Best TWAS P=1.64e-14 · Best GWAS P=1.45e-14 conditioned to 0.0579
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | POLK | 0.27 | 0.20 | lasso | 6 | 0.16 | 8.3e-05 | 5.5 | 5.3 | 1.2e-07 | 0.64 | 0.27 | 0.34 | FALSE |
| 2 | GTEx | Esophagus Mucosa | COL4A3BP | 0.09 | 0.06 | lasso | 5 | 0.05 | 4.2e-04 | 6.5 | -6.5 | 8.8e-11 | -0.69 | 0.31 | 0.63 | FALSE |
| 3 | GTEx | Spleen | POLK | 0.18 | -0.01 | lasso | 16 | 0.03 | 5.1e-02 | 6.2 | 5.8 | 7.8e-09 | 0.60 | 0.16 | 0.26 | FALSE |
| 4 | GTEx | Thyroid | CTC-366B18.2 | 0.06 | 0.03 | lasso | 9 | 0.02 | 6.2e-03 | 5.1 | 5.4 | 6.5e-08 | 0.57 | 0.28 | 0.21 | FALSE |
| 5 | METSIM | Adipose | POLK | 0.05 | 0.01 | enet | 16 | 0.03 | 4.3e-05 | 6.4 | 5.7 | 1.6e-08 | 0.68 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | HMGCR | 0.04 | 0.02 | enet | 4 | 0.03 | 6.0e-03 | 7.7 | 7.7 | 1.6e-14 | 0.89 | 0.00 | 0.92 | TRUE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | POLK | 0.03 | 0.01 | blup | 53 | 0.01 | 1.6e-02 | 4.7 | -5.5 | 4.6e-08 | -0.63 | 0.34 | 0.38 | FALSE |