Hub : Genes

SPOCK2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Visceral Omentum 0.1690 0.0650 1.5e-03 0.059 NA 0.035 NA 0.048 5.2e-04 NA 6.3e-03 NA 1.6e-03
2 GTEx Adrenal Gland 0.4419 0.0694 1.6e-13 0.463 NA 0.438 NA 0.456 1.5e-18 NA 2.5e-17 NA 3.5e-18
3 GTEx Breast Mammary Tissue (Male) 0.1686 0.1126 8.6e-02 -0.011 NA -0.011 NA -0.012 7.3e-01 NA 6.8e-01 NA 7.6e-01
4 GTEx Breast Mammary Tissue (Female) 0.0474 0.0498 1.9e-01 0.027 NA -0.005 NA -0.005 5.5e-02 NA 4.7e-01 NA 4.9e-01
5 GTEx Heart Left Ventricle 0.2534 0.0656 2.6e-06 0.220 NA 0.261 NA 0.240 6.1e-12 NA 3.7e-14 NA 4.9e-13
6 GTEx Muscle Skeletal 0.0815 0.0284 3.0e-05 0.032 NA 0.031 NA 0.046 4.1e-04 NA 4.9e-04 NA 2.5e-05
7 GTEx Pancreas 0.1480 0.0640 2.3e-03 0.121 NA 0.119 NA 0.130 9.2e-06 NA 1.0e-05 NA 4.0e-06
8 GTEx Thyroid 0.0970 0.0410 8.2e-04 0.046 NA 0.013 NA 0.032 1.8e-04 NA 3.3e-02 NA 1.7e-03
9 METSIM Adipose 0.0558 0.0169 2.6e-10 0.057 0.060 0.063 0.058 0.070 6.2e-09 2.6e-09 1.0e-09 5.1e-09 1.3e-10
10 NTR Blood 0.0291 0.0106 9.7e-06 0.023 0.019 0.021 0.021 0.018 4.5e-08 5.3e-07 1.3e-07 2.3e-07 1.4e-06
11 YFS Blood 0.0519 0.0169 3.0e-05 0.021 0.021 0.021 0.024 0.021 1.3e-07 1.1e-07 1.3e-07 1.8e-08 1.0e-07
12 TCGA Breast Invasive Carcinoma 0.0173 0.0102 1.1e-03 0.011 0.013 0.012 NA 0.009 1.9e-03 7.8e-04 1.1e-03 NA 3.8e-03
13 TCGA Kidney Renal Clear Cell Carcinoma 0.1053 0.0462 7.2e-10 0.078 0.084 0.074 NA 0.088 4.1e-09 1.0e-09 1.0e-08 NA 3.9e-10
14 TCGA Soft Tissue Sarcoma 0.0720 0.0480 1.5e-04 0.078 0.056 0.071 NA 0.070 2.3e-05 2.9e-04 5.4e-05 NA 5.9e-05
15 TCGA Stomach Adenocarcinoma 0.0480 0.0310 7.1e-03 0.052 0.005 0.016 NA 0.020 1.2e-04 1.2e-01 2.2e-02 NA 1.2e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bipolar Disorder (2018) 0.2 0.3 1.2 -0.7 0.6 0.4 -0.3 -0.1 -0.3 -0.1 -0.2 -0.6 -0.1 1.1 -0.3 -0.3 -0.7 0.6
Bipolar Disorder or Schizophrenia 0.7 1.7 2.7 1.3 -1.3 1.6 1.4 1.5 1.4 1.3 1.3 1.1 0.8 0.4 1.5 1.5 1.3 -1.3
Depressed Affect (Nagel 2018) 0.7 1.4 3.1 1.4 -0.8 0.5 1.2 1.2 1.5 1.2 1.3 1.1 0.8 -0.7 1.8 1.3 1.7 -0.5
Depression (Nagel 2018) 0.1 0.1 0.4 0.2 0.4 0.1 0.1 -0.1 -0.4 0.0 0.1 -0.6 0.1 0.1 0.1 0.1 -0.7 0.3
Intelligence (Savage-Jansen 2018) 0.9 2.6 6.1 -1.3 1.9 -2.5 -1.0 -1.3 -1.5 -0.3 -0.7 -2.3 -1.8 -1.4 -1.4 -1.3 -2.0 1.9
Neuroticism (Nagel 2018) 0.5 1.3 4.0 1.3 -0.8 0.3 1.1 1.0 1.2 1.2 1.1 0.9 0.3 -0.9 1.6 1.2 2.0 -0.7
Schizophrenia (2018) 1.8 3.7 5.1 2.2 -2.2 1.9 2.0 2.0 2.1 1.7 1.8 1.9 1.1 0.5 2.1 2.1 2.2 -2.2
Schizophrenia vs Biploar Disorder 2.1 2.8 6.5 2.5 -0.6 1.2 2.4 2.0 1.5 2.1 2.3 1.1 0.2 0.4 2.0 2.0 1.4 -0.9
Worry (Nagel 2018) 0.4 0.8 1.5 1.2 -0.4 0.2 1.1 1.1 0.6 1.2 1.1 0.2 -0.3 -1.0 1.2 1.1 1.0 -0.7
Alzheimer’s Disease (in mother) 0.1 0.1 0.3 0.3 -0.5 0.3 0.4 0.3 0.1 0.4 0.5 -0.1 -0.0 -0.6 0.3 0.4 0.4 -0.5
Alzheimer’s Disease (in father) 0.3 0.3 1.9 0.5 0.3 0.7 -0.1 -0.4 -0.1 -0.6 -0.3 -0.2 0.0 1.4 -0.1 -0.2 -0.8 0.2
Alzheimer’s Disease (including proxy) 0.0 0.1 0.2 0.0 0.1 0.3 -0.2 -0.3 -0.2 -0.5 -0.3 -0.5 0.4 0.1 -0.1 -0.2 -0.1 0.2
Crohns Disease (2017) 0.1 0.2 0.6 -0.6 0.1 -0.2 -0.5 -0.8 -0.6 -0.1 -0.3 -0.3 0.3 0.2 -0.3 -0.4 0.4 0.2
Irritable Bowel Disease (IBD) 0.3 0.7 1.7 -0.9 0.2 -0.5 -1.1 -1.1 -1.3 -1.0 -1.1 -0.9 0.2 1.0 -0.9 -0.8 -0.4 -0.1
Ulcerative Colitis (UC) 0.2 0.3 1.3 -0.1 0.0 -0.3 -0.6 -0.5 -0.9 -0.9 -0.7 -0.5 0.2 1.1 -0.5 -0.4 -0.3 -0.3
Major Depression (MDD) 0.5 0.6 1.5 -0.4 0.9 0.7 -0.5 -0.5 -1.1 -0.4 -0.4 -1.1 -0.8 -1.0 -0.6 -0.6 -1.2 0.6
Reaction Time 0.9 1.7 3.2 1.2 -1.3 -0.4 1.5 1.4 1.4 1.8 1.6 1.2 0.7 1.4 1.4 1.6 0.9 -1.2
Verbal and Numeric Reasoning (VNR) 0.2 0.6 2.8 -0.0 0.6 -0.8 0.4 -0.4 -0.2 0.7 0.6 -0.9 -1.0 -1.7 -0.3 -0.1 -1.2 0.5
Breast Cancer 0.8 2.0 4.4 -1.7 1.2 -0.5 -1.7 -2.1 -1.8 -1.2 -1.4 -1.8 -0.7 -1.5 -1.4 -1.5 -1.0 1.1
Ovarian Cancer 0.2 0.2 0.6 -0.2 0.6 0.1 -0.4 -0.5 -0.6 -0.0 -0.2 -0.7 -0.8 -0.3 -0.1 -0.4 -0.4 0.7
Prostate Cancer 0.1 0.2 1.3 0.2 -0.2 -0.4 -0.2 -0.2 -0.3 -0.3 -0.2 -0.1 1.2 -0.9 -0.0 -0.1 0.7 -0.1
Age at First Birth 0.5 0.8 2.4 -0.8 1.3 -1.1 -0.7 -0.5 -0.3 -0.6 -0.7 -0.6 -1.5 -0.3 -0.5 -1.0 -0.8 1.5
Bipolar Disorder (2011) 0.5 0.5 1.9 -0.8 0.6 -1.4 -0.7 -0.5 -0.9 0.0 -0.6 -0.8 0.2 -0.4 -0.9 -0.7 -0.7 0.5
Body Mass Index (BMI) (2010) 0.9 1.2 3.0 0.8 -0.3 0.2 1.1 0.6 1.7 1.6 1.4 1.5 0.1 -0.1 1.6 1.1 1.3 0.3
Coronary Artery Disease (CAD) 3.7 4.4 6.7 2.5 -1.9 1.8 2.3 2.2 2.3 2.0 2.1 2.2 1.7 1.0 2.3 2.3 2.6 -1.9
Crohns Disease (2012) 0.2 0.4 1.4 -1.1 0.1 -0.9 -0.8 -1.2 -0.9 0.0 -0.4 -0.6 0.2 -0.0 -0.3 -0.6 0.1 0.3
Mean Putamen Volume 0.6 0.6 1.8 -0.9 0.7 -0.3 -1.1 -1.4 -0.4 -0.6 -0.8 -0.4 -0.0 -1.0 -0.4 -1.1 -0.8 1.0
Fasting Glucose 0.4 0.5 1.2 0.5 0.1 1.1 0.6 0.6 1.0 0.5 0.5 1.0 0.4 -0.8 0.8 0.3 0.7 0.4
HbA1C 1.1 1.2 2.3 -0.4 1.2 -1.1 -0.9 -1.0 -1.5 -0.9 -0.7 -1.2 -1.0 -1.5 -1.2 -1.0 -0.7 1.4
HDL Cholesterol 0.7 1.2 3.7 -0.5 1.0 -1.3 -0.5 -0.2 -1.7 -1.2 -0.8 -1.9 -1.2 -0.0 -1.4 -0.7 -1.6 0.3
LDL Cholesterol 0.2 0.3 1.1 -0.7 0.7 -1.0 -0.3 -0.7 -0.6 0.1 -0.2 -0.2 0.0 -0.8 -0.6 -0.4 -0.4 0.8
Lupus 0.4 0.7 4.1 0.1 -1.0 2.0 0.1 -0.3 0.5 0.1 0.3 0.7 0.9 1.1 0.5 0.3 1.0 -0.8
Neuroticism (2016) 2.9 4.1 7.0 2.3 -1.6 1.5 2.4 2.3 2.1 2.6 2.6 1.7 1.0 -1.0 2.6 2.4 1.9 -1.4
Primary Biliary Cirrhosis 0.9 1.2 2.6 0.9 -1.0 1.3 0.6 0.8 1.3 1.3 0.9 1.6 0.9 -1.0 1.4 0.9 1.6 -0.5
Rheumatoid Arthritis 0.3 0.3 3.0 -0.0 0.8 -0.2 -0.1 0.0 -0.5 0.0 0.0 -0.3 -1.7 -0.5 -0.2 -0.3 -0.6 0.6
Schizophrenia (2014) 0.8 1.9 2.9 1.7 -1.5 1.3 1.5 1.7 1.5 1.1 1.4 1.2 0.8 -0.3 1.5 1.5 1.3 -1.5
Triglycerides 0.4 0.7 2.3 0.4 -0.4 0.2 0.7 0.1 1.1 1.5 1.2 0.9 0.1 -1.0 1.3 0.8 0.6 0.1
Type 2 Diabetes (T2D) (2012) 3.0 3.4 6.2 1.5 -2.5 0.9 1.3 1.5 2.2 1.6 1.2 2.5 2.5 0.6 1.9 1.7 2.2 -2.3
Ulcerative Colitis 0.2 0.3 1.1 0.3 -0.8 0.7 -0.0 0.3 -0.1 -0.1 -0.2 0.2 0.9 1.0 0.2 0.3 0.6 -1.0
Blood Eosinophil Count 0.4 2.7 6.5 -1.6 0.2 1.1 -2.0 -2.1 -2.5 -2.1 -2.1 -2.3 0.2 0.5 -1.7 -1.5 -1.5 -0.1
Blood Platelet Count 0.1 1.6 2.8 -0.9 1.5 -0.2 -1.4 -1.1 -1.2 -1.7 -1.6 -1.1 -0.5 1.4 -1.3 -1.6 -0.8 1.4
Blood Red Count 0.9 8.7 12.7 3.2 -3.5 1.0 2.7 3.0 3.1 2.3 2.4 3.5 3.4 1.4 3.3 3.2 3.6 -3.3
Blood White Count 0.6 4.2 7.7 -2.1 1.2 -1.7 -2.5 -2.6 -2.3 -2.8 -2.6 -2.1 -1.1 0.6 -2.4 -2.5 -1.4 1.3
Heel T-Score 0.5 3.8 7.1 -2.6 1.8 -0.4 -2.4 -2.3 -1.8 -1.7 -2.0 -2.1 -2.7 -0.4 -1.6 -2.1 -1.8 1.9
BMI 0.6 3.6 8.0 1.3 -2.4 2.3 1.4 1.1 2.4 1.5 1.5 2.4 2.8 0.1 2.0 1.7 2.0 -1.7
Height 1.5 28.1 57.8 -4.5 6.4 -5.3 -3.9 -4.1 -6.3 -3.5 -3.7 -6.6 -6.2 -2.3 -6.2 -4.7 -7.6 5.4
Waist Hip Ratio (WHR) 0.4 1.9 4.2 0.9 -1.7 -0.5 1.0 1.0 1.7 1.1 1.1 1.8 2.0 0.3 1.5 1.3 2.0 -1.4
Systolic Blood Pressure 0.7 3.3 6.8 -1.9 0.5 -1.2 -2.2 -2.0 -2.0 -2.6 -2.5 -2.2 -1.5 -0.8 -2.1 -1.9 -1.8 -0.2
Smoking Status 0.1 0.2 1.1 0.1 0.3 -0.4 0.1 0.0 -0.6 -0.2 0.0 -0.2 -1.1 0.7 -0.6 -0.2 -0.4 -0.1
Allergy or Eczema 0.5 1.4 2.7 -1.4 -0.1 -0.8 -1.3 -1.6 -1.1 -1.6 -1.6 -1.0 -0.2 1.0 -1.5 -1.1 -1.6 -0.4
Cardiovascular Disease 0.2 0.7 2.8 0.5 -1.4 0.7 0.0 0.3 0.3 -0.3 -0.1 0.7 1.7 -1.1 0.1 0.3 0.6 -1.6
Hypothyroidism (self reported) 0.4 0.9 5.1 0.8 0.1 2.2 0.7 0.9 1.1 0.6 0.7 0.8 -0.7 0.3 1.1 0.5 0.9 0.3
Respiratory disease 1.2 2.6 4.8 -1.7 0.8 -0.8 -2.1 -2.0 -2.2 -2.1 -2.1 -1.8 0.0 -1.3 -1.9 -1.9 -1.2 0.8
Type 2 Diabetes (T2D) (2018) 0.3 0.6 3.4 0.2 -0.9 0.9 0.1 0.1 1.1 -0.4 -0.2 1.0 1.8 0.8 0.1 0.2 0.4 -0.9
Lung FEV1/FVC ratio 0.4 1.8 4.1 2.0 -0.4 -1.4 1.6 1.4 1.6 1.3 1.7 1.4 0.5 -0.4 1.7 1.3 1.7 -0.1
Lung FVC 1.1 5.8 10.9 -2.7 3.0 -1.6 -2.4 -2.5 -2.3 -1.7 -2.3 -2.9 -2.9 -0.5 -2.2 -2.7 -1.5 3.3
Neuroticism 1.4 3.5 5.8 2.0 -1.6 1.2 2.1 2.0 1.9 2.3 2.2 1.5 1.0 0.1 2.4 2.2 2.3 -1.5
Chronotype (morning person) 1.0 2.4 4.5 1.9 -1.3 0.3 2.0 1.6 1.5 2.0 2.1 1.3 1.0 0.7 1.7 2.1 0.6 -1.6
Hair Pigment 0.2 6.4 13.8 -3.1 2.5 -3.7 -2.5 -2.7 -2.1 -1.7 -1.9 -2.7 -2.3 -1.4 -2.2 -2.5 -2.7 2.9
Tanning 0.3 3.1 6.2 2.0 -1.7 1.3 2.0 2.5 1.6 1.7 1.6 1.9 1.1 1.7 1.5 2.0 1.5 -1.9
Hand grip strength (left) 0.1 0.3 1.1 0.4 -0.4 0.7 0.5 0.3 0.4 1.1 0.6 0.3 -0.2 0.2 0.5 0.6 0.3 -0.3
Number of treatments/medications taken 0.7 1.3 3.4 -1.2 0.6 -0.5 -1.5 -1.3 -1.1 -1.8 -1.8 -1.1 -0.4 0.2 -1.4 -1.4 -0.7 0.4
Average weekly spirits intake 0.8 1.0 1.7 -1.1 0.8 -1.3 -1.2 -1.1 -0.8 -1.0 -1.1 -0.8 -1.1 0.9 -0.8 -1.3 -0.3 0.9
Sensitivity / hurt feelings 0.4 0.6 1.8 0.9 -0.2 -0.5 0.9 1.0 0.7 0.9 1.1 0.4 0.1 -0.6 0.9 0.8 1.3 -0.0
Frequency of depressed mood in last 2 weeks 0.3 0.4 2.2 0.1 0.9 -0.5 -0.1 -0.2 -0.4 -0.0 -0.0 -0.7 -0.3 -1.5 -0.1 -0.2 -0.9 0.8
Hearing difficulty/problems: Yes 0.7 1.0 1.9 0.4 -1.3 1.4 0.7 0.7 1.2 1.1 1.0 1.0 0.7 0.2 1.4 1.0 1.2 -1.1
Relative age of first facial hair 0.5 1.1 2.3 1.5 -0.8 0.5 1.2 1.5 0.9 0.9 0.9 0.9 1.3 -0.4 1.2 1.3 1.1 -0.9
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.9 -0.4 -0.5 0.4 -0.3 -0.1 0.7 -0.6 -0.6 0.8 0.8 0.9 -0.1 -0.4 0.7 -0.1
Ever used hormone-replacement therapy (HRT) 0.7 0.8 3.6 -0.9 0.8 -1.9 -0.8 -0.4 -0.8 -0.7 -0.8 -1.1 -1.2 -0.1 -0.7 -0.9 -0.5 0.9
Ever had hysterectomy (womb removed) 0.8 0.9 2.1 -1.1 0.7 -0.5 -0.7 -0.5 -1.1 -0.4 -0.5 -1.4 -1.2 -1.1 -1.1 -0.7 -1.5 0.5
Systolic blood pressure, automated reading 0.4 1.2 2.6 -1.5 -0.5 -0.3 -1.6 -1.4 -1.0 -1.4 -1.3 -1.1 -0.0 -1.6 -0.8 -0.9 -1.0 -0.6
Eye problems/disorders: Diabetes related eye disease 1.8 2.0 3.0 -1.0 1.6 -1.4 -1.3 -1.1 -1.3 -1.7 -1.6 -1.5 -1.3 -0.4 -1.6 -1.6 -1.4 1.6
Angina 1.0 1.4 2.0 -0.8 1.1 -1.1 -1.1 -1.4 -1.2 -1.4 -1.2 -1.1 -1.3 -0.2 -1.4 -1.3 -1.2 1.0
Medication for hormone replacement therapy 2.3 2.6 6.1 -1.1 2.5 -1.5 -1.0 -0.5 -1.7 -1.2 -1.2 -1.9 -2.4 -0.5 -1.6 -1.4 -1.8 2.2
Vitamin and mineral supplements 0.1 0.2 2.0 -0.3 0.2 0.5 0.0 -0.1 0.1 0.3 0.3 -0.2 -1.4 0.0 0.1 -0.0 -0.2 0.2
Supplements: Zinc 0.1 0.1 1.1 -0.0 -0.3 0.1 0.0 0.4 -0.1 0.2 -0.0 -0.2 1.1 0.4 0.2 0.3 -0.1 -0.2
Medication: Co-codamol 1.4 1.7 2.9 1.7 -1.0 1.4 1.6 1.3 1.0 1.4 1.6 0.8 1.2 0.6 1.7 1.6 0.9 -0.8
Medication: Metformin 1.0 1.4 5.8 0.8 -1.3 1.2 0.8 0.8 1.7 0.2 0.5 1.4 2.4 -0.8 1.0 1.0 1.0 -1.1
Diabetes (father) 0.4 0.6 1.7 0.8 -0.3 -0.6 1.3 0.7 0.7 1.0 1.3 0.5 0.1 -0.1 0.4 1.2 0.0 -0.5
Diabetes (mother) 0.3 0.3 0.7 0.5 -0.2 0.2 0.8 0.5 0.2 0.8 0.8 0.3 0.6 -0.8 0.5 0.8 0.6 -0.1
Severe depression (siblings) 0.4 0.4 1.2 -0.7 -1.0 -1.1 -0.8 -0.9 -0.4 -0.4 -0.6 -0.1 0.3 0.0 -0.3 -0.3 0.4 -1.0
Pack years adult smoking proportion 0.9 1.4 3.2 -1.6 0.0 1.3 -1.8 -1.7 -1.0 -1.3 -1.6 -0.6 0.4 -1.6 -0.9 -1.4 -0.4 0.4
Impedance of leg (right) 0.1 0.4 1.7 -0.6 0.8 -1.3 -0.1 -0.1 -0.9 0.5 0.1 -0.5 -1.1 -0.2 -0.5 -0.0 0.3 0.6
Leg fat-free mass (left) 0.1 0.4 2.1 -0.3 0.6 0.1 -0.5 -0.5 -0.1 -0.8 -0.6 -0.3 0.3 -0.8 -0.6 -0.7 -1.4 0.8
Trunk fat percentage 0.3 1.2 2.8 0.4 -1.2 0.7 0.7 0.5 1.7 1.1 1.1 1.7 1.5 -1.0 1.3 0.9 1.1 -0.3
Hand grip strength (right) 0.1 0.2 1.6 0.1 -0.2 0.7 0.3 0.0 0.4 1.3 0.7 0.2 0.0 0.2 0.5 0.4 -0.0 -0.1
Townsend deprivation index at recruitment 0.1 0.2 0.6 0.1 -0.3 -0.6 0.0 0.6 0.1 -0.3 -0.1 0.4 0.8 -0.7 -0.2 0.0 0.1 -0.2
Current tobacco smoking 0.2 0.3 1.1 -0.4 -0.5 1.0 -0.6 -0.8 -0.5 -0.7 -0.6 0.1 -0.3 -0.3 -0.6 -0.5 0.3 -0.6
Average weekly fortified wine intake 0.4 0.5 2.0 -0.6 1.0 -0.4 -0.5 -0.6 -0.6 0.1 -0.2 -0.5 -0.8 0.1 -0.5 -0.5 -1.4 1.2
Maternal smoking around birth 0.4 0.6 2.4 -1.1 0.1 1.4 -0.8 -0.5 -0.4 -0.6 -1.0 -0.1 0.5 -1.6 -0.7 -0.7 -0.2 0.4
Fed-up feelings 0.3 0.6 3.2 1.0 -0.1 0.6 0.7 0.7 0.8 0.7 0.7 0.7 0.6 -1.8 1.0 0.6 0.5 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.7 -0.5 0.4 -0.7 -0.5 -0.8 -0.8 -0.3 -0.4 -0.8 0.1 -1.0 -0.7 -0.4 -1.3 0.1
Relative age voice broke 1.7 2.6 5.3 2.1 -0.7 1.0 1.9 1.9 2.2 1.6 1.6 2.3 1.5 -0.2 1.7 1.7 1.5 -0.2
Taking other prescription medications 0.2 0.3 1.7 -0.0 0.9 1.1 -0.4 -0.5 -0.1 -0.3 -0.3 -0.1 -0.4 -0.3 -0.1 -0.6 -0.1 1.3
Age when periods started (menarche) 4.6 11.2 15.5 3.5 -3.6 2.4 3.3 3.1 3.8 2.9 3.0 3.9 3.0 2.3 3.9 3.6 3.9 -3.1
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 1.1 -1.0 -0.0 -0.5 -0.9 -0.8 -0.7 -0.9 -0.9 -0.9 -0.5 0.2 -0.6 -0.6 -0.2 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.5 2.9 -1.6 0.8 1.4 -1.7 -1.6 -1.1 -1.6 -1.7 -1.1 -0.3 -0.3 -1.1 -1.5 -0.6 0.8
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.4 -0.1 -0.4 -0.5 -0.6 -0.4 -0.5 -1.2 -0.9 -0.1 0.1 -0.1 -0.3 -0.6 0.4 -0.4
Qualifications: CSEs or equivalent 0.4 0.5 2.0 -0.8 -1.4 -0.0 -0.7 -0.9 -0.1 -0.6 -0.6 0.0 0.6 -0.1 -0.5 -0.2 -0.3 -1.4
Serious illness, injury or assault to yourself 1.3 1.6 4.9 1.2 -1.2 0.7 1.1 0.6 1.8 1.3 1.4 1.8 0.9 2.2 1.2 1.0 0.4 -0.9
High blood pressure 0.4 1.2 3.8 0.9 -1.6 1.4 0.4 1.0 0.8 -0.4 -0.0 0.9 1.9 1.1 0.3 0.8 0.6 -1.9
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.4 -0.9 -0.3 -0.4 -0.9 -1.1 -0.8 -0.9 -1.0 -0.7 0.5 1.1 -0.8 -0.7 -1.2 -0.4
Multivitamins +/- minerals 0.3 0.4 1.2 -0.4 0.5 -0.4 -0.8 -0.4 -0.4 -0.9 -1.1 -0.3 0.5 -0.1 -0.7 -0.9 -0.1 0.7
Stomach or abdominal pain in last month 0.8 0.9 2.6 0.5 -1.2 0.7 0.5 0.9 1.4 0.5 0.6 1.0 1.6 -0.4 1.1 0.9 1.4 -0.8
Supplements: Glucosamine 1.6 2.0 4.5 -1.8 1.0 -1.1 -1.8 -1.6 -1.5 -2.0 -2.1 -1.6 -0.3 -0.4 -1.5 -1.6 -0.5 1.0
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 1.1 -0.6 -0.1 0.9 0.1 -0.1 0.2 0.3 0.4 -0.1 -0.0 1.1 0.2 0.4 -0.2 -0.1
Medication: Atenolol 0.5 0.7 1.4 -0.6 0.8 -1.2 -0.7 -0.7 -1.0 -0.9 -0.7 -1.0 -0.7 1.0 -0.8 -0.8 -0.5 0.7
Medication: Levothyroxine sodium 0.2 0.3 0.9 0.8 0.9 0.8 0.4 0.1 0.0 0.2 0.5 -0.2 -1.0 -0.5 0.3 0.1 -0.2 0.9
Sitting height 1.2 8.7 16.2 -2.9 3.0 -2.1 -2.9 -3.0 -3.4 -2.6 -2.7 -3.2 -2.5 -1.8 -3.6 -3.0 -4.0 2.7
Chronic bronchitis/emphysema (father) 0.2 0.2 0.6 -0.3 -0.7 0.5 -0.5 -0.2 -0.2 -0.4 -0.6 0.1 0.3 -0.8 -0.2 -0.2 0.2 -0.5
High blood pressure (mother) 0.4 0.6 3.6 -0.2 -1.5 -0.0 0.1 0.3 0.4 0.1 0.1 0.2 0.9 -1.1 0.4 0.6 0.3 -1.9
Body mass index (BMI) 0.7 2.8 6.6 1.2 -1.8 2.2 1.3 1.3 2.6 1.0 1.2 2.4 2.4 -0.5 1.8 1.4 1.4 -1.1
Impedance of leg (left) 0.1 0.4 2.2 -0.2 0.5 -1.5 0.3 0.3 -0.7 0.9 0.5 -0.4 -1.3 -0.3 -0.1 0.4 0.2 0.3
Leg predicted mass (left) 0.1 0.5 2.1 -0.3 0.6 0.1 -0.5 -0.6 -0.2 -0.8 -0.6 -0.4 0.3 -0.8 -0.7 -0.7 -1.4 0.8
Trunk fat mass 0.1 0.6 1.4 0.2 -0.7 0.4 0.5 0.2 1.2 0.7 0.7 1.1 1.1 -1.2 0.8 0.6 0.3 0.1
Waist circumference 0.8 3.0 7.8 1.0 -2.3 1.1 1.2 1.2 2.6 1.1 1.3 2.5 2.8 -0.3 1.7 1.5 1.6 -1.6
Number of incorrect matches in round 0.0 0.1 0.3 -0.2 -0.4 -0.6 -0.1 0.4 0.1 0.1 -0.0 -0.0 -0.0 -0.1 -0.1 -0.0 -0.5 -0.5
Past tobacco smoking 0.1 0.1 0.6 -0.2 -0.3 0.8 -0.4 -0.4 -0.0 -0.4 -0.4 -0.2 0.4 -0.6 0.1 -0.1 0.3 -0.4
Alcohol usually taken with meals 1.2 1.9 4.4 -1.5 1.9 -1.1 -1.1 -1.1 -1.0 -1.0 -1.0 -1.1 -1.6 0.8 -1.5 -1.5 -1.4 2.1
Nervous feelings 0.8 1.5 5.8 1.2 -0.6 -0.4 1.3 1.2 0.9 1.6 1.5 0.3 -0.5 -2.4 1.6 1.4 0.9 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.7 0.4 1.0 -0.8 0.8 0.9 0.2 1.1 1.0 -0.3 -0.7 -1.3 0.1 0.4 -0.6 0.9
Hearing difficulty/problems with background noise 1.9 3.1 5.5 1.5 -2.3 1.4 1.8 1.6 1.5 2.2 2.1 1.3 1.3 -0.7 2.0 2.2 0.9 -2.4
Hair/balding pattern: Pattern 2 0.1 0.2 0.5 -0.5 0.3 -0.1 -0.5 -0.7 -0.1 -0.3 -0.4 -0.1 0.4 -0.5 -0.2 -0.4 -0.0 0.6
Had menopause 0.5 0.7 1.8 1.1 -0.9 0.2 0.9 1.4 1.1 0.2 0.4 1.1 0.5 0.1 0.8 0.8 0.5 -0.9
Had other major operations 0.3 0.4 1.5 0.6 -0.1 0.6 0.6 0.6 1.2 0.1 0.3 0.9 -0.2 -0.9 0.6 0.2 0.7 0.2
Forced vital capacity (FVC) 1.6 6.0 11.4 -2.3 3.0 -1.9 -2.1 -2.2 -2.8 -1.5 -2.0 -3.4 -3.3 -0.4 -2.5 -2.4 -2.7 2.7
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 2.1 -1.4 0.7 0.8 -1.5 -1.4 -1.0 -1.4 -1.4 -1.1 -0.8 0.1 -0.9 -1.3 -0.3 0.7
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 2.1 0.5 -0.1 0.8 0.9 0.1 0.5 1.4 1.4 0.7 0.8 -0.9 0.4 0.7 -0.2 0.1
Qualifications: None of the above 0.9 2.0 4.7 1.1 -1.5 1.5 0.9 0.8 1.9 0.9 1.1 2.2 1.7 0.5 1.5 1.1 2.2 -1.1
Financial difficulties in last 2 years 1.9 2.5 3.9 1.2 -1.8 2.0 1.3 0.7 1.4 1.9 1.8 1.9 2.0 -0.6 1.3 1.5 1.9 -1.6
Mouth/teeth dental problems 1.0 1.5 4.4 -0.8 0.8 -1.3 -0.8 -1.4 -1.9 -0.5 -0.5 -1.7 -1.2 -1.3 -1.3 -0.7 -2.1 0.3
Heart attack 1.1 1.4 2.4 1.5 -1.4 1.2 1.2 1.3 1.4 0.6 0.9 1.5 1.4 0.1 1.1 1.0 0.7 -1.4
Allergy 0.4 0.9 1.8 1.1 -0.2 0.1 1.2 1.3 1.2 1.2 1.3 0.9 -0.3 -0.5 1.1 1.0 1.0 -0.0
Pain all over the body in last month 2.4 2.6 4.6 1.4 -1.1 1.9 1.9 1.9 1.5 1.8 1.8 1.5 1.3 2.1 1.4 1.7 1.1 -1.2
Diabetes (self-reported) 0.2 0.2 1.0 0.5 -0.2 -0.3 0.2 0.1 0.8 -0.4 -0.1 0.5 1.0 -1.0 0.0 0.1 0.0 -0.2
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 3.0 -1.3 0.3 -1.7 -1.2 -1.3 -1.7 -1.1 -1.3 -1.5 -0.5 1.7 -1.7 -1.0 -1.4 -0.1
Medication: Ramipril 2.3 2.9 6.2 1.6 -2.1 1.9 1.6 1.7 1.9 1.0 1.3 2.2 2.5 0.5 1.3 1.7 0.9 -2.3
Medication: Simvastatin 0.2 0.3 1.1 0.0 -0.9 -0.1 -0.0 0.1 0.5 -0.1 -0.1 0.5 0.6 -0.9 0.1 0.1 0.5 -1.0
Fluid intelligence score 0.2 0.3 1.1 -0.1 0.4 -1.0 0.2 -0.5 -0.2 0.4 0.3 -0.9 -1.0 -0.7 -0.3 -0.1 -0.8 0.1
Illnesses of siblings 0.5 0.8 2.2 1.4 0.3 -1.5 1.1 0.8 0.7 0.9 1.0 0.3 -0.9 0.7 0.9 0.7 0.2 0.2
Neuroticism score 0.9 1.9 3.6 1.6 -0.6 1.0 1.7 1.6 1.5 1.9 1.7 1.1 0.2 -1.2 1.8 1.5 1.3 -0.6
Weight 0.0 0.2 1.0 -0.0 0.1 0.3 0.0 -0.0 0.5 -0.1 0.0 0.4 0.6 -1.0 -0.0 -0.0 -1.0 0.5
Impedance of arm (right) 0.1 0.3 2.2 -0.0 0.4 -1.5 0.1 -0.2 -0.4 0.8 0.5 -0.1 -0.8 0.2 0.2 0.0 0.6 0.4
Arm fat percentage (right) 0.8 3.2 7.0 1.1 -2.0 1.8 1.2 1.0 2.6 1.5 1.5 2.6 2.3 -0.7 2.1 1.5 2.1 -1.1
Trunk fat-free mass 0.3 1.7 7.4 -0.7 1.5 -0.5 -0.8 -0.8 -1.2 -1.4 -1.1 -1.5 -0.7 -0.6 -1.6 -1.2 -2.7 1.2
Hip circumference 0.2 0.8 2.8 0.6 -0.9 1.0 0.8 0.7 1.7 0.5 0.8 1.4 1.2 -0.1 0.9 0.7 0.2 -0.4
Time employed in main current job 0.1 0.1 0.5 -0.2 0.1 -0.5 -0.3 0.1 0.3 0.1 -0.3 0.3 0.1 0.7 0.0 -0.3 -0.3 0.2
Alcohol intake versus 10 years previously 1.3 1.9 7.4 0.8 -2.0 2.1 0.0 -0.6 0.8 0.0 0.0 1.6 2.7 1.0 0.7 0.5 1.9 -1.8
Father’s age at death 2.8 3.8 6.6 2.3 -1.6 0.1 2.4 2.0 2.3 2.4 2.6 2.1 0.9 1.0 2.4 2.3 1.7 -1.3
Worrier / anxious feelings 0.2 0.4 2.8 0.8 -0.6 -0.1 0.5 0.3 0.4 0.3 0.4 0.1 0.5 -1.7 0.6 0.5 0.0 -0.9
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 2.0 0.9 -0.2 -0.2 1.1 1.1 0.2 1.2 1.4 0.1 0.3 -1.2 0.7 1.0 0.0 -0.2
Falls in the last year 2.2 3.0 4.7 2.1 -1.3 0.7 2.0 1.8 2.2 1.6 1.9 2.1 1.6 1.3 1.8 1.9 1.8 -1.0
Hair/balding pattern: Pattern 3 0.5 0.8 2.6 0.8 -0.0 1.2 0.9 0.6 0.7 1.6 1.2 0.7 -0.4 1.5 0.8 0.6 0.2 0.0
Number of live births 0.4 0.6 1.8 0.5 -0.5 -0.2 0.6 1.1 1.3 0.3 0.4 1.1 0.8 -0.2 0.8 0.6 1.4 -0.1
Forced expiratory volume in 1-second (FEV1) 0.8 2.7 5.7 -1.5 2.2 -1.7 -1.2 -1.3 -1.8 -0.6 -1.1 -2.4 -2.4 -0.2 -1.5 -1.4 -1.8 2.0
Pulse rate 0.5 0.8 3.6 0.6 -0.6 1.9 0.3 0.5 0.4 0.0 -0.1 0.3 0.9 1.9 0.5 0.5 1.4 -0.9
Happiness 0.5 0.6 2.0 0.8 -0.5 0.5 1.0 0.7 0.2 1.4 1.1 -0.0 0.0 0.2 0.9 1.1 0.3 -0.8
Noisy workplace 2.1 2.6 4.4 -1.8 1.1 -0.3 -2.0 -2.0 -1.9 -1.9 -2.1 -1.1 -0.2 -2.0 -1.9 -1.9 -1.1 1.2
Qualifications: A levels/AS levels or equivalent 0.3 0.7 2.0 0.4 0.4 -1.2 0.7 0.6 -0.7 0.9 0.8 -1.3 -1.1 0.7 0.2 0.5 -1.4 -0.0
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 2.7 0.7 -1.0 0.7 0.6 0.3 1.4 0.5 0.4 1.6 1.4 -1.3 0.5 0.5 0.8 -0.5
Mouth/teeth dental problems: Dentures 1.1 1.8 3.8 -1.9 0.7 1.7 -1.9 -1.6 -0.3 -1.7 -1.9 -0.3 -0.9 0.4 -1.3 -1.9 -0.1 1.1
Asthma 0.9 1.8 3.2 -1.6 0.2 -0.9 -1.8 -1.6 -1.8 -1.6 -1.8 -1.4 0.3 -1.1 -1.5 -1.4 -0.9 0.2
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.4 -0.1 0.4 0.2 -0.1 0.1 -0.3 -0.6 -0.5 -0.5 -0.5 -0.0 -0.3 -0.3 0.0 0.3
Medication: Cholesterol lowering 0.2 0.3 0.8 -0.4 0.5 -0.9 -0.6 -0.4 -0.2 -0.6 -0.8 -0.2 -0.2 -0.5 -0.6 -0.7 -0.7 0.6
Depression (self-reported) 0.6 0.7 2.6 0.4 1.4 -1.3 0.1 -0.1 -0.4 -0.1 0.0 -0.6 -0.5 -1.6 -0.2 -0.5 -0.8 1.5
Medication: Lansoprazole 0.2 0.2 1.2 -0.3 0.6 1.1 -0.1 -0.2 -0.2 -0.2 -0.2 -0.3 -0.4 0.2 -0.6 -0.3 -0.7 0.6
Prospective memory result 0.9 1.1 4.2 1.0 -0.9 0.6 1.0 1.2 1.1 1.1 1.0 1.2 2.0 0.1 0.8 0.9 0.8 -0.7
Lung cancer (father) 0.6 0.7 3.6 0.2 1.0 0.7 0.4 0.3 -0.0 1.0 0.6 0.3 0.1 -1.9 0.4 0.1 1.1 1.5
Illnesses of mother 0.3 0.3 2.9 0.5 0.6 -0.7 -0.1 -0.3 -0.3 -0.4 -0.3 -0.2 -0.0 1.7 -0.1 -0.2 0.2 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 2.5 -0.3 1.4 -1.6 -0.3 -0.4 -0.8 0.1 -0.4 -1.3 -1.5 -0.2 -0.7 -0.5 -1.4 1.3
Pulse wave Arterial Stiffness index 0.4 0.5 1.4 1.1 -0.3 -0.3 0.8 1.2 0.8 0.5 0.8 0.6 -0.1 -0.3 0.8 0.9 0.2 -0.2
Impedance of arm (left) 0.1 0.5 2.9 -0.5 0.6 -1.7 -0.4 -0.6 -0.9 0.5 0.1 -0.6 -1.0 0.3 -0.1 -0.3 0.4 0.7
Arm fat mass (right) 0.3 1.4 3.9 0.5 -1.3 1.4 0.7 0.4 2.0 0.7 0.8 1.9 2.0 -0.7 1.2 0.9 0.9 -0.5
Trunk predicted mass 0.3 1.7 7.3 -0.7 1.5 -0.4 -0.9 -0.9 -1.3 -1.5 -1.2 -1.5 -0.6 -0.6 -1.7 -1.2 -2.7 1.2
Standing height 1.0 9.9 24.8 -2.2 3.8 -3.5 -2.3 -2.4 -3.8 -2.2 -2.3 -3.8 -3.5 -1.1 -3.4 -2.7 -5.0 3.2
Length of working week for main job 0.5 0.5 2.1 0.5 -1.1 1.4 0.3 0.7 0.3 -0.5 -0.2 0.2 1.2 0.4 0.3 0.4 0.3 -1.3
Exposure to tobacco smoke at home 0.2 0.2 0.9 -0.5 0.2 -1.0 -0.3 -0.2 0.1 -0.3 -0.3 0.3 0.1 0.7 -0.3 -0.3 -0.1 0.5
Breastfed as a baby 1.4 1.7 4.9 1.6 -0.5 -0.1 1.9 1.6 1.0 2.1 2.2 0.6 0.3 -0.1 1.5 1.7 -0.1 -0.6
Tense / ‘highly strung’ 1.7 2.8 4.8 2.0 -0.7 1.2 2.1 2.1 1.8 2.2 2.1 1.5 0.6 -0.1 2.2 1.8 2.0 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 2.7 0.8 -0.0 -0.3 0.8 0.2 0.4 1.1 1.2 0.5 0.1 -1.6 1.0 0.6 0.6 0.2
Hair/balding pattern: Pattern 4 0.8 2.1 4.1 -1.5 0.6 -0.8 -1.6 -1.4 -1.9 -1.7 -1.7 -2.0 -0.6 -2.0 -1.5 -1.4 -0.9 0.2
Birth weight of first child 0.4 0.7 1.8 1.3 0.2 0.8 1.2 1.3 0.4 0.7 1.0 0.2 -0.9 -0.5 0.5 0.8 -0.8 -0.1
Peak expiratory flow (PEF) 0.5 1.1 4.1 -1.1 0.9 -2.0 -0.9 -0.5 -1.1 -0.8 -1.0 -1.4 -0.8 -0.2 -1.0 -0.9 -1.2 0.8
Pulse wave reflection index 0.6 0.8 1.9 0.4 1.2 -1.2 0.6 1.0 0.1 0.7 0.9 -0.3 -1.4 -1.3 0.2 0.3 -1.1 1.2
Ever highly irritable/argumentative for 2 days 0.9 1.1 2.3 1.3 -0.6 1.0 1.2 1.0 1.3 0.8 1.0 1.5 1.5 -0.5 1.0 1.2 0.6 -0.6
Loud music exposure frequency 1.0 1.1 2.2 0.8 -1.2 0.5 1.1 0.6 0.9 1.2 1.1 0.7 1.5 -0.5 1.3 1.2 1.2 -1.0
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.4 0.7 -0.1 -1.2 0.8 0.7 -0.2 1.0 0.8 -0.6 -0.4 0.9 0.3 0.8 -0.7 -0.5
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 3.2 1.7 -0.1 -0.4 1.6 1.8 1.1 1.6 1.8 1.0 -0.1 1.4 1.5 1.3 0.8 -0.1
Blood clot in the leg (DVT) 0.5 0.7 1.7 1.2 -0.1 1.3 1.0 0.8 0.7 1.0 1.0 0.5 0.6 0.7 0.8 0.8 0.2 -0.1
Medication: Paracetamol 0.2 0.3 0.8 -0.4 0.2 -0.2 -0.8 -0.7 -0.6 -0.9 -0.8 -0.7 -0.1 -0.9 -0.2 -0.6 0.1 0.3
Headache pain in last month 0.4 0.7 1.8 0.1 1.3 0.3 0.2 -0.1 -0.9 0.4 0.3 -1.3 -1.1 -1.0 -0.4 -0.1 -1.3 1.2
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.6 0.3 0.1 -0.5 0.5 0.1 0.2 0.8 0.8 -0.2 -0.8 -0.3 0.6 0.5 -0.1 -0.0
Glaucoma (self-reported) 0.2 0.2 1.1 0.1 0.8 -0.2 0.3 0.3 -0.1 0.1 0.2 -0.4 -1.1 -0.5 -0.1 -0.1 -0.2 0.8
Gout (self-reported) 0.6 0.9 4.0 0.7 -0.9 0.3 0.6 0.2 0.7 0.4 0.3 0.8 1.6 2.0 0.4 0.6 1.4 -0.9
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 3.7 0.6 0.7 1.9 0.6 0.6 0.6 0.6 0.8 0.3 -1.4 0.4 0.7 0.3 0.3 0.8
Medication: Amlodipine 0.7 1.0 3.7 0.4 -1.2 1.3 0.3 0.5 1.2 -0.3 0.1 1.4 1.6 1.9 0.4 0.4 0.7 -1.1
Medication: Ventolin 100micrograms inhaler 0.2 0.3 1.1 -0.3 -1.1 -0.0 -0.3 -0.3 0.5 -0.0 -0.1 1.0 0.8 -0.4 0.2 0.1 1.0 -0.6
Birth weight 0.5 1.1 2.5 1.2 1.2 0.8 1.4 1.6 0.1 1.4 1.3 -0.1 -0.9 0.7 0.6 0.8 -0.9 1.2
Chronic bronchitis/emphysema (mother) 4.2 4.9 8.2 -2.8 1.7 -0.8 -2.9 -2.6 -2.3 -1.9 -2.5 -2.2 -1.3 -1.7 -2.3 -2.7 -2.3 2.0
High blood pressure (siblings) 0.6 0.8 3.4 -0.2 -1.2 1.8 -0.1 -0.2 0.8 0.4 0.2 1.0 1.1 -1.4 0.3 0.2 1.0 -0.9
Forced vital capacity (FVC), Best measure 0.8 2.9 6.5 -1.2 2.3 -1.6 -1.0 -1.1 -1.8 -0.6 -1.1 -2.3 -2.5 -0.3 -1.7 -1.4 -2.6 2.0
Body fat percentage 0.4 1.7 4.0 0.7 -1.3 1.1 1.0 0.8 2.0 1.4 1.3 1.9 1.7 -1.1 1.6 1.2 1.3 -0.5
Leg fat percentage (right) 0.5 1.7 3.8 0.8 -1.1 1.5 1.2 1.1 2.0 1.2 1.3 1.8 1.7 -0.7 1.3 1.3 1.1 -0.5
Arm fat-free mass (right) 0.2 1.2 5.3 -0.7 1.2 -0.1 -0.7 -0.7 -0.9 -1.3 -1.0 -1.1 -0.4 -1.1 -1.3 -1.0 -2.3 1.1
Exposure to tobacco smoke outside home 0.4 0.5 1.0 0.6 -0.7 0.9 0.6 0.5 1.0 0.4 0.6 1.0 0.9 -0.4 0.9 0.5 0.9 -0.2
Comparative body size at age 10 0.5 1.4 2.6 -1.1 1.5 -0.5 -1.2 -0.8 -1.0 -1.0 -1.3 -1.0 -0.9 -1.0 -1.3 -1.4 -1.3 1.6
Number of full brothers 0.2 0.3 0.9 0.0 -0.8 -0.3 -0.2 0.3 0.1 -0.5 -0.4 0.6 0.9 -0.3 -0.6 -0.1 0.3 -1.0
Worry too long after embarrassment 0.1 0.2 0.9 -0.3 0.1 -0.8 -0.2 -0.4 -0.6 -0.2 -0.3 -0.9 -0.5 0.4 -0.4 -0.2 -0.5 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 1.4 0.0 -0.7 -1.2 -0.0 0.2 -0.3 0.1 0.1 -0.3 0.3 0.2 0.0 0.2 -0.2 -0.9
Wheeze or whistling in the chest in last year 0.3 0.6 2.3 0.9 -0.9 0.7 0.6 0.6 0.4 0.6 0.7 0.8 1.5 -0.5 0.4 0.7 0.4 -1.0
Number of children fathered 0.1 0.1 0.3 -0.6 -0.5 0.1 -0.4 -0.2 -0.3 -0.3 -0.3 -0.4 0.1 -0.4 0.1 0.1 0.4 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 3.0 -0.1 1.2 -0.7 0.3 0.2 -0.1 0.7 0.6 -0.5 -1.7 0.3 0.1 0.0 -0.9 1.2
Age at first live birth 0.1 0.2 0.8 -0.1 -0.0 -0.9 0.1 -0.2 0.1 0.5 0.3 -0.0 -0.7 -0.7 0.2 0.2 -0.1 0.0
Pulse wave peak to peak time 0.6 0.7 1.7 -1.2 0.4 0.0 -1.0 -1.3 -1.0 -0.6 -1.0 -0.8 -0.1 0.4 -1.0 -1.0 -0.6 0.3
Health satisfaction 0.6 0.8 1.8 0.5 -1.3 0.2 0.9 0.8 0.8 0.8 0.8 0.7 1.0 1.0 0.7 1.1 0.4 -1.4
Shortness of breath walking on level ground 2.7 3.2 4.7 1.8 -2.1 2.2 1.8 1.7 1.8 1.8 2.0 1.7 1.5 0.1 1.9 2.0 1.5 -2.0
Qualifications: College or University degree 0.5 1.5 3.1 1.7 -0.5 1.8 1.6 1.4 0.8 1.4 1.5 0.6 0.4 1.3 1.4 1.4 0.6 -0.7
Eye problems/disorders: None of the above 2.7 3.1 7.8 1.1 -2.2 2.0 1.2 1.0 1.5 1.7 1.5 2.0 2.4 0.0 1.7 1.6 2.8 -1.9
Mouth/teeth dental problems: Loose teeth 0.8 1.0 2.7 -0.7 1.3 0.5 -0.7 -0.5 -0.7 -0.8 -0.9 -0.9 -1.6 0.5 -1.0 -1.0 -1.4 1.2
Emphysema/chronic bronchitis 0.1 0.2 0.6 0.5 -0.0 0.8 0.3 0.2 0.2 0.4 0.3 0.4 -0.2 0.6 0.3 0.2 0.6 0.1
Medication for pain relief, constipation, heartburn 0.0 0.1 0.3 -0.3 -0.1 0.3 -0.0 -0.2 0.2 0.5 0.3 0.4 -0.1 -0.4 -0.0 0.0 0.2 0.1
Neck or shoulder pain in last month 0.6 0.9 1.8 1.3 -0.7 0.2 1.1 0.9 0.8 1.0 1.1 0.4 0.5 -1.0 1.2 1.0 1.4 -0.6
Medication: Blood pressure 0.2 0.4 1.1 -0.2 -0.3 0.6 -0.5 0.0 0.0 -1.0 -0.9 0.5 1.1 0.6 -0.8 -0.5 0.2 -0.2
Angina (self-reported) 1.7 2.2 3.8 -1.2 1.2 -1.3 -1.6 -1.8 -1.5 -2.0 -1.8 -1.4 -1.2 -0.5 -1.8 -1.7 -1.5 1.2
Migraine (self-reported) 0.4 0.5 1.3 -0.8 0.6 0.5 -0.9 -1.2 -0.9 -0.3 -0.5 -1.1 -0.7 -0.7 -0.4 -0.7 -0.4 0.7
Medication: Ibuprofen 0.3 0.4 1.2 -0.5 0.6 -0.4 -0.6 -0.3 -0.9 -0.9 -0.8 -1.1 -0.7 -0.3 -0.5 -0.6 -0.2 0.4
Medication: Allopurinol 0.5 0.7 2.4 0.6 -0.9 0.4 0.6 0.5 0.7 0.4 0.3 0.6 1.1 1.5 0.5 0.6 1.6 -0.9
Medication: Omeprazole 0.7 0.9 2.0 1.1 0.7 0.1 1.3 1.4 1.2 1.2 1.2 0.8 0.2 -0.7 0.9 0.9 -0.0 0.8
Medication: Seretide 50 evohaler 0.3 0.3 1.5 0.7 -1.0 0.8 0.4 0.5 0.2 0.3 0.4 0.4 0.2 -0.2 0.3 0.5 -0.5 -1.2
Mean time to correctly identify matches 0.5 1.0 2.4 0.8 -0.8 -0.8 1.1 1.1 0.9 1.6 1.3 0.7 0.4 0.9 1.2 1.1 0.9 -0.5
Heart disease (mother) 0.6 0.8 3.3 0.5 0.3 1.2 0.9 1.8 1.2 0.6 0.6 1.2 -0.3 -0.7 0.3 0.6 0.5 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.0 3.1 -1.1 0.0 -0.5 -1.4 -1.3 -0.6 -1.7 -1.8 -0.1 0.5 0.2 -1.2 -1.4 0.2 0.3
Whole body fat mass 0.2 0.9 2.6 0.4 -0.9 0.9 0.7 0.5 1.6 0.8 0.9 1.5 1.4 -1.1 1.0 0.8 0.5 -0.1
Leg fat mass (right) 0.3 1.1 2.7 0.5 -0.9 1.5 0.8 0.6 1.7 0.9 0.9 1.5 1.6 -0.9 0.9 0.9 0.5 -0.3
Arm predicted mass (right) 0.3 1.3 6.1 -0.8 1.2 -0.4 -0.8 -0.8 -0.9 -1.3 -1.0 -1.1 -0.3 -1.0 -1.4 -1.0 -2.5 1.1
Pulse rate, automated reading 0.3 1.1 4.0 0.4 -1.7 1.5 0.3 0.6 0.5 -0.1 -0.1 0.7 1.9 0.1 0.2 0.6 1.1 -2.0
Alcohol intake frequency. 0.2 0.4 1.0 -0.7 -0.3 0.8 -0.8 -0.7 -0.2 -0.7 -0.9 0.3 1.0 -0.4 -0.6 -0.6 0.5 0.0
Comparative height size at age 10 5.0 27.7 43.2 -5.2 5.4 -4.8 -5.2 -5.2 -6.2 -4.9 -4.9 -6.0 -4.2 -2.5 -6.1 -5.5 -6.6 5.0
Number of full sisters 0.2 0.3 0.8 -0.9 -0.4 -0.6 -0.7 -0.8 -0.6 -0.4 -0.4 -0.5 0.0 -0.6 -0.6 -0.3 -0.5 -0.2
Suffer from ‘nerves’ 0.4 0.6 2.0 -0.5 0.5 -1.1 -0.6 -0.6 -0.7 -0.7 -0.6 -1.0 -0.9 -1.4 -0.4 -0.6 -0.3 0.3
Overall health rating 1.2 2.5 5.9 1.2 -2.4 1.2 1.0 1.0 1.8 0.9 1.0 2.0 2.3 0.2 1.7 1.4 1.8 -2.0
Chest pain or discomfort 0.6 0.9 2.6 1.6 0.1 -0.4 1.4 1.4 0.7 0.9 1.3 1.0 0.4 -0.8 0.6 1.1 0.2 0.1
Had major operations 0.3 0.4 1.2 0.8 -0.3 1.0 0.4 0.5 0.9 0.1 0.2 0.8 0.3 -0.4 0.7 0.3 1.1 -0.1
Age at last live birth 2.3 3.3 6.1 2.2 -1.2 -0.2 2.4 2.1 1.8 2.5 2.4 1.7 1.1 -0.7 2.2 2.3 1.5 -1.1
Family relationship satisfaction 0.8 1.0 4.6 0.6 0.5 0.1 1.3 0.9 -0.0 2.2 1.8 -0.4 -1.2 -0.7 0.9 1.1 0.0 0.5
Leg pain on walking 0.4 0.5 1.2 0.8 -0.4 1.1 0.6 0.5 0.8 0.2 0.4 1.1 1.1 0.2 0.7 0.6 0.7 -0.2
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 2.8 -1.6 0.1 -0.4 -1.7 -1.6 -1.0 -1.4 -1.5 -0.7 -0.4 0.2 -1.1 -1.3 -0.4 0.3
Commuting to job workplace: Car/motor vehicle 0.4 0.5 2.8 -0.5 0.3 -1.4 0.0 0.0 0.1 -0.1 0.4 -0.4 -1.0 -1.7 0.1 -0.0 -0.4 0.6
Illness, injury, bereavement, stress in last 2 years 1.4 1.8 4.5 -1.2 1.5 -1.2 -1.1 -0.7 -1.7 -1.0 -1.2 -2.1 -2.0 -0.2 -1.2 -1.2 -1.4 1.1
Medication: Aspirin 1.0 1.4 2.3 -1.1 0.6 -1.4 -1.4 -1.4 -1.1 -1.5 -1.4 -1.1 -0.1 1.5 -1.1 -1.3 -1.1 0.5
Supplements: Vitamin C 0.6 0.7 1.6 1.2 -0.2 -0.8 1.2 1.0 -0.0 1.3 1.2 0.3 0.9 -0.3 0.5 1.0 0.3 -0.3
Knee pain experienced in last month 3.0 4.7 12.2 -1.4 2.9 -1.9 -1.6 -1.4 -2.2 -2.3 -1.9 -2.3 -3.5 -0.2 -2.2 -2.1 -1.9 2.7
Hypertension (Self-reported) 0.3 0.9 3.6 0.5 -1.4 1.2 -0.0 0.5 0.5 -0.9 -0.4 0.7 1.9 0.6 -0.1 0.3 0.3 -1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.8 0.9 0.2 -0.8 0.5 0.4 0.3 -0.1 0.1 -0.1 -0.7 -0.3 0.4 0.3 -0.5 -0.1
Illnesses of father: Heart disease 0.6 0.8 2.1 0.6 -1.4 0.8 0.6 0.4 1.2 -0.1 0.2 1.4 1.4 -0.5 0.5 0.6 0.7 -1.2
Illnesses of siblings: Diabetes 1.9 2.3 5.1 -2.3 1.2 0.3 -1.9 -1.5 -1.7 -1.8 -1.8 -1.6 -0.7 0.2 -2.1 -1.7 -1.5 1.1
Smoking status: Previous 0.2 0.2 1.1 0.2 0.6 -0.3 0.5 0.5 -0.0 0.5 0.5 0.1 -0.6 1.0 0.1 0.2 -0.4 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.1 0.7 0.2 0.5 0.5 0.1 -0.1 -0.4 -0.3 -0.1 -0.1 -0.3 0.3 -0.4 -0.0 -0.8 0.3
Whole body fat-free mass 0.2 1.0 5.1 -0.5 1.1 -0.2 -0.7 -0.7 -0.8 -1.2 -0.9 -1.0 -0.2 -0.8 -1.2 -0.9 -2.3 1.0
Leg fat-free mass (right) 0.1 0.4 2.4 -0.2 0.6 -0.1 -0.4 -0.5 -0.2 -0.7 -0.5 -0.4 0.1 -0.7 -0.6 -0.6 -1.6 0.7
Arm fat percentage (left) 0.9 3.5 7.2 1.3 -2.1 1.9 1.4 1.1 2.7 1.7 1.7 2.6 2.4 -0.6 2.3 1.7 2.1 -1.2
Average weekly red wine intake 0.3 0.4 1.7 0.6 0.3 -0.4 0.8 1.3 0.7 0.7 0.7 0.3 -0.0 0.0 0.7 0.6 0.6 0.3
Handedness (chirality/laterality): Left-handed 3.8 4.6 8.1 2.0 -2.5 1.7 2.0 2.1 2.5 1.7 1.8 2.1 2.1 1.5 2.6 2.2 2.9 -2.2
Mood swings 1.0 1.9 3.8 1.8 -0.5 0.5 1.8 1.3 1.7 2.0 1.9 1.3 0.2 -0.5 1.8 1.5 1.0 -0.3
Loneliness, isolation 0.6 0.8 2.5 1.3 0.1 0.7 1.0 0.8 0.8 1.1 1.0 0.7 0.6 -1.6 1.1 0.8 0.2 0.3
Long-standing illness, disability or infirmity 0.2 0.3 1.0 -0.4 -0.6 0.3 -0.2 -0.2 1.0 -0.1 -0.1 1.0 0.9 0.8 0.2 -0.1 0.6 0.0
Ever had bowel cancer screening 0.2 0.2 0.9 0.8 0.5 -0.0 0.4 1.0 -0.0 -0.3 -0.2 -0.1 0.2 0.5 0.1 0.1 0.5 0.5
Diabetes diagnosed by doctor 0.2 0.3 2.2 0.4 -0.4 0.3 0.3 0.2 0.9 -0.3 -0.0 0.8 1.5 -0.5 0.0 0.2 0.3 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 2.2 1.1 -0.9 -0.5 1.3 1.4 1.4 1.0 1.1 1.4 1.0 0.0 1.4 1.3 1.5 -0.8
Friendships satisfaction 0.2 0.3 1.4 0.1 0.8 -0.5 0.4 0.1 -0.3 0.8 0.6 -0.4 -1.2 -0.2 -0.1 0.1 -0.6 0.7
Qualifications: nursing, teaching 1.9 3.0 7.3 -0.9 2.3 -1.1 -1.1 -0.7 -2.3 -1.4 -1.3 -2.5 -1.7 -1.3 -1.9 -1.5 -2.7 1.6
Commuting to job workplace: Walk 1.8 2.0 3.6 1.2 -1.5 1.0 1.3 0.7 1.2 1.9 1.6 1.3 1.7 0.3 1.8 1.5 1.9 -1.2
Eye problems/disorders: Cataract 3.8 4.4 7.4 -1.8 2.5 -2.7 -1.8 -1.6 -2.3 -1.6 -1.7 -2.3 -2.5 0.0 -2.2 -2.1 -2.7 2.2
Mouth/teeth dental problems: Mouth ulcers 4.1 6.5 10.0 2.9 -2.2 0.5 2.8 2.7 2.8 2.6 2.6 2.6 3.1 -0.5 2.9 2.8 3.2 -2.0
Medication for cholesterol 0.3 0.5 2.4 0.4 -0.4 0.3 0.4 0.2 0.7 1.2 0.8 0.9 0.1 0.3 1.1 0.5 1.5 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 1.7 -0.9 1.0 -0.6 -1.2 -0.9 -1.1 -1.3 -1.2 -1.2 -0.8 0.9 -1.0 -1.3 -0.1 0.9
Back pain experienced in last month 11.7 17.1 29.7 3.5 -5.5 3.9 3.2 3.3 5.2 2.9 3.2 5.2 4.6 0.0 4.9 4.0 5.1 -4.4
Mineral and other dietary supplements 0.9 1.2 2.4 1.3 -0.7 1.3 1.3 1.5 0.7 1.4 1.5 1.0 0.5 0.3 1.0 1.2 0.7 -0.8
Breast cancer (self-reported) 0.6 0.8 1.8 -1.2 0.5 -0.3 -1.1 -0.9 -0.7 -1.3 -1.3 -0.2 -0.0 0.6 -1.3 -1.1 -0.3 0.4
Asthma (self-reported) 1.0 2.0 3.6 -1.7 0.2 -1.2 -1.9 -1.7 -1.9 -1.7 -1.9 -1.5 0.2 -1.0 -1.6 -1.5 -1.1 0.2
Osteoporosis (self-reported) 0.2 0.3 0.6 0.5 -0.3 0.7 0.5 0.4 0.5 0.7 0.5 0.8 0.4 0.1 0.6 0.5 0.6 -0.2
Osteoarthritis (self-reported) 0.8 1.1 4.9 0.2 1.5 -1.4 0.0 -0.1 -0.6 -0.5 -0.2 -1.1 -2.2 -1.1 -0.7 -0.6 -1.2 1.2
Medication: Aspirin 0.8 1.1 2.0 -0.9 0.5 -1.2 -1.2 -1.3 -1.0 -1.4 -1.2 -1.0 -0.1 1.3 -1.1 -1.1 -1.1 0.3
Medication: Gliclazide 0.3 0.4 2.4 0.3 -0.9 0.6 0.1 -0.3 0.3 -0.0 0.1 0.4 1.5 0.2 0.4 0.5 0.6 -1.0
Illnesses of father: None of the above (group 1) 1.2 1.5 6.6 -0.5 1.9 -2.6 -0.4 -0.4 -0.9 0.0 -0.1 -1.3 -1.7 -0.5 -0.4 -0.6 -1.3 1.9
Smoking status: Current 0.1 0.2 0.5 -0.3 -0.6 0.7 -0.5 -0.6 -0.3 -0.5 -0.4 0.2 -0.2 -0.1 -0.4 -0.4 0.5 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 3.7 -0.6 1.4 -1.0 -0.2 -0.1 -0.0 0.5 -0.1 -0.6 -1.5 0.4 -0.1 -0.4 -0.6 1.9
Whole body water mass 0.2 1.0 5.0 -0.5 1.0 -0.1 -0.7 -0.7 -0.7 -1.2 -0.9 -0.9 -0.2 -0.8 -1.2 -0.9 -2.2 0.9
Leg predicted mass (right) 0.1 0.4 2.5 -0.2 0.6 -0.1 -0.5 -0.5 -0.2 -0.8 -0.6 -0.5 0.0 -0.7 -0.7 -0.7 -1.6 0.7
Arm fat mass (left) 0.4 1.7 4.1 0.7 -1.5 1.7 0.8 0.7 2.0 0.9 1.0 2.0 2.0 -0.6 1.4 1.1 1.0 -0.7
Number of self-reported non-cancer illnesses 0.1 0.1 0.6 0.3 0.0 -0.4 -0.2 -0.3 -0.1 -0.4 -0.2 -0.1 0.2 -0.6 -0.2 -0.3 -0.8 0.1
Average weekly champagne plus white wine intake 0.6 0.8 1.6 0.8 0.8 1.0 1.0 1.1 0.7 1.1 1.2 0.2 -0.8 1.3 0.7 0.6 -0.4 1.0
Miserableness 0.7 1.2 10.4 -0.3 1.2 -0.4 -0.2 -0.3 -0.8 0.2 0.0 -1.3 -1.3 -3.2 -0.2 -0.4 -0.6 1.1
Guilty feelings 1.0 1.5 3.2 -1.4 1.4 -0.9 -1.3 -1.3 -0.6 -1.2 -1.4 -0.6 -1.6 -0.7 -1.3 -1.5 -0.4 1.8
Wears glasses or contact lenses 2.2 2.6 6.7 -0.8 1.8 -2.5 -0.9 -1.1 -1.9 -0.5 -0.5 -2.2 -2.6 0.1 -1.3 -1.2 -2.5 1.4
Ever taken oral contraceptive pill 1.9 2.2 4.3 -1.1 1.3 -0.9 -1.3 -1.1 -1.8 -1.8 -1.6 -1.5 -1.5 -0.4 -2.1 -1.6 -2.0 1.0
Hearing aid user 0.1 0.1 0.7 -0.0 0.4 0.1 -0.1 -0.1 -0.3 -0.0 -0.0 -0.4 -0.6 0.9 0.1 -0.2 -0.5 0.4
Mother’s age at death 0.2 0.2 1.3 0.1 -0.9 -0.4 0.2 0.2 0.0 -0.1 0.2 -0.4 0.3 -0.9 0.4 0.4 -0.1 -1.2
Financial situation satisfaction 0.5 0.6 2.3 0.8 -0.2 0.3 0.9 0.8 0.5 1.5 1.2 0.6 -0.5 -0.5 0.6 0.8 0.7 -0.1
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.3 -0.5 1.1 -0.0 -0.3 -0.4 -0.6 -0.2 -0.0 -1.2 -1.1 -0.2 -0.4 -0.5 -1.1 1.0
Commuting to job workplace: Public transport 0.7 0.9 6.7 -0.2 -0.1 1.7 -0.7 -0.5 -0.2 -0.8 -1.0 -0.0 0.3 2.6 -0.4 -0.5 -0.4 -0.3
Eye problems/disorders: Glaucoma 0.5 0.6 2.2 -0.3 1.2 -0.5 -0.2 0.1 -0.5 -0.3 -0.2 -0.8 -1.5 -1.1 -0.5 -0.5 -0.9 1.1
Medication: Blood pressure 0.1 0.2 0.8 0.5 -0.2 0.5 0.3 0.6 0.3 -0.6 -0.1 -0.0 0.3 0.8 -0.3 0.3 -0.9 -0.8
Pain type(s) experienced in last month: Hip pain 3.2 4.0 5.9 2.1 -2.4 1.9 1.8 1.9 2.2 1.7 1.6 2.3 1.8 0.1 2.4 1.9 2.3 -2.2
Supplements: Fish oil (including cod liver oil) 1.1 1.5 2.3 -1.4 1.4 -1.3 -1.2 -1.5 -1.0 -1.2 -1.3 -1.3 -1.3 -0.3 -1.1 -1.2 -1.0 1.4
High cholesterol (Self-reported) 0.1 0.2 0.4 -0.5 -0.5 0.3 -0.5 -0.5 -0.5 -0.3 -0.5 -0.3 0.6 -0.6 -0.6 -0.5 -0.4 -0.7
Medication: Bendroflumethiazide 0.1 0.2 1.0 0.4 -0.3 0.4 -0.2 0.0 -0.2 -1.0 -0.7 0.1 0.1 0.4 -0.3 -0.2 0.1 -0.8
Medication: Paracetamol 0.5 0.8 1.8 -1.0 0.3 -0.6 -1.2 -1.2 -0.9 -1.3 -1.3 -0.9 -0.1 -1.1 -0.5 -1.0 0.3 0.5
Medication: Lisinopril 1.0 1.3 4.1 -0.8 0.2 -1.4 -1.3 -1.2 -0.8 -2.0 -1.7 -0.6 -0.1 1.0 -1.4 -1.2 -0.8 0.1
Medication: Atorvastatin 0.2 0.2 0.9 0.5 -0.3 0.1 0.4 0.7 0.7 -0.1 0.2 0.5 0.9 -0.2 0.4 0.3 -0.3 -0.2
Illnesses of father: High blood pressure 0.7 0.9 3.2 0.7 -1.4 1.8 0.7 0.9 0.8 0.8 0.6 0.9 0.8 -0.6 0.5 0.8 0.1 -1.5
Alcohol drinker status: Never 0.7 0.8 1.3 -1.1 1.0 0.2 -0.9 -0.8 -0.9 -1.0 -0.9 -0.8 -0.8 -1.0 -1.1 -1.0 -0.9 1.0
Ever smoked 0.2 0.3 1.3 0.3 -0.6 -0.9 0.4 0.1 0.0 0.5 0.5 0.4 0.1 1.1 -0.0 0.4 -0.2 -0.8
Basal metabolic rate 0.1 0.6 3.4 -0.3 0.8 -0.0 -0.4 -0.5 -0.3 -0.9 -0.6 -0.6 0.1 -0.8 -0.9 -0.7 -1.8 0.8
Leg fat percentage (left) 0.7 2.5 5.2 1.2 -1.5 1.5 1.5 1.4 2.3 1.6 1.7 2.1 1.7 -0.8 1.8 1.7 1.3 -0.8
Arm fat-free mass (left) 0.1 0.5 4.1 -0.3 0.6 0.1 -0.3 -0.3 -0.4 -0.9 -0.6 -0.6 0.1 -0.6 -0.9 -0.5 -2.0 0.4
Number of operations (self-reported) 0.7 1.1 2.8 -1.2 1.3 0.2 -1.2 -1.3 -0.5 -0.8 -1.1 -0.7 -1.4 -0.8 -0.5 -1.4 0.2 1.7
Average weekly beer plus cider intake 0.6 0.9 2.7 0.0 -1.4 1.1 -0.0 -0.4 1.1 0.1 0.0 1.2 1.6 -0.3 0.5 0.3 1.6 -0.9
Irritability 0.8 1.3 2.4 1.1 -1.1 1.3 1.1 0.7 1.4 1.4 1.1 1.4 0.2 0.4 1.5 1.1 1.3 -0.8
Risk taking 0.3 0.5 1.9 -0.6 1.1 -1.0 -0.4 -0.3 -0.2 -0.7 -0.4 -0.5 -0.6 -0.7 -0.5 -0.6 -0.7 1.4
Ever had prostate specific antigen (PSA) test 0.4 0.4 0.9 -0.3 0.7 -0.2 -0.6 -0.3 -0.6 -0.7 -0.8 -0.6 -1.0 0.8 -0.8 -0.8 -0.3 0.6
Fractured/broken bones in last 5 years 0.4 0.5 1.0 1.0 0.7 0.7 0.8 0.6 0.0 0.9 1.0 -0.1 -0.7 -0.9 0.9 0.6 -0.3 0.7
Age started oral contraceptive pill 2.3 2.9 4.8 2.1 -1.6 1.7 1.7 1.9 1.8 1.3 1.3 1.6 1.5 0.9 2.2 1.7 1.8 -1.6
Diastolic blood pressure, automated reading 1.0 3.2 5.5 -2.3 0.8 -1.3 -2.2 -2.2 -2.1 -1.6 -1.8 -2.1 -1.2 -2.0 -1.8 -1.8 -1.5 0.7
Ever depressed for a whole week 0.3 0.3 1.6 0.3 0.6 -0.1 0.6 -0.0 -0.3 0.7 0.9 -0.5 -0.5 -1.3 0.1 0.3 -0.7 0.4
Unable to work because of sickness or disability 2.5 3.3 6.6 2.0 -2.1 1.2 1.9 1.5 1.7 1.5 1.6 1.8 2.6 0.1 1.9 2.1 2.0 -2.1
Commuting to job workplace: Cycle 0.2 0.3 1.8 0.3 0.0 -1.0 0.1 0.7 0.0 -0.3 -0.4 0.2 0.2 1.3 -0.3 -0.0 -0.5 -0.3
Myopia 1.3 1.9 3.3 1.5 -1.4 0.9 1.4 1.8 0.9 1.6 1.5 0.6 1.5 0.4 1.5 1.5 1.4 -1.7
Vascular/heart problems diagnosed by doctor 0.7 2.0 5.2 -1.5 1.9 -1.6 -0.9 -1.4 -1.4 0.1 -0.3 -1.6 -2.3 -1.3 -0.8 -1.2 -0.9 2.2
Cholesterol lowering medication 0.4 0.6 3.3 0.3 -1.5 0.7 0.1 0.2 0.3 -0.4 -0.2 0.3 1.7 -0.5 0.1 0.4 0.3 -1.8
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 3.6 1.4 0.5 -0.1 1.7 1.9 1.3 1.3 1.4 0.9 -0.1 -1.1 0.9 1.2 -0.3 0.4
Pain experienced in last month 1.3 2.2 3.2 -1.7 1.1 -1.5 -1.8 -1.6 -1.6 -1.6 -1.8 -1.4 -0.8 0.8 -1.8 -1.6 -1.8 0.8
Supplements: Calcium 0.3 0.3 2.0 -0.2 -0.5 -0.6 0.2 0.7 0.2 0.0 -0.1 0.2 0.8 1.4 0.0 0.3 -0.1 -0.5
Basal cell carcinoma (self-reported) 2.0 2.3 5.6 -1.3 2.4 -0.2 -1.2 -1.0 -1.7 -0.8 -1.1 -1.5 -2.0 0.3 -1.9 -1.7 -1.5 2.2
Heart attack/myocardial infarction (self-reported) 1.2 1.5 2.7 1.6 -1.5 1.3 1.2 1.3 1.4 0.6 0.9 1.5 1.5 0.2 1.0 1.1 0.6 -1.5
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 2.8 1.4 -0.3 1.7 1.2 1.0 1.0 1.3 1.2 0.8 0.7 1.0 1.0 1.1 0.4 -0.3
Heart disease (siblings) 2.1 2.6 6.3 -2.5 1.0 -0.3 -2.2 -1.6 -1.4 -2.4 -2.5 -1.2 -0.2 -0.3 -2.0 -2.0 -0.4 1.1
Alcohol drinker status: Previous 0.1 0.1 0.4 0.3 0.1 -0.6 -0.0 0.2 -0.3 -0.5 -0.4 -0.2 0.6 0.1 -0.2 -0.1 -0.3 -0.0
Pack years of smoking 1.0 1.5 3.3 -1.7 0.3 1.1 -1.8 -1.7 -1.2 -1.3 -1.6 -0.9 0.1 -1.3 -1.0 -1.5 -0.7 0.7
Impedance of whole body 0.1 0.4 3.2 -0.4 0.5 -1.8 -0.0 -0.2 -0.8 0.7 0.3 -0.5 -1.1 -0.1 -0.1 0.1 0.2 0.5
Leg fat mass (left) 0.3 1.1 2.7 0.5 -1.0 1.3 0.8 0.7 1.6 0.9 1.0 1.5 1.5 -1.1 1.0 0.9 0.4 -0.3
Arm predicted mass (left) 0.1 0.7 4.6 -0.3 0.7 -0.1 -0.4 -0.4 -0.4 -1.0 -0.7 -0.7 0.0 -1.1 -1.0 -0.6 -2.1 0.6