Best TWAS P=3.57e-32 · Best GWAS P=2.6e-37 conditioned to 0.000349
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AAGAB | 0.06 | 0.05 | enet | 11 | 0.05 | 3.2e-07 | -6.00 | -6.1 | 1.4e-09 | -0.04 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | IQCH | 0.13 | 0.11 | bslmm | 597 | 0.10 | 5.9e-12 | -7.37 | 6.0 | 1.6e-09 | 0.06 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Brain Cerebellum | MAP2K5 | 0.27 | 0.12 | lasso | 5 | 0.14 | 7.9e-05 | -7.18 | 5.4 | 5.7e-08 | -0.02 | 0.49 | 0.03 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | SMAD3 | 0.12 | 0.01 | lasso | 9 | 0.06 | 3.6e-05 | -0.34 | -6.0 | 2.0e-09 | -0.05 | 0.24 | 0.08 | TRUE |
| 5 | GTEx | Thyroid | SMAD3 | 0.19 | 0.02 | enet | 3 | 0.03 | 2.3e-03 | 12.76 | -10.0 | 2.2e-23 | -0.75 | 0.00 | 0.97 | TRUE |
| 6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | IQCH | 0.13 | 0.07 | blup | 112 | 0.10 | 5.2e-09 | -4.22 | 5.6 | 2.5e-08 | 0.00 | 0.07 | 0.93 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IQCH | 0.06 | 0.05 | blup | 112 | 0.06 | 5.2e-12 | -7.18 | 5.9 | 3.3e-09 | -0.01 | 0.02 | 0.98 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | IQCH | 0.08 | 0.02 | blup | 111 | 0.05 | 4.2e-04 | -4.16 | 6.2 | 7.0e-10 | 0.00 | 0.05 | 0.88 | TRUE |
| 9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | IQCH | 0.35 | 0.04 | blup | 112 | 0.12 | 1.5e-05 | -4.22 | 5.4 | 7.4e-08 | -0.06 | 0.05 | 0.90 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | SMAD3 | 0.22 | 0.12 | enet | 12 | 0.11 | 5.2e-11 | 10.99 | -11.8 | 3.6e-32 | -0.88 | 0.01 | 0.99 | TRUE |