Hub : Traits :

Back pain experienced in last month

16 significantly associated models · 9 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	10	73027892	74809596	4	1	1.3e-11	7.5e-12	1.00	100	CHST3
2	10	123965678	124462596	1	1	1.3e-10	3.4e-10	1.00	100	ARMS2
3	12	5860179	6956462	2	1	2.8e-08	1.8e-08	0.12	92	MRPL51
4	15	66662107	68183665	1	1	1.5e-07	2.2e-07	1.00	100	SMAD3
5	20	33343157	33923566	1	1	1.8e-07	3.9e-05	0.90	100	TRPC4AP

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Tanning	14.17	1	1	2.2	0.00	1.00	TRPC4AP
Hair Pigment	7.47	1	1	2.2	0.00	1.00	TRPC4AP
Lung FVC	5.02	3	2	4.4	0.00	1.00	ARMS2 SMAD3 TRPC4AP
Impedance of arm (right)	4.41	2	2	4.4	0.00	1.00	SMAD3 TRPC4AP
Comparative height size at age 10	4.38	4	2	4.4	0.33	0.67	ARMS2 CHST3 SMAD3 TRPC4AP
Impedance of arm (left)	4.13	2	2	4.4	0.00	1.00	SMAD3 TRPC4AP
Forced vital capacity (FVC)	3.90	3	1	2.2	0.00	1.00	ARMS2 CHST3 TRPC4AP
Other serious medical condition/disability diagnosed by doctor	3.85	1	0	0.0	0.00	1.00	TRPC4AP
Heel T-Score	3.64	4	3	6.7	0.02	0.98	ARMS2 MRPL51 SMAD3 TRPC4AP
Loud music exposure frequency	3.60	1	0	0.0	0.00	1.00	TRPC4AP
Forced vital capacity (FVC), Best measure	3.59	2	1	2.2	0.00	1.00	ARMS2 TRPC4AP
Forced expiratory volume in 1-second (FEV1)	3.28	2	0	0.0	0.00	1.00	ARMS2 TRPC4AP
Bipolar Disorder (2011)	3.27	1	0	0.0	0.00	1.00	TRPC4AP
Impedance of whole body	3.17	2	1	2.2	0.00	1.00	SMAD3 TRPC4AP
Knee pain experienced in last month	3.06	2	0	0.0	0.00	1.00	CHST3 TRPC4AP
Birth weight	3.04	1	0	0.0	0.00	1.00	TRPC4AP
Osteoarthritis (self-reported)	3.00	1	0	0.0	0.00	1.00	MRPL51
Peak expiratory flow (PEF)	2.97	2	0	0.0	0.00	1.00	SMAD3 TRPC4AP
Trunk fat percentage	2.95	1	1	2.2	0.00	1.00	SMAD3
Hypothyroidism (self reported)	2.94	1	0	0.0	0.00	1.00	ARMS2
Hand grip strength (left)	2.83	2	0	0.0	0.00	1.00	ARMS2 SMAD3
Hand grip strength (right)	2.64	2	0	0.0	0.00	1.00	ARMS2 SMAD3
Heel bone mineral density (BMD) T-score, automated (left)	2.64	2	0	0.0	0.00	1.00	SMAD3 TRPC4AP
Forced expiratory volume in 1-second (FEV1), Best measure	2.64	1	0	0.0	0.00	1.00	TRPC4AP
Age at last live birth	2.60	1	0	0.0	0.00	1.00	ARMS2
Heel bone mineral density (BMD) T-score, automated (right)	2.55	2	0	0.0	0.00	1.00	SMAD3 TRPC4AP
Frequency of tenseness / restlessness in last 2 weeks	2.54	2	0	0.0	0.00	1.00	SMAD3 TRPC4AP
Birth weight of first child	2.52	1	0	0.0	0.00	1.00	TRPC4AP
Schizophrenia vs Biploar Disorder	2.47	1	0	0.0	0.00	1.00	MRPL51
Body fat percentage	2.39	1	1	2.2	0.00	1.00	SMAD3
Financial situation satisfaction	2.39	1	0	0.0	0.00	1.00	MRPL51
Fractured/broken bones in last 5 years	2.31	1	0	0.0	0.00	1.00	SMAD3
Medication: Levothyroxine sodium	2.27	1	0	0.0	0.00	1.00	ARMS2
Height	2.25	4	4	8.9	0.37	0.63	ARMS2 CHST3 SMAD3 TRPC4AP
Bipolar Disorder (2018)	2.24	1	0	0.0	0.00	1.00	TRPC4AP
Trunk fat mass	2.24	2	1	2.2	0.00	1.00	ARMS2 SMAD3
Osteoporosis (self-reported)	2.19	1	0	0.0	0.00	1.00	SMAD3
Age at first live birth	2.14	1	0	0.0	0.00	1.00	ARMS2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.12	1	0	0.0	0.00	1.00	TRPC4AP
Sensitivity / hurt feelings	2.09	1	0	0.0	0.00	1.00	TRPC4AP
Verbal and Numeric Reasoning (VNR)	2.05	1	0	0.0	0.00	1.00	SMAD3
Age when periods started (menarche)	2.05	1	0	0.0	0.00	1.00	CHST3
Intelligence (Savage-Jansen 2018)	1.95	2	0	0.0	0.00	1.00	MRPL51 SMAD3
Fluid intelligence score	1.94	1	0	0.0	0.00	1.00	SMAD3
Number of self-reported non-cancer illnesses	1.94	1	0	0.0	0.00	1.00	ARMS2
Arm fat percentage (right)	1.86	2	0	0.0	0.00	1.00	CHST3 SMAD3
Maternal smoking around birth	1.79	1	0	0.0	0.00	1.00	TRPC4AP
Impedance of leg (right)	1.77	1	1	2.2	0.00	1.00	SMAD3
Hypothyroidism/myxoedema (self-reported)	1.77	1	0	0.0	0.00	1.00	ARMS2
Arm fat percentage (left)	1.75	2	0	0.0	0.00	1.00	CHST3 SMAD3
Whole body fat mass	1.74	2	0	0.0	0.00	1.00	ARMS2 SMAD3
Tense / 'highly strung'	1.71	1	0	0.0	0.00	1.00	TRPC4AP
Impedance of leg (left)	1.70	1	1	2.2	0.00	1.00	SMAD3
Arm fat-free mass (right)	1.70	1	1	2.2	0.00	1.00	ARMS2
Standing height	1.69	4	1	2.2	0.30	0.70	ARMS2 CHST3 SMAD3 TRPC4AP
Arm predicted mass (right)	1.63	1	1	2.2	0.00	1.00	ARMS2
Lung FEV1/FVC ratio	1.56	1	1	2.2	0.00	1.00	ARMS2
Arm predicted mass (left)	1.55	1	1	2.2	0.00	1.00	ARMS2
Trunk fat-free mass	1.54	1	1	2.2	0.00	1.00	ARMS2
Trunk predicted mass	1.53	1	1	2.2	0.00	1.00	ARMS2
Arm fat-free mass (left)	1.47	1	1	2.2	0.00	1.00	ARMS2
Waist circumference	1.45	1	0	0.0	0.00	1.00	CHST3
Nervous feelings	1.41	1	0	0.0	0.00	1.00	TRPC4AP
Neuroticism score	1.37	1	0	0.0	0.00	1.00	TRPC4AP
Whole body water mass	1.37	1	1	2.2	0.00	1.00	ARMS2
Whole body fat-free mass	1.33	1	1	2.2	0.00	1.00	ARMS2
Leg fat percentage (left)	1.32	1	0	0.0	0.00	1.00	SMAD3
Leg fat percentage (right)	1.25	1	0	0.0	0.00	1.00	SMAD3
Systolic blood pressure, automated reading	1.21	1	0	0.0	0.00	1.00	TRPC4AP
Systolic Blood Pressure	1.19	1	0	0.0	0.00	1.00	TRPC4AP
Basal metabolic rate	1.18	1	1	2.2	0.00	1.00	ARMS2
Hip circumference	1.15	1	0	0.0	0.00	1.00	ARMS2
Comparative body size at age 10	1.11	1	0	0.0	0.00	1.00	SMAD3
Weight	1.07	1	0	0.0	0.00	1.00	ARMS2
Body mass index (BMI)	1.03	1	0	0.0	0.00	1.00	CHST3
Leg predicted mass (right)	0.96	1	0	0.0	0.00	1.00	ARMS2
Leg fat-free mass (right)	0.94	1	0	0.0	0.00	1.00	ARMS2
Leg predicted mass (left)	0.92	1	0	0.0	0.00	1.00	ARMS2
BMI	0.89	1	0	0.0	0.00	1.00	TRPC4AP
Sitting height	0.85	2	0	0.0	0.00	1.00	CHST3 SMAD3
Leg fat-free mass (left)	0.84	1	0	0.0	0.00	1.00	ARMS2
Pulse rate, automated reading	0.63	1	0	0.0	0.00	1.00	TRPC4AP
Blood Eosinophil Count	0.55	1	0	0.0	0.00	1.00	ARMS2

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.6
GTEx	Colon Sigmoid	0	0.000	1.6
GTEx	Ovary	0	0.000	1.6
GTEx	Pancreas	0	0.000	1.6
GTEx	Prostate	0	0.000	1.6
GTEx	Spleen	0	0.000	1.6
GTEx	Uterus	0	0.000	1.6
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.6
GTEx	Adipose Subcutaneous	0	0.000	1.5
GTEx	Adipose Visceral Omentum	0	0.000	1.5
GTEx	Adrenal Gland	2	0.137	1.5
GTEx	Artery Aorta	0	0.000	1.5
GTEx	Artery Coronary	0	0.000	1.5
GTEx	Artery Tibial	0	0.000	1.5
GTEx	Brain Cerebellum	0	0.000	1.5
GTEx	Brain Cortex	0	0.000	1.5
GTEx	Brain Frontal Cortex BA9	0	0.000	1.5
GTEx	Brain Hypothalamus	0	0.000	1.5
GTEx	Breast Mammary Tissue	0	0.000	1.5
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.5
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.5
GTEx	Cells Transformed fibroblasts	1	0.024	1.5
GTEx	Colon Transverse	0	0.000	1.5
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.5
GTEx	Esophagus Mucosa	0	0.000	1.5
GTEx	Esophagus Muscularis	1	0.031	1.5
GTEx	Heart Atrial Appendage	0	0.000	1.5
GTEx	Liver	0	0.000	1.5
GTEx	Lung	0	0.000	1.5
GTEx	Muscle Skeletal	2	0.069	1.5
GTEx	Nerve Tibial	0	0.000	1.5
GTEx	Pituitary	0	0.000	1.5
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.5
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.5
GTEx	Stomach	0	0.000	1.5
GTEx	Testis	0	0.000	1.5
GTEx	Thyroid	0	0.000	1.5
GTEx	Vagina	0	0.000	1.5
METSIM	Adipose	1	0.022	1.5
NTR	Blood	1	0.042	1.5
ROSMAP	Brain Pre-frontal Cortex	1	0.023	1.5
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.5
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.5
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.5
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.5
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.5
GTEx	Brain Caudate basal ganglia	0	0.000	1.4
GTEx	Brain Hippocampus	0	0.000	1.4
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.4
GTEx	Brain Putamen basal ganglia	0	0.000	1.4
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.4
GTEx	Heart Left Ventricle	0	0.000	1.4
GTEx	Small Intestine Terminal Ileum	0	0.000	1.4
GTEx	Whole Blood	0	0.000	1.4
YFS	Blood	0	0.000	1.4
CommonMind	Brain Pre-frontal Cortex	2	0.037	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	1	0.023	1.4
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	1	0.090	1.4
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.4