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chr4:103,020,804-104,627,833

Best TWAS P=3.96e-08 · Best GWAS P=5.57e-08 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SLC9B1	0.13	0.23	enet	24	0.24	4.4e-29	-5.4	5.5	4.1e-08	-0.93	0.04	0.96	FALSE
2	GTEx	Adrenal Gland	CISD2	0.08	0.03	lasso	2	0.03	4.1e-02	-5.4	5.5	4.5e-08	-0.94	0.05	0.87	FALSE
3	GTEx	Artery Aorta	UBE2D3	0.07	0.06	lasso	5	0.04	3.5e-03	-5.4	5.3	8.9e-08	-0.97	0.05	0.92	FALSE
4	GTEx	Artery Aorta	CISD2	0.10	0.08	lasso	4	0.06	1.8e-04	-5.2	5.3	1.3e-07	-0.99	0.05	0.95	FALSE
5	GTEx	Artery Tibial	CISD2	0.11	0.12	lasso	4	0.10	3.1e-08	-5.4	5.2	1.6e-07	-0.98	0.05	0.95	FALSE
6	GTEx	Brain Cerebellum	CISD2	0.13	0.18	lasso	3	0.17	1.1e-05	-5.4	5.3	1.1e-07	-0.98	0.05	0.94	FALSE
7	GTEx	Cells Transformed fibroblasts	UBE2D3	0.11	0.09	enet	13	0.08	2.3e-06	-5.2	5.2	1.9e-07	-0.99	0.05	0.95	FALSE
8	GTEx	Cells Transformed fibroblasts	CISD2	0.16	0.17	enet	12	0.13	9.7e-10	-5.4	5.2	1.8e-07	-0.96	0.05	0.95	FALSE
9	GTEx	Colon Sigmoid	CISD2	0.20	0.24	enet	15	0.13	2.1e-05	-5.2	5.3	9.4e-08	-0.95	0.05	0.95	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	CISD2	0.10	0.05	enet	6	0.04	1.6e-02	5.3	5.3	1.1e-07	-0.98	0.05	0.84	FALSE
11	GTEx	Esophagus Mucosa	CISD2	0.12	0.06	enet	13	0.05	2.1e-04	-5.3	5.3	1.0e-07	-0.98	0.05	0.95	FALSE
12	GTEx	Esophagus Muscularis	CISD2	0.19	0.22	enet	25	0.21	6.2e-13	-5.3	5.4	6.3e-08	-0.94	0.05	0.95	FALSE
13	GTEx	Ovary	CISD2	0.12	0.12	lasso	4	0.07	6.9e-03	-5.4	5.5	4.0e-08	-0.96	0.05	0.78	TRUE
14	GTEx	Pancreas	UBE2D3	0.13	0.09	enet	12	0.12	6.7e-06	-4.5	5.2	1.8e-07	-0.88	0.05	0.95	FALSE
15	GTEx	Skin Sun Exposed Lower leg	CISD2	0.12	0.20	lasso	14	0.20	1.1e-16	-5.2	5.3	1.1e-07	-0.99	0.05	0.95	FALSE
16	GTEx	Thyroid	CISD2	0.12	0.07	lasso	3	0.05	8.8e-05	-5.4	5.5	5.0e-08	-0.97	0.04	0.96	FALSE
17	GTEx	Uterus	CISD2	0.34	0.22	enet	25	0.19	8.9e-05	-5.4	5.4	7.3e-08	-0.92	0.05	0.91	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	UBE2D3	0.05	0.06	blup	337	0.07	5.0e-09	-5.4	5.3	1.3e-07	-0.95	0.04	0.96	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	CISD2	0.15	0.34	lasso	9	0.34	1.2e-44	-5.4	5.4	6.0e-08	-0.98	0.05	0.95	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	RP11-10L12.4	0.08	0.10	lasso	7	0.09	5.1e-12	-5.2	5.2	2.4e-07	-0.98	0.04	0.96	FALSE
21	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CISD2	0.05	0.01	blup	18	0.06	1.9e-03	-5.1	5.3	9.2e-08	-0.98	0.01	0.68	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	UBE2D3	0.03	0.04	enet	11	0.03	1.4e-04	-5.2	5.2	1.6e-07	-0.97	0.02	0.97	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	CISD2	0.05	0.08	enet	5	0.06	1.9e-06	-5.2	5.2	2.1e-07	-0.97	0.01	0.99	FALSE