Best TWAS P=1.21e-12 · Best GWAS P=8.03e-12 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SLC45A1 | 0.04 | 0.05 | enet | 9 | 0.02 | 1.8e-03 | -5.2 | -5.8 | 8.0e-09 | 0.79 | 0.65 | 0.29 | FALSE |
2 | GTEx | Adipose Subcutaneous | RERE | 0.20 | 0.23 | lasso | 2 | 0.24 | 1.7e-19 | 5.7 | 6.3 | 2.2e-10 | -0.76 | 0.56 | 0.44 | FALSE |
3 | GTEx | Adipose Subcutaneous | RP5-1115A15.1 | 0.14 | 0.07 | enet | 20 | 0.10 | 2.6e-08 | -6.5 | 5.8 | 8.5e-09 | -0.87 | 0.01 | 0.99 | FALSE |
4 | GTEx | Adipose Visceral Omentum | RERE | 0.22 | 0.17 | lasso | 5 | 0.17 | 5.2e-09 | -6.8 | 6.0 | 1.9e-09 | -0.91 | 0.00 | 1.00 | FALSE |
5 | GTEx | Breast Mammary Tissue | RERE | 0.19 | 0.08 | enet | 10 | 0.14 | 8.0e-08 | 6.0 | 5.6 | 2.1e-08 | -0.70 | 0.19 | 0.79 | FALSE |
6 | GTEx | Breast Mammary Tissue | RP5-1115A15.1 | 0.10 | 0.07 | lasso | 2 | 0.03 | 7.0e-03 | 5.7 | 5.7 | 9.3e-09 | -0.62 | 0.15 | 0.77 | FALSE |
7 | GTEx | Breast Mammary Tissue (Male) | RP5-1115A15.1 | 0.18 | 0.07 | lasso | 3 | 0.06 | 1.7e-02 | -3.3 | 5.3 | 9.3e-08 | -0.67 | 0.02 | 0.61 | FALSE |
8 | GTEx | Cells Transformed fibroblasts | RERE | 0.12 | 0.08 | lasso | 4 | 0.05 | 6.0e-05 | 5.9 | 6.0 | 2.6e-09 | -0.66 | 0.24 | 0.75 | FALSE |
9 | GTEx | Esophagus Mucosa | RERE | 0.13 | 0.16 | lasso | 3 | 0.16 | 7.2e-11 | -6.8 | 6.8 | 8.0e-12 | -1.00 | 0.00 | 1.00 | FALSE |
10 | GTEx | Esophagus Mucosa | RP5-1115A15.1 | 0.06 | 0.06 | lasso | 4 | 0.05 | 3.0e-04 | -6.8 | 7.1 | 1.2e-12 | -0.97 | 0.00 | 0.99 | TRUE |
11 | GTEx | Lung | RERE | 0.07 | 0.05 | lasso | 4 | 0.05 | 2.0e-04 | -6.1 | 6.3 | 3.7e-10 | -0.87 | 0.04 | 0.96 | FALSE |
12 | GTEx | Lung | RP5-1115A15.1 | 0.05 | 0.08 | lasso | 1 | 0.07 | 1.0e-05 | -6.5 | 6.5 | 6.3e-11 | -0.98 | 0.01 | 0.98 | FALSE |
13 | GTEx | Nerve Tibial | RERE | 0.12 | 0.09 | enet | 16 | 0.11 | 5.6e-08 | 5.4 | 5.8 | 6.1e-09 | -0.61 | 0.55 | 0.45 | FALSE |
14 | GTEx | Pancreas | RERE | 0.11 | 0.12 | lasso | 4 | 0.07 | 5.9e-04 | 5.9 | 6.4 | 1.8e-10 | -0.63 | 0.06 | 0.82 | FALSE |
15 | GTEx | Skin Not Sun Exposed Suprapubic | RP5-1115A15.1 | 0.08 | 0.04 | enet | 8 | 0.04 | 3.0e-03 | -6.4 | 6.6 | 3.1e-11 | -0.95 | 0.01 | 0.98 | FALSE |
16 | GTEx | Skin Sun Exposed Lower leg | RERE | 0.14 | 0.05 | lasso | 8 | 0.08 | 4.3e-07 | -6.8 | 5.7 | 1.0e-08 | -0.89 | 0.01 | 0.99 | FALSE |
17 | GTEx | Skin Sun Exposed Lower leg | RP5-1115A15.1 | 0.07 | 0.03 | enet | 13 | 0.03 | 1.5e-03 | -6.8 | 5.6 | 2.3e-08 | -0.87 | 0.01 | 0.99 | FALSE |
18 | GTEx | Thyroid | RP5-1115A15.1 | 0.09 | 0.12 | lasso | 2 | 0.09 | 1.5e-07 | -6.5 | 6.7 | 2.2e-11 | -0.98 | 0.01 | 0.99 | FALSE |
19 | GTEx | Whole Blood | RERE | 0.19 | 0.15 | lasso | 4 | 0.13 | 2.7e-12 | -6.8 | 6.9 | 4.2e-12 | -1.00 | 0.00 | 1.00 | FALSE |
20 | METSIM | Adipose | RERE | 0.08 | 0.12 | lasso | 17 | 0.13 | 1.8e-19 | 5.7 | 7.1 | 1.7e-12 | -0.80 | 0.46 | 0.54 | FALSE |
21 | NTR | Blood | RERE | 0.04 | 0.04 | lasso | 8 | 0.03 | 2.0e-11 | -6.5 | 6.2 | 5.5e-10 | -0.87 | 0.04 | 0.96 | FALSE |
22 | ROSMAP | Brain Pre-frontal Cortex | RERE | 0.15 | 0.15 | lasso | 7 | 0.15 | 1.5e-18 | 5.9 | 6.1 | 9.7e-10 | -0.71 | 0.44 | 0.56 | FALSE |
23 | YFS | Blood | ENO1 | 0.07 | 0.06 | lasso | 7 | 0.06 | 5.1e-19 | 4.8 | -5.4 | 6.3e-08 | 0.36 | 0.99 | 0.01 | FALSE |
24 | YFS | Blood | RERE | 0.09 | 0.15 | lasso | 4 | 0.16 | 5.7e-49 | -6.7 | 6.9 | 6.7e-12 | -0.97 | 0.01 | 0.99 | FALSE |
25 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RERE | 0.02 | 0.03 | lasso | 2 | 0.03 | 4.7e-07 | -6.7 | 6.4 | 1.7e-10 | -0.96 | 0.00 | 0.99 | FALSE |
26 | The Cancer Genome Atlas | Esophageal Carcinoma | RERE | 0.10 | 0.07 | blup | 154 | 0.06 | 5.2e-03 | -5.3 | 5.8 | 5.5e-09 | -0.83 | 0.03 | 0.69 | FALSE |
27 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RERE | 0.22 | 0.04 | lasso | 10 | 0.08 | 4.1e-04 | -6.8 | 6.8 | 1.5e-11 | -0.89 | 0.01 | 0.96 | FALSE |
28 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | RERE | 0.12 | 0.01 | enet | 10 | 0.03 | 4.6e-02 | -6.1 | 5.4 | 6.5e-08 | -0.81 | 0.03 | 0.64 | FALSE |