[Hub]/) : Traits : Cholesterol lowering medication : ← →

chr6:160,071,844-161,571,560

Best TWAS P=3.18e-12 · Best GWAS P=4.96e-15 conditioned to 0.000146

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex SLC22A3 0.10 0.02 blup 582 0.05 4.4e-07 5.8 6.6 3.6e-11 0.73 0.01 0.99 FALSE
2 GTEx Adipose Visceral Omentum SLC22A3 0.13 0.06 enet 7 0.09 1.3e-05 6.0 6.0 2.5e-09 0.95 0.08 0.92 FALSE
3 GTEx Brain Caudate basal ganglia SLC22A3 0.15 0.10 enet 39 0.11 5.6e-04 6.7 5.6 2.6e-08 0.78 0.06 0.85 FALSE
4 GTEx Brain Frontal Cortex BA9 SLC22A3 0.26 0.08 lasso 6 0.05 1.5e-02 5.8 7.0 3.2e-12 0.55 0.22 0.38 TRUE
5 GTEx Esophagus Mucosa SLC22A3 0.19 0.08 enet 47 0.12 1.7e-08 -5.1 5.4 7.0e-08 0.44 0.83 0.17 TRUE
6 GTEx Skin Not Sun Exposed Suprapubic SLC22A3 0.15 0.05 lasso 9 0.05 9.9e-04 3.5 5.7 9.0e-09 0.56 0.09 0.88 FALSE
7 GTEx Skin Sun Exposed Lower leg SLC22A3 0.29 0.14 lasso 10 0.20 3.7e-16 -4.6 6.0 1.9e-09 0.79 0.05 0.95 FALSE
8 ROSMAP Brain Pre-frontal Cortex SLC22A3 0.14 0.20 lasso 10 0.19 2.4e-24 5.8 6.5 7.6e-11 0.95 0.17 0.83 FALSE
9 The Cancer Genome Atlas Colon Adenocarcinoma SLC22A3 0.17 0.06 lasso 5 0.04 2.8e-03 5.5 -6.2 7.5e-10 -0.64 0.03 0.66 FALSE
10 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma LPAL2 0.07 0.00 blup 74 0.04 1.1e-03 1.8 -5.6 2.7e-08 -0.74 0.02 0.75 FALSE