Best TWAS P=9.34e-12 · Best GWAS P=5.78e-14 conditioned to 0.000975
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CRTC2 | 0.04 | 0.00 | lasso | 3 | 0.01 | 6.7e-02 | 2.45 | -5.7 | 1.0e-08 | -0.45 | 0.05 | 0.60 | FALSE |
| 2 | GTEx | Colon Sigmoid | IL6R | 0.22 | 0.08 | lasso | 4 | 0.05 | 9.2e-03 | 6.83 | -5.8 | 7.1e-09 | -0.93 | 0.03 | 0.73 | FALSE |
| 3 | GTEx | Colon Transverse | IL6R | 0.18 | 0.06 | lasso | 3 | 0.06 | 9.2e-04 | 6.48 | -6.4 | 1.3e-10 | -0.92 | 0.09 | 0.79 | FALSE |
| 4 | GTEx | Esophagus Muscularis | IL6R | 0.10 | 0.00 | enet | 15 | 0.00 | 5.3e-01 | 6.94 | -6.8 | 1.3e-11 | -0.67 | 0.01 | 0.87 | FALSE |
| 5 | GTEx | Whole Blood | C1orf43 | 0.10 | 0.00 | enet | 37 | 0.00 | 2.8e-01 | 0.83 | 5.2 | 2.6e-07 | 0.24 | 0.05 | 0.11 | TRUE |
| 6 | YFS | Blood | IL6R | 0.04 | 0.04 | lasso | 3 | 0.04 | 5.1e-12 | 6.83 | -6.8 | 9.3e-12 | -0.95 | 0.01 | 0.99 | TRUE |