Best TWAS P=7.43e-28 · Best GWAS P=6.15e-24 conditioned to 0.187
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | CCDC171 | 0.18 | 0.05 | lasso | 5 | 0.08 | 2.2e-05 | -4.3 | -6.0 | 1.7e-09 | 0.32 | 0.33 | 0.08 | FALSE |
2 | GTEx | Artery Tibial | CCDC171 | 0.10 | 0.09 | enet | 9 | 0.12 | 7.2e-10 | 5.1 | -7.0 | 2.4e-12 | 0.62 | 0.82 | 0.18 | FALSE |
3 | GTEx | Artery Tibial | RP11-408A13.4 | 0.22 | 0.08 | lasso | 10 | 0.12 | 1.0e-09 | 4.8 | 5.7 | 1.2e-08 | 0.00 | 0.93 | 0.07 | FALSE |
4 | GTEx | Brain Caudate basal ganglia | CCDC171 | 0.30 | 0.18 | lasso | 4 | 0.23 | 2.4e-07 | 9.4 | -9.9 | 4.1e-23 | 0.96 | 0.09 | 0.91 | FALSE |
5 | GTEx | Brain Caudate basal ganglia | RP11-408A13.4 | 0.30 | 0.17 | lasso | 9 | 0.16 | 2.5e-05 | 5.5 | 6.0 | 1.4e-09 | 0.03 | 0.21 | 0.11 | TRUE |
6 | GTEx | Brain Cerebellar Hemisphere | CCDC171 | 0.46 | 0.19 | lasso | 7 | 0.23 | 1.3e-06 | -9.5 | -10.9 | 7.4e-28 | 0.88 | 0.19 | 0.77 | TRUE |
7 | GTEx | Brain Cerebellar Hemisphere | RP11-408A13.4 | 0.71 | 0.05 | lasso | 20 | 0.13 | 4.0e-04 | 4.8 | 5.5 | 4.2e-08 | 0.04 | 0.13 | 0.12 | FALSE |
8 | GTEx | Brain Cerebellum | CCDC171 | 0.46 | 0.22 | lasso | 7 | 0.15 | 3.4e-05 | -10.0 | -10.1 | 5.5e-24 | 0.97 | 0.06 | 0.93 | FALSE |
9 | GTEx | Brain Cortex | CCDC171 | 0.26 | 0.15 | lasso | 2 | 0.16 | 2.8e-05 | -7.9 | -9.1 | 6.4e-20 | 0.91 | 0.16 | 0.75 | FALSE |
10 | GTEx | Brain Frontal Cortex BA9 | CCDC171 | 0.27 | 0.18 | enet | 10 | 0.19 | 8.3e-06 | 9.2 | -9.2 | 2.7e-20 | 0.86 | 0.09 | 0.84 | FALSE |
11 | GTEx | Brain Hypothalamus | CCDC171 | 0.32 | 0.17 | enet | 6 | 0.09 | 4.0e-03 | -9.5 | -8.4 | 6.5e-17 | 0.88 | 0.12 | 0.58 | FALSE |
12 | GTEx | Breast Mammary Tissue | CCDC171 | 0.21 | 0.01 | lasso | 5 | 0.03 | 1.5e-02 | 8.2 | -5.9 | 3.8e-09 | 0.55 | 0.36 | 0.21 | FALSE |
13 | GTEx | Esophagus Gastroesophageal Junction | RP11-408A13.4 | 0.30 | 0.16 | lasso | 3 | 0.09 | 3.1e-04 | 5.4 | 5.3 | 9.6e-08 | 0.01 | 0.24 | 0.17 | FALSE |
14 | GTEx | Lung | CCDC171 | 0.13 | 0.03 | enet | 9 | 0.01 | 5.0e-02 | 5.3 | -7.4 | 1.1e-13 | 0.71 | 0.34 | 0.46 | FALSE |
15 | GTEx | Nerve Tibial | CCDC171 | 0.25 | 0.16 | lasso | 6 | 0.14 | 2.1e-10 | -9.4 | -9.5 | 1.7e-21 | 0.95 | 0.27 | 0.73 | FALSE |
16 | GTEx | Ovary | CCDC171 | 0.21 | 0.19 | lasso | 4 | 0.16 | 7.7e-05 | 8.8 | 8.4 | 3.5e-17 | -0.89 | 0.11 | 0.66 | FALSE |
17 | GTEx | Pituitary | CCDC171 | 0.28 | 0.16 | enet | 29 | 0.12 | 5.2e-04 | 8.6 | -9.3 | 1.2e-20 | 0.90 | 0.25 | 0.66 | FALSE |
18 | GTEx | Prostate | RP11-408A13.4 | 0.30 | 0.03 | lasso | 7 | 0.05 | 2.1e-02 | 4.5 | 5.5 | 3.7e-08 | 0.02 | 0.15 | 0.10 | FALSE |
19 | GTEx | Skin Not Sun Exposed Suprapubic | CCDC171 | 0.20 | 0.04 | enet | 45 | 0.06 | 4.9e-04 | 9.0 | -5.5 | 3.1e-08 | 0.41 | 0.65 | 0.24 | FALSE |
20 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-408A13.4 | 0.26 | 0.05 | lasso | 6 | 0.10 | 6.4e-06 | 4.8 | 5.2 | 2.2e-07 | 0.00 | 0.87 | 0.06 | FALSE |
21 | GTEx | Skin Sun Exposed Lower leg | CCDC171 | 0.14 | 0.09 | enet | 13 | 0.12 | 1.9e-10 | 8.8 | -6.8 | 1.0e-11 | 0.65 | 0.96 | 0.04 | FALSE |
22 | GTEx | Stomach | RP11-408A13.4 | 0.32 | 0.26 | lasso | 7 | 0.25 | 3.1e-12 | 4.8 | 5.1 | 2.9e-07 | 0.00 | 0.95 | 0.05 | FALSE |
23 | METSIM | Adipose | CCDC171 | 0.03 | 0.00 | blup | 828 | 0.01 | 4.0e-02 | 9.1 | -8.1 | 6.3e-16 | 0.80 | 0.20 | 0.58 | FALSE |
24 | ROSMAP | Brain Pre-frontal Cortex | CCDC171 | 0.14 | 0.11 | enet | 21 | 0.11 | 8.3e-14 | 9.5 | -8.7 | 4.1e-18 | 0.84 | 0.78 | 0.22 | FALSE |
25 | The Cancer Genome Atlas | Soft Tissue Sarcoma | C9orf93 | 0.06 | 0.05 | lasso | 3 | 0.03 | 5.3e-03 | 8.2 | -7.3 | 3.9e-13 | 0.69 | 0.13 | 0.28 | FALSE |