Best TWAS P=1.13e-09 · Best GWAS P=1.31e-09 conditioned to 0.00566
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ABO | 0.07 | 0.08 | lasso | 3 | 0.08 | 5.0e-16 | 5.2 | 5.2 | 2.3e-07 | 0.63 | 0.02 | 0.98 | FALSE |
2 | The Cancer Genome Atlas | Esophageal Carcinoma | ABO | 0.27 | 0.13 | lasso | 2 | 0.11 | 1.8e-04 | 5.2 | 5.2 | 2.6e-07 | 0.63 | 0.01 | 0.97 | FALSE |
3 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ABO | 0.31 | 0.38 | lasso | 5 | 0.42 | 3.1e-26 | 5.5 | 5.2 | 1.6e-07 | 0.54 | 0.00 | 1.00 | FALSE |
4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ABO | 0.26 | 0.23 | enet | 10 | 0.26 | 6.0e-29 | 5.2 | 5.2 | 2.2e-07 | 0.66 | 0.02 | 0.98 | FALSE |
5 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ABO | 0.23 | 0.23 | lasso | 2 | 0.24 | 2.2e-11 | 5.5 | 5.5 | 2.9e-08 | 0.53 | 0.00 | 1.00 | FALSE |
6 | The Cancer Genome Atlas | Lung Adenocarcinoma | ABO | 0.21 | 0.25 | lasso | 5 | 0.25 | 2.1e-29 | 5.2 | 5.2 | 1.6e-07 | 0.59 | 0.01 | 0.99 | FALSE |
7 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ABO | 0.28 | 0.22 | lasso | 8 | 0.22 | 1.2e-14 | 5.2 | 5.3 | 1.5e-07 | 0.63 | 0.01 | 0.99 | FALSE |
8 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ABO | 0.23 | 0.23 | lasso | 3 | 0.23 | 2.0e-09 | 5.2 | 5.3 | 1.4e-07 | 0.61 | 0.00 | 0.99 | FALSE |
9 | The Cancer Genome Atlas | Rectum Adenocarcinoma | ABO | 0.48 | 0.23 | enet | 10 | 0.27 | 4.7e-07 | 5.7 | 6.1 | 1.1e-09 | 0.65 | 0.00 | 0.98 | TRUE |