Best TWAS P=6.39e-08 · Best GWAS P=1.15e-07 conditioned to 0.415
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | ACO2 | 0.08 | 0.08 | lasso | 5 | 0.06 | 2.8e-04 | 5.3 | 5.2 | 1.7e-07 | 0.98 | 0.03 | 0.93 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | PMM1 | 0.20 | 0.16 | lasso | 7 | 0.14 | 1.9e-05 | 5.3 | -5.3 | 1.1e-07 | -0.98 | 0.04 | 0.95 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | TEF | 0.23 | 0.13 | lasso | 7 | 0.16 | 6.9e-06 | 5.3 | 5.2 | 1.9e-07 | 0.99 | 0.04 | 0.96 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ACO2 | 0.03 | 0.01 | blup | 41 | 0.04 | 3.9e-03 | -3.7 | 5.3 | 9.3e-08 | 0.95 | 0.02 | 0.56 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PHF5A | 0.03 | 0.00 | blup | 30 | 0.01 | 2.9e-02 | 5.2 | 5.4 | 6.4e-08 | 0.92 | 0.01 | 0.56 | TRUE |
| 6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TOB2 | 0.03 | 0.00 | blup | 28 | 0.02 | 3.4e-03 | 5.0 | 5.2 | 1.9e-07 | 0.96 | 0.01 | 0.60 | FALSE |