Best TWAS P=4.33e-09 · Best GWAS P=2.71e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Putamen basal ganglia | LAYN | 0.24 | 0.12 | lasso | 7 | 0.13 | 6.2e-04 | 4.7 | -5.2 | 1.8e-07 | -0.81 | 0.10 | 0.52 | FALSE |
| 2 | GTEx | Esophagus Mucosa | SIK2 | 0.13 | 0.03 | lasso | 4 | 0.02 | 2.2e-02 | 5.2 | 5.4 | 7.2e-08 | 0.90 | 0.09 | 0.70 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SIK2 | 0.04 | 0.01 | blup | 35 | 0.01 | 6.7e-03 | 5.9 | 5.6 | 2.3e-08 | 0.95 | 0.01 | 0.94 | FALSE |
| 4 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SIK2 | 0.05 | 0.06 | lasso | 1 | 0.05 | 2.6e-06 | 5.9 | 5.9 | 4.3e-09 | 0.99 | 0.01 | 0.99 | TRUE |