Best TWAS P=1.11e-19 · Best GWAS P=1.41e-26 conditioned to 1.7e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | DEXI | 0.17 | 0.02 | enet | 27 | 0.03 | 1.3e-02 | -6.9 | -5.2 | 1.9e-07 | 0.53 | 0.07 | 0.85 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | RP11-876N24.5 | 0.11 | 0.08 | lasso | 2 | 0.10 | 6.0e-06 | -8.2 | -8.3 | 8.7e-17 | 0.68 | 0.06 | 0.92 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | DEXI | 0.12 | 0.07 | enet | 14 | 0.08 | 6.9e-05 | -7.8 | -7.7 | 2.0e-14 | 0.72 | 0.06 | 0.89 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | RP11-876N24.5 | 0.15 | 0.11 | enet | 19 | 0.12 | 1.4e-06 | -7.8 | -8.7 | 2.7e-18 | 0.73 | 0.28 | 0.70 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Male) | DEXI | 0.18 | 0.04 | lasso | 3 | -0.01 | 4.9e-01 | -6.5 | -6.8 | 8.6e-12 | 0.63 | 0.03 | 0.64 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Male) | RP11-876N24.5 | 0.16 | 0.24 | lasso | 2 | 0.21 | 1.5e-05 | -5.7 | -5.8 | 5.3e-09 | 0.36 | 0.07 | 0.22 | FALSE |
| 7 | GTEx | Breast Mammary Tissue (Female) | DEXI | 0.13 | 0.06 | lasso | 2 | 0.04 | 2.0e-02 | -8.4 | -8.4 | 3.6e-17 | 0.79 | 0.05 | 0.52 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Female) | RP11-876N24.5 | 0.22 | 0.14 | enet | 11 | 0.13 | 1.0e-04 | -6.6 | -8.0 | 1.4e-15 | 0.77 | 0.14 | 0.75 | FALSE |
| 9 | GTEx | Cells Transformed fibroblasts | DEXI | 0.12 | 0.05 | lasso | 5 | 0.08 | 9.6e-07 | -6.0 | -7.3 | 1.9e-13 | 0.72 | 0.17 | 0.82 | FALSE |
| 10 | GTEx | Cells Transformed fibroblasts | RP11-876N24.4 | 0.12 | 0.04 | lasso | 5 | 0.08 | 2.1e-06 | -6.0 | -7.4 | 1.2e-13 | 0.73 | 0.17 | 0.82 | FALSE |
| 11 | GTEx | Nerve Tibial | DEXI | 0.11 | 0.05 | enet | 7 | 0.07 | 1.7e-05 | -7.8 | -8.4 | 4.8e-17 | 0.81 | 0.64 | 0.28 | FALSE |
| 12 | GTEx | Pancreas | DEXI | 0.13 | 0.06 | lasso | 4 | 0.07 | 5.7e-04 | -6.3 | -6.7 | 1.6e-11 | 0.67 | 0.18 | 0.68 | FALSE |
| 13 | GTEx | Pancreas | RP11-876N24.4 | 0.11 | 0.05 | lasso | 3 | 0.04 | 8.6e-03 | -6.3 | -6.8 | 1.4e-11 | 0.67 | 0.15 | 0.67 | FALSE |
| 14 | GTEx | Skin Sun Exposed Lower leg | DEXI | 0.05 | 0.06 | lasso | 2 | 0.03 | 7.8e-04 | -6.3 | -6.2 | 4.2e-10 | 0.65 | 0.70 | 0.21 | FALSE |
| 15 | GTEx | Testis | CLEC16A | 0.15 | 0.00 | enet | 20 | 0.01 | 1.2e-01 | -8.2 | -9.1 | 1.1e-19 | 0.71 | 0.02 | 0.92 | TRUE |
| 16 | GTEx | Testis | DEXI | 0.21 | 0.11 | lasso | 3 | 0.08 | 2.1e-04 | -7.5 | -7.0 | 1.8e-12 | 0.68 | 0.29 | 0.32 | FALSE |
| 17 | GTEx | Testis | RP11-876N24.4 | 0.21 | 0.06 | lasso | 5 | 0.07 | 6.0e-04 | -7.5 | -7.4 | 1.0e-13 | 0.70 | 0.22 | 0.30 | FALSE |
| 18 | GTEx | Thyroid | DEXI | 0.08 | 0.00 | enet | 18 | 0.03 | 1.8e-03 | -6.3 | -6.6 | 5.5e-11 | 0.53 | 0.18 | 0.65 | FALSE |
| 19 | GTEx | Thyroid | RP11-876N24.4 | 0.06 | 0.00 | enet | 17 | 0.02 | 1.5e-02 | 3.1 | -5.3 | 9.6e-08 | 0.43 | 0.18 | 0.33 | FALSE |
| 20 | GTEx | Thyroid | RP11-396B14.2 | 0.12 | 0.01 | lasso | 6 | 0.01 | 4.0e-02 | -7.5 | 8.6 | 9.9e-18 | -0.80 | 0.01 | 0.96 | TRUE |
| 21 | ROSMAP | Brain Pre-frontal Cortex | DEXI | 0.12 | 0.12 | lasso | 6 | 0.13 | 5.9e-16 | -5.8 | -6.7 | 1.9e-11 | 0.70 | 1.00 | 0.00 | FALSE |
| 22 | YFS | Blood | DEXI | 0.11 | 0.15 | enet | 29 | 0.16 | 2.6e-51 | -5.8 | -6.0 | 1.5e-09 | 0.66 | 1.00 | 0.00 | FALSE |
| 23 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DEXI | 0.04 | 0.02 | blup | 49 | 0.04 | 8.6e-08 | -8.2 | -6.7 | 2.4e-11 | 0.66 | 0.02 | 0.98 | FALSE |
| 24 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DEXI | 0.05 | 0.02 | lasso | 4 | 0.03 | 1.7e-04 | -5.5 | -6.6 | 5.0e-11 | 0.64 | 0.02 | 0.84 | FALSE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | CLEC16A | 0.14 | 0.06 | lasso | 4 | 0.09 | 6.8e-09 | -7.8 | 5.2 | 2.5e-07 | -0.63 | 0.22 | 0.78 | FALSE |