Hub : Genes

RANBP6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0430	0.0220	0.00760	0.016	0.009	0.003	0.009	0.011	0.0046	0.0260	0.1400	0.0250	0.0130
2	GTEx	Colon Transverse	0.0850	0.0390	0.00630	0.033	NA	0.047	NA	0.042	0.0100	NA	0.0026	NA	0.0042
3	ROSMAP	Brain Pre-frontal Cortex	0.0688	0.0264	0.00057	0.011	0.018	0.011	0.014	0.006	0.0140	0.0017	0.0110	0.0062	0.0530
4	TCGA	Pancreatic Adenocarcinoma	0.2420	0.1000	0.00660	0.048	0.043	0.035	NA	0.038	0.0044	0.0066	0.0130	NA	0.0100

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.2	3.8	-0.7	2.0	-0.4	-0.4
Bipolar Disorder or Schizophrenia	0.7	1.6	3.1	-1.2	1.5	0.2	1.8
Depressed Affect (Nagel 2018)	0.6	1.3	4.8	-0.6	2.2	0.2	0.1
Depression (Nagel 2018)	1.0	1.5	3.4	0.1	0.9	1.4	1.9
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.5	1.1	1.2	-0.1	1.2
Neuroticism (Nagel 2018)	0.8	1.8	5.7	-0.9	0.9	-0.2	2.4
Schizophrenia (2018)	0.9	1.8	5.8	-1.0	0.3	0.6	2.4
Schizophrenia vs Biploar Disorder	1.0	1.3	2.3	-1.4	0.5	0.7	1.5
Worry (Nagel 2018)	1.2	2.5	9.5	-0.5	0.3	-0.6	3.1
Alzheimer’s Disease (in mother)	0.6	0.7	1.6	-0.1	1.3	-0.3	-1.1
Alzheimer’s Disease (in father)	0.4	0.4	1.1	0.1	0.1	1.1	0.6
Alzheimer’s Disease (including proxy)	0.6	0.9	2.2	0.0	0.9	0.7	-1.5
Crohns Disease (2017)	0.5	1.2	4.5	0.1	-0.4	2.1	-0.3
Irritable Bowel Disease (IBD)	0.7	1.7	3.8	-0.2	-1.7	1.9	0.6
Ulcerative Colitis (UC)	0.8	1.5	3.2	-0.2	-1.8	1.3	1.1
Major Depression (MDD)	3.5	4.2	11.1	-0.3	-2.4	-0.1	3.3
Reaction Time	0.5	1.0	2.8	-0.3	0.8	-0.6	-1.7
Verbal and Numeric Reasoning (VNR)	0.6	1.5	4.0	2.0	0.4	0.4	1.3
Breast Cancer	3.6	8.6	19.2	4.4	1.7	3.3	1.1
Ovarian Cancer	0.5	0.6	1.5	-0.1	-0.7	0.6	-1.2
Prostate Cancer	0.5	0.8	2.6	-1.6	-0.3	-0.3	-0.5
Age at First Birth	0.3	0.4	1.1	0.8	0.1	1.0	0.3
Bipolar Disorder (2011)	0.6	0.6	1.5	0.2	1.2	0.7	0.5
Body Mass Index (BMI) (2010)	0.9	1.2	4.9	-0.2	0.1	0.0	-2.2
Coronary Artery Disease (CAD)	1.7	2.0	3.7	0.8	1.3	1.9	1.4
Crohns Disease (2012)	0.6	1.0	3.5	0.6	-0.2	1.9	-0.0
Mean Putamen Volume	1.4	1.6	2.7	-0.8	-1.5	-0.9	1.7
Fasting Glucose	0.4	0.5	1.0	1.0	-0.9	-0.3	-0.2
HbA1C	0.7	0.8	2.7	1.7	0.1	-0.2	-0.6
HDL Cholesterol	0.9	1.5	3.8	-1.0	-1.0	-2.0	-0.0
LDL Cholesterol	0.2	0.3	0.5	-0.0	0.7	0.2	-0.7
Lupus	0.7	1.1	3.2	1.8	0.8	0.5	-0.5
Neuroticism (2016)	1.1	1.6	2.2	-1.1	-1.2	-1.5	1.3
Primary Biliary Cirrhosis	0.2	0.2	0.9	1.0	-0.0	0.3	-0.0
Rheumatoid Arthritis	1.7	2.3	3.5	-1.6	-1.7	-1.9	0.7
Schizophrenia (2014)	0.8	1.7	2.6	-1.6	1.4	0.7	1.4
Triglycerides	0.0	0.1	0.1	0.3	0.4	0.1	0.0
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.1	-0.9	1.8	-1.1	0.0
Ulcerative Colitis	0.5	0.8	1.5	-0.4	-1.2	0.8	0.9
Blood Eosinophil Count	2.5	19.2	47.1	-1.8	1.3	5.0	-6.9
Blood Platelet Count	0.3	3.1	8.4	0.8	2.9	1.5	-1.1
Blood Red Count	0.4	4.1	8.0	2.6	-0.1	1.2	2.8
Blood White Count	1.0	7.5	12.3	2.5	2.3	3.5	-2.5
Heel T-Score	0.6	4.5	8.9	-1.5	-2.1	-3.0	1.6
BMI	0.3	2.0	6.4	-1.0	-0.2	-0.8	-2.5
Height	0.2	3.5	8.9	0.8	-3.0	-0.3	2.1
Waist Hip Ratio (WHR)	0.4	2.0	5.0	1.0	2.2	1.3	0.4
Systolic Blood Pressure	0.0	0.1	0.2	0.5	0.1	0.3	0.2
Smoking Status	0.5	1.2	3.4	-0.8	0.1	-0.9	-1.8
Allergy or Eczema	9.9	26.0	79.8	4.2	2.1	8.9	1.5
Cardiovascular Disease	0.3	1.0	2.9	-0.4	1.7	-0.1	-0.9
Hypothyroidism (self reported)	0.4	0.8	3.2	-0.0	-0.2	-0.2	-1.8
Respiratory disease	5.5	12.3	48.1	0.4	0.9	6.9	-0.2
Type 2 Diabetes (T2D) (2018)	1.2	2.2	3.6	-1.5	-0.2	-1.9	1.8
Lung FEV1/FVC ratio	0.6	3.3	9.0	-0.4	0.1	-2.0	3.0
Lung FVC	0.1	0.3	0.5	-0.1	-0.7	0.4	-0.6
Neuroticism	0.6	1.6	3.1	-0.7	0.7	-1.5	1.8
Chronotype (morning person)	0.6	1.3	2.0	0.9	-1.2	1.4	-1.0
Hair Pigment	0.5	15.4	30.9	-1.6	-5.1	-1.3	5.6
Tanning	0.4	4.7	10.4	-2.2	1.2	-1.4	-3.2
Hand grip strength (left)	1.5	3.9	5.4	-2.3	-2.3	-2.2	-0.0
Number of treatments/medications taken	0.5	0.8	1.3	-0.7	-0.9	0.8	-1.1
Average weekly spirits intake	1.1	1.4	2.3	1.5	1.0	1.2	-0.9
Sensitivity / hurt feelings	0.2	0.3	0.7	-0.2	-0.5	-0.8	-0.4
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.2	-0.6	0.5	0.1	1.8
Hearing difficulty/problems: Yes	0.1	0.2	0.6	0.1	0.0	-0.4	-0.8
Relative age of first facial hair	0.5	1.1	1.9	1.4	-0.8	-0.4	1.3
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.3	-1.0	-0.8	-1.1	1.2
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.4	0.2	-0.2	0.6	0.4
Ever had hysterectomy (womb removed)	1.3	1.5	3.0	1.6	0.2	1.7	-0.7
Systolic blood pressure, automated reading	0.2	0.6	1.4	1.2	0.3	0.6	-0.6
Eye problems/disorders: Diabetes related eye disease	3.5	3.9	7.5	-2.7	0.1	-2.6	-1.1
Angina	3.8	5.0	8.7	-1.2	2.9	-1.5	-2.7
Medication for hormone replacement therapy	1.4	1.6	3.9	0.6	-0.8	1.2	-2.0
Vitamin and mineral supplements	1.4	1.8	3.3	1.8	0.2	1.7	-1.0
Supplements: Zinc	0.2	0.2	0.4	0.5	0.1	0.6	-0.4
Medication: Co-codamol	0.8	1.0	1.8	-1.1	-0.5	-1.3	0.8
Medication: Metformin	2.2	3.1	5.8	-1.4	-1.1	-2.4	1.9
Diabetes (father)	1.1	1.4	4.4	0.6	-2.1	-1.0	0.1
Diabetes (mother)	0.7	0.9	2.4	0.3	-1.5	-0.8	0.8
Severe depression (siblings)	1.3	1.4	5.0	0.2	-2.2	-0.1	0.9
Pack years adult smoking proportion	1.0	1.6	3.2	-1.6	-0.1	-1.8	0.6
Impedance of leg (right)	3.1	15.1	24.6	5.0	3.9	3.8	2.6
Leg fat-free mass (left)	1.3	6.9	10.6	-3.1	-3.3	-2.4	-1.3
Trunk fat percentage	0.6	2.3	5.1	2.2	1.4	1.5	0.2
Hand grip strength (right)	0.9	2.5	7.7	-0.9	-2.8	-1.2	0.3
Townsend deprivation index at recruitment	0.7	1.0	3.5	-1.9	0.4	-0.2	0.5
Current tobacco smoking	0.2	0.4	0.9	0.7	0.4	0.0	-1.0
Average weekly fortified wine intake	0.3	0.4	0.6	-0.7	-0.1	0.6	-0.8
Maternal smoking around birth	0.4	0.6	1.8	1.3	-0.1	0.7	0.3
Fed-up feelings	0.1	0.2	0.5	-0.7	0.5	-0.0	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.5	2.8	0.1	1.7	1.4	1.2
Relative age voice broke	0.8	1.2	2.4	0.3	-1.2	-0.8	1.5
Taking other prescription medications	0.7	1.2	3.9	0.2	-0.4	2.0	-0.7
Age when periods started (menarche)	0.5	1.3	3.6	0.5	0.5	1.0	1.9
Bilateral oophorectomy (both ovaries removed)	2.1	2.4	4.3	2.1	0.9	1.8	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	3.5	-1.6	-0.3	-1.9	1.3
Tinnitus: Yes, but not now, but have in the past	1.6	1.8	4.6	-0.3	-2.2	-0.2	1.5
Qualifications: CSEs or equivalent	3.1	4.1	9.8	-0.8	-3.1	-2.4	-0.2
Serious illness, injury or assault to yourself	0.7	0.9	2.7	-0.6	-0.4	-0.5	-1.6
High blood pressure	0.4	1.0	3.0	-0.8	0.3	-0.5	-1.7
Hayfever, allergic rhinitis or eczema	11.5	25.0	69.3	4.4	1.9	8.3	2.9
Multivitamins +/- minerals	0.5	0.6	1.4	-0.7	1.2	0.1	0.7
Stomach or abdominal pain in last month	1.1	1.3	3.1	-1.2	0.7	-1.8	0.4
Supplements: Glucosamine	2.0	2.6	4.7	1.2	2.2	1.5	-1.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.6	-0.3	0.8	0.6	-0.6
Medication: Atenolol	0.2	0.3	0.6	-0.7	0.2	-0.8	0.3
Medication: Levothyroxine sodium	1.7	2.8	4.2	-1.6	-0.7	-2.0	-2.0
Sitting height	0.2	1.1	2.3	0.1	-1.4	0.3	1.5
Chronic bronchitis/emphysema (father)	0.4	0.5	0.8	0.9	-0.4	0.9	0.4
High blood pressure (mother)	0.6	0.8	1.5	-0.6	-1.2	-0.2	1.2
Body mass index (BMI)	0.5	2.1	5.7	-1.3	-0.3	-0.8	-2.4
Impedance of leg (left)	2.8	13.7	22.2	4.7	3.3	3.3	3.2
Leg predicted mass (left)	1.4	7.2	11.0	-3.1	-3.3	-2.5	-1.3
Trunk fat mass	0.1	0.4	0.9	0.9	0.4	0.4	-0.5
Waist circumference	0.2	0.6	1.8	-0.1	0.4	-0.5	-1.4
Number of incorrect matches in round	0.2	0.3	0.7	-0.2	-0.7	-0.9	-0.2
Past tobacco smoking	0.6	1.1	2.3	1.4	0.4	1.5	0.3
Alcohol usually taken with meals	0.2	0.3	0.4	-0.4	0.6	0.5	-0.6
Nervous feelings	1.3	2.4	8.6	0.2	-0.8	0.4	2.9
Frequency of tenseness / restlessness in last 2 weeks	1.3	1.9	4.5	-1.4	-0.6	-0.9	2.1
Hearing difficulty/problems with background noise	0.8	1.3	2.8	-0.4	1.7	1.1	-1.1
Hair/balding pattern: Pattern 2	1.0	1.2	3.2	0.5	1.1	-0.4	-1.8
Had menopause	0.2	0.2	0.5	-0.0	-0.7	-0.0	0.7
Had other major operations	0.8	0.9	1.6	0.4	-1.2	1.3	0.7
Forced vital capacity (FVC)	0.3	1.1	4.0	-0.5	-2.0	0.1	0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	4.7	-2.2	-0.8	-2.0	1.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.8	-0.4	-0.1	0.3	0.9
Qualifications: None of the above	3.1	6.6	22.6	1.0	1.6	0.5	-4.8
Financial difficulties in last 2 years	2.3	3.0	3.9	-1.8	-2.0	-1.7	1.5
Mouth/teeth dental problems	0.4	0.6	1.6	-0.3	1.3	-0.3	-0.8
Heart attack	0.6	0.8	2.2	-0.5	-0.1	-1.5	-0.9
Allergy	10.8	24.9	82.0	-3.0	-2.4	-9.1	-1.6
Pain all over the body in last month	1.8	1.9	4.4	0.9	1.2	0.9	-2.1
Diabetes (self-reported)	1.3	2.1	4.0	-2.0	0.8	-1.6	0.9
Hayfever/allergic rhinitis (self-reported)	6.7	8.9	27.6	2.6	0.6	5.2	0.9
Medication: Ramipril	0.9	1.1	4.0	-0.4	-2.0	-0.5	0.3
Medication: Simvastatin	0.4	0.6	1.7	-0.1	0.8	0.3	-1.3
Fluid intelligence score	1.5	3.1	6.1	1.8	1.1	1.3	2.5
Illnesses of siblings	2.3	3.2	4.4	1.9	2.0	2.1	-1.0
Neuroticism score	0.3	0.6	1.5	-0.3	0.4	-0.8	1.2
Weight	0.4	1.7	2.4	-1.4	-1.6	-1.0	-1.3
Impedance of arm (right)	2.8	13.1	24.7	5.0	2.0	2.9	3.9
Arm fat percentage (right)	0.2	0.8	1.2	1.0	1.1	0.1	-0.9
Trunk fat-free mass	1.7	9.7	14.7	-3.8	-3.5	-2.5	-2.3
Hip circumference	0.1	0.6	1.2	-0.7	-0.6	-0.7	-1.1
Time employed in main current job	0.1	0.1	0.2	0.1	0.2	0.5	0.1
Alcohol intake versus 10 years previously	1.1	1.6	4.4	-1.0	0.8	-2.1	0.7
Father’s age at death	1.4	1.8	3.0	0.7	1.6	1.0	-1.7
Worrier / anxious feelings	0.2	0.4	1.1	-0.6	0.3	-0.5	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.3	-0.6	-0.4	-0.5
Falls in the last year	0.7	0.9	1.4	1.1	1.0	1.2	-0.2
Hair/balding pattern: Pattern 3	3.0	4.4	13.8	-0.0	-3.7	0.8	1.8
Number of live births	0.5	0.7	1.8	1.0	0.0	1.4	0.3
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	5.1	-0.6	-2.0	-0.7	2.3
Pulse rate	0.6	1.0	2.6	0.4	1.1	1.6	-0.0
Happiness	0.4	0.5	0.9	-1.0	-0.9	-0.5	0.4
Noisy workplace	2.0	2.4	5.5	-1.4	-0.7	-2.3	-1.3
Qualifications: A levels/AS levels or equivalent	1.3	2.9	7.7	-1.4	0.9	-1.1	2.8
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.4	4.9	-0.4	-2.2	-0.4	-0.7
Mouth/teeth dental problems: Dentures	0.4	0.6	1.3	-1.0	-0.3	-1.1	-0.3
Asthma	6.5	12.8	48.4	0.8	1.2	7.0	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.4	-0.0	-0.1	0.4	-1.5
Medication: Cholesterol lowering	1.2	1.9	3.9	-1.7	-0.4	-2.0	-0.8
Depression (self-reported)	0.3	0.3	0.6	0.7	-0.2	0.8	0.4
Medication: Lansoprazole	0.1	0.1	0.2	0.1	-0.1	0.2	-0.5
Prospective memory result	1.4	1.7	4.6	-1.5	-0.4	-0.1	-2.1
Lung cancer (father)	1.1	1.2	3.2	-0.6	-1.8	0.3	1.1
Illnesses of mother	0.4	0.5	2.0	-0.1	1.4	0.2	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	5.2	-0.5	-1.9	-0.4	2.3
Pulse wave Arterial Stiffness index	3.1	3.6	6.7	2.2	0.8	2.6	-1.4
Impedance of arm (left)	2.8	12.9	23.9	4.9	1.4	2.5	4.4
Arm fat mass (right)	0.1	0.6	2.1	-0.3	-0.0	-0.4	-1.5
Trunk predicted mass	1.7	9.9	15.4	-3.9	-3.5	-2.6	-2.3
Standing height	0.4	3.7	10.3	-0.1	-3.2	-0.4	2.1
Length of working week for main job	0.4	0.4	0.8	0.2	-0.9	-0.9	-0.3
Exposure to tobacco smoke at home	0.3	0.3	0.8	-0.5	0.5	0.9	-0.1
Breastfed as a baby	0.2	0.3	1.0	-1.0	0.2	-0.1	-0.1
Tense / ‘highly strung’	0.2	0.4	0.7	-0.8	0.1	-0.9	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	6.1	0.5	-0.4	0.2	2.5
Hair/balding pattern: Pattern 4	1.0	2.5	6.2	-1.4	-2.5	-1.1	0.8
Birth weight of first child	0.5	0.9	2.5	-0.5	-0.9	1.6	0.2
Peak expiratory flow (PEF)	1.4	3.2	7.1	0.3	-2.7	0.0	2.4
Pulse wave reflection index	0.1	0.1	0.2	0.1	0.3	-0.3	-0.5
Ever highly irritable/argumentative for 2 days	0.8	1.0	1.6	-1.0	-1.1	0.5	-1.3
Loud music exposure frequency	0.1	0.1	0.4	-0.2	0.6	0.1	-0.3
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	3.2	-0.6	1.7	-0.9	1.8
Mouth/teeth dental problems: Bleeding gums	2.6	3.4	8.7	1.9	0.1	3.0	1.2
Blood clot in the leg (DVT)	0.6	0.7	1.3	-0.6	0.4	1.0	-1.1
Medication: Paracetamol	0.4	0.7	1.7	-0.5	1.3	-0.4	-0.9
Headache pain in last month	0.1	0.1	0.3	0.2	-0.5	0.4	0.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.5	0.2	-0.8	0.3	1.6
Glaucoma (self-reported)	0.1	0.1	0.2	0.4	-0.2	0.4	-0.1
Gout (self-reported)	1.5	2.1	4.6	-1.8	0.7	-2.1	0.1
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	5.7	-0.5	-0.4	-1.3	-2.4
Medication: Amlodipine	0.5	0.7	1.2	0.8	-1.0	0.1	-1.1
Medication: Ventolin 100micrograms inhaler	5.2	6.7	16.0	0.2	2.3	4.0	-2.4
Birth weight	0.1	0.3	0.7	-0.8	-0.2	0.2	-0.6
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.3	-0.7	-1.1	0.3	-0.7
High blood pressure (siblings)	0.6	0.8	1.4	-0.7	-1.2	-0.5	1.1
Forced vital capacity (FVC), Best measure	0.4	1.6	3.4	-0.3	-1.9	0.8	1.5
Body fat percentage	0.4	1.8	3.6	1.9	1.5	1.0	-0.4
Leg fat percentage (right)	0.9	3.1	6.0	1.8	2.5	1.2	-1.4
Arm fat-free mass (right)	1.4	7.2	11.6	-3.4	-3.1	-2.0	-2.0
Exposure to tobacco smoke outside home	0.2	0.3	1.0	0.1	-1.0	-0.1	0.4
Comparative body size at age 10	1.3	3.6	9.0	-1.4	-1.2	-3.0	-1.4
Number of full brothers	0.6	0.7	1.0	-0.5	-1.0	-1.0	0.8
Worry too long after embarrassment	1.1	1.9	6.9	-0.6	-0.3	-0.2	2.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.6	-1.2	0.6	-0.9	0.6
Wheeze or whistling in the chest in last year	2.2	4.0	13.3	-0.5	1.2	3.6	-0.9
Number of children fathered	0.5	0.5	1.3	0.1	-0.7	-1.1	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.3	4.0	0.8	0.5	2.0	-0.8
Age at first live birth	0.4	0.8	2.0	-1.0	-0.2	0.2	-1.4
Pulse wave peak to peak time	2.9	3.4	5.6	-2.0	-1.1	-2.4	1.6
Health satisfaction	0.9	1.2	2.5	-1.4	0.3	-1.6	-0.4
Shortness of breath walking on level ground	0.5	0.6	1.4	-1.2	-0.7	0.5	0.2
Qualifications: College or University degree	1.9	6.1	21.3	1.0	-0.6	1.2	4.6
Eye problems/disorders: None of the above	0.8	0.9	1.1	1.1	-1.0	0.8	0.8
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.3	-0.2	-0.7	-1.1	-0.8
Emphysema/chronic bronchitis	0.5	0.5	1.2	0.6	-1.1	0.8	0.0
Medication for pain relief, constipation, heartburn	0.8	1.4	3.3	1.1	-0.8	0.7	1.8
Neck or shoulder pain in last month	0.4	0.6	1.3	0.3	1.1	0.6	-0.7
Medication: Blood pressure	0.8	1.4	4.3	0.7	0.8	-0.3	-2.1
Angina (self-reported)	3.5	4.6	8.7	-1.0	2.9	-1.4	-2.6
Migraine (self-reported)	1.2	1.5	4.2	0.4	2.0	1.2	0.5
Medication: Ibuprofen	0.9	1.1	3.0	0.3	0.2	1.1	-1.7
Medication: Allopurinol	2.5	3.3	6.3	-2.0	1.7	-2.5	-0.5
Medication: Omeprazole	0.7	0.9	2.2	-0.6	-1.5	-0.9	0.3
Medication: Seretide 50 evohaler	1.1	1.2	2.0	-0.8	-1.4	1.4	0.4
Mean time to correctly identify matches	0.8	1.5	5.4	0.0	0.8	-0.2	-2.3
Heart disease (mother)	0.1	0.2	0.3	-0.5	-0.4	-0.2	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	3.3	-0.2	1.6	0.9	-1.8
Whole body fat mass	0.1	0.4	1.2	0.5	0.3	0.0	-1.1
Leg fat mass (right)	0.2	0.9	2.8	0.4	0.8	-0.2	-1.7
Arm predicted mass (right)	1.5	7.7	11.5	-3.4	-3.1	-2.2	-2.1
Pulse rate, automated reading	0.5	1.7	4.8	0.3	1.2	2.2	-0.6
Alcohol intake frequency.	0.5	1.2	2.9	-0.9	-0.9	-1.7	0.6
Comparative height size at age 10	0.4	2.2	6.2	-0.8	-2.5	-0.2	-1.4
Number of full sisters	0.7	0.9	1.7	-1.0	-0.7	-0.6	-1.3
Suffer from ‘nerves’	1.3	2.1	7.3	0.8	-0.1	0.6	2.7
Overall health rating	0.6	1.3	2.2	-0.9	-1.2	-0.8	-1.5
Chest pain or discomfort	0.4	0.6	1.5	-1.2	0.1	-0.4	-0.8
Had major operations	1.3	1.5	3.5	-0.9	-1.9	-1.2	-0.5
Age at last live birth	0.3	0.5	1.5	-0.5	0.4	0.3	-1.2
Family relationship satisfaction	0.9	1.1	4.2	-0.1	2.0	0.2	-0.3
Leg pain on walking	0.9	1.1	3.0	-0.9	0.3	-0.7	-1.7
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	4.1	-0.6	-1.7	-1.4	2.0
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.1	-0.6	-0.2	-0.6	-1.4
Illness, injury, bereavement, stress in last 2 years	3.5	4.2	11.2	1.9	3.3	1.4	0.4
Medication: Aspirin	0.3	0.4	1.1	-0.5	-0.5	-1.0	-0.4
Supplements: Vitamin C	0.6	0.7	1.5	-1.2	-0.4	-1.0	-0.5
Knee pain experienced in last month	0.2	0.2	0.6	-0.8	-0.1	-0.5	0.4
Hypertension (Self-reported)	0.4	1.2	3.3	-1.0	0.2	-0.6	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	0.7	0.3	0.4	-0.3
Illnesses of father: Heart disease	0.6	0.8	2.0	-0.7	0.1	-1.4	-0.8
Illnesses of siblings: Diabetes	0.4	0.5	1.0	0.3	-0.5	-0.8	1.0
Smoking status: Previous	1.4	2.1	4.7	-2.2	-0.6	-1.8	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.9	-0.5	-0.6	-1.0	-0.6
Whole body fat-free mass	1.6	9.1	13.8	-3.7	-3.5	-2.6	-1.9
Leg fat-free mass (right)	1.6	8.5	14.3	-3.4	-3.8	-2.7	-0.9
Arm fat percentage (left)	0.1	0.5	0.9	1.0	0.8	-0.1	-0.7
Average weekly red wine intake	0.2	0.3	0.8	-0.9	0.4	0.6	-0.0
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.6	0.0	0.5	0.1	0.8
Mood swings	1.4	2.5	5.1	-1.4	2.3	-0.6	-1.6
Loneliness, isolation	1.8	2.4	5.2	-2.3	0.9	-1.7	-0.8
Long-standing illness, disability or infirmity	0.5	0.8	1.9	-1.4	-0.6	-0.8	-0.4
Ever had bowel cancer screening	0.5	0.5	1.0	-0.9	-1.0	-0.5	0.3
Diabetes diagnosed by doctor	1.6	2.6	4.7	-2.2	0.2	-2.0	1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	3.0	0.5	1.3	1.7	0.7
Friendships satisfaction	0.8	1.0	2.3	-0.3	1.5	-0.7	-1.1
Qualifications: nursing, teaching	0.9	1.3	2.2	-0.7	0.7	-1.5	1.5
Commuting to job workplace: Walk	3.0	3.3	9.2	-1.5	-1.0	-0.9	3.0
Eye problems/disorders: Cataract	1.2	1.4	3.4	0.1	1.5	0.1	-1.8
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	6.4	-0.8	-2.5	-1.3	-0.1
Medication for cholesterol	0.5	0.8	1.8	-0.2	0.9	-1.4	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.8	0.8	-0.5	0.6	-0.9
Back pain experienced in last month	0.8	1.1	2.0	0.5	-1.4	0.5	1.4
Mineral and other dietary supplements	0.3	0.4	1.7	0.0	-1.3	0.3	0.1
Breast cancer (self-reported)	0.9	1.1	3.3	-0.2	0.7	1.8	-0.6
Asthma (self-reported)	6.5	13.0	49.3	0.7	1.3	7.0	-0.9
Osteoporosis (self-reported)	1.2	1.5	3.5	0.8	-1.1	0.8	1.9
Osteoarthritis (self-reported)	1.8	2.4	4.3	-2.1	-0.9	-0.6	-2.0
Medication: Aspirin	0.4	0.5	1.0	-0.7	-0.4	-1.0	-0.4
Medication: Gliclazide	3.8	4.3	9.6	-2.4	-1.2	-3.1	-0.8
Illnesses of father: None of the above (group 1)	0.3	0.4	1.0	0.2	-0.7	0.3	1.0
Smoking status: Current	0.3	0.5	1.7	0.5	0.4	-0.1	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	3.4	-1.6	-0.3	-0.7	1.8
Whole body water mass	1.6	9.2	13.7	-3.7	-3.6	-2.5	-1.9
Leg predicted mass (right)	1.7	8.8	14.5	-3.5	-3.8	-2.8	-0.9
Arm fat mass (left)	0.2	0.7	2.3	-0.3	-0.1	-0.6	-1.5
Number of self-reported non-cancer illnesses	1.1	1.9	6.6	-0.2	-0.8	2.6	0.6
Average weekly champagne plus white wine intake	0.8	1.0	3.1	0.3	-0.6	0.8	-1.8
Miserableness	0.4	0.7	1.6	0.7	1.3	0.6	0.5
Guilty feelings	1.4	2.0	7.2	-0.9	0.0	-0.2	2.7
Wears glasses or contact lenses	0.9	1.1	2.0	1.4	-0.2	0.7	1.3
Ever taken oral contraceptive pill	0.6	0.7	1.3	-1.1	0.8	-0.8	0.5
Hearing aid user	1.6	1.8	3.8	-1.3	-0.8	-1.9	1.0
Mother’s age at death	0.4	0.5	1.4	-0.3	-1.2	0.5	-0.5
Financial situation satisfaction	0.9	1.1	2.2	-1.5	-0.5	-1.1	0.8
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.2	0.0	1.0	1.2	-1.5
Commuting to job workplace: Public transport	0.6	0.7	2.2	-1.5	0.2	-0.7	0.2
Eye problems/disorders: Glaucoma	0.2	0.2	0.7	-0.2	0.0	-0.2	-0.8
Medication: Blood pressure	0.4	0.8	1.4	-0.2	-0.6	1.2	-1.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	-1.1	0.7	0.1	-0.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.6	-0.1	1.3	-0.1	-0.3
High cholesterol (Self-reported)	0.4	0.6	1.0	-0.5	1.0	-0.8	-0.8
Medication: Bendroflumethiazide	0.4	0.6	0.9	0.7	0.9	1.0	-0.5
Medication: Paracetamol	0.1	0.1	0.2	-0.4	0.4	-0.2	0.2
Medication: Lisinopril	0.4	0.5	1.0	0.4	0.7	0.6	-1.0
Medication: Atorvastatin	1.4	1.7	2.9	-0.6	-1.7	-1.6	0.9
Illnesses of father: High blood pressure	2.2	2.7	3.9	-2.0	-1.7	-1.9	0.8
Alcohol drinker status: Never	0.1	0.2	0.2	-0.4	0.4	-0.3	0.4
Ever smoked	0.1	0.1	0.2	-0.5	0.3	-0.1	-0.2
Basal metabolic rate	1.3	7.0	10.1	-3.2	-3.0	-2.3	-1.8
Leg fat percentage (left)	0.5	1.9	3.9	1.3	2.0	0.7	-1.2
Arm fat-free mass (left)	1.4	6.9	11.3	-3.4	-2.6	-1.8	-2.6
Number of operations (self-reported)	1.0	1.5	5.8	-0.2	-2.4	0.3	-0.4
Average weekly beer plus cider intake	0.5	0.8	2.2	-0.4	-0.7	-1.5	0.4
Irritability	0.6	1.1	3.9	-0.1	2.0	-0.6	-0.4
Risk taking	0.9	1.3	3.1	0.3	-1.8	0.7	-1.3
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.3	0.5	1.5	-0.4	0.2
Fractured/broken bones in last 5 years	1.2	1.5	4.5	0.9	0.3	2.1	0.9
Age started oral contraceptive pill	0.3	0.4	1.2	0.4	1.1	-0.1	-0.4
Diastolic blood pressure, automated reading	0.4	1.1	1.7	-0.4	1.3	1.2	-1.1
Ever depressed for a whole week	0.2	0.2	0.3	0.2	-0.5	0.4	0.6
Unable to work because of sickness or disability	0.5	0.6	1.5	-0.7	-0.2	-0.7	-1.2
Commuting to job workplace: Cycle	0.8	1.0	1.9	-1.2	-0.7	-1.4	-0.4
Myopia	0.3	0.5	1.2	0.8	-0.1	1.1	0.2
Vascular/heart problems diagnosed by doctor	0.6	1.6	4.7	1.0	-0.6	0.7	2.2
Cholesterol lowering medication	0.5	0.8	1.2	1.1	0.7	1.1	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	-0.6	-1.0	-0.7	0.0
Pain experienced in last month	0.5	0.9	1.4	0.5	-1.1	-0.9	1.2
Supplements: Calcium	0.2	0.2	0.8	0.1	0.4	-0.9	0.2
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	0.6	-0.4	0.4	0.5
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.6	-0.5	0.1	-1.6	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	2.2	-0.9	0.5	1.0	-1.5
Heart disease (siblings)	0.4	0.5	1.2	-0.8	0.2	-1.1	0.4
Alcohol drinker status: Previous	0.7	0.8	1.9	-1.4	-0.6	-1.1	0.2
Pack years of smoking	0.8	1.1	2.5	-1.3	-0.1	-1.6	0.4
Impedance of whole body	3.4	17.5	31.4	5.6	2.8	3.5	4.3
Leg fat mass (left)	0.2	0.7	2.2	0.1	0.5	-0.5	-1.5
Arm predicted mass (left)	1.2	6.3	10.6	-3.3	-2.6	-1.7	-2.2