Hub : Traits :

Medication: Ibuprofen (e.g. Nurofen)

9 significantly associated models · 6 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	6	12020241	13990267	2	1	2.7e-09	4.5e-09	1.0000	100	RP1-257A7.5
2	12	56805309	58303535	3	2	7.0e-14	4.8e-14	1.0000	100	LRP1 STAT6
3	17	42814955	43913030	1	1	2.3e-07	6.3e-07	0.0041	67	PLEKHM1

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Headache pain in last month	52.14	4	4	8.9	0.99	1.4e-02	LRP1 PLEKHM1 RP1-257A7.5 STAT6
Migraine (self-reported)	43.75	3	3	6.7	0.00	1.0e+00	LRP1 RP1-257A7.5 STAT6
Medication: Ibuprofen	26.00	4	3	6.7	1.00	4.9e-05	LRP1 PLEKHM1 RP1-257A7.5 STAT6
Medication: Paracetamol	22.85	4	2	4.4	0.99	1.4e-02	LRP1 PLEKHM1 RP1-257A7.5 STAT6
Medication for pain relief, constipation, heartburn	22.33	4	2	4.4	-0.98	2.1e-02	LRP1 PLEKHM1 RP1-257A7.5 STAT6
Medication: Paracetamol	18.20	4	1	2.2	0.98	1.9e-02	LRP1 PLEKHM1 RP1-257A7.5 STAT6
Pain experienced in last month	12.92	4	1	2.2	-0.99	1.1e-02	LRP1 PLEKHM1 RP1-257A7.5 STAT6
Heart attack/myocardial infarction (self-reported)	12.39	1	1	2.2	0.00	1.0e+00	RP1-257A7.5
Heart attack	11.96	1	1	2.2	0.00	1.0e+00	RP1-257A7.5
Respiratory disease	11.63	2	2	4.4	0.00	1.0e+00	LRP1 STAT6
Illnesses of father: Heart disease	9.78	2	1	2.2	0.00	1.0e+00	PLEKHM1 RP1-257A7.5
Asthma (self-reported)	9.77	2	1	2.2	0.00	1.0e+00	LRP1 STAT6
Coronary Artery Disease (CAD)	9.68	1	1	2.2	0.00	1.0e+00	RP1-257A7.5
Asthma	9.26	2	1	2.2	0.00	1.0e+00	LRP1 STAT6
Vitamin and mineral supplements	9.06	2	1	2.2	0.00	1.0e+00	LRP1 STAT6
Alcohol intake frequency.	8.91	4	0	0.0	0.99	1.3e-02	LRP1 PLEKHM1 RP1-257A7.5 STAT6
Lung FEV1/FVC ratio	8.81	2	2	4.4	0.00	1.0e+00	LRP1 STAT6
Hair/balding pattern: Pattern 4	8.72	1	1	2.2	0.00	1.0e+00	PLEKHM1
Neuroticism	8.16	3	1	2.2	0.00	1.0e+00	LRP1 PLEKHM1 STAT6
Depressed Affect (Nagel 2018)	8.10	3	1	2.2	0.00	1.0e+00	LRP1 PLEKHM1 STAT6
Sensitivity / hurt feelings	7.99	2	1	2.2	0.00	1.0e+00	LRP1 PLEKHM1
Allergy	7.83	2	1	2.2	0.00	1.0e+00	LRP1 STAT6
Mood swings	7.52	2	1	2.2	0.00	1.0e+00	LRP1 PLEKHM1
Heart disease (siblings)	7.41	2	1	2.2	0.00	1.0e+00	PLEKHM1 RP1-257A7.5
Frequency of tenseness / restlessness in last 2 weeks	7.05	1	1	2.2	0.00	1.0e+00	PLEKHM1
Hayfever/allergic rhinitis (self-reported)	6.89	2	0	0.0	0.00	1.0e+00	LRP1 STAT6
Neuroticism score	6.80	1	1	2.2	0.00	1.0e+00	PLEKHM1
Myopia	6.62	2	0	0.0	0.00	1.0e+00	LRP1 STAT6
Angina (self-reported)	6.48	1	1	2.2	0.00	1.0e+00	RP1-257A7.5
Neuroticism (Nagel 2018)	6.43	1	1	2.2	0.00	1.0e+00	PLEKHM1
Angina	6.42	1	1	2.2	0.00	1.0e+00	RP1-257A7.5
Blood Red Count	5.87	2	1	2.2	0.00	1.0e+00	PLEKHM1 RP1-257A7.5
Primary Biliary Cirrhosis	5.79	3	0	0.0	0.00	1.0e+00	LRP1 PLEKHM1 STAT6
Supplements: Fish oil (including cod liver oil)	5.56	2	0	0.0	0.00	1.0e+00	LRP1 STAT6
Mineral and other dietary supplements	5.45	2	0	0.0	0.00	1.0e+00	LRP1 STAT6
Number of treatments/medications taken	5.41	2	0	0.0	0.00	1.0e+00	LRP1 RP1-257A7.5
Miserableness	5.33	3	0	0.0	0.00	1.0e+00	LRP1 PLEKHM1 STAT6
Average weekly beer plus cider intake	5.24	2	0	0.0	0.00	1.0e+00	LRP1 STAT6
Pulse wave Arterial Stiffness index	5.17	1	0	0.0	0.00	1.0e+00	RP1-257A7.5
Medication: Ventolin 100micrograms inhaler	5.11	1	0	0.0	0.00	1.0e+00	STAT6
Fed-up feelings	4.98	1	1	2.2	0.00	1.0e+00	PLEKHM1
Hand grip strength (right)	4.93	3	0	0.0	0.00	1.0e+00	LRP1 RP1-257A7.5 STAT6
Ever unenthusiastic/disinterested for a whole week	4.92	1	0	0.0	0.00	1.0e+00	PLEKHM1
Systolic blood pressure, automated reading	4.83	2	0	0.0	0.00	1.0e+00	PLEKHM1 RP1-257A7.5
Hayfever, allergic rhinitis or eczema	4.65	2	0	0.0	0.00	1.0e+00	LRP1 STAT6
Multivitamins +/- minerals	4.56	1	0	0.0	0.00	1.0e+00	LRP1
Pulse wave peak to peak time	4.37	1	0	0.0	0.00	1.0e+00	RP1-257A7.5
Heart disease (mother)	4.37	1	0	0.0	0.00	1.0e+00	RP1-257A7.5
Allergy or Eczema	4.32	2	0	0.0	0.00	1.0e+00	LRP1 STAT6
Relative age of first facial hair	4.32	1	1	2.2	0.00	1.0e+00	PLEKHM1
Trunk predicted mass	4.23	3	2	4.4	0.00	1.0e+00	LRP1 PLEKHM1 STAT6
Trunk fat-free mass	4.18	3	2	4.4	0.00	1.0e+00	LRP1 PLEKHM1 STAT6
Mouth/teeth dental problems: Mouth ulcers	4.18	1	0	0.0	0.00	1.0e+00	PLEKHM1
Fluid intelligence score	4.07	3	0	0.0	0.00	1.0e+00	LRP1 PLEKHM1 STAT6
Hair/balding pattern: Pattern 2	4.01	1	0	0.0	0.00	1.0e+00	PLEKHM1
Nervous feelings	3.98	1	1	2.2	0.00	1.0e+00	PLEKHM1
Birth weight	3.97	3	0	0.0	0.00	1.0e+00	LRP1 RP1-257A7.5 STAT6
Hair/balding pattern: Pattern 3	3.91	1	0	0.0	0.00	1.0e+00	PLEKHM1
Medication: Seretide 50 evohaler	3.89	1	0	0.0	0.00	1.0e+00	STAT6
Blood Eosinophil Count	3.78	3	2	4.4	0.00	1.0e+00	LRP1 PLEKHM1 STAT6
Hand grip strength (left)	3.69	1	1	2.2	0.00	1.0e+00	RP1-257A7.5
Systolic Blood Pressure	3.56	2	2	4.4	0.00	1.0e+00	PLEKHM1 RP1-257A7.5
Supplements: Calcium	3.55	1	0	0.0	0.00	1.0e+00	LRP1
Worrier / anxious feelings	3.52	1	0	0.0	0.00	1.0e+00	PLEKHM1
High blood pressure (mother)	3.45	1	0	0.0	0.00	1.0e+00	RP1-257A7.5
Sitting height	3.42	2	2	4.4	0.00	1.0e+00	LRP1 STAT6
Loneliness, isolation	3.41	1	0	0.0	0.00	1.0e+00	PLEKHM1
Back pain experienced in last month	3.41	1	0	0.0	0.00	1.0e+00	LRP1
Neuroticism (2016)	3.39	1	0	0.0	0.00	1.0e+00	PLEKHM1
Whole body water mass	3.39	3	2	4.4	0.00	1.0e+00	LRP1 PLEKHM1 STAT6
Number of operations (self-reported)	3.39	1	0	0.0	0.00	1.0e+00	LRP1
Had major operations	3.35	1	0	0.0	0.00	1.0e+00	RP1-257A7.5
Illnesses of father: None of the above (group 1)	3.34	2	0	0.0	0.00	1.0e+00	PLEKHM1 RP1-257A7.5
Whole body fat-free mass	3.31	3	2	4.4	0.00	1.0e+00	LRP1 PLEKHM1 STAT6
Gout (self-reported)	3.24	1	0	0.0	0.00	1.0e+00	LRP1
Schizophrenia (2018)	3.21	2	0	0.0	0.00	1.0e+00	LRP1 STAT6
Frequency of depressed mood in last 2 weeks	3.16	1	0	0.0	0.00	1.0e+00	PLEKHM1
Depression (Nagel 2018)	3.15	1	0	0.0	0.00	1.0e+00	PLEKHM1
Hearing difficulty/problems with background noise	3.11	1	0	0.0	0.00	1.0e+00	PLEKHM1
Waist Hip Ratio (WHR)	3.09	1	1	2.2	0.00	1.0e+00	PLEKHM1
Relative age voice broke	3.09	1	0	0.0	0.00	1.0e+00	PLEKHM1
Arm predicted mass (right)	3.01	2	1	2.2	0.00	1.0e+00	PLEKHM1 STAT6
Arm fat-free mass (left)	2.97	2	1	2.2	0.00	1.0e+00	PLEKHM1 STAT6
Schizophrenia (2014)	2.96	2	0	0.0	0.00	1.0e+00	PLEKHM1 STAT6
Worry (Nagel 2018)	2.91	1	0	0.0	0.00	1.0e+00	PLEKHM1
Major Depression (MDD)	2.87	1	0	0.0	0.00	1.0e+00	PLEKHM1
Arm fat-free mass (right)	2.86	2	1	2.2	0.00	1.0e+00	PLEKHM1 STAT6
Impedance of whole body	2.82	2	1	2.2	0.00	1.0e+00	PLEKHM1 STAT6
Arm predicted mass (left)	2.82	2	1	2.2	0.00	1.0e+00	PLEKHM1 STAT6
Impedance of arm (left)	2.78	2	1	2.2	0.00	1.0e+00	PLEKHM1 STAT6
Intelligence (Savage-Jansen 2018)	2.74	2	0	0.0	0.00	1.0e+00	PLEKHM1 STAT6
High blood pressure (siblings)	2.72	1	0	0.0	0.00	1.0e+00	LRP1
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.61	1	0	0.0	0.00	1.0e+00	PLEKHM1
Basal metabolic rate	2.61	2	1	2.2	0.00	1.0e+00	PLEKHM1 STAT6
Guilty feelings	2.59	1	0	0.0	0.00	1.0e+00	PLEKHM1
Leg fat percentage (right)	2.58	1	0	0.0	0.00	1.0e+00	LRP1
Bipolar Disorder or Schizophrenia	2.57	2	0	0.0	0.00	1.0e+00	LRP1 STAT6
Lung FVC	2.53	1	1	2.2	0.00	1.0e+00	PLEKHM1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.50	1	0	0.0	0.00	1.0e+00	PLEKHM1
Qualifications: A levels/AS levels or equivalent	2.50	1	0	0.0	0.00	1.0e+00	PLEKHM1
Schizophrenia vs Biploar Disorder	2.49	1	0	0.0	0.00	1.0e+00	PLEKHM1
Handedness (chirality/laterality): Left-handed	2.48	1	0	0.0	0.00	1.0e+00	PLEKHM1
Leg fat percentage (left)	2.47	1	0	0.0	0.00	1.0e+00	LRP1
Prospective memory result	2.40	1	0	0.0	0.00	1.0e+00	LRP1
Knee pain experienced in last month	2.37	1	0	0.0	0.00	1.0e+00	RP1-257A7.5
Impedance of arm (right)	2.36	1	1	2.2	0.00	1.0e+00	PLEKHM1
Leg predicted mass (right)	2.36	2	1	2.2	0.00	1.0e+00	PLEKHM1 STAT6
Leg fat-free mass (right)	2.35	2	1	2.2	0.00	1.0e+00	PLEKHM1 STAT6
Mouth/teeth dental problems	2.32	1	0	0.0	0.00	1.0e+00	PLEKHM1
Breast Cancer	2.30	1	0	0.0	0.00	1.0e+00	PLEKHM1
Standing height	2.29	3	2	4.4	0.00	1.0e+00	LRP1 PLEKHM1 STAT6
Worry too long after embarrassment	2.20	1	0	0.0	0.00	1.0e+00	PLEKHM1
Body fat percentage	2.17	2	0	0.0	0.00	1.0e+00	LRP1 RP1-257A7.5
Forced expiratory volume in 1-second (FEV1), predicted	2.16	1	0	0.0	0.00	1.0e+00	STAT6
Medication: Aspirin	2.08	1	0	0.0	0.00	1.0e+00	RP1-257A7.5
Trunk fat percentage	2.06	3	0	0.0	0.00	1.0e+00	LRP1 PLEKHM1 RP1-257A7.5
Leg predicted mass (left)	2.05	2	0	0.0	0.00	1.0e+00	PLEKHM1 STAT6
Medication: Bendroflumethiazide	2.05	1	0	0.0	0.00	1.0e+00	RP1-257A7.5
Leg fat-free mass (left)	2.00	2	0	0.0	0.00	1.0e+00	PLEKHM1 STAT6
Verbal and Numeric Reasoning (VNR)	1.99	1	0	0.0	0.00	1.0e+00	PLEKHM1
Impedance of leg (right)	1.84	1	1	2.2	0.00	1.0e+00	PLEKHM1
Forced vital capacity (FVC)	1.84	2	0	0.0	0.00	1.0e+00	PLEKHM1 STAT6
Forced vital capacity (FVC), Best measure	1.83	2	0	0.0	0.00	1.0e+00	PLEKHM1 STAT6
Impedance of leg (left)	1.82	1	1	2.2	0.00	1.0e+00	PLEKHM1
Medication: Blood pressure	1.82	1	0	0.0	0.00	1.0e+00	PLEKHM1
Arm fat percentage (left)	1.77	2	0	0.0	0.00	1.0e+00	LRP1 RP1-257A7.5
Irritability	1.76	1	0	0.0	0.00	1.0e+00	PLEKHM1
Qualifications: College or University degree	1.75	1	0	0.0	0.00	1.0e+00	PLEKHM1
Height	1.71	3	2	4.4	0.00	1.0e+00	LRP1 PLEKHM1 STAT6
Arm fat percentage (right)	1.62	1	0	0.0	0.00	1.0e+00	LRP1
Age when periods started (menarche)	1.55	1	0	0.0	0.00	1.0e+00	PLEKHM1
Hypertension (Self-reported)	1.51	1	0	0.0	0.00	1.0e+00	RP1-257A7.5
High blood pressure	1.48	1	0	0.0	0.00	1.0e+00	RP1-257A7.5
BMI	1.45	1	0	0.0	0.00	1.0e+00	LRP1
Pulse rate, automated reading	1.27	1	0	0.0	0.00	1.0e+00	RP1-257A7.5
Body mass index (BMI)	1.10	1	0	0.0	0.00	1.0e+00	LRP1
Qualifications: None of the above	1.06	1	0	0.0	0.00	1.0e+00	LRP1
Forced expiratory volume in 1-second (FEV1), Best measure	1.00	1	0	0.0	0.00	1.0e+00	PLEKHM1
Diastolic blood pressure, automated reading	1.00	1	0	0.0	0.00	1.0e+00	RP1-257A7.5
Forced expiratory volume in 1-second (FEV1)	0.98	1	0	0.0	0.00	1.0e+00	PLEKHM1
Blood White Count	0.93	1	0	0.0	0.00	1.0e+00	PLEKHM1
Leg fat mass (right)	0.93	1	0	0.0	0.00	1.0e+00	LRP1
Leg fat mass (left)	0.91	1	0	0.0	0.00	1.0e+00	LRP1
Weight	0.86	1	0	0.0	0.00	1.0e+00	PLEKHM1
Blood Platelet Count	0.52	1	0	0.0	0.00	1.0e+00	LRP1
Tanning	0.30	1	0	0.0	0.00	1.0e+00	PLEKHM1
Hair Pigment	0.24	1	0	0.0	0.00	1.0e+00	LRP1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Small Intestine Terminal Ileum	0	0.000	1.5
GTEx	Adipose Visceral Omentum	0	0.000	1.4
GTEx	Adrenal Gland	1	0.069	1.4
GTEx	Artery Coronary	1	0.085	1.4
GTEx	Artery Tibial	2	0.053	1.4
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.4
GTEx	Brain Cortex	0	0.000	1.4
GTEx	Brain Frontal Cortex BA9	0	0.000	1.4
GTEx	Brain Hypothalamus	0	0.000	1.4
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.4
GTEx	Brain Putamen basal ganglia	0	0.000	1.4
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.4
GTEx	Colon Transverse	0	0.000	1.4
GTEx	Esophagus Mucosa	0	0.000	1.4
GTEx	Heart Left Ventricle	0	0.000	1.4
GTEx	Ovary	0	0.000	1.4
GTEx	Prostate	0	0.000	1.4
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.4
GTEx	Stomach	0	0.000	1.4
GTEx	Uterus	0	0.000	1.4
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Artery Aorta	2	0.067	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Cerebellum	0	0.000	1.3
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Breast Mammary Tissue	0	0.000	1.3
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.3
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.3
GTEx	Cells Transformed fibroblasts	0	0.000	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Liver	0	0.000	1.3
GTEx	Lung	0	0.000	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Nerve Tibial	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.3
GTEx	Spleen	0	0.000	1.3
GTEx	Testis	0	0.000	1.3
GTEx	Thyroid	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
NTR	Blood	0	0.000	1.3
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.3
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.3
GTEx	Whole Blood	0	0.000	1.2
METSIM	Adipose	2	0.043	1.2
YFS	Blood	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.1
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.1
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.1