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Medication: Ibuprofen (e.g. Nurofen)
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chr6:12,020,241-13,990,267
Best TWAS P=2.75e-09 · Best GWAS P=4.52e-09 conditioned to 1
12M
12.5M
13M
13.5M
14M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Artery Aorta
RP1-257A7.5
0.11
0.14
lasso
3
0.13
1.7e-07
-5.9
5.9
2.7e-09
-0.95
0
1.00
TRUE
1
GTEx
Artery Aorta
PHACTR1
0.19
0.09
enet
25
0.12
5.7e-07
-5.9
5.8
5.7e-09
-0.86
0
1.00
FALSE
3
GTEx
Artery Coronary
RP1-257A7.5
0.25
0.07
lasso
5
0.09
5.5e-04
4.2
5.4
5.7e-08
-0.88
0
0.99
FALSE