Best TWAS P=7.43e-13 · Best GWAS P=8.65e-14 conditioned to 0.000369
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CRTC2 | 0.04 | 0.00 | lasso | 3 | 0.01 | 6.7e-02 | -3.4 | 6.6 | 4.9e-11 | -0.45 | 0.06 | 0.53 | FALSE |
| 2 | GTEx | Brain Caudate basal ganglia | RP11-216N14.8 | 0.33 | 0.03 | lasso | 12 | 0.12 | 3.1e-04 | -4.5 | -5.1 | 2.6e-07 | 0.01 | 0.12 | 0.05 | FALSE |
| 3 | GTEx | Colon Sigmoid | IL6R | 0.22 | 0.08 | lasso | 4 | 0.05 | 9.2e-03 | -7.2 | 5.9 | 2.9e-09 | -0.93 | 0.02 | 0.83 | FALSE |
| 4 | GTEx | Colon Transverse | SLC39A1 | 0.11 | -0.01 | lasso | 6 | -0.01 | 7.9e-01 | 2.0 | -6.5 | 8.2e-11 | 0.59 | 0.05 | 0.45 | FALSE |
| 5 | GTEx | Colon Transverse | IL6R | 0.18 | 0.06 | lasso | 3 | 0.06 | 9.2e-04 | -6.8 | 6.5 | 1.0e-10 | -0.92 | 0.05 | 0.89 | FALSE |
| 6 | GTEx | Esophagus Muscularis | IL6R | 0.10 | 0.00 | enet | 15 | 0.00 | 5.3e-01 | -7.2 | 7.2 | 7.4e-13 | -0.67 | 0.02 | 0.86 | TRUE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-422P24.10 | 0.07 | 0.08 | lasso | 2 | 0.08 | 6.3e-05 | -4.5 | 5.3 | 1.3e-07 | -0.07 | 0.42 | 0.05 | FALSE |
| 8 | GTEx | Thyroid | C1orf43 | 0.04 | 0.00 | enet | 18 | 0.03 | 2.1e-03 | 4.0 | -5.5 | 3.2e-08 | 0.03 | 0.18 | 0.04 | FALSE |
| 9 | GTEx | Whole Blood | SLC39A1 | 0.13 | 0.01 | enet | 19 | 0.05 | 1.6e-05 | -2.8 | -6.2 | 6.6e-10 | 0.28 | 0.24 | 0.09 | FALSE |
| 10 | GTEx | Whole Blood | C1orf43 | 0.10 | 0.00 | enet | 37 | 0.00 | 2.8e-01 | -2.8 | -6.0 | 1.5e-09 | 0.24 | 0.05 | 0.12 | FALSE |
| 11 | YFS | Blood | IL6R | 0.04 | 0.04 | lasso | 3 | 0.04 | 5.1e-12 | -7.2 | 7.1 | 1.1e-12 | -0.95 | 0.01 | 0.99 | FALSE |