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chr12:120,502,726-122,873,570

Best TWAS P=3.07e-10 · Best GWAS P=3.07e-10 conditioned to 1

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SPPL3	0.11	0.01	lasso	1	0.01	1.0e-01	6.3	6.3	3.1e-10	1.00	0.00	0.87	TRUE
9	GTEx	Pancreas	SPPL3	0.14	0.10	lasso	3	0.09	9.3e-05	6.3	6.0	1.5e-09	0.97	0.01	0.97	FALSE
6	GTEx	Breast Mammary Tissue (Female)	SPPL3	0.24	0.14	enet	7	0.03	5.1e-02	6.3	6.0	2.4e-09	0.97	0.01	0.96	FALSE
4	GTEx	Brain Cerebellum	SPPL3	0.29	0.22	enet	9	0.24	8.6e-08	5.6	5.9	2.8e-09	0.94	0.02	0.97	FALSE
10	GTEx	Testis	SPPL3	0.31	0.30	lasso	3	0.27	2.0e-12	5.6	5.8	5.0e-09	0.95	0.02	0.98	FALSE
7	GTEx	Esophagus Muscularis	SPPL3	0.16	0.14	lasso	2	0.16	3.8e-10	5.6	5.8	6.7e-09	0.93	0.06	0.94	FALSE
13	The Cancer Genome Atlas	Brain Lower Grade Glioma	SPPL3	0.07	0.09	lasso	3	0.09	9.9e-11	5.6	5.8	6.8e-09	0.94	0.03	0.97	FALSE
11	METSIM	Adipose	SPPL3	0.12	0.15	lasso	8	0.16	1.6e-22	6.3	5.7	1.4e-08	0.97	0.00	1.00	FALSE
14	The Cancer Genome Atlas	Prostate Adenocarcinoma	SPPL3	0.04	0.04	blup	95	0.04	3.7e-05	6.3	5.6	2.5e-08	0.94	0.01	0.99	FALSE
1	GTEx	Adipose Subcutaneous	SPPL3	0.19	0.19	lasso	8	0.19	3.7e-15	5.6	5.5	2.9e-08	0.91	0.05	0.95	FALSE
8	GTEx	Nerve Tibial	SPPL3	0.24	0.16	enet	33	0.21	4.8e-15	5.6	5.4	5.5e-08	0.88	0.01	0.99	FALSE
15	The Cancer Genome Atlas	Thyroid Carcinoma	SPPL3	0.04	0.05	enet	7	0.03	6.6e-04	-5.4	5.4	6.2e-08	0.88	0.08	0.89	FALSE
3	GTEx	Artery Tibial	SPPL3	0.08	0.05	enet	16	0.05	1.2e-04	5.6	5.3	9.8e-08	0.85	0.02	0.96	FALSE
5	GTEx	Breast Mammary Tissue (Female)	CAMKK2	0.08	0.00	lasso	4	0.02	6.8e-02	-5.4	5.3	1.2e-07	0.87	0.03	0.45	FALSE
2	GTEx	Artery Aorta	SPPL3	0.18	0.15	enet	13	0.17	1.4e-09	6.3	5.2	2.1e-07	0.91	0.00	1.00	FALSE