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chr6:160,071,844-161,571,560

Best TWAS P=3.18e-12 · Best GWAS P=4.96e-15 conditioned to 0.000146

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Brain Frontal Cortex BA9	SLC22A3	0.26	0.08	lasso	6	0.05	1.5e-02	5.8	7.0	3.2e-12	0.55	0.22	0.38	TRUE
5	GTEx	Esophagus Mucosa	SLC22A3	0.19	0.08	enet	47	0.12	1.7e-08	-5.1	5.4	7.0e-08	0.44	0.83	0.17	TRUE
1	CommonMind	Brain Pre-frontal Cortex	SLC22A3	0.10	0.02	blup	582	0.05	4.4e-07	5.8	6.6	3.6e-11	0.73	0.01	0.99	FALSE
8	ROSMAP	Brain Pre-frontal Cortex	SLC22A3	0.14	0.20	lasso	10	0.19	2.4e-24	5.8	6.5	7.6e-11	0.95	0.17	0.83	FALSE
9	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC22A3	0.17	0.06	lasso	5	0.04	2.8e-03	5.5	-6.2	7.5e-10	-0.64	0.03	0.66	FALSE
7	GTEx	Skin Sun Exposed Lower leg	SLC22A3	0.29	0.14	lasso	10	0.20	3.7e-16	-4.6	6.0	1.9e-09	0.79	0.05	0.95	FALSE
2	GTEx	Adipose Visceral Omentum	SLC22A3	0.13	0.06	enet	7	0.09	1.3e-05	6.0	6.0	2.5e-09	0.95	0.08	0.92	FALSE
6	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A3	0.15	0.05	lasso	9	0.05	9.9e-04	3.5	5.7	9.0e-09	0.56	0.09	0.88	FALSE
3	GTEx	Brain Caudate basal ganglia	SLC22A3	0.15	0.10	enet	39	0.11	5.6e-04	6.7	5.6	2.6e-08	0.78	0.06	0.85	FALSE
10	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LPAL2	0.07	0.00	blup	74	0.04	1.1e-03	1.8	-5.6	2.7e-08	-0.74	0.02	0.75	FALSE