Hub : Genes

LAYN

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1940	0.0420	0.0e+00	0.244	0.194	0.243	0.247	0.243	1.8e-29	3.8e-23	3.0e-29	8.0e-30	2.7e-29
2	GTEx	Brain Putamen basal ganglia	0.2360	0.0850	1.2e-03	0.119	NA	0.091	NA	0.128	9.6e-04	NA	3.6e-03	NA	6.2e-04
3	METSIM	Adipose	0.0313	0.0173	1.3e-02	0.005	0.002	0.000	0.015	0.005	4.6e-02	1.4e-01	3.5e-01	2.2e-03	5.8e-02
4	ROSMAP	Brain Pre-frontal Cortex	0.1922	0.0376	0.0e+00	0.230	0.229	0.253	0.240	0.238	4.2e-29	5.5e-29	2.9e-32	1.4e-30	2.9e-30
5	TCGA	Breast Invasive Carcinoma	0.0178	0.0094	2.6e-06	0.028	0.026	0.025	NA	0.024	1.6e-06	3.7e-06	5.9e-06	NA	7.7e-06
6	TCGA	Pancreatic Adenocarcinoma	0.1260	0.0980	1.7e-03	0.073	0.065	0.066	NA	0.048	5.6e-04	1.0e-03	9.9e-04	NA	4.5e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	2.8	4.4	6.1	-2.4	-2.1	-2.0	-2.3	2.5	1.1
Bipolar Disorder or Schizophrenia	1.0	2.4	3.3	-1.8	-1.4	-1.7	-1.6	1.7	0.8
Depressed Affect (Nagel 2018)	0.2	0.5	0.9	0.9	0.4	0.6	0.5	-0.7	-0.8
Depression (Nagel 2018)	0.7	1.1	1.9	1.4	1.0	-0.9	1.0	-1.2	-0.6
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.2	0.7	1.0	0.1	0.6	-0.9	-1.1
Neuroticism (Nagel 2018)	0.1	0.2	0.4	0.6	0.2	0.0	0.3	-0.6	-0.7
Schizophrenia (2018)	0.1	0.1	0.4	-0.4	-0.1	-0.7	-0.3	0.2	0.2
Schizophrenia vs Biploar Disorder	1.3	1.7	3.0	1.6	1.1	0.0	1.7	-1.7	-0.9
Worry (Nagel 2018)	0.5	1.1	1.8	1.2	0.6	0.7	1.0	-1.2	-1.3
Alzheimer’s Disease (in mother)	0.6	0.7	1.9	-0.8	-0.4	1.4	-0.5	0.6	1.0
Alzheimer’s Disease (in father)	1.0	1.1	1.8	0.8	1.1	0.3	1.2	-1.0	-1.3
Alzheimer’s Disease (including proxy)	0.2	0.4	1.3	0.1	0.7	1.2	0.4	-0.3	0.1
Crohns Disease (2017)	0.3	0.8	2.6	1.0	0.1	-0.3	0.7	-0.5	-1.6
Irritable Bowel Disease (IBD)	0.3	0.7	2.2	-0.3	-1.5	-0.6	-0.5	0.7	-1.0
Ulcerative Colitis (UC)	0.9	1.6	3.9	-1.1	-2.0	-1.0	-1.3	1.4	0.0
Major Depression (MDD)	0.2	0.3	1.1	-0.0	-0.4	-1.0	-0.0	0.0	-0.6
Reaction Time	0.2	0.5	0.7	-0.2	-0.7	-0.5	-0.9	0.8	0.8
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.3	0.2	0.3	-0.1	0.1	-0.3	-0.5
Breast Cancer	6.9	16.5	22.4	-4.1	-4.7	-3.6	-4.4	4.3	3.1
Ovarian Cancer	0.1	0.1	0.3	0.3	-0.2	-0.6	0.1	-0.1	-0.6
Prostate Cancer	4.8	6.7	9.5	-3.1	-2.5	-1.0	-3.0	2.8	2.6
Age at First Birth	1.4	2.0	3.9	-1.5	-2.0	0.8	-1.4	1.7	0.7
Bipolar Disorder (2011)	1.7	1.7	4.0	-1.4	-1.1	-2.0	-1.2	1.1	0.5
Body Mass Index (BMI) (2010)	0.1	0.1	0.6	0.1	-0.2	-0.8	0.1	-0.1	0.1
Coronary Artery Disease (CAD)	1.2	1.5	2.5	-1.3	-1.3	-0.1	-1.6	1.4	0.9
Crohns Disease (2012)	0.3	0.4	1.0	1.0	0.1	-0.7	0.8	-0.5	-0.4
Mean Putamen Volume	0.1	0.1	0.2	-0.2	0.4	0.4	0.3	-0.2	0.4
Fasting Glucose	0.9	1.0	1.5	1.1	0.7	1.2	1.2	-1.1	-0.7
HbA1C	1.9	2.1	3.8	-1.4	-1.8	-1.3	-1.9	1.3	0.7
HDL Cholesterol	0.6	0.9	1.3	1.1	1.0	-0.5	1.1	-1.2	-0.8
LDL Cholesterol	0.3	0.4	1.4	0.7	0.1	-1.2	0.4	-0.5	-0.1
Lupus	4.1	6.1	8.7	-2.3	-2.9	-0.4	-2.8	2.9	2.5
Neuroticism (2016)	1.1	1.5	2.2	1.4	1.2	-0.5	1.2	-1.4	-1.5
Primary Biliary Cirrhosis	5.6	8.0	12.1	-3.1	-2.7	-0.8	-3.0	3.1	3.5
Rheumatoid Arthritis	0.3	0.4	1.9	-0.1	0.5	1.4	0.3	-0.5	-0.2
Schizophrenia (2014)	0.1	0.1	0.6	-0.4	0.1	-0.8	-0.1	0.1	0.1
Triglycerides	0.2	0.3	0.7	0.7	0.6	-0.1	0.8	-0.5	-0.3
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.3	-1.5	-0.9	-0.9	-1.1	1.0	0.5
Ulcerative Colitis	0.2	0.3	0.8	0.6	-0.5	-0.9	0.4	-0.1	-0.2
Blood Eosinophil Count	2.6	19.7	33.4	-4.2	-5.8	-1.0	-5.3	5.2	3.3
Blood Platelet Count	1.8	21.0	30.4	4.2	4.5	3.5	4.6	-4.9	-5.5
Blood Red Count	0.2	1.5	3.3	-0.2	1.8	-1.4	0.9	-0.7	1.6
Blood White Count	0.5	3.7	7.2	1.8	1.7	0.7	2.1	-2.1	-2.7
Heel T-Score	1.9	14.8	20.9	-4.4	-4.0	-0.4	-3.9	4.6	4.2
BMI	0.5	3.1	4.7	-1.9	-1.7	-0.7	-1.4	2.2	2.1
Height	0.2	3.6	7.3	2.1	2.7	0.0	2.4	-1.9	-0.3
Waist Hip Ratio (WHR)	3.7	16.7	46.5	-3.8	-1.9	2.8	-3.7	3.8	6.8
Systolic Blood Pressure	4.4	21.9	26.8	-4.1	-5.2	-4.4	-5.0	5.0	4.3
Smoking Status	0.4	0.9	2.0	0.9	1.2	-0.2	1.4	-0.8	-0.6
Allergy or Eczema	13.5	35.5	42.9	6.1	6.1	3.3	6.6	-6.4	-6.5
Cardiovascular Disease	5.8	19.2	21.6	-3.9	-4.5	-4.7	-4.2	4.6	4.5
Hypothyroidism (self reported)	1.2	2.8	3.8	-1.9	-1.9	-1.6	-1.9	1.7	0.6
Respiratory disease	5.3	11.7	15.6	3.0	3.7	2.4	3.4	-4.0	-3.8
Type 2 Diabetes (T2D) (2018)	0.6	1.1	1.9	-0.8	-1.4	-0.8	-0.8	1.4	0.8
Lung FEV1/FVC ratio	0.2	0.8	1.3	0.8	1.1	-0.9	1.1	-0.8	-0.5
Lung FVC	0.2	1.2	1.6	-1.1	-1.2	-0.7	-1.2	1.2	1.1
Neuroticism	0.0	0.1	0.1	0.1	-0.3	-0.2	-0.2	-0.1	-0.3
Chronotype (morning person)	0.3	0.6	1.1	-0.4	-0.8	0.3	-0.8	0.9	1.0
Hair Pigment	0.3	7.8	13.5	-2.9	-3.7	-2.3	-2.8	3.0	1.6
Tanning	0.2	3.0	7.6	-1.4	-0.9	1.5	-1.6	1.7	2.8
Hand grip strength (left)	0.8	2.2	3.1	1.5	1.7	1.4	1.7	-1.5	-0.9
Number of treatments/medications taken	1.7	3.1	3.6	-1.8	-1.7	-1.9	-1.6	1.8	1.8
Average weekly spirits intake	0.3	0.3	1.0	-0.1	-0.0	-1.0	0.0	-0.4	-0.9
Sensitivity / hurt feelings	3.4	5.8	12.3	2.4	1.9	0.8	2.5	-2.6	-3.5
Frequency of depressed mood in last 2 weeks	1.7	2.4	4.3	2.1	1.6	-0.3	1.7	-1.7	-1.4
Hearing difficulty/problems: Yes	0.3	0.4	2.3	-0.4	-0.1	1.5	-0.3	0.2	0.1
Relative age of first facial hair	0.0	0.1	0.5	0.1	-0.0	0.7	-0.2	-0.2	-0.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.4	0.8	0.6	-1.2	0.2	-0.6	0.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	0.2	0.9	0.8	0.7	-0.7	-0.2
Ever had hysterectomy (womb removed)	0.6	0.6	1.2	0.7	1.0	-0.3	1.1	-0.8	-0.6
Systolic blood pressure, automated reading	2.6	7.6	10.3	-2.6	-3.2	-2.9	-2.9	2.9	2.0
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.3	-1.1	-1.1	-0.4	-0.9	0.9	0.5
Angina	0.9	1.2	2.5	-1.1	-0.9	-0.8	-1.1	1.0	1.6
Medication for hormone replacement therapy	0.3	0.3	0.9	-0.0	0.6	1.0	0.0	-0.2	0.8
Vitamin and mineral supplements	0.5	0.7	1.4	-0.6	-1.1	-1.2	-0.7	0.7	-0.1
Supplements: Zinc	0.1	0.1	0.2	0.4	0.3	-0.2	0.5	-0.1	-0.1
Medication: Co-codamol	5.2	6.1	7.6	2.3	2.5	2.0	2.8	-2.7	-2.5
Medication: Metformin	1.6	2.3	3.3	-1.4	-1.8	-1.1	-1.3	1.8	1.5
Diabetes (father)	0.2	0.2	0.6	0.2	-0.8	-0.1	0.1	0.2	-0.7
Diabetes (mother)	0.1	0.2	0.3	0.5	0.5	-0.4	0.4	-0.4	0.2
Severe depression (siblings)	0.6	0.7	1.5	1.2	0.6	-1.2	0.5	-0.7	0.4
Pack years adult smoking proportion	0.1	0.1	0.3	-0.1	0.4	0.5	-0.1	-0.2	0.5
Impedance of leg (right)	2.5	12.1	16.5	3.6	4.0	2.1	3.5	-4.1	-3.1
Leg fat-free mass (left)	0.3	1.8	3.8	-1.1	-1.0	-1.3	-0.8	1.6	1.9
Trunk fat percentage	0.1	0.6	1.1	-1.0	-0.6	-1.1	-0.4	0.7	0.6
Hand grip strength (right)	0.6	1.5	2.3	1.3	1.4	0.5	1.5	-1.3	-1.2
Townsend deprivation index at recruitment	1.6	2.3	3.8	2.0	1.9	-0.2	1.8	-1.6	-0.8
Current tobacco smoking	4.0	6.5	8.6	2.9	2.7	-0.0	2.7	-2.9	-2.7
Average weekly fortified wine intake	0.4	0.5	0.9	-0.7	-1.0	-0.8	-0.8	0.6	-0.1
Maternal smoking around birth	0.1	0.1	0.5	-0.3	0.7	-0.1	0.2	-0.3	0.4
Fed-up feelings	1.7	3.2	4.3	2.1	1.6	1.9	1.6	-1.8	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.2	4.1	2.0	1.6	-0.1	1.6	-1.7	-1.0
Relative age voice broke	0.4	0.7	1.2	0.7	1.0	0.1	0.7	-1.1	-1.0
Taking other prescription medications	0.1	0.2	1.0	-0.0	0.0	-1.0	0.0	-0.1	-0.2
Age when periods started (menarche)	0.4	1.1	1.9	0.9	1.3	-0.7	0.7	-1.4	-0.8
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	1.8	0.9	1.4	0.2	1.4	-1.3	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	4.4	-0.9	-0.8	-1.5	-0.5	1.4	2.1
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.5	0.6	-0.1	-1.4	0.9	-0.7	-1.6
Qualifications: CSEs or equivalent	2.1	2.8	4.2	1.9	1.6	0.4	2.0	-1.6	-2.0
Serious illness, injury or assault to yourself	0.5	0.6	1.4	0.6	1.2	0.6	0.6	-0.9	-0.1
High blood pressure	9.8	27.4	30.8	-5.0	-5.4	-5.0	-4.9	5.5	5.5
Hayfever, allergic rhinitis or eczema	17.4	37.9	47.3	6.4	6.4	2.7	6.9	-6.7	-6.7
Multivitamins +/- minerals	2.8	3.6	5.1	2.0	2.2	1.6	1.9	-2.0	-1.6
Stomach or abdominal pain in last month	1.7	2.1	2.9	1.3	1.7	0.9	1.6	-1.6	-1.4
Supplements: Glucosamine	1.4	1.8	3.2	1.2	1.7	1.8	1.1	-1.2	-0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.0	-1.0	-0.3	-0.6	-0.4	0.2	0.1
Medication: Atenolol	11.1	13.9	18.4	-4.3	-3.6	-2.3	-3.9	3.9	4.0
Medication: Levothyroxine sodium	0.7	1.2	2.3	-1.5	-1.2	-0.7	-1.3	0.9	0.5
Sitting height	0.4	2.7	4.8	2.0	2.1	-0.3	2.2	-1.6	-0.8
Chronic bronchitis/emphysema (father)	1.5	1.8	3.6	1.2	1.9	0.8	1.6	-1.4	-0.5
High blood pressure (mother)	3.1	4.4	7.0	-1.8	-2.6	-2.6	-1.9	2.2	1.0
Body mass index (BMI)	0.8	3.4	4.8	-2.2	-1.9	-1.2	-1.6	2.2	1.8
Impedance of leg (left)	2.5	12.0	16.2	3.6	3.9	2.0	3.4	-4.0	-3.4
Leg predicted mass (left)	0.3	1.8	4.0	-1.1	-1.0	-1.3	-0.8	1.6	2.0
Trunk fat mass	0.3	1.1	1.8	-1.2	-0.8	-1.3	-0.6	1.1	1.1
Waist circumference	1.1	4.0	10.1	-2.1	-1.3	-0.4	-1.7	2.2	3.2
Number of incorrect matches in round	0.1	0.1	0.3	0.0	-0.3	-0.6	-0.1	-0.0	-0.3
Past tobacco smoking	0.8	1.4	4.0	1.4	0.3	0.4	0.8	-1.3	-2.0
Alcohol usually taken with meals	0.1	0.1	0.3	0.5	0.2	-0.4	-0.1	-0.3	0.0
Nervous feelings	1.9	3.5	5.0	2.2	1.9	1.1	2.0	-2.0	-1.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.2	1.1	1.0	-0.2	0.9	-1.0	-0.2
Hearing difficulty/problems with background noise	0.3	0.4	0.9	-0.4	-0.4	1.0	-0.6	0.5	0.7
Hair/balding pattern: Pattern 2	2.5	3.1	5.5	2.2	2.3	0.7	1.9	-2.0	-0.7
Had menopause	0.2	0.2	0.7	-0.5	0.1	-0.8	-0.2	0.1	0.4
Had other major operations	1.8	2.2	3.8	1.8	1.8	-0.7	2.0	-1.5	-0.5
Forced vital capacity (FVC)	0.7	2.9	4.1	2.0	2.0	1.5	2.0	-1.5	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.6	0.6	0.9	-0.8	0.9	-0.0	1.3
Ever unenthusiastic/disinterested for a whole week	0.9	1.0	1.5	1.0	0.9	1.0	0.9	-1.0	-1.2
Qualifications: None of the above	0.1	0.2	0.6	-0.2	0.6	0.2	0.7	-0.1	0.3
Financial difficulties in last 2 years	2.4	3.3	4.3	2.1	1.9	1.7	2.0	-1.7	-1.3
Mouth/teeth dental problems	2.1	3.3	4.7	-1.8	-1.8	-0.3	-2.0	2.0	2.2
Heart attack	0.4	0.5	1.2	-0.5	-0.6	0.5	-0.7	0.7	1.1
Allergy	19.4	44.7	56.6	-6.8	-6.9	-3.3	-7.2	7.3	7.5
Pain all over the body in last month	0.1	0.1	0.2	0.0	0.2	0.1	0.2	-0.4	-0.4
Diabetes (self-reported)	2.2	3.4	5.1	-2.2	-2.3	-1.0	-1.8	2.2	1.3
Hayfever/allergic rhinitis (self-reported)	5.4	7.2	8.8	3.0	2.8	2.0	2.9	-2.8	-2.5
Medication: Ramipril	6.1	7.9	10.8	-2.9	-3.3	-1.4	-3.2	3.1	2.6
Medication: Simvastatin	5.0	7.4	9.3	-3.0	-2.9	-1.0	-2.7	3.0	3.0
Fluid intelligence score	0.2	0.4	0.6	-0.6	-0.3	-0.6	-0.8	0.5	0.7
Illnesses of siblings	3.6	5.1	8.4	2.2	2.9	1.3	2.1	-2.8	-1.8
Neuroticism score	1.2	2.4	4.1	2.0	1.5	1.4	1.5	-1.6	-1.2
Weight	0.3	1.6	3.1	-1.3	-0.9	-1.2	-0.7	1.5	1.8
Impedance of arm (right)	1.4	6.5	10.0	2.8	2.2	1.8	2.2	-2.9	-3.2
Arm fat percentage (right)	0.6	2.5	3.7	-1.9	-1.9	-0.7	-1.5	1.9	1.1
Trunk fat-free mass	0.3	1.7	4.8	-1.1	-0.8	-0.8	-0.7	1.6	2.2
Hip circumference	0.2	0.7	0.9	0.9	0.7	-0.9	1.0	-0.6	-0.8
Time employed in main current job	0.5	0.6	0.8	-0.8	-0.7	0.6	-0.6	0.9	0.8
Alcohol intake versus 10 years previously	0.9	1.4	4.1	0.7	0.6	-0.6	1.3	-1.2	-2.0
Father’s age at death	0.8	1.0	2.2	0.9	0.5	-1.2	0.8	-1.0	-1.5
Worrier / anxious feelings	0.0	0.1	0.2	0.4	-0.4	0.1	-0.1	0.1	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.3	1.1	0.5	-0.9	0.9	-0.5	-0.9
Falls in the last year	0.3	0.4	0.7	-0.7	-0.8	0.2	-0.6	0.7	0.4
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	-0.8	-0.5	0.5	-0.6	0.4	-0.6
Number of live births	1.4	1.9	3.8	-1.9	-1.1	-0.6	-1.5	1.5	1.3
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	3.5	1.9	1.6	0.7	1.8	-1.2	-0.5
Pulse rate	3.0	5.0	6.6	2.0	2.4	1.3	2.5	-2.6	-2.3
Happiness	0.1	0.1	0.4	0.1	0.4	0.7	-0.2	-0.2	0.4
Noisy workplace	0.4	0.4	1.3	-0.4	-0.6	0.1	-0.5	0.7	1.1
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	0.6	0.4	0.5	0.0	-0.6	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.1	-0.4	-0.3	-1.1	-0.7	0.3	0.6
Mouth/teeth dental problems: Dentures	3.2	5.4	8.2	2.3	2.6	0.7	2.9	-2.5	-2.3
Asthma	8.5	16.7	21.7	3.9	4.2	2.8	4.2	-4.5	-4.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.2	0.7	0.6	0.2	0.9	-0.4	-1.1
Medication: Cholesterol lowering	5.6	8.7	11.3	-3.4	-3.0	-1.1	-3.1	3.2	3.2
Depression (self-reported)	0.4	0.4	0.9	0.4	0.8	-0.3	0.5	-0.8	-0.9
Medication: Lansoprazole	1.5	1.7	3.3	-1.5	-0.8	0.7	-1.3	1.4	1.8
Prospective memory result	1.0	1.3	2.5	1.3	0.6	-0.8	1.1	-1.0	-1.6
Lung cancer (father)	2.3	2.7	5.3	1.3	1.8	2.3	1.4	-1.6	-1.1
Illnesses of mother	1.3	1.6	3.6	0.9	1.9	1.6	0.9	-1.2	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	5.1	2.2	2.3	0.5	2.1	-1.7	-0.7
Pulse wave Arterial Stiffness index	1.9	2.2	3.0	-1.4	-1.7	-0.7	-1.4	1.7	1.7
Impedance of arm (left)	1.7	7.9	12.6	3.0	2.6	1.2	2.6	-3.2	-3.6
Arm fat mass (right)	0.5	2.1	2.9	-1.6	-1.4	-1.2	-1.2	1.7	1.4
Trunk predicted mass	0.3	1.6	4.7	-1.0	-0.7	-0.8	-0.6	1.5	2.2
Standing height	0.3	2.9	5.7	2.1	2.4	-0.1	2.1	-1.7	-0.3
Length of working week for main job	0.4	0.5	0.9	-0.8	-0.4	0.0	-0.9	0.7	0.9
Exposure to tobacco smoke at home	0.9	1.0	1.8	0.7	1.3	-0.1	1.3	-1.2	-0.9
Breastfed as a baby	3.9	4.8	6.8	-2.6	-2.0	-1.0	-2.2	2.5	2.5
Tense / ‘highly strung’	0.2	0.3	1.3	0.1	0.2	1.2	0.0	-0.1	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	3.3	1.5	1.5	0.6	1.6	-1.6	-1.8
Hair/balding pattern: Pattern 4	0.4	0.9	3.0	-0.1	0.1	-1.7	-0.2	0.3	1.5
Birth weight of first child	0.4	0.8	3.4	-0.6	-0.6	1.9	-0.3	0.8	-0.1
Peak expiratory flow (PEF)	1.2	2.7	4.7	2.2	1.8	0.4	2.0	-1.8	-1.1
Pulse wave reflection index	2.3	2.9	4.2	-1.6	-1.8	-0.4	-1.7	2.1	2.0
Ever highly irritable/argumentative for 2 days	2.1	2.5	3.6	1.6	1.8	-0.1	1.9	-1.8	-1.7
Loud music exposure frequency	0.4	0.5	1.1	0.1	0.8	1.0	0.2	-0.1	1.1
Qualifications: O levels/GCSEs or equivalent	0.0	0.1	0.2	0.4	0.3	-0.2	0.0	-0.3	-0.0
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	0.5	-0.0	0.2	0.2	-0.4	-0.5
Blood clot in the leg (DVT)	0.2	0.3	1.1	0.3	0.4	0.2	0.3	-0.6	-1.1
Medication: Paracetamol	0.3	0.4	0.9	0.9	0.3	-0.6	0.5	-0.6	-0.8
Headache pain in last month	1.0	1.7	3.2	1.8	1.6	0.4	1.4	-1.3	-0.8
Medication for cholesterol, blood pressure or diabetes	14.0	23.1	28.1	5.2	5.3	2.3	5.1	-5.3	-5.0
Glaucoma (self-reported)	0.3	0.4	1.7	-0.0	-0.5	-1.3	-0.0	0.4	-0.2
Gout (self-reported)	1.0	1.3	2.3	1.5	0.9	-0.6	1.2	-1.1	-1.3
Hypothyroidism/myxoedema (self-reported)	2.9	5.6	8.4	-2.9	-2.8	-1.5	-2.6	2.5	1.4
Medication: Amlodipine	2.9	4.1	8.9	-2.0	-1.3	-1.8	-1.8	1.9	3.0
Medication: Ventolin 100micrograms inhaler	2.0	2.5	5.2	1.3	1.3	1.1	1.7	-1.6	-2.3
Birth weight	4.4	9.6	15.8	2.8	4.0	1.8	3.8	-3.4	-2.2
Chronic bronchitis/emphysema (mother)	7.7	9.0	12.3	3.1	2.8	1.5	3.5	-3.3	-3.4
High blood pressure (siblings)	2.9	4.2	7.6	-1.9	-2.8	-1.2	-2.1	2.5	1.3
Forced vital capacity (FVC), Best measure	1.0	3.6	6.5	2.1	2.5	1.3	2.2	-1.9	-0.8
Body fat percentage	0.2	0.6	1.1	-1.1	-0.7	-1.0	-0.5	0.8	0.6
Leg fat percentage (right)	0.1	0.2	0.7	-0.8	-0.1	-0.5	-0.1	0.3	0.3
Arm fat-free mass (right)	0.3	1.8	4.6	-1.1	-0.6	-1.6	-0.6	1.4	2.1
Exposure to tobacco smoke outside home	0.1	0.1	0.1	-0.3	-0.4	-0.3	0.1	0.4	-0.1
Comparative body size at age 10	1.0	2.8	5.3	-2.3	-1.2	-0.8	-1.8	1.6	1.9
Number of full brothers	0.2	0.2	1.2	0.3	-0.1	1.1	0.1	0.1	0.1
Worry too long after embarrassment	0.3	0.4	1.1	1.1	0.7	0.3	0.6	-0.6	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.7	1.5	1.6	-0.4	1.2	-1.2	-0.7
Wheeze or whistling in the chest in last year	7.3	13.0	16.2	3.6	3.8	1.6	4.0	-4.0	-4.0
Number of children fathered	1.5	1.7	5.5	-1.3	0.0	1.2	-0.7	1.1	2.3
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	1.8	1.0	1.1	-0.0	1.1	-1.2	-1.4
Age at first live birth	1.8	3.1	5.0	-1.7	-2.2	-0.2	-2.1	2.0	1.7
Pulse wave peak to peak time	1.9	2.2	3.1	1.4	1.8	0.8	1.5	-1.7	-1.6
Health satisfaction	0.6	0.8	1.4	1.0	1.2	1.0	0.8	-0.8	-0.0
Shortness of breath walking on level ground	0.0	0.0	0.1	0.1	0.3	-0.3	0.2	-0.2	0.1
Qualifications: College or University degree	1.6	4.9	7.1	-2.2	-2.2	-1.8	-2.7	2.1	2.3
Eye problems/disorders: None of the above	1.6	1.9	2.6	1.6	1.6	-0.2	1.5	-1.6	-1.2
Mouth/teeth dental problems: Loose teeth	5.4	6.4	8.6	2.8	2.5	-0.3	2.9	-2.7	-2.9
Emphysema/chronic bronchitis	0.9	1.0	1.8	1.0	1.3	-0.5	0.7	-1.3	-0.8
Medication for pain relief, constipation, heartburn	0.2	0.3	0.8	0.2	0.2	0.7	0.3	-0.6	-0.9
Neck or shoulder pain in last month	1.2	1.7	2.6	1.1	1.2	1.6	1.1	-1.2	-1.4
Medication: Blood pressure	12.1	21.4	27.2	-4.7	-5.2	-3.1	-4.6	5.1	4.7
Angina (self-reported)	0.7	0.9	1.8	-0.9	-0.7	-0.8	-1.0	0.9	1.3
Migraine (self-reported)	0.1	0.1	0.4	-0.6	-0.3	-0.4	-0.4	0.2	-0.1
Medication: Ibuprofen	1.0	1.2	1.8	1.3	1.1	0.6	1.4	-0.9	-1.2
Medication: Allopurinol	0.1	0.2	0.8	0.2	-0.3	-0.9	-0.1	0.3	0.3
Medication: Omeprazole	0.1	0.1	0.4	-0.6	-0.0	-0.2	-0.4	0.3	0.5
Medication: Seretide 50 evohaler	0.5	0.5	0.9	0.6	0.7	-0.3	0.9	-0.7	-0.9
Mean time to correctly identify matches	3.3	6.3	8.9	-2.4	-3.0	-0.9	-2.9	2.8	2.4
Heart disease (mother)	1.2	1.4	3.0	-1.1	-1.7	-1.3	-1.0	1.3	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	1.8	1.3	0.7	0.5	1.0	-1.0	-1.3
Whole body fat mass	0.3	1.2	1.6	-1.3	-0.9	-1.3	-0.6	1.2	1.1
Leg fat mass (right)	0.2	0.9	1.4	-1.1	-0.7	-1.2	-0.5	1.0	1.1
Arm predicted mass (right)	0.4	1.8	4.4	-1.1	-0.6	-1.6	-0.6	1.4	2.1
Pulse rate, automated reading	5.8	18.7	23.9	4.3	4.9	3.2	4.8	-4.8	-3.7
Alcohol intake frequency.	0.3	0.7	2.0	0.8	0.2	-1.0	0.5	-0.8	-1.4
Comparative height size at age 10	0.1	0.4	0.9	0.5	0.9	0.7	0.8	-0.4	-0.0
Number of full sisters	3.2	3.9	6.2	2.2	1.6	-0.5	2.1	-2.3	-2.5
Suffer from ‘nerves’	4.1	6.4	14.0	2.2	1.8	1.6	2.6	-2.6	-3.7
Overall health rating	1.6	3.4	4.6	2.1	1.8	0.8	2.0	-1.9	-2.1
Chest pain or discomfort	1.5	2.2	5.0	1.3	1.3	0.4	1.4	-1.7	-2.2
Had major operations	0.4	0.4	1.8	-0.6	-0.4	-1.3	-0.4	0.3	0.3
Age at last live birth	0.9	1.3	2.5	-1.1	-1.6	0.3	-1.3	1.3	0.9
Family relationship satisfaction	0.1	0.1	0.4	0.7	0.4	-0.4	-0.0	-0.2	0.3
Leg pain on walking	0.3	0.4	1.5	-0.3	-0.0	-0.5	-0.5	0.5	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.9	0.6	-0.2	0.2	0.6	-0.4	-1.4
Commuting to job workplace: Car/motor vehicle	0.3	0.4	2.0	-0.5	0.0	1.4	-0.4	0.1	0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.9	-0.1	-0.2	-0.5	-0.1	-0.1	-1.0
Medication: Aspirin	8.3	10.9	15.2	-3.3	-3.4	-1.5	-3.3	3.7	3.9
Supplements: Vitamin C	0.5	0.6	2.1	-0.6	-0.4	-0.4	-0.5	0.8	1.5
Knee pain experienced in last month	0.3	0.4	1.2	-0.8	-0.1	0.3	-0.2	0.6	1.1
Hypertension (Self-reported)	11.3	31.3	36.5	-5.5	-5.8	-4.6	-5.5	6.0	6.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.3	0.7	0.7	1.2	0.7	-0.7	-0.5
Illnesses of father: Heart disease	4.0	5.5	8.3	-1.9	-2.7	-0.1	-2.5	2.9	2.9
Illnesses of siblings: Diabetes	0.6	0.8	1.9	1.0	0.4	-0.4	1.4	-0.7	-0.9
Smoking status: Previous	2.0	3.0	6.7	-2.0	-1.1	-0.2	-1.4	2.0	2.6
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.2	7.8	2.8	2.5	0.6	2.4	-2.1	-0.9
Whole body fat-free mass	0.3	1.7	4.5	-1.0	-0.8	-1.1	-0.7	1.6	2.1
Leg fat-free mass (right)	0.4	2.0	3.8	-1.1	-1.1	-1.4	-0.9	1.7	1.9
Arm fat percentage (left)	0.5	1.9	2.9	-1.7	-1.6	-1.0	-1.2	1.6	0.9
Average weekly red wine intake	0.6	0.9	1.7	-1.1	-1.3	0.4	-1.2	0.9	0.1
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.4	0.6	0.3	-0.6	0.4	-0.3	-0.1
Mood swings	0.1	0.2	0.6	0.5	0.3	0.8	0.4	-0.2	0.0
Loneliness, isolation	0.1	0.1	0.5	0.7	0.5	-0.0	0.2	-0.2	0.1
Long-standing illness, disability or infirmity	0.1	0.2	0.4	-0.5	-0.5	-0.2	-0.6	0.2	0.0
Ever had bowel cancer screening	12.3	14.4	21.8	-3.7	-4.7	-2.0	-4.5	4.2	3.1
Diabetes diagnosed by doctor	3.8	6.2	9.5	-2.7	-3.1	-1.9	-2.4	2.9	1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	4.4	0.6	1.1	2.1	0.4	-0.7	-0.0
Friendships satisfaction	0.2	0.2	0.7	-0.2	-0.1	0.4	-0.5	0.4	0.8
Qualifications: nursing, teaching	0.5	0.8	1.6	-1.1	-0.7	0.2	-1.2	0.9	0.9
Commuting to job workplace: Walk	2.1	2.3	3.4	-1.7	-1.8	-1.4	-1.5	1.6	0.8
Eye problems/disorders: Cataract	3.2	3.7	5.6	-2.0	-1.7	1.0	-2.1	2.1	2.4
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	3.1	-1.8	-1.4	-1.5	-1.6	1.4	0.9
Medication for cholesterol	2.5	3.8	5.2	1.9	1.9	2.3	2.0	-1.8	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	0.1	0.2	0.5	-0.1	-0.1	-0.1
Back pain experienced in last month	0.3	0.5	1.1	0.8	1.0	-0.4	0.9	-0.4	0.1
Mineral and other dietary supplements	0.0	0.1	0.1	-0.1	-0.4	0.4	0.0	0.2	-0.0
Breast cancer (self-reported)	0.3	0.3	0.8	-0.3	-0.9	-0.4	-0.3	0.9	0.3
Asthma (self-reported)	7.4	14.7	19.4	3.6	4.0	2.5	3.9	-4.2	-4.4
Osteoporosis (self-reported)	0.2	0.2	1.0	0.5	0.1	-1.0	0.3	-0.2	-0.2
Osteoarthritis (self-reported)	4.8	6.3	8.2	1.7	2.6	2.2	2.6	-2.8	-2.9
Medication: Aspirin	10.2	13.3	20.4	-3.6	-3.6	-1.9	-3.6	4.1	4.5
Medication: Gliclazide	1.2	1.4	3.4	-0.4	-1.9	-1.7	-0.7	1.2	-0.3
Illnesses of father: None of the above (group 1)	0.9	1.1	2.1	0.9	1.1	-0.4	0.9	-1.3	-1.5
Smoking status: Current	3.7	5.9	7.7	2.7	2.6	-0.1	2.6	-2.8	-2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	0.2	0.5	0.7	0.3	-0.4	0.2
Whole body water mass	0.3	1.9	4.8	-1.1	-0.9	-1.2	-0.7	1.6	2.2
Leg predicted mass (right)	0.4	2.1	4.0	-1.2	-1.2	-1.4	-0.9	1.8	2.0
Arm fat mass (left)	0.4	1.8	2.4	-1.6	-1.3	-1.2	-1.1	1.5	1.2
Number of self-reported non-cancer illnesses	0.4	0.8	1.2	-1.1	-0.7	-0.5	-1.1	0.8	0.9
Average weekly champagne plus white wine intake	0.3	0.4	0.8	-0.4	-0.6	0.9	-0.9	0.6	0.5
Miserableness	0.1	0.1	0.2	0.4	-0.4	0.1	-0.2	0.2	-0.5
Guilty feelings	0.2	0.4	1.2	0.5	0.7	-0.4	0.3	-0.2	1.1
Wears glasses or contact lenses	2.8	3.3	4.6	-2.1	-1.7	0.2	-2.1	1.9	2.0
Ever taken oral contraceptive pill	3.8	4.2	6.9	2.6	2.1	1.3	2.0	-2.1	-2.0
Hearing aid user	1.3	1.4	2.2	-1.2	-1.5	1.0	-1.3	1.3	0.7
Mother’s age at death	0.2	0.2	0.3	-0.5	-0.2	-0.6	-0.5	0.3	0.4
Financial situation satisfaction	0.0	0.1	0.1	-0.3	0.3	-0.2	0.0	-0.3	0.3
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.8	-0.1	0.2	0.5	0.1	0.2	0.9
Commuting to job workplace: Public transport	0.1	0.2	0.5	0.4	0.4	0.7	0.4	-0.2	0.2
Eye problems/disorders: Glaucoma	0.4	0.5	1.1	0.7	0.4	0.0	0.8	-0.6	-1.1
Medication: Blood pressure	7.6	14.4	16.2	-3.8	-3.6	-3.6	-3.9	3.8	4.0
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.2	0.9	1.3	1.5	0.9	-1.2	-1.3
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	-0.0	0.2	-0.4	-0.0	-0.2	-0.6
High cholesterol (Self-reported)	1.1	2.0	3.5	-1.4	-1.3	-1.0	-1.4	1.3	1.9
Medication: Bendroflumethiazide	7.7	11.7	16.5	-3.9	-4.1	-1.8	-3.5	3.8	3.0
Medication: Paracetamol	0.4	0.7	1.7	1.3	0.4	-0.7	0.7	-0.7	-0.9
Medication: Lisinopril	4.1	5.3	7.8	-2.1	-2.8	-1.3	-2.6	2.6	2.2
Medication: Atorvastatin	0.7	0.8	1.6	-1.1	-0.8	-0.1	-0.8	0.9	1.3
Illnesses of father: High blood pressure	1.6	2.0	3.1	-1.5	-1.8	-0.4	-1.5	1.7	1.2
Alcohol drinker status: Never	3.9	4.7	6.2	2.5	2.5	1.0	2.2	-2.4	-2.0
Ever smoked	0.3	0.4	1.5	0.2	1.2	-0.6	0.7	-0.5	0.3
Basal metabolic rate	0.3	1.5	4.0	-1.0	-0.7	-1.2	-0.6	1.5	2.0
Leg fat percentage (left)	0.1	0.2	0.6	-0.8	-0.2	-0.8	-0.0	0.3	0.0
Arm fat-free mass (left)	0.3	1.7	4.8	-1.1	-0.6	-1.2	-0.5	1.4	2.2
Number of operations (self-reported)	0.8	1.2	2.8	1.0	1.7	-0.0	1.1	-1.3	-0.4
Average weekly beer plus cider intake	0.3	0.4	0.7	-0.8	-0.4	0.1	-0.6	0.8	0.8
Irritability	0.2	0.3	1.0	-0.1	0.2	0.5	-0.4	0.2	1.0
Risk taking	0.2	0.3	0.7	-0.8	-0.2	-0.3	-0.6	0.3	0.5
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.2	-0.8	-0.9	0.4	-1.1	0.7	0.5
Fractured/broken bones in last 5 years	3.4	4.4	7.6	2.0	2.8	1.8	2.5	-2.2	-0.8
Age started oral contraceptive pill	0.2	0.3	0.6	-0.4	-0.7	-0.7	-0.3	-0.1	-0.8
Diastolic blood pressure, automated reading	2.1	6.6	9.9	-2.1	-3.0	-3.1	-2.4	2.7	1.8
Ever depressed for a whole week	1.4	1.7	3.2	1.3	1.0	-0.0	1.4	-1.4	-1.8
Unable to work because of sickness or disability	1.3	1.7	3.5	1.3	1.9	0.5	1.4	-1.5	-0.7
Commuting to job workplace: Cycle	1.2	1.4	2.0	-1.0	-1.0	-1.3	-1.1	1.3	1.4
Myopia	2.4	3.5	5.5	-1.5	-1.9	-1.2	-2.4	1.9	2.1
Vascular/heart problems diagnosed by doctor	9.6	26.1	31.0	4.8	5.3	4.6	4.9	-5.4	-5.6
Cholesterol lowering medication	0.2	0.3	0.5	-0.7	-0.4	-0.4	-0.3	0.5	0.7
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.4	0.1	0.3	-0.2	0.2	0.3
Pain experienced in last month	0.1	0.2	0.4	-0.4	-0.5	-0.6	-0.4	0.1	-0.1
Supplements: Calcium	0.6	0.7	1.2	1.0	0.6	0.3	0.9	-0.8	-1.1
Basal cell carcinoma (self-reported)	1.2	1.5	3.1	-1.1	-0.7	0.4	-1.4	1.3	1.8
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.7	-0.7	-0.7	0.3	-0.9	0.9	1.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.3	0.3	0.3	0.1	0.4	-0.6	-1.1
Heart disease (siblings)	0.5	0.6	1.3	-0.7	-1.1	-1.0	-0.6	0.8	-0.2
Alcohol drinker status: Previous	0.1	0.2	0.4	0.4	0.3	0.3	0.3	-0.4	-0.7
Pack years of smoking	0.3	0.5	1.0	-0.9	-0.4	0.1	-0.8	0.5	1.0
Impedance of whole body	2.2	11.1	15.5	3.5	3.5	1.7	3.2	-3.9	-3.7
Leg fat mass (left)	0.2	0.8	1.8	-1.0	-0.6	-1.4	-0.4	0.9	0.9
Arm predicted mass (left)	0.2	1.2	3.9	-0.9	-0.3	-1.0	-0.3	1.2	2.0