RP11-282O18.3	0.18	0.19	enet	8	0.19	1.8e-09	5.9	-6.0	2.6e-09	-0.96	0.03	0.97	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	CDK2AP1	0.14	0.06	lasso	8	0.06	4.7e-03	5.7	-5.2	2.2e-07	-0.80	0.04	0.68	FALSE
29	GTEx	Esophagus Mucosa	CDK2AP1	0.30	0.36	lasso	5	0.38	1.9e-26	5.8	-5.8	4.8e-09	-0.96	0.04	0.96	FALSE
30	GTEx	Esophagus Mucosa	ABCB9	0.10	0.03	lasso	5	0.05	5.4e-04	5.8	5.9	3.7e-09	0.89	0.04	0.95	FALSE
31	GTEx	Esophagus Mucosa	RP11-282O18.3	0.29	0.34	lasso	4	0.34	1.9e-23	5.7	-5.8	7.0e-09	-0.95	0.04	0.96	FALSE
32	GTEx	Esophagus Muscularis	MPHOSPH9	0.18	0.18	enet	17	0.18	4.8e-11	5.8	6.7	2.9e-11	0.92	0.04	0.96	TRUE
33	GTEx	Esophagus Muscularis	C12orf65	0.06	0.04	lasso	4	0.04	2.0e-03	6.0	-5.8	8.1e-09	-0.92	0.04	0.94	FALSE
34	GTEx	Esophagus Muscularis	ABCB9	0.10	0.08	lasso	6	0.05	3.8e-04	5.7	5.9	4.6e-09	0.93	0.02	0.97	FALSE
35	GTEx	Esophagus Muscularis	RP11-282O18.3	0.19	0.11	lasso	6	0.10	2.1e-06	5.8	-5.4	5.5e-08	-0.94	0.03	0.97	FALSE
36	GTEx	Heart Left Ventricle	MPHOSPH9	0.06	0.04	lasso	5	0.04	4.2e-03	5.9	5.8	9.1e-09	0.86	0.06	0.84	FALSE
37	GTEx	Lung	CDK2AP1	0.08	0.03	lasso	4	0.00	2.0e-01	5.9	-5.3	8.8e-08	-0.91	0.04	0.94	FALSE
38	GTEx	Lung	ABCB9	0.04	0.02	lasso	3	0.02	8.0e-03	5.9	6.0	2.4e-09	0.97	0.05	0.89	FALSE
39	GTEx	Lung	RP11-282O18.3	0.06	0.02	lasso	7	0.00	6.1e-01	5.9	-5.5	4.1e-08	-0.93	0.04	0.91	FALSE
40	GTEx	Muscle Skeletal	SETD8	0.16	0.02	lasso	4	0.03	3.8e-04	6.0	5.6	2.6e-08	0.85	0.03	0.96	FALSE
41	GTEx	Nerve Tibial	MPHOSPH9	0.07	0.04	lasso	4	0.01	7.0e-02	6.2	6.2	5.5e-10	0.97	0.01	0.97	FALSE
42	GTEx	Nerve Tibial	CDK2AP1	0.11	0.11	enet	25	0.09	4.4e-07	5.4	-5.9	3.9e-09	-0.92	0.04	0.96	FALSE
43	GTEx	Nerve Tibial	ABCB9	0.06	0.04	lasso	3	0.05	3.5e-04	5.3	6.0	2.3e-09	0.95	0.02	0.97	FALSE
44	GTEx	Nerve Tibial	RP11-282O18.3	0.10	0.10	enet	28	0.08	1.9e-06	5.4	-5.7	1.2e-08	-0.85	0.04	0.96	FALSE
45	GTEx	Pancreas	CDK2AP1	0.24	0.27	lasso	3	0.26	3.1e-11	5.9	-6.0	2.5e-09	-0.95	0.03	0.97	FALSE
46	GTEx	Pancreas	ARL6IP4	0.07	0.07	lasso	2	0.07	9.6e-04	5.0	-5.5	2.9e-08	-0.86	0.04	0.85	FALSE
47	GTEx	Pancreas	SETD8	0.20	0.12	lasso	5	0.13	3.4e-06	5.9	-5.9	3.4e-09	-0.90	0.03	0.97	FALSE
48	GTEx	Pancreas	RP11-282O18.3	0.22	0.24	lasso	5	0.24	2.3e-10	5.9	-6.0	2.2e-09	-0.95	0.03	0.97	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	CDK2AP1	0.17	0.12	lasso	10	0.12	3.4e-07	6.2	-6.0	2.8e-09	-0.97	0.02	0.98	FALSE
50	GTEx	Skin Not Sun Exposed Suprapubic	ABCB9	0.13	0.15	lasso	11	0.11	2.1e-06	5.0	5.6	2.4e-08	0.84	0.22	0.78	FALSE
51	GTEx	Skin Not Sun Exposed Suprapubic	RP11-282O18.3	0.13	0.10	lasso	6	0.09	1.9e-05	5.8	-6.0	2.4e-09	-0.97	0.03	0.97	FALSE
52	GTEx	Skin Sun Exposed Lower leg	MPHOSPH9	0.06	0.05	enet	9	0.06	2.1e-05	5.9	5.8	8.7e-09	0.90	0.04	0.95	FALSE
53	GTEx	Skin Sun Exposed Lower leg	CDK2AP1	0.21	0.22	lasso	5	0.22	3.4e-18	5.9	-5.7	9.8e-09	-0.92	0.04	0.96	FALSE
54	GTEx	Skin Sun Exposed Lower leg	ABCB9	0.09	0.08	lasso	5	0.08	4.3e-07	5.0	5.2	2.2e-07	0.81	0.29	0.70	FALSE
55	GTEx	Skin Sun Exposed Lower leg	RP11-282O18.3	0.17	0.20	lasso	6	0.20	2.2e-16	5.9	-5.8	9.0e-09	-0.92	0.04	0.96	FALSE
56	GTEx	Small Intestine Terminal Ileum	ABCB9	0.23	0.21	enet	12	0.22	1.0e-05	5.9	6.0	2.5e-09	0.92	0.04	0.87	FALSE
57	GTEx	Stomach	MPHOSPH9	0.17	0.08	lasso	5	0.10	1.2e-05	5.7	5.7	1.2e-08	0.94	0.05	0.94	FALSE
58	GTEx	Testis	MPHOSPH9	0.28	0.27	enet	23	0.32	1.3e-14	5.8	5.9	4.3e-09	0.95	0.09	0.91	FALSE
59	GTEx	Thyroid	PITPNM2	0.04	0.07	lasso	2	0.06	1.6e-05	5.8	5.8	5.7e-09	0.96	0.03	0.96	FALSE
60	GTEx	Thyroid	CDK2AP1	0.08	0.09	enet	7	0.10	8.2e-08	5.9	-5.8	4.8e-09	-0.94	0.03	0.97	FALSE
61	GTEx	Thyroid	RP11-282O18.3	0.06	0.06	enet	6	0.06	3.6e-05	5.9	-5.8	8.2e-09	-0.94	0.03	0.97	FALSE
62	METSIM	Adipose	CDK2AP1	0.11	0.14	enet	23	0.14	1.7e-20	5.6	-5.1	2.8e-07	-0.90	0.06	0.94	FALSE
63	YFS	Blood	MPHOSPH9	0.05	0.07	enet	31	0.07	3.7e-23	5.9	5.7	1.3e-08	0.95	0.06	0.94	FALSE
64	YFS	Blood	SBNO1	0.03	0.03	lasso	6	0.03	1.2e-09	5.7	-5.9	3.2e-09	-0.93	0.05	0.95	FALSE
65	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ABCB9	0.05	0.04	enet	5	0.04	2.4e-04	5.9	5.7	1.3e-08	0.94	0.00	0.98	FALSE
66	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CDK2AP1	0.09	0.08	lasso	2	0.06	5.9e-06	5.7	-5.7	1.2e-08	-0.93	0.00	0.99	FALSE
67	The Cancer Genome Atlas	Breast Invasive Carcinoma	CDK2AP1	0.07	0.08	lasso	7	0.08	5.0e-16	5.7	-5.8	5.8e-09	-0.95	0.01	0.99	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	RILPL2	0.02	0.01	enet	8	0.01	2.6e-02	5.9	5.8	8.1e-09	0.87	0.00	0.98	FALSE
69	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CDK2AP1	0.07	0.07	blup	34	0.05	1.1e-03	5.5	-5.5	2.9e-08	-0.91	0.01	0.90	FALSE
70	The Cancer Genome Atlas	Colon Adenocarcinoma	CDK2AP1	0.12	0.17	lasso	4	0.17	6.3e-10	5.7	-5.7	9.5e-09	-0.93	0.01	0.99	FALSE
71	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CDK2AP1	0.14	0.15	lasso	2	0.14	7.8e-16	5.7	-5.7	1.0e-08	-0.92	0.01	0.99	FALSE
72	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CDK2AP1	0.11	0.13	lasso	5	0.14	5.9e-16	5.9	-5.9	3.3e-09	-0.94	0.01	0.99	FALSE
73	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CDK2AP1	0.12	0.10	lasso	2	0.11	6.3e-07	5.7	-5.7	1.0e-08	-0.92	0.01	0.99	FALSE
74	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PITPNM2	0.06	0.07	lasso	5	0.09	1.2e-05	5.7	-5.6	2.7e-08	-0.95	0.04	0.96	FALSE
75	The Cancer Genome Atlas	Brain Lower Grade Glioma	CDK2AP1	0.02	0.01	blup	34	0.02	5.4e-03	4.9	-5.4	6.3e-08	-0.80	0.03	0.64	FALSE
76	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CDK2AP1	0.11	0.11	enet	5	0.11	1.2e-05	5.9	-5.8	4.9e-09	-0.93	0.01	0.99	FALSE
77	The Cancer Genome Atlas	Lung Adenocarcinoma	CDK2AP1	0.03	0.04	lasso	1	0.04	1.2e-05	5.7	-5.7	1.2e-08	-0.93	0.01	0.99	FALSE
78	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ABCB9	0.06	0.06	enet	7	0.07	5.2e-08	4.9	5.3	1.0e-07	0.86	0.04	0.95	FALSE
79	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CDK2AP1	0.04	0.04	lasso	3	0.03	3.8e-04	5.9	-5.9	3.4e-09	-0.92	0.01	0.98	FALSE
80	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CDK2AP1	0.07	0.06	enet	7	0.06	7.0e-05	5.9	-5.6	1.9e-08	-0.90	0.01	0.97	FALSE
81	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CDK2AP1	0.12	0.14	blup	34	0.15	7.2e-07	5.0	-5.5	2.9e-08	-0.89	0.02	0.98	FALSE
82	The Cancer Genome Atlas	Prostate Adenocarcinoma	ARL6IP4	0.03	0.04	blup	17	0.04	1.6e-05	4.9	-5.3	1.3e-07	-0.84	0.04	0.95	FALSE
83	The Cancer Genome Atlas	Prostate Adenocarcinoma	CDK2AP1	0.06	0.07	lasso	2	0.06	1.7e-06	5.9	-5.9	4.5e-09	-0.92	0.00	1.00	FALSE
84	The Cancer Genome Atlas	Stomach Adenocarcinoma	CDK2AP1	0.09	0.10	lasso	2	0.10	1.8e-07	5.9	-5.8	4.9e-09	-0.92	0.01	0.99	FALSE
85	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CDK2AP1	0.13	0.10	blup	34	0.11	8.2e-05	5.0	-5.7	1.4e-08	-0.89	0.02	0.96	FALSE
86	The Cancer Genome Atlas	Thyroid Carcinoma	CDK2AP1	0.08	0.10	lasso	2	0.10	1.3e-09	5.9	-5.9	4.5e-09	-0.93	0.00	1.00	FALSE
87	The Cancer Genome Atlas	Thyroid Carcinoma	PITPNM2	0.04	0.03	enet	5	0.05	8.1e-06	3.6	5.5	5.1e-08	0.76	0.05	0.95	FALSE