Best TWAS P=2.34e-28 · Best GWAS P=1.12e-56 conditioned to 1.17e-22
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | GLDC | 0.24 | 0.10 | lasso | 6 | 0.15 | 8.5e-18 | 5.284 | 6.4 | 1.2e-10 | 0.14 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | KIAA1432 | 0.04 | 0.00 | blup | 514 | 0.03 | 2.7e-04 | -0.310 | 8.8 | 1.3e-18 | 0.24 | 0.07 | 0.04 | TRUE |
| 3 | GTEx | Esophagus Muscularis | IL33 | 0.17 | 0.03 | enet | 29 | 0.06 | 1.7e-04 | -5.234 | 6.7 | 2.9e-11 | 0.38 | 0.07 | 0.42 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | RANBP6 | 0.07 | 0.01 | blup | 396 | 0.02 | 1.7e-03 | 0.078 | 7.0 | 3.4e-12 | -0.03 | 0.89 | 0.00 | TRUE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | GLDC | 0.11 | 0.00 | enet | 5 | 0.01 | 7.4e-03 | 15.104 | 11.0 | 2.3e-28 | 0.56 | 0.04 | 0.52 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ERMP1 | 0.05 | 0.02 | blup | 80 | 0.02 | 3.3e-04 | 7.018 | -5.7 | 1.4e-08 | 0.01 | 0.02 | 0.96 | FALSE |