Best TWAS P=1.31e-11 · Best GWAS P=7.54e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CHST3 | 0.12 | 0.12 | lasso | 6 | 0.11 | 1.1e-13 | -6.6 | -6.8 | 1.3e-11 | 0.98 | 0.02 | 0.98 | TRUE |
| 2 | GTEx | Adrenal Gland | SPOCK2 | 0.44 | 0.46 | lasso | 15 | 0.46 | 3.5e-18 | 4.4 | -5.5 | 5.0e-08 | 0.70 | 0.91 | 0.09 | FALSE |
| 3 | GTEx | Adrenal Gland | DNAJB12 | 0.18 | 0.06 | lasso | 5 | 0.10 | 2.2e-04 | -3.8 | -5.3 | 1.1e-07 | 0.52 | 0.26 | 0.54 | FALSE |
| 4 | GTEx | Esophagus Muscularis | ASCC1 | 0.16 | 0.03 | enet | 23 | 0.04 | 2.0e-03 | 3.1 | -5.4 | 7.9e-08 | 0.46 | 0.52 | 0.16 | FALSE |
| 5 | GTEx | Muscle Skeletal | SPOCK2 | 0.08 | 0.03 | lasso | 3 | 0.05 | 2.5e-05 | 3.1 | 5.2 | 2.4e-07 | -0.76 | 0.28 | 0.70 | FALSE |
| 6 | METSIM | Adipose | SPOCK2 | 0.06 | 0.06 | lasso | 10 | 0.07 | 1.3e-10 | -6.0 | 5.2 | 1.8e-07 | -0.80 | 0.12 | 0.88 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | CHST3 | 0.15 | 0.18 | lasso | 5 | 0.18 | 1.1e-22 | -6.3 | -6.4 | 2.0e-10 | 0.96 | 0.07 | 0.93 | FALSE |
| 8 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | CHST3 | 0.10 | 0.03 | blup | 99 | 0.04 | 5.8e-03 | -6.0 | -5.7 | 1.0e-08 | 0.89 | 0.02 | 0.51 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | CHST3 | 0.05 | 0.03 | lasso | 2 | 0.03 | 4.0e-04 | 3.8 | -5.4 | 8.3e-08 | 0.59 | 0.15 | 0.77 | FALSE |