Hub : Genes

CAMKK2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Breast Mammary Tissue (Female) 0.0835 0.0603 9.3e-02 -0.003 NA 0.010 NA 0.023 3.9e-01 NA 1.6e-01 NA 6.80e-02
2 GTEx Muscle Skeletal 0.2313 0.0549 7.8e-06 0.083 NA 0.074 NA 0.079 1.4e-08 NA 8.9e-08 NA 3.50e-08
3 NTR Blood 0.0362 0.0132 2.0e-04 0.017 0.012 0.018 0.019 0.014 2.0e-06 8.5e-05 8.8e-07 6.1e-07 2.30e-05
4 YFS Blood 0.7767 0.0205 0.0e+00 0.483 0.623 0.698 0.665 0.691 2.6e-183 2.9e-269 0.0e+00 8.0e-302 9.88e-324
5 TCGA Kidney Renal Papillary Cell Carcinoma 0.1100 0.0550 5.0e-03 -0.004 0.037 0.049 NA -0.005 6.6e-01 3.3e-03 8.6e-04 NA 8.40e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.9 3.0 8.5 -2.9 -1.1 -2.1 0.0 1.1
Bipolar Disorder or Schizophrenia 5.1 12.5 21.4 -4.1 -0.2 -4.6 -2.9 4.0
Depressed Affect (Nagel 2018) 0.8 1.6 4.6 -1.3 -0.4 -2.1 -1.3 -0.0
Depression (Nagel 2018) 2.5 3.8 7.2 -2.7 -0.8 -2.5 -2.1 0.7
Intelligence (Savage-Jansen 2018) 2.4 7.2 14.2 2.4 -1.2 2.6 2.9 -3.8
Neuroticism (Nagel 2018) 0.3 0.7 1.6 -1.0 -0.8 -1.3 -0.3 0.4
Schizophrenia (2018) 5.5 11.5 18.0 -2.9 0.6 -4.2 -3.8 4.0
Schizophrenia vs Biploar Disorder 3.3 4.3 8.6 0.2 1.3 -1.9 -2.8 2.9
Worry (Nagel 2018) 0.4 0.9 2.7 -0.8 0.1 -1.1 0.2 1.7
Alzheimer’s Disease (in mother) 0.6 0.7 1.9 1.4 0.4 0.8 0.8 -0.5
Alzheimer’s Disease (in father) 0.4 0.4 1.7 -0.4 1.3 -0.2 0.0 0.3
Alzheimer’s Disease (including proxy) 0.3 0.5 1.5 0.7 1.2 0.3 0.6 -0.2
Crohns Disease (2017) 0.3 0.7 1.5 -1.2 -0.3 1.0 0.1 -1.0
Irritable Bowel Disease (IBD) 0.2 0.5 1.6 -0.7 0.4 1.3 0.3 -0.2
Ulcerative Colitis (UC) 0.1 0.2 0.9 0.1 0.4 0.9 0.3 0.3
Major Depression (MDD) 1.3 1.5 2.7 -1.2 -1.6 -1.6 -0.8 -0.5
Reaction Time 0.9 1.8 6.6 -2.6 1.1 -0.6 0.4 -0.6
Verbal and Numeric Reasoning (VNR) 2.9 7.0 11.1 1.9 -1.1 3.0 3.3 -3.2
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.9 1.2 2.0 -1.4 0.1 1.2 1.0 -1.2
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.8 2.7 6.3 2.5 0.4 2.4 1.0 -0.6
Bipolar Disorder (2011) 1.1 1.1 4.6 -2.1 -0.4 -0.4 0.7 0.0
Body Mass Index (BMI) (2010) 0.3 0.4 1.0 -1.0 0.5 -0.5 -0.4 -0.6
Coronary Artery Disease (CAD) 1.5 1.8 3.6 -1.9 -1.5 -0.6 -1.4 -0.8
Crohns Disease (2012) 0.4 0.6 1.3 -1.0 -0.4 -0.8 -1.1 0.4
Mean Putamen Volume 0.9 1.0 3.9 -0.1 2.0 0.1 0.8 0.7
Fasting Glucose 2.0 2.3 10.5 -0.3 -3.2 0.2 -0.7 -0.8
HbA1C 1.7 1.9 2.8 -1.7 1.3 -1.4 -1.4 1.2
HDL Cholesterol 0.9 1.6 3.0 -1.7 -0.1 -0.8 -1.2 1.7
LDL Cholesterol 4.1 6.4 10.6 -2.4 2.0 -2.5 -2.3 3.3
Lupus 0.7 1.0 3.6 -1.9 0.9 -0.3 -0.0 0.7
Neuroticism (2016) 1.6 2.3 6.0 0.2 -0.3 -2.5 -1.4 1.8
Primary Biliary Cirrhosis 3.4 4.9 9.0 -3.0 1.2 -2.1 -2.1 2.2
Rheumatoid Arthritis 0.8 1.2 2.0 1.4 -0.6 1.1 1.4 -0.4
Schizophrenia (2014) 4.6 10.1 15.1 -2.8 -0.0 -3.8 -3.6 3.9
Triglycerides 1.1 1.8 4.0 -0.8 -1.1 -2.0 -1.8 -0.2
Type 2 Diabetes (T2D) (2012) 3.1 3.6 10.7 -3.3 -0.4 -0.9 -2.2 1.2
Ulcerative Colitis 0.3 0.4 1.0 -0.7 0.4 -0.3 -1.0 0.4
Blood Eosinophil Count 1.7 13.0 64.3 8.0 -0.3 -0.2 0.6 0.3
Blood Platelet Count 1.0 11.3 46.5 6.8 -0.5 -0.5 -1.9 -2.4
Blood Red Count 0.3 3.2 5.2 -1.0 1.5 2.3 2.0 -1.9
Blood White Count 0.6 4.3 17.6 4.2 -0.4 -1.4 0.4 1.4
Heel T-Score 0.5 4.0 7.1 2.4 -1.2 -1.9 -2.7 1.4
BMI 0.4 2.6 8.4 0.4 1.1 -2.9 -1.2 -1.3
Height 1.1 21.0 83.8 9.2 -0.5 4.2 1.8 0.0
Waist Hip Ratio (WHR) 1.3 6.0 12.0 -0.6 1.9 -3.5 -2.8 2.5
Systolic Blood Pressure 0.6 3.2 7.3 2.7 0.0 -1.0 -1.8 2.0
Smoking Status 2.5 6.1 11.6 -3.4 0.9 -3.2 -2.0 1.9
Allergy or Eczema 4.7 12.3 58.5 7.7 -0.8 0.4 0.6 1.3
Cardiovascular Disease 1.3 4.1 6.3 -2.5 -1.5 -2.4 -2.5 0.2
Hypothyroidism (self reported) 0.9 2.0 8.4 2.9 -0.7 0.0 0.7 0.8
Respiratory disease 1.8 4.1 18.5 4.3 0.3 -0.0 0.5 1.2
Type 2 Diabetes (T2D) (2018) 2.6 4.9 13.2 -2.6 0.7 -1.9 -3.6 0.6
Lung FEV1/FVC ratio 0.4 1.9 4.5 -1.0 0.1 -2.1 -2.1 -0.2
Lung FVC 0.4 2.0 8.6 -2.9 -0.0 1.1 0.3 0.5
Neuroticism 0.9 2.3 6.1 -1.4 -0.6 -2.5 -1.1 1.3
Chronotype (morning person) 1.1 2.4 4.8 0.6 1.6 1.8 1.1 -2.2
Hair Pigment 0.1 2.3 8.8 3.0 1.4 0.5 0.8 0.1
Tanning 0.2 2.6 6.4 -0.3 1.6 2.5 0.9 -1.7
Hand grip strength (left) 0.6 1.7 3.6 1.9 -1.3 1.6 0.6 -0.2
Number of treatments/medications taken 3.0 5.3 13.0 -1.9 -0.1 -3.6 -2.6 1.8
Average weekly spirits intake 0.2 0.3 0.5 0.4 0.7 -0.5 -0.1 0.6
Sensitivity / hurt feelings 1.0 1.6 3.6 0.4 0.2 1.0 1.8 1.9
Frequency of depressed mood in last 2 weeks 2.6 3.7 9.1 -3.0 -0.9 -2.1 -1.6 1.1
Hearing difficulty/problems: Yes 0.5 0.8 2.3 0.2 -1.5 -0.9 -0.7 -0.7
Relative age of first facial hair 2.3 4.8 20.5 4.5 -0.7 0.9 0.8 -1.3
Other serious medical condition/disability diagnosed by doctor 1.8 2.3 4.5 -0.9 1.4 -2.1 -1.5 1.4
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.5 0.7 -1.1 -1.2 -0.5 0.3
Ever had hysterectomy (womb removed) 0.2 0.3 0.6 -0.0 0.6 -0.5 -0.8 0.1
Systolic blood pressure, automated reading 1.0 2.9 9.5 3.1 -0.7 -0.9 -1.5 1.3
Eye problems/disorders: Diabetes related eye disease 3.0 3.3 6.4 -0.9 0.1 -2.5 -2.4 1.9
Angina 0.9 1.2 2.8 -1.1 -1.1 -0.8 -1.7 0.4
Medication for hormone replacement therapy 0.5 0.6 2.1 0.6 -1.4 -0.3 0.1 -0.5
Vitamin and mineral supplements 0.9 1.2 3.8 0.6 0.0 1.3 0.5 -1.9
Supplements: Zinc 1.0 1.1 2.4 -1.6 -1.3 -0.3 0.5 -0.9
Medication: Co-codamol 3.3 3.8 6.8 -2.6 -1.6 -1.9 -2.4 0.6
Medication: Metformin 0.2 0.3 0.9 -0.1 0.1 0.5 -0.6 -0.9
Diabetes (father) 1.0 1.3 2.3 1.2 1.3 -0.8 -1.5 0.5
Diabetes (mother) 1.9 2.4 4.8 -2.2 -0.7 -1.2 -2.2 -0.7
Severe depression (siblings) 1.7 1.8 3.8 -2.0 1.1 -1.0 -0.1 1.8
Pack years adult smoking proportion 3.3 5.1 9.7 -0.8 1.5 -2.1 -2.9 3.1
Impedance of leg (right) 0.2 0.9 3.1 -1.8 0.3 -0.5 0.3 0.9
Leg fat-free mass (left) 0.7 3.6 15.7 4.0 1.1 0.6 0.0 -0.9
Trunk fat percentage 1.3 5.2 19.7 0.3 0.8 -4.4 -2.3 0.6
Hand grip strength (right) 0.8 2.1 4.6 2.1 -1.1 1.9 1.0 0.2
Townsend deprivation index at recruitment 1.8 2.5 3.6 -1.1 -1.4 -1.9 -1.8 1.6
Current tobacco smoking 2.5 4.1 8.0 -1.4 0.6 -2.8 -1.9 2.6
Average weekly fortified wine intake 1.1 1.3 3.9 -0.3 0.5 -1.5 -0.1 2.0
Maternal smoking around birth 1.3 1.9 4.7 0.9 0.5 -1.4 -2.2 1.3
Fed-up feelings 1.5 2.6 4.6 -1.9 -0.4 -2.1 -1.8 1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 2.9 3.9 8.6 -1.8 -0.6 -2.9 -2.4 1.2
Relative age voice broke 2.1 3.2 12.4 3.5 -0.6 0.6 1.0 -1.4
Taking other prescription medications 2.0 3.0 8.4 -0.8 -1.2 -2.9 -1.9 1.1
Age when periods started (menarche) 2.4 5.8 15.3 3.9 1.2 1.8 2.4 -1.8
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.7 0.2 0.7 -0.6 -1.0 1.6
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.2 1.1 0.7 -0.2 -0.2 0.4
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.9 -1.4 -0.4 -0.1 0.1 -0.8
Qualifications: CSEs or equivalent 0.4 0.5 1.4 -0.8 0.5 0.5 1.2 0.3
Serious illness, injury or assault to yourself 0.4 0.5 1.4 -0.6 -1.2 -0.1 -0.6 -0.4
High blood pressure 0.4 1.2 2.9 -1.2 -1.7 -1.2 -0.2 0.7
Hayfever, allergic rhinitis or eczema 2.9 6.2 28.0 5.3 -0.2 0.7 1.0 1.2
Multivitamins +/- minerals 1.7 2.2 4.1 -0.5 1.2 -2.0 -1.3 1.8
Stomach or abdominal pain in last month 1.1 1.4 2.3 -1.5 -1.5 -1.2 -0.4 0.9
Supplements: Glucosamine 0.7 0.9 2.2 -0.0 0.6 1.4 1.5 -0.1
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 2.0 -0.3 0.0 -1.4 -0.3 1.4
Medication: Atenolol 2.6 3.3 6.9 -2.5 -0.2 -1.7 -2.6 0.6
Medication: Levothyroxine sodium 0.4 0.7 3.1 1.8 -0.3 0.4 0.3 -0.1
Sitting height 0.4 2.8 7.6 1.6 1.1 2.8 1.7 -0.1
Chronic bronchitis/emphysema (father) 0.9 1.0 2.1 -0.9 -1.4 -0.5 -0.3 -1.4
High blood pressure (mother) 0.2 0.3 0.9 -0.5 -0.9 -0.5 -0.3 -0.1
Body mass index (BMI) 1.1 4.6 15.5 -0.1 0.4 -3.9 -2.7 -0.4
Impedance of leg (left) 0.2 1.2 4.2 -2.0 -0.2 -0.8 0.3 1.0
Leg predicted mass (left) 0.7 3.7 16.0 4.0 1.0 0.7 0.1 -0.9
Trunk fat mass 1.0 4.3 14.5 1.3 0.8 -3.8 -2.1 0.3
Waist circumference 1.2 4.4 13.2 1.7 0.9 -3.6 -2.3 0.3
Number of incorrect matches in round 0.6 1.0 1.7 -0.8 0.3 -1.2 -1.1 1.3
Past tobacco smoking 0.7 1.3 2.8 1.1 -1.1 1.7 1.1 -0.6
Alcohol usually taken with meals 4.2 6.7 13.1 2.2 -0.3 3.6 3.4 -2.1
Nervous feelings 1.2 2.3 6.8 1.5 0.1 -1.5 -0.5 2.6
Frequency of tenseness / restlessness in last 2 weeks 2.3 3.6 5.9 -1.5 -0.8 -2.4 -2.1 2.2
Hearing difficulty/problems with background noise 0.5 0.8 1.9 0.7 -1.0 0.6 0.2 -1.4
Hair/balding pattern: Pattern 2 0.4 0.6 1.7 -0.1 -0.3 -1.0 0.0 1.3
Had menopause 1.6 2.0 4.4 1.6 -0.2 -2.1 -1.7 0.5
Had other major operations 1.7 2.1 6.8 -2.6 0.8 1.1 1.3 -0.4
Forced vital capacity (FVC) 0.5 1.8 4.9 0.7 0.2 2.2 1.4 1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.0 0.7 1.0 0.6 0.2 0.6
Ever unenthusiastic/disinterested for a whole week 3.0 3.7 7.6 -2.8 -0.4 -2.6 -1.8 0.8
Qualifications: None of the above 1.7 3.7 7.6 -1.4 -0.2 -2.8 -2.6 1.6
Financial difficulties in last 2 years 2.0 2.8 7.2 -2.7 0.6 -2.1 -1.2 0.7
Mouth/teeth dental problems 0.7 1.1 2.0 1.4 0.7 1.1 1.3 0.0
Heart attack 3.1 4.0 8.3 -1.0 0.4 -2.9 -2.8 1.7
Allergy 2.5 5.7 24.5 -5.0 -0.5 0.6 -0.3 -1.8
Pain all over the body in last month 0.2 0.2 0.8 -0.9 0.1 0.0 -0.1 -0.4
Diabetes (self-reported) 1.2 1.9 5.8 -0.7 0.6 -1.2 -2.4 1.0
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 4.6 2.1 -0.2 0.7 0.5 0.4
Medication: Ramipril 0.1 0.1 0.4 0.2 -0.5 0.1 0.6 -0.2
Medication: Simvastatin 1.2 1.7 4.2 -2.1 -0.5 -1.0 -1.8 0.0
Fluid intelligence score 2.5 5.3 13.0 1.7 -0.9 2.2 2.3 -3.6
Illnesses of siblings 1.1 1.6 4.1 2.0 0.5 1.4 1.1 -0.5
Neuroticism score 1.5 3.1 7.6 -0.7 -0.4 -2.4 -1.2 2.8
Weight 0.5 2.4 6.6 2.6 0.9 -1.8 -1.1 -0.5
Impedance of arm (right) 0.2 1.1 3.3 0.2 -0.5 -0.0 1.4 1.8
Arm fat percentage (right) 1.2 4.7 18.2 0.1 0.1 -4.3 -2.3 0.3
Trunk fat-free mass 0.8 4.6 17.1 4.1 0.7 2.0 0.6 -1.2
Hip circumference 0.4 1.7 4.4 2.1 0.4 -1.3 -0.1 -1.5
Time employed in main current job 0.2 0.2 0.7 -0.3 -0.2 0.4 -0.2 0.8
Alcohol intake versus 10 years previously 1.0 1.5 6.0 -2.5 -0.9 0.3 -0.0 -0.7
Father’s age at death 1.9 2.6 4.9 2.2 -0.0 1.3 1.7 -1.9
Worrier / anxious feelings 0.8 1.6 4.3 -2.1 -0.9 -1.2 -0.4 1.1
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.7 4.4 -1.8 -1.1 -2.1 -1.9 1.0
Falls in the last year 1.7 2.3 7.8 0.2 0.2 -1.8 -0.8 2.8
Hair/balding pattern: Pattern 3 1.2 1.8 3.9 -0.6 1.1 2.0 1.8 -0.5
Number of live births 0.9 1.3 2.3 1.5 0.8 -1.2 -1.2 0.7
Forced expiratory volume in 1-second (FEV1) 0.5 1.7 3.7 0.3 0.9 1.9 1.2 1.5
Pulse rate 1.1 1.9 7.9 2.8 -0.6 1.0 0.3 0.5
Happiness 2.8 3.4 7.1 0.3 -1.8 -2.6 -2.7 -0.1
Noisy workplace 1.5 1.8 3.6 -1.3 -0.5 -1.9 -1.3 1.3
Qualifications: A levels/AS levels or equivalent 2.1 4.8 12.9 1.0 -0.9 2.3 2.0 -3.6
Serious illness, injury or assault of a close relative in last 2 years 1.7 1.9 3.0 -1.7 -1.3 1.0 1.2 -1.6
Mouth/teeth dental problems: Dentures 0.7 1.1 2.7 -1.7 1.0 -1.0 -0.8 0.6
Asthma 2.6 5.1 22.4 4.7 -0.1 -0.8 0.1 1.5
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.7 0.3 0.7 -0.8 -0.3 0.0
Medication: Cholesterol lowering 1.7 2.6 4.8 -1.7 -0.6 -1.9 -2.2 1.0
Depression (self-reported) 3.7 4.4 8.7 -3.0 -0.4 -2.8 -1.6 1.6
Medication: Lansoprazole 0.8 1.0 2.8 -1.7 -0.0 -1.0 -0.9 0.4
Prospective memory result 0.4 0.5 0.8 -0.6 0.2 -0.6 -0.9 0.9
Lung cancer (father) 0.9 1.1 1.3 -1.0 -1.1 -0.9 -0.9 1.1
Illnesses of mother 1.0 1.2 2.7 1.2 -0.5 1.6 1.3 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 4.1 0.2 -0.1 2.0 0.9 0.1
Pulse wave Arterial Stiffness index 0.4 0.5 1.4 0.7 -0.7 -0.2 -0.3 -1.2
Impedance of arm (left) 0.2 1.1 2.7 -0.5 -0.5 -0.2 1.5 1.7
Arm fat mass (right) 0.8 3.4 11.3 1.2 0.6 -3.4 -2.0 -0.0
Trunk predicted mass 0.8 4.6 17.1 4.1 0.6 1.9 0.5 -1.1
Standing height 1.2 12.1 35.9 6.0 0.9 4.0 2.8 -0.1
Length of working week for main job 0.3 0.3 0.9 0.9 0.3 0.3 -0.2 0.8
Exposure to tobacco smoke at home 1.7 1.9 5.7 0.0 1.7 -1.0 -0.1 2.4
Breastfed as a baby 0.8 1.0 2.5 0.3 -1.6 1.0 1.1 -0.5
Tense / ‘highly strung’ 0.6 0.9 2.3 -0.4 -0.9 -1.2 -0.2 1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 3.5 5.3 10.7 -3.2 -0.6 -3.3 -1.6 1.8
Hair/balding pattern: Pattern 4 0.9 2.1 4.6 -1.7 -1.4 -1.2 -2.1 0.1
Birth weight of first child 1.2 2.1 5.8 -0.1 -0.3 2.0 0.7 -2.4
Peak expiratory flow (PEF) 0.4 1.0 3.7 0.3 0.6 0.8 0.1 1.9
Pulse wave reflection index 1.1 1.4 4.0 -0.1 0.1 1.2 1.2 -2.0
Ever highly irritable/argumentative for 2 days 1.2 1.4 2.7 -1.5 0.4 -1.3 -1.6 0.4
Loud music exposure frequency 0.2 0.3 0.7 -0.1 -0.4 -0.7 -0.8 0.2
Qualifications: O levels/GCSEs or equivalent 2.5 3.9 8.3 1.2 -0.9 2.6 1.5 -2.9
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.7 -1.3 -1.1 -0.6 -0.2 0.8
Blood clot in the leg (DVT) 1.0 1.3 2.5 -1.1 1.4 0.7 1.6 -0.6
Medication: Paracetamol 1.1 1.8 4.4 -2.1 -0.6 0.6 1.3 -1.4
Headache pain in last month 0.4 0.7 2.3 0.3 -1.5 -0.8 0.1 -0.7
Medication for cholesterol, blood pressure or diabetes 1.5 2.6 5.0 1.9 -0.3 2.0 2.2 -0.5
Glaucoma (self-reported) 0.3 0.3 1.4 -0.0 -0.4 0.1 -0.4 -1.2
Gout (self-reported) 0.9 1.2 4.8 -2.2 0.7 0.2 0.3 -0.7
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 3.7 1.9 0.0 0.2 0.5 1.4
Medication: Amlodipine 0.8 1.1 3.8 0.3 -1.9 -0.9 -0.9 0.2
Medication: Ventolin 100micrograms inhaler 1.4 1.7 7.2 2.7 -0.3 -0.5 0.1 1.1
Birth weight 0.5 1.1 2.3 1.5 0.0 1.2 0.7 -1.0
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.4 0.5 0.7 0.8 1.2 0.4
High blood pressure (siblings) 0.6 0.8 1.5 -1.1 0.4 -1.2 -0.8 0.7
Forced vital capacity (FVC), Best measure 0.5 1.9 6.4 0.8 -0.9 2.5 1.4 -0.2
Body fat percentage 1.6 6.2 23.3 0.0 0.5 -4.8 -2.7 0.5
Leg fat percentage (right) 2.2 8.1 27.5 -0.7 0.4 -5.2 -3.5 0.2
Arm fat-free mass (right) 0.5 2.6 9.6 3.1 1.3 0.7 -0.2 -1.2
Exposure to tobacco smoke outside home 0.3 0.3 0.7 0.5 0.7 -0.0 -0.8 0.5
Comparative body size at age 10 0.8 2.3 6.6 -2.6 1.2 0.2 -0.0 -1.9
Number of full brothers 0.6 0.8 1.7 -0.6 0.8 1.3 1.1 -0.5
Worry too long after embarrassment 0.4 0.7 1.9 1.4 -0.4 0.9 0.9 -0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 2.6 3.4 5.4 -2.3 -0.6 -2.3 -1.7 1.7
Wheeze or whistling in the chest in last year 4.0 7.1 16.8 0.7 -0.9 -4.1 -3.3 2.6
Number of children fathered 1.0 1.2 3.8 1.9 -0.9 -0.7 -0.8 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 3.3 -0.3 0.6 -1.8 -0.7 1.6
Age at first live birth 1.0 1.9 3.4 1.8 1.1 1.9 1.2 -0.3
Pulse wave peak to peak time 0.4 0.5 1.7 -0.3 0.6 0.4 0.4 1.3
Health satisfaction 3.4 4.4 10.6 1.3 -1.0 -3.3 -2.7 1.2
Shortness of breath walking on level ground 0.6 0.7 1.4 1.2 -1.0 -0.7 -0.6 0.2
Qualifications: College or University degree 0.1 0.5 1.4 1.2 0.5 0.6 0.2 -0.6
Eye problems/disorders: None of the above 1.4 1.6 4.8 -1.2 2.2 -0.6 -0.1 1.1
Mouth/teeth dental problems: Loose teeth 1.1 1.3 2.9 0.7 -0.2 -1.6 -1.7 0.6
Emphysema/chronic bronchitis 3.8 4.3 8.3 -1.8 -0.3 -2.7 -2.9 1.5
Medication for pain relief, constipation, heartburn 0.3 0.6 2.0 1.4 0.6 0.7 -0.3 -0.1
Neck or shoulder pain in last month 1.7 2.5 6.2 -2.5 -1.7 -0.9 -1.4 0.8
Medication: Blood pressure 1.4 2.4 4.2 -1.8 -0.0 -1.9 -2.1 0.9
Angina (self-reported) 0.9 1.1 2.7 -1.1 -1.1 -0.7 -1.6 0.0
Migraine (self-reported) 1.8 2.3 5.2 -1.4 0.3 -2.3 -1.0 1.8
Medication: Ibuprofen 0.5 0.6 1.3 0.5 0.1 -1.1 -1.0 0.3
Medication: Allopurinol 0.4 0.5 1.1 -0.7 1.1 -0.4 0.0 0.8
Medication: Omeprazole 0.4 0.5 1.1 -0.4 -0.3 -0.9 -1.0 0.6
Medication: Seretide 50 evohaler 1.3 1.4 4.1 -0.7 0.2 -2.0 -1.6 0.1
Mean time to correctly identify matches 1.3 2.4 8.3 -2.9 1.6 -1.2 0.1 0.3
Heart disease (mother) 1.2 1.4 3.1 -1.5 1.8 -1.0 -0.0 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.0 -1.0 1.0 -0.4 -0.5 1.0
Whole body fat mass 1.0 4.2 13.7 1.4 0.7 -3.7 -2.2 -0.1
Leg fat mass (right) 1.0 3.7 12.5 0.6 0.7 -3.5 -2.2 -0.6
Arm predicted mass (right) 0.5 2.6 8.9 3.0 1.0 1.1 0.1 -1.4
Pulse rate, automated reading 0.1 0.2 0.6 -0.0 -0.1 -0.8 -0.4 0.5
Alcohol intake frequency. 0.9 2.1 6.9 -2.6 0.0 1.3 1.2 -0.5
Comparative height size at age 10 0.1 0.6 1.3 0.8 -0.5 0.7 -0.7 1.1
Number of full sisters 0.5 0.6 0.9 0.4 0.9 0.6 0.8 -1.0
Suffer from ‘nerves’ 1.6 2.5 4.7 -1.4 0.6 -2.0 -1.2 2.2
Overall health rating 4.2 9.0 19.7 -1.0 -2.3 -4.4 -3.7 2.2
Chest pain or discomfort 3.6 5.2 12.7 -1.9 -0.5 -3.6 -2.8 1.3
Had major operations 1.1 1.2 4.4 -2.1 -0.5 0.6 0.5 -1.0
Age at last live birth 0.5 0.7 1.9 0.3 1.1 1.4 0.6 0.1
Family relationship satisfaction 0.7 0.9 1.4 0.1 -1.0 -1.2 -1.2 0.7
Leg pain on walking 0.9 1.1 2.0 0.4 -1.0 -1.4 -1.4 0.5
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 3.1 1.1 1.7 -0.2 0.6 0.9
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.4 0.6 -0.9 0.7 1.2 -1.0
Illness, injury, bereavement, stress in last 2 years 1.5 1.8 6.6 2.6 1.0 0.7 -0.7 0.8
Medication: Aspirin 0.4 0.5 1.8 -1.3 -0.1 -0.4 -0.2 0.8
Supplements: Vitamin C 1.3 1.6 5.2 0.2 -0.9 1.4 2.3 -0.1
Knee pain experienced in last month 0.1 0.2 0.4 0.3 0.4 -0.6 -0.7 0.1
Hypertension (Self-reported) 0.4 1.2 3.9 -0.9 -2.0 -0.9 -0.2 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 2.9 1.1 -0.6 -1.7 -0.6 1.7
Illnesses of father: Heart disease 0.7 1.0 2.4 -1.2 1.6 -0.3 -0.7 -0.7
Illnesses of siblings: Diabetes 0.8 1.0 1.9 -1.3 -1.0 -0.4 -1.4 -0.1
Smoking status: Previous 0.3 0.4 1.4 -0.6 1.2 -0.5 -0.4 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 1.7 3.5 11.0 3.3 -0.3 2.2 1.3 -0.3
Whole body fat-free mass 0.7 4.2 17.1 4.1 0.9 1.4 0.3 -1.1
Leg fat-free mass (right) 0.6 3.5 15.1 3.9 0.8 0.8 0.3 -0.9
Arm fat percentage (left) 1.2 5.0 19.7 -0.3 0.0 -4.4 -2.2 0.2
Average weekly red wine intake 0.1 0.2 0.5 0.7 -0.2 -0.6 -0.2 -0.4
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.3 -0.3 -0.3 -0.0 -0.2 -0.5
Mood swings 3.1 5.6 12.8 -0.6 0.1 -3.6 -2.9 2.5
Loneliness, isolation 4.9 6.8 16.1 -1.5 0.6 -4.0 -3.6 1.6
Long-standing illness, disability or infirmity 2.8 4.3 10.8 -0.1 0.2 -3.3 -3.1 0.9
Ever had bowel cancer screening 0.7 0.9 3.0 0.6 0.7 -0.8 0.1 1.7
Diabetes diagnosed by doctor 2.0 3.2 8.2 -1.4 1.6 -1.5 -2.9 0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 2.4 -0.1 1.6 0.3 0.3 0.3
Friendships satisfaction 1.1 1.4 3.6 -0.5 -1.9 -1.3 -0.8 -1.0
Qualifications: nursing, teaching 0.4 0.6 1.4 -1.2 0.6 -0.8 -0.5 0.3
Commuting to job workplace: Walk 1.0 1.1 5.0 -0.0 2.2 -0.3 -0.5 0.2
Eye problems/disorders: Cataract 0.6 0.7 2.4 0.3 -1.6 0.8 0.4 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 1.6 -0.6 -1.3 0.3 0.3 0.1
Medication for cholesterol 0.3 0.4 0.8 -0.0 0.7 0.9 0.8 0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.0 1.0 0.5 -0.5 -0.2 0.5
Back pain experienced in last month 1.2 1.8 3.7 -1.9 -1.5 -1.0 -1.3 -0.6
Mineral and other dietary supplements 0.9 1.2 2.6 1.3 -1.6 0.6 0.1 -1.2
Breast cancer (self-reported) 0.4 0.5 1.2 0.6 0.5 0.9 1.1 0.1
Asthma (self-reported) 2.4 4.8 21.2 4.6 -0.3 -0.9 -0.0 1.5
Osteoporosis (self-reported) 1.3 1.6 6.1 -2.5 -1.1 -0.4 0.1 -0.6
Osteoarthritis (self-reported) 0.4 0.5 2.3 -1.5 -0.6 -0.0 -0.1 0.1
Medication: Aspirin 0.2 0.3 0.9 -1.0 -0.1 -0.4 -0.3 0.4
Medication: Gliclazide 0.5 0.6 1.3 0.4 -0.2 1.1 -0.2 -1.1
Illnesses of father: None of the above (group 1) 0.4 0.5 1.2 0.7 -1.1 0.9 0.4 -0.0
Smoking status: Current 3.1 4.9 9.4 -1.6 0.3 -3.1 -2.3 2.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.7 8.6 -2.9 -0.6 -0.3 -1.3 1.7
Whole body water mass 0.8 4.3 16.4 4.0 0.9 1.5 0.5 -1.3
Leg predicted mass (right) 0.7 3.5 15.5 3.9 0.7 0.8 0.3 -0.9
Arm fat mass (left) 0.7 2.9 10.2 1.1 0.4 -3.2 -1.7 -0.2
Number of self-reported non-cancer illnesses 2.3 4.0 9.5 -1.6 -1.2 -3.1 -2.1 1.3
Average weekly champagne plus white wine intake 0.9 1.2 2.7 1.6 1.2 1.1 0.8 -0.0
Miserableness 1.2 2.1 4.8 -1.8 -1.1 -2.2 -0.9 0.3
Guilty feelings 2.4 3.6 9.2 -1.4 -0.2 -3.0 -2.1 1.4
Wears glasses or contact lenses 0.3 0.3 0.9 -0.0 -0.8 0.2 -0.4 -0.9
Ever taken oral contraceptive pill 2.4 2.7 7.6 -0.3 1.4 2.8 1.9 -0.1
Hearing aid user 0.4 0.4 1.0 -1.0 0.5 -0.4 -0.5 0.6
Mother’s age at death 0.3 0.4 1.3 -0.1 0.2 0.7 1.1 -0.0
Financial situation satisfaction 2.7 3.4 8.1 0.6 -1.0 -2.8 -2.4 1.4
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.8 1.4 0.5 0.0 -0.3 0.9
Commuting to job workplace: Public transport 1.3 1.5 4.6 -0.4 0.2 -1.1 -1.2 2.2
Eye problems/disorders: Glaucoma 0.7 0.8 3.2 0.6 -0.4 0.5 -0.1 -1.8
Medication: Blood pressure 0.3 0.5 1.9 0.5 -1.4 -0.1 0.5 -0.0
Pain type(s) experienced in last month: Hip pain 1.6 2.0 5.9 -2.4 -0.4 -1.4 -1.1 0.8
Supplements: Fish oil (including cod liver oil) 0.9 1.2 5.0 0.1 2.2 -0.6 -0.1 0.9
High cholesterol (Self-reported) 2.6 4.6 15.1 -3.9 -1.9 -1.0 -1.9 0.3
Medication: Bendroflumethiazide 0.1 0.2 0.4 -0.0 -0.6 0.2 -0.6 0.4
Medication: Paracetamol 1.6 2.5 3.7 -1.6 -1.5 1.1 1.7 -1.9
Medication: Lisinopril 0.8 1.0 1.8 -0.0 0.7 -1.1 -1.1 1.4
Medication: Atorvastatin 3.4 4.3 6.4 -1.6 0.2 -2.5 -2.5 2.5
Illnesses of father: High blood pressure 0.3 0.4 1.3 -0.2 -0.3 -0.6 -1.1 -0.2
Alcohol drinker status: Never 0.4 0.4 1.6 -0.5 -1.3 -0.5 -0.2 -0.1
Ever smoked 0.4 0.7 1.8 -0.6 0.7 -1.4 -0.7 0.2
Basal metabolic rate 0.6 3.5 14.8 3.8 1.0 0.8 0.1 -1.1
Leg fat percentage (left) 2.3 8.5 29.5 -0.9 -0.0 -5.4 -3.5 0.2
Arm fat-free mass (left) 0.6 2.9 10.9 3.3 1.1 0.9 -0.1 -1.4
Number of operations (self-reported) 2.0 3.0 13.9 -3.7 -0.9 -0.2 -0.5 -0.5
Average weekly beer plus cider intake 0.9 1.3 3.6 1.9 -0.7 -0.3 -1.1 0.9
Irritability 0.1 0.2 0.5 0.7 -0.6 0.3 0.6 0.1
Risk taking 0.6 0.9 3.2 0.4 1.8 -0.4 0.7 0.8
Ever had prostate specific antigen (PSA) test 0.8 0.9 1.6 -0.9 -0.0 -1.3 -1.2 0.9
Fractured/broken bones in last 5 years 0.2 0.3 0.6 -0.5 -0.4 -0.8 -0.6 -0.3
Age started oral contraceptive pill 0.9 1.1 2.5 1.6 -0.4 0.8 0.8 -1.3
Diastolic blood pressure, automated reading 0.7 2.3 5.1 2.3 -1.1 -1.2 -1.7 0.7
Ever depressed for a whole week 1.9 2.3 4.5 -2.1 -1.2 -1.9 -1.1 0.8
Unable to work because of sickness or disability 0.3 0.4 1.2 -1.1 -0.2 -0.4 -0.9 -0.1
Commuting to job workplace: Cycle 0.1 0.1 0.2 -0.0 -0.5 -0.4 -0.1 0.1
Myopia 1.8 2.6 3.6 1.9 1.7 -1.4 -1.3 1.7
Vascular/heart problems diagnosed by doctor 0.8 2.2 3.9 1.5 1.7 2.0 1.0 -0.9
Cholesterol lowering medication 1.4 2.0 4.0 -2.0 0.9 -1.0 -1.3 1.6
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 2.0 -0.6 -0.3 -1.1 -1.4 0.5
Pain experienced in last month 0.2 0.4 1.0 -0.3 -0.5 0.9 1.0 0.2
Supplements: Calcium 0.3 0.4 1.0 0.4 -0.1 -0.4 -0.6 1.0
Basal cell carcinoma (self-reported) 0.8 1.0 2.2 0.8 1.2 -1.5 -0.7 -0.5
Heart attack/myocardial infarction (self-reported) 3.6 4.6 10.3 -0.5 0.1 -3.1 -3.2 1.7
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 2.8 -1.4 1.7 0.5 1.4 -0.0
Heart disease (siblings) 0.7 0.8 1.4 -1.2 0.2 -1.1 -1.2 -0.1
Alcohol drinker status: Previous 2.0 2.3 7.2 -2.7 1.7 0.1 1.0 0.4
Pack years of smoking 2.1 3.1 6.0 -0.7 1.2 -1.5 -2.3 2.4
Impedance of whole body 0.2 1.1 2.6 -1.2 -0.2 -0.6 1.0 1.6
Leg fat mass (left) 0.9 3.6 12.2 0.8 0.5 -3.5 -2.2 -0.6
Arm predicted mass (left) 0.6 2.9 10.3 3.2 1.2 0.9 -0.1 -1.4