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chr12:120,502,726-122,873,570

Best TWAS P=3.07e-10 · Best GWAS P=3.07e-10 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous SPPL3 0.19 0.19 lasso 8 0.19 3.7e-15 5.6 5.5 2.9e-08 0.91 0.05 0.95 FALSE
2 GTEx Artery Aorta SPPL3 0.18 0.15 enet 13 0.17 1.4e-09 6.3 5.2 2.1e-07 0.91 0.00 1.00 FALSE
3 GTEx Artery Tibial SPPL3 0.08 0.05 enet 16 0.05 1.2e-04 5.6 5.3 9.8e-08 0.85 0.02 0.96 FALSE
4 GTEx Brain Cerebellum SPPL3 0.29 0.22 enet 9 0.24 8.6e-08 5.6 5.9 2.8e-09 0.94 0.02 0.97 FALSE
5 GTEx Breast Mammary Tissue (Female) CAMKK2 0.08 0.00 lasso 4 0.02 6.8e-02 -5.4 5.3 1.2e-07 0.87 0.03 0.45 FALSE
6 GTEx Breast Mammary Tissue (Female) SPPL3 0.24 0.14 enet 7 0.03 5.1e-02 6.3 6.0 2.4e-09 0.97 0.01 0.96 FALSE
7 GTEx Esophagus Muscularis SPPL3 0.16 0.14 lasso 2 0.16 3.8e-10 5.6 5.8 6.7e-09 0.93 0.06 0.94 FALSE
8 GTEx Nerve Tibial SPPL3 0.24 0.16 enet 33 0.21 4.8e-15 5.6 5.4 5.5e-08 0.88 0.01 0.99 FALSE
9 GTEx Pancreas SPPL3 0.14 0.10 lasso 3 0.09 9.3e-05 6.3 6.0 1.5e-09 0.97 0.01 0.97 FALSE
10 GTEx Testis SPPL3 0.31 0.30 lasso 3 0.27 2.0e-12 5.6 5.8 5.0e-09 0.95 0.02 0.98 FALSE
11 METSIM Adipose SPPL3 0.12 0.15 lasso 8 0.16 1.6e-22 6.3 5.7 1.4e-08 0.97 0.00 1.00 FALSE
12 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SPPL3 0.11 0.01 lasso 1 0.01 1.0e-01 6.3 6.3 3.1e-10 1.00 0.00 0.87 TRUE
13 The Cancer Genome Atlas Brain Lower Grade Glioma SPPL3 0.07 0.09 lasso 3 0.09 9.9e-11 5.6 5.8 6.8e-09 0.94 0.03 0.97 FALSE
14 The Cancer Genome Atlas Prostate Adenocarcinoma SPPL3 0.04 0.04 blup 95 0.04 3.7e-05 6.3 5.6 2.5e-08 0.94 0.01 0.99 FALSE
15 The Cancer Genome Atlas Thyroid Carcinoma SPPL3 0.04 0.05 enet 7 0.03 6.6e-04 -5.4 5.4 6.2e-08 0.88 0.08 0.89 FALSE