[Hub]/) : Traits : Cholesterol lowering medication :

chr20:62,008,975-62,912,463

Best TWAS P=8.09e-09 · Best GWAS P=1.78e-08 conditioned to 0.402

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Aorta OPRL1 0.27 0.19 lasso 4 0.17 1.4e-09 -5.2 -5.2 1.9e-07 -0.80 0.01 0.99 FALSE
2 GTEx Artery Tibial OPRL1 0.10 0.10 lasso 2 0.06 1.1e-05 -5.2 -5.4 7.1e-08 -0.88 0.01 0.99 FALSE
3 GTEx Artery Tibial RGS19 0.12 0.07 lasso 2 0.07 2.8e-06 5.4 -5.4 8.0e-08 -0.95 0.00 1.00 FALSE
4 GTEx Brain Cerebellar Hemisphere OPRL1 0.27 0.14 lasso 7 0.17 4.4e-05 -5.2 -5.1 2.9e-07 -0.77 0.02 0.82 FALSE
5 GTEx Brain Cerebellum RGS19 0.28 0.22 lasso 4 0.18 7.2e-06 -5.2 -5.2 2.6e-07 -0.81 0.01 0.95 FALSE
6 GTEx Cells Transformed fibroblasts RGS19 0.37 0.28 lasso 8 0.29 3.2e-22 5.4 -5.7 1.5e-08 -0.93 0.00 1.00 FALSE
7 GTEx Esophagus Mucosa RGS19 0.43 0.28 enet 17 0.34 7.9e-24 -5.2 -5.4 6.1e-08 -0.91 0.00 1.00 FALSE
8 GTEx Esophagus Muscularis OPRL1 0.17 0.14 lasso 1 0.13 4.7e-08 -5.2 -5.2 1.8e-07 -0.84 0.01 0.99 FALSE
9 GTEx Esophagus Muscularis RGS19 0.22 0.10 lasso 4 0.10 1.6e-06 -5.2 -5.3 1.3e-07 -0.80 0.01 0.99 FALSE
10 GTEx Nerve Tibial OPRL1 0.20 0.15 lasso 3 0.14 3.3e-10 -5.2 -5.1 3.0e-07 -0.82 0.01 0.99 FALSE
11 GTEx Pancreas OPRL1 0.39 0.27 lasso 5 0.32 6.9e-14 -5.2 -5.5 3.7e-08 -0.90 0.01 0.99 FALSE
12 GTEx Skin Not Sun Exposed Suprapubic RGS19 0.51 0.28 enet 28 0.32 4.3e-18 -5.2 -5.1 3.0e-07 -0.80 0.01 0.99 FALSE
13 GTEx Skin Sun Exposed Lower leg OPRL1 0.14 0.10 lasso 6 0.11 4.4e-09 5.4 -5.7 1.3e-08 -0.93 0.00 1.00 FALSE
14 GTEx Skin Sun Exposed Lower leg RGS19 0.42 0.26 lasso 6 0.33 4.6e-28 -5.2 -5.6 2.4e-08 -0.95 0.00 1.00 FALSE
15 GTEx Stomach RGS19 0.18 0.25 lasso 2 0.25 2.2e-12 -5.2 -5.2 1.6e-07 -0.84 0.01 0.99 FALSE
16 GTEx Thyroid RGS19 0.23 0.14 enet 11 0.19 3.3e-14 5.4 -5.2 2.5e-07 -0.92 0.00 1.00 FALSE
17 GTEx Vagina RGS19 0.39 0.08 lasso 8 0.03 7.5e-02 5.4 -5.5 3.1e-08 -0.91 0.01 0.87 FALSE
18 GTEx Whole Blood OPRL1 0.09 0.06 enet 8 0.07 4.3e-07 5.6 5.8 8.1e-09 0.92 0.00 1.00 TRUE
19 ROSMAP Brain Pre-frontal Cortex C20orf201 0.10 0.09 enet 9 0.10 9.9e-13 -4.4 5.4 6.2e-08 0.68 0.19 0.80 FALSE
20 YFS Blood OPRL1 0.07 0.07 lasso 5 0.09 5.0e-27 -5.2 5.5 4.1e-08 0.82 0.02 0.98 FALSE
21 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma RGS19 0.06 0.06 blup 47 0.05 1.4e-06 -5.2 -5.2 2.1e-07 -0.80 0.00 1.00 FALSE
22 The Cancer Genome Atlas Brain Lower Grade Glioma OPRL1 0.03 0.02 lasso 1 0.01 3.5e-02 -5.2 -5.2 1.8e-07 -0.84 0.01 0.91 FALSE
23 The Cancer Genome Atlas Prostate Adenocarcinoma RGS19 0.07 0.05 blup 48 0.07 1.1e-07 -4.4 -5.3 1.1e-07 -0.79 0.02 0.98 FALSE