Best TWAS P=7.42e-20 · Best GWAS P=1.8e-19 conditioned to 0
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Colon Sigmoid | S100A11 | 0.18 | 0.13 | lasso | 3 | 0.14 | 1.1e-05 | 5.16 | 5.2 | 2.5e-07 | -0.08 | 0.22 | 0.04 | TRUE |
2 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LINGO4 | 0.15 | 0.03 | lasso | 4 | 0.05 | 8.9e-10 | 5.94 | 5.8 | 8.0e-09 | 0.02 | 0.96 | 0.00 | FALSE |
3 | The Cancer Genome Atlas | Colon Adenocarcinoma | LINGO4 | 0.29 | 0.07 | enet | 15 | 0.07 | 8.3e-05 | 5.94 | 9.1 | 7.4e-20 | -0.28 | 0.06 | 0.12 | TRUE |
4 | The Cancer Genome Atlas | Glioblastoma Multiforme | TDRKH | 0.24 | 0.05 | blup | 49 | 0.05 | 1.0e-02 | 0.44 | 5.5 | 4.1e-08 | -0.46 | 0.01 | 0.36 | TRUE |
5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LINGO4 | 0.24 | 0.07 | lasso | 4 | 0.11 | 1.7e-12 | 5.94 | 5.6 | 2.0e-08 | 0.03 | 0.98 | 0.00 | TRUE |
6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LINGO4 | 0.24 | 0.00 | enet | 10 | 0.09 | 9.5e-06 | -0.01 | 6.4 | 1.6e-10 | -0.08 | 0.02 | 0.04 | FALSE |
7 | The Cancer Genome Atlas | Lung Adenocarcinoma | LINGO4 | 0.20 | 0.07 | lasso | 4 | 0.07 | 3.7e-08 | 5.94 | 5.2 | 2.5e-07 | 0.00 | 1.00 | 0.00 | TRUE |
8 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LINGO4 | 0.32 | 0.09 | lasso | 8 | 0.13 | 3.3e-06 | 5.94 | 6.7 | 1.6e-11 | -0.21 | 0.07 | 0.28 | TRUE |
9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LINGO4 | 0.53 | 0.20 | lasso | 4 | 0.23 | 1.1e-23 | 5.94 | 5.5 | 3.4e-08 | 0.04 | 1.00 | 0.00 | TRUE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | THEM4 | 0.03 | 0.01 | blup | 59 | 0.01 | 9.8e-03 | 3.94 | -5.7 | 1.4e-08 | 0.31 | 0.05 | 0.22 | TRUE |
11 | The Cancer Genome Atlas | Thyroid Carcinoma | LINGO4 | 0.43 | 0.15 | lasso | 7 | 0.20 | 2.3e-19 | 5.94 | 5.6 | 2.2e-08 | 0.04 | 1.00 | 0.00 | FALSE |