Best TWAS P=5.51e-21 · Best GWAS P=4.34e-19 conditioned to 0.857
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 | The Cancer Genome Atlas | Colon Adenocarcinoma | LINGO4 | 0.29 | 0.07 | enet | 15 | 0.07 | 8.3e-05 | -6.79 | -9.4 | 5.5e-21 | -0.28 | 0.06 | 0.12 | TRUE |
| 7 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LINGO4 | 0.32 | 0.09 | lasso | 8 | 0.13 | 3.3e-06 | -6.79 | -8.1 | 5.0e-16 | -0.21 | 0.07 | 0.28 | TRUE |
| 2 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LINGO4 | 0.15 | 0.03 | lasso | 4 | 0.05 | 8.9e-10 | -6.79 | -6.3 | 2.6e-10 | 0.02 | 0.96 | 0.00 | TRUE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LINGO4 | 0.53 | 0.20 | lasso | 4 | 0.23 | 1.1e-23 | -6.79 | -6.2 | 5.6e-10 | 0.04 | 1.00 | 0.00 | TRUE |
| 1 | GTEx | Colon Sigmoid | S100A11 | 0.18 | 0.13 | lasso | 3 | 0.14 | 1.1e-05 | -5.27 | -5.4 | 8.2e-08 | -0.08 | 0.22 | 0.04 | TRUE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | LINGO4 | 0.43 | 0.15 | lasso | 7 | 0.20 | 2.3e-19 | -6.79 | -6.1 | 9.1e-10 | 0.04 | 1.00 | 0.00 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LINGO4 | 0.24 | 0.07 | lasso | 4 | 0.11 | 1.7e-12 | -6.79 | -6.1 | 1.4e-09 | 0.03 | 0.98 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | LINGO4 | 0.20 | 0.07 | lasso | 4 | 0.07 | 3.7e-08 | -6.79 | -6.0 | 1.7e-09 | 0.00 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LINGO4 | 0.24 | 0.00 | enet | 10 | 0.09 | 9.5e-06 | 0.56 | -5.5 | 4.9e-08 | -0.08 | 0.02 | 0.04 | FALSE |