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chr1:11,060,075-12,600,396

Best TWAS P=1.34e-14 · Best GWAS P=3.03e-13 conditioned to 0.0239

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Cells Transformed fibroblasts	CLCN6	0.08	0.02	enet	17	0.05	1.6e-04	-7.3	-5.2	1.9e-07	0.75	0.01	0.99	FALSE
2	GTEx	Cells Transformed fibroblasts	MTHFR	0.13	0.03	enet	30	0.05	6.8e-05	-5.7	-5.9	3.8e-09	0.57	0.04	0.93	FALSE
3	GTEx	Skin Not Sun Exposed Suprapubic	CLCN6	0.12	0.03	lasso	3	0.04	3.3e-03	-3.6	-5.8	6.8e-09	0.83	0.01	0.96	FALSE
4	GTEx	Spleen	CLCN6	0.21	0.10	lasso	3	0.06	1.3e-02	-5.1	-5.7	1.3e-08	0.86	0.04	0.73	FALSE
5	METSIM	Adipose	DRAXIN	0.09	0.01	enet	21	0.04	1.6e-06	-2.1	5.5	4.0e-08	-0.51	0.03	0.92	FALSE
6	NTR	Blood	MTHFR	0.09	0.07	enet	17	0.10	4.4e-31	-3.5	-5.2	2.1e-07	0.66	1.00	0.00	FALSE
7	The Cancer Genome Atlas	Breast Invasive Carcinoma	CLCN6	0.06	0.06	blup	104	0.06	5.0e-12	-5.9	-7.7	1.3e-14	0.75	0.22	0.78	TRUE
8	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CLCN6	0.04	0.06	lasso	2	0.05	1.1e-06	-5.9	-6.5	6.9e-11	0.69	0.10	0.89	FALSE
9	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CLCN6	0.05	0.05	lasso	6	0.05	9.2e-07	-3.7	-5.6	2.6e-08	0.51	0.52	0.45	FALSE
10	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CLCN6	0.07	0.00	blup	104	0.03	7.9e-03	2.1	-5.2	1.6e-07	0.60	0.06	0.28	FALSE
11	The Cancer Genome Atlas	Lung Adenocarcinoma	CLCN6	0.06	0.04	blup	104	0.04	5.2e-06	-7.3	-7.2	4.9e-13	0.91	0.01	0.99	FALSE
12	The Cancer Genome Atlas	Prostate Adenocarcinoma	CLCN6	0.10	0.07	blup	104	0.07	3.9e-08	-5.0	-6.4	1.5e-10	0.58	0.20	0.80	FALSE
13	The Cancer Genome Atlas	Stomach Adenocarcinoma	CLCN6	0.07	0.04	blup	104	0.05	2.4e-04	-7.1	-6.6	4.5e-11	0.94	0.01	0.98	FALSE
14	The Cancer Genome Atlas	Thyroid Carcinoma	CLCN6	0.08	0.02	blup	104	0.05	2.5e-05	-5.1	-6.0	2.1e-09	0.63	0.13	0.86	FALSE