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chr1:112,312,154-114,196,883

Best TWAS P=7.31e-18 · Best GWAS P=4e-15 conditioned to 0.393

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex WNT2B 0.43 0.46 enet 44 0.47 7.4e-64 5.6 6.4 2.0e-10 -0.27 1.00 0.00 FALSE
2 GTEx Artery Aorta WNT2B 0.15 0.01 enet 7 0.01 1.0e-01 -6.2 -6.0 2.1e-09 0.75 0.06 0.75 FALSE
3 GTEx Breast Mammary Tissue (Male) WNT2B 0.18 0.07 lasso 6 0.05 2.3e-02 -6.2 -6.2 5.4e-10 0.76 0.07 0.22 FALSE
4 GTEx Muscle Skeletal WNT2B 0.06 0.02 lasso 7 0.03 9.4e-04 -6.1 -6.7 2.0e-11 0.83 0.03 0.94 FALSE
5 GTEx Nerve Tibial CAPZA1 0.17 0.16 lasso 4 0.16 2.4e-11 -6.0 -5.5 3.9e-08 0.75 0.99 0.01 FALSE
6 GTEx Nerve Tibial RP4-671G15.2 0.07 0.06 lasso 2 0.06 2.9e-05 -5.9 6.1 1.0e-09 -0.77 0.83 0.12 FALSE
7 GTEx Skin Not Sun Exposed Suprapubic SLC16A1 0.12 0.00 lasso 5 0.04 5.0e-03 5.3 -5.4 7.2e-08 0.20 0.11 0.45 TRUE
8 GTEx Skin Sun Exposed Lower leg MOV10 0.05 0.02 lasso 5 0.02 1.1e-02 5.3 5.7 9.0e-09 -0.51 0.20 0.42 FALSE
9 GTEx Skin Sun Exposed Lower leg RHOC 0.07 0.02 lasso 3 0.02 1.5e-02 -5.9 -5.9 3.1e-09 0.72 0.15 0.72 FALSE
10 ROSMAP Brain Pre-frontal Cortex CAPZA1 0.05 0.06 lasso 3 0.06 1.1e-07 -5.9 -5.9 2.7e-09 0.77 1.00 0.00 TRUE
11 The Cancer Genome Atlas Liver Hepatocellular Carcinoma WNT2B 0.09 0.02 enet 13 0.04 5.1e-03 -6.2 -5.8 5.3e-09 0.64 0.02 0.03 TRUE
12 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma WNT2B 0.05 0.02 blup 46 0.05 4.7e-04 -5.9 -7.6 2.6e-14 0.67 0.06 0.11 FALSE
13 The Cancer Genome Atlas Thyroid Carcinoma RHOC 0.04 0.03 enet 9 0.04 1.4e-04 -7.9 -8.6 7.3e-18 0.90 0.01 0.98 TRUE