TWAS
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Models
Genes
Traits
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Traits
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Medication: Blood pressure
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chr1:230,142,626-231,548,480
Best TWAS P=2.97e-14 · Best GWAS P=1.39e-13 conditioned to 1
230.2M
230.4M
230.6M
230.8M
231M
231.2M
231.4M
231.6M
0
5
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Brain Cerebellum
AGT
0.60
0.40
lasso
6
0.36
1.4e-11
7.4
7.6
3.0e-14
0.96
0.00
1.00
TRUE
4
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
AGT
0.07
0.02
enet
12
0.04
1.8e-05
5.2
7.3
2.6e-13
0.75
0.02
0.98
FALSE
1
GTEx
Brain Cerebellar Hemisphere
AGT
0.67
0.50
enet
12
0.40
3.4e-11
7.0
-7.1
1.1e-12
-0.98
0.00
1.00
FALSE
5
The Cancer Genome Atlas
Kidney Renal Papillary Cell Carcinoma
AGT
0.11
0.05
blup
125
0.04
1.4e-03
6.3
5.6
2.0e-08
0.70
0.02
0.85
FALSE
3
The Cancer Genome Atlas
Colon Adenocarcinoma
AGT
0.07
0.05
lasso
3
0.04
3.6e-03
4.4
5.3
9.7e-08
0.89
0.01
0.96
FALSE