Hub : Traits :

Medication: Ibuprofen (e.g. Nurofen)

9 significantly associated models · 6 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 6 12020241 13990267 2 1 2.7e-09 4.5e-09 1.0000 100 RP1-257A7.5
2 12 56805309 58303535 3 2 7.0e-14 4.8e-14 1.0000 100 LRP1 STAT6
3 17 42814955 43913030 1 1 2.3e-07 6.3e-07 0.0041 67 PLEKHM1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 2.57 2 0 0.0 0.00 1.0e+00 LRP1 STAT6
Depressed Affect (Nagel 2018) 8.10 3 1 2.2 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Depression (Nagel 2018) 3.15 1 0 0.0 0.00 1.0e+00 PLEKHM1
Intelligence (Savage-Jansen 2018) 2.74 2 0 0.0 0.00 1.0e+00 PLEKHM1 STAT6
Neuroticism (Nagel 2018) 6.43 1 1 2.2 0.00 1.0e+00 PLEKHM1
Schizophrenia (2018) 3.21 2 0 0.0 0.00 1.0e+00 LRP1 STAT6
Schizophrenia vs Biploar Disorder 2.49 1 0 0.0 0.00 1.0e+00 PLEKHM1
Worry (Nagel 2018) 2.91 1 0 0.0 0.00 1.0e+00 PLEKHM1
Major Depression (MDD) 2.87 1 0 0.0 0.00 1.0e+00 PLEKHM1
Verbal and Numeric Reasoning (VNR) 1.99 1 0 0.0 0.00 1.0e+00 PLEKHM1
Breast Cancer 2.30 1 0 0.0 0.00 1.0e+00 PLEKHM1
Coronary Artery Disease (CAD) 9.68 1 1 2.2 0.00 1.0e+00 RP1-257A7.5
Neuroticism (2016) 3.39 1 0 0.0 0.00 1.0e+00 PLEKHM1
Primary Biliary Cirrhosis 5.79 3 0 0.0 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Schizophrenia (2014) 2.96 2 0 0.0 0.00 1.0e+00 PLEKHM1 STAT6
Blood Eosinophil Count 3.78 3 2 4.4 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Blood Platelet Count 0.52 1 0 0.0 0.00 1.0e+00 LRP1
Blood Red Count 5.87 2 1 2.2 0.00 1.0e+00 PLEKHM1 RP1-257A7.5
Blood White Count 0.93 1 0 0.0 0.00 1.0e+00 PLEKHM1
BMI 1.45 1 0 0.0 0.00 1.0e+00 LRP1
Height 1.71 3 2 4.4 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Waist Hip Ratio (WHR) 3.09 1 1 2.2 0.00 1.0e+00 PLEKHM1
Systolic Blood Pressure 3.56 2 2 4.4 0.00 1.0e+00 PLEKHM1 RP1-257A7.5
Allergy or Eczema 4.32 2 0 0.0 0.00 1.0e+00 LRP1 STAT6
Respiratory disease 11.63 2 2 4.4 0.00 1.0e+00 LRP1 STAT6
Lung FEV1/FVC ratio 8.81 2 2 4.4 0.00 1.0e+00 LRP1 STAT6
Lung FVC 2.53 1 1 2.2 0.00 1.0e+00 PLEKHM1
Neuroticism 8.16 3 1 2.2 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Hair Pigment 0.24 1 0 0.0 0.00 1.0e+00 LRP1
Tanning 0.30 1 0 0.0 0.00 1.0e+00 PLEKHM1
Hand grip strength (left) 3.69 1 1 2.2 0.00 1.0e+00 RP1-257A7.5
Number of treatments/medications taken 5.41 2 0 0.0 0.00 1.0e+00 LRP1 RP1-257A7.5
Sensitivity / hurt feelings 7.99 2 1 2.2 0.00 1.0e+00 LRP1 PLEKHM1
Frequency of depressed mood in last 2 weeks 3.16 1 0 0.0 0.00 1.0e+00 PLEKHM1
Relative age of first facial hair 4.32 1 1 2.2 0.00 1.0e+00 PLEKHM1
Systolic blood pressure, automated reading 4.83 2 0 0.0 0.00 1.0e+00 PLEKHM1 RP1-257A7.5
Angina 6.42 1 1 2.2 0.00 1.0e+00 RP1-257A7.5
Vitamin and mineral supplements 9.06 2 1 2.2 0.00 1.0e+00 LRP1 STAT6
Impedance of leg (right) 1.84 1 1 2.2 0.00 1.0e+00 PLEKHM1
Leg fat-free mass (left) 2.00 2 0 0.0 0.00 1.0e+00 PLEKHM1 STAT6
Trunk fat percentage 2.06 3 0 0.0 0.00 1.0e+00 LRP1 PLEKHM1 RP1-257A7.5
Hand grip strength (right) 4.93 3 0 0.0 0.00 1.0e+00 LRP1 RP1-257A7.5 STAT6
Fed-up feelings 4.98 1 1 2.2 0.00 1.0e+00 PLEKHM1
Frequency of unenthusiasm / disinterest in last 2 weeks 2.50 1 0 0.0 0.00 1.0e+00 PLEKHM1
Relative age voice broke 3.09 1 0 0.0 0.00 1.0e+00 PLEKHM1
Age when periods started (menarche) 1.55 1 0 0.0 0.00 1.0e+00 PLEKHM1
High blood pressure 1.48 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Hayfever, allergic rhinitis or eczema 4.65 2 0 0.0 0.00 1.0e+00 LRP1 STAT6
Multivitamins +/- minerals 4.56 1 0 0.0 0.00 1.0e+00 LRP1
Sitting height 3.42 2 2 4.4 0.00 1.0e+00 LRP1 STAT6
High blood pressure (mother) 3.45 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Body mass index (BMI) 1.10 1 0 0.0 0.00 1.0e+00 LRP1
Impedance of leg (left) 1.82 1 1 2.2 0.00 1.0e+00 PLEKHM1
Leg predicted mass (left) 2.05 2 0 0.0 0.00 1.0e+00 PLEKHM1 STAT6
Nervous feelings 3.98 1 1 2.2 0.00 1.0e+00 PLEKHM1
Frequency of tenseness / restlessness in last 2 weeks 7.05 1 1 2.2 0.00 1.0e+00 PLEKHM1
Hearing difficulty/problems with background noise 3.11 1 0 0.0 0.00 1.0e+00 PLEKHM1
Hair/balding pattern: Pattern 2 4.01 1 0 0.0 0.00 1.0e+00 PLEKHM1
Forced vital capacity (FVC) 1.84 2 0 0.0 0.00 1.0e+00 PLEKHM1 STAT6
Ever unenthusiastic/disinterested for a whole week 4.92 1 0 0.0 0.00 1.0e+00 PLEKHM1
Qualifications: None of the above 1.06 1 0 0.0 0.00 1.0e+00 LRP1
Mouth/teeth dental problems 2.32 1 0 0.0 0.00 1.0e+00 PLEKHM1
Heart attack 11.96 1 1 2.2 0.00 1.0e+00 RP1-257A7.5
Allergy 7.83 2 1 2.2 0.00 1.0e+00 LRP1 STAT6
Hayfever/allergic rhinitis (self-reported) 6.89 2 0 0.0 0.00 1.0e+00 LRP1 STAT6
Fluid intelligence score 4.07 3 0 0.0 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Neuroticism score 6.80 1 1 2.2 0.00 1.0e+00 PLEKHM1
Weight 0.86 1 0 0.0 0.00 1.0e+00 PLEKHM1
Impedance of arm (right) 2.36 1 1 2.2 0.00 1.0e+00 PLEKHM1
Arm fat percentage (right) 1.62 1 0 0.0 0.00 1.0e+00 LRP1
Trunk fat-free mass 4.18 3 2 4.4 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Worrier / anxious feelings 3.52 1 0 0.0 0.00 1.0e+00 PLEKHM1
Hair/balding pattern: Pattern 3 3.91 1 0 0.0 0.00 1.0e+00 PLEKHM1
Forced expiratory volume in 1-second (FEV1) 0.98 1 0 0.0 0.00 1.0e+00 PLEKHM1
Qualifications: A levels/AS levels or equivalent 2.50 1 0 0.0 0.00 1.0e+00 PLEKHM1
Asthma 9.26 2 1 2.2 0.00 1.0e+00 LRP1 STAT6
Prospective memory result 2.40 1 0 0.0 0.00 1.0e+00 LRP1
Forced expiratory volume in 1-second (FEV1), Best measure 1.00 1 0 0.0 0.00 1.0e+00 PLEKHM1
Pulse wave Arterial Stiffness index 5.17 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Impedance of arm (left) 2.78 2 1 2.2 0.00 1.0e+00 PLEKHM1 STAT6
Trunk predicted mass 4.23 3 2 4.4 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Standing height 2.29 3 2 4.4 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Hair/balding pattern: Pattern 4 8.72 1 1 2.2 0.00 1.0e+00 PLEKHM1
Medication: Paracetamol 22.85 4 2 4.4 0.99 1.4e-02 LRP1 PLEKHM1 RP1-257A7.5 STAT6
Headache pain in last month 52.14 4 4 8.9 0.99 1.4e-02 LRP1 PLEKHM1 RP1-257A7.5 STAT6
Gout (self-reported) 3.24 1 0 0.0 0.00 1.0e+00 LRP1
Medication: Ventolin 100micrograms inhaler 5.11 1 0 0.0 0.00 1.0e+00 STAT6
Birth weight 3.97 3 0 0.0 0.00 1.0e+00 LRP1 RP1-257A7.5 STAT6
High blood pressure (siblings) 2.72 1 0 0.0 0.00 1.0e+00 LRP1
Forced vital capacity (FVC), Best measure 1.83 2 0 0.0 0.00 1.0e+00 PLEKHM1 STAT6
Body fat percentage 2.17 2 0 0.0 0.00 1.0e+00 LRP1 RP1-257A7.5
Leg fat percentage (right) 2.58 1 0 0.0 0.00 1.0e+00 LRP1
Arm fat-free mass (right) 2.86 2 1 2.2 0.00 1.0e+00 PLEKHM1 STAT6
Worry too long after embarrassment 2.20 1 0 0.0 0.00 1.0e+00 PLEKHM1
Pulse wave peak to peak time 4.37 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Qualifications: College or University degree 1.75 1 0 0.0 0.00 1.0e+00 PLEKHM1
Medication for pain relief, constipation, heartburn 22.33 4 2 4.4 -0.98 2.1e-02 LRP1 PLEKHM1 RP1-257A7.5 STAT6
Angina (self-reported) 6.48 1 1 2.2 0.00 1.0e+00 RP1-257A7.5
Migraine (self-reported) 43.75 3 3 6.7 0.00 1.0e+00 LRP1 RP1-257A7.5 STAT6
Medication: Ibuprofen 26.00 4 3 6.7 1.00 4.9e-05 LRP1 PLEKHM1 RP1-257A7.5 STAT6
Medication: Seretide 50 evohaler 3.89 1 0 0.0 0.00 1.0e+00 STAT6
Heart disease (mother) 4.37 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Leg fat mass (right) 0.93 1 0 0.0 0.00 1.0e+00 LRP1
Arm predicted mass (right) 3.01 2 1 2.2 0.00 1.0e+00 PLEKHM1 STAT6
Pulse rate, automated reading 1.27 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Alcohol intake frequency. 8.91 4 0 0.0 0.99 1.3e-02 LRP1 PLEKHM1 RP1-257A7.5 STAT6
Had major operations 3.35 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Knee pain experienced in last month 2.37 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Hypertension (Self-reported) 1.51 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Illnesses of father: Heart disease 9.78 2 1 2.2 0.00 1.0e+00 PLEKHM1 RP1-257A7.5
Forced expiratory volume in 1-second (FEV1), predicted 2.16 1 0 0.0 0.00 1.0e+00 STAT6
Whole body fat-free mass 3.31 3 2 4.4 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Leg fat-free mass (right) 2.35 2 1 2.2 0.00 1.0e+00 PLEKHM1 STAT6
Arm fat percentage (left) 1.77 2 0 0.0 0.00 1.0e+00 LRP1 RP1-257A7.5
Handedness (chirality/laterality): Left-handed 2.48 1 0 0.0 0.00 1.0e+00 PLEKHM1
Mood swings 7.52 2 1 2.2 0.00 1.0e+00 LRP1 PLEKHM1
Loneliness, isolation 3.41 1 0 0.0 0.00 1.0e+00 PLEKHM1
Mouth/teeth dental problems: Mouth ulcers 4.18 1 0 0.0 0.00 1.0e+00 PLEKHM1
Back pain experienced in last month 3.41 1 0 0.0 0.00 1.0e+00 LRP1
Mineral and other dietary supplements 5.45 2 0 0.0 0.00 1.0e+00 LRP1 STAT6
Asthma (self-reported) 9.77 2 1 2.2 0.00 1.0e+00 LRP1 STAT6
Medication: Aspirin 2.08 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Illnesses of father: None of the above (group 1) 3.34 2 0 0.0 0.00 1.0e+00 PLEKHM1 RP1-257A7.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.61 1 0 0.0 0.00 1.0e+00 PLEKHM1
Whole body water mass 3.39 3 2 4.4 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Leg predicted mass (right) 2.36 2 1 2.2 0.00 1.0e+00 PLEKHM1 STAT6
Miserableness 5.33 3 0 0.0 0.00 1.0e+00 LRP1 PLEKHM1 STAT6
Guilty feelings 2.59 1 0 0.0 0.00 1.0e+00 PLEKHM1
Medication: Blood pressure 1.82 1 0 0.0 0.00 1.0e+00 PLEKHM1
Supplements: Fish oil (including cod liver oil) 5.56 2 0 0.0 0.00 1.0e+00 LRP1 STAT6
Medication: Bendroflumethiazide 2.05 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Medication: Paracetamol 18.20 4 1 2.2 0.98 1.9e-02 LRP1 PLEKHM1 RP1-257A7.5 STAT6
Basal metabolic rate 2.61 2 1 2.2 0.00 1.0e+00 PLEKHM1 STAT6
Leg fat percentage (left) 2.47 1 0 0.0 0.00 1.0e+00 LRP1
Arm fat-free mass (left) 2.97 2 1 2.2 0.00 1.0e+00 PLEKHM1 STAT6
Number of operations (self-reported) 3.39 1 0 0.0 0.00 1.0e+00 LRP1
Average weekly beer plus cider intake 5.24 2 0 0.0 0.00 1.0e+00 LRP1 STAT6
Irritability 1.76 1 0 0.0 0.00 1.0e+00 PLEKHM1
Diastolic blood pressure, automated reading 1.00 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Myopia 6.62 2 0 0.0 0.00 1.0e+00 LRP1 STAT6
Pain experienced in last month 12.92 4 1 2.2 -0.99 1.1e-02 LRP1 PLEKHM1 RP1-257A7.5 STAT6
Supplements: Calcium 3.55 1 0 0.0 0.00 1.0e+00 LRP1
Heart attack/myocardial infarction (self-reported) 12.39 1 1 2.2 0.00 1.0e+00 RP1-257A7.5
Heart disease (siblings) 7.41 2 1 2.2 0.00 1.0e+00 PLEKHM1 RP1-257A7.5
Impedance of whole body 2.82 2 1 2.2 0.00 1.0e+00 PLEKHM1 STAT6
Leg fat mass (left) 0.91 1 0 0.0 0.00 1.0e+00 LRP1
Arm predicted mass (left) 2.82 2 1 2.2 0.00 1.0e+00 PLEKHM1 STAT6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.3
GTEx Adipose Visceral Omentum 0 0.000 1.4
GTEx Adrenal Gland 1 0.069 1.4
GTEx Artery Aorta 2 0.067 1.3
GTEx Artery Coronary 1 0.085 1.4
GTEx Artery Tibial 2 0.053 1.4
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.4
GTEx Brain Cerebellum 0 0.000 1.3
GTEx Brain Cortex 0 0.000 1.4
GTEx Brain Frontal Cortex BA9 0 0.000 1.4
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.4
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.4
GTEx Brain Putamen basal ganglia 0 0.000 1.4
GTEx Breast Mammary Tissue 0 0.000 1.3
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.3
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.4
GTEx Cells Transformed fibroblasts 0 0.000 1.3
GTEx Colon Sigmoid 0 0.000 1.3
GTEx Colon Transverse 0 0.000 1.4
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.4
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.4
GTEx Liver 0 0.000 1.3
GTEx Lung 0 0.000 1.3
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.3
GTEx Ovary 0 0.000 1.4
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.4
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.4
GTEx Skin Sun Exposed Lower leg 0 0.000 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.5
GTEx Spleen 0 0.000 1.3
GTEx Stomach 0 0.000 1.4
GTEx Testis 0 0.000 1.3
GTEx Thyroid 0 0.000 1.3
GTEx Uterus 0 0.000 1.4
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 2 0.043 1.2
NTR Blood 0 0.000 1.3
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.3
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.3
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.1
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.1
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.1
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 1 0.019 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2