Best TWAS P=6.18e-10 · Best GWAS P=1.66e-10 conditioned to 0.044
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | RPP25L | 0.10 | 0.09 | enet | 10 | 0.05 | 8.5e-04 | -4.6 | -5.4 | 5.6e-08 | -0.32 | 0.73 | 0.09 | FALSE |
| 2 | GTEx | Brain Caudate basal ganglia | RPP25L | 0.17 | 0.02 | lasso | 7 | 0.00 | 3.5e-01 | -4.5 | -5.7 | 1.5e-08 | -0.41 | 0.10 | 0.28 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | UBE2R2 | 0.14 | 0.05 | enet | 28 | 0.15 | 1.2e-11 | -6.1 | 6.2 | 6.2e-10 | 0.54 | 0.03 | 0.97 | TRUE |
| 4 | GTEx | Nerve Tibial | DCAF12 | 0.08 | 0.01 | enet | 17 | 0.02 | 2.3e-02 | 6.4 | 5.9 | 3.0e-09 | 0.72 | 0.01 | 0.91 | FALSE |
| 5 | METSIM | Adipose | UBE2R2 | 0.03 | 0.00 | bslmm | 347 | 0.00 | 9.7e-02 | -6.2 | 6.0 | 1.6e-09 | 0.43 | 0.03 | 0.94 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | UBE2R2 | 0.22 | 0.20 | bslmm | 338 | 0.21 | 1.9e-26 | -5.9 | 6.0 | 2.4e-09 | 0.44 | 0.02 | 0.98 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | RPP25L | 0.12 | 0.09 | enet | 20 | 0.12 | 1.0e-14 | -3.4 | -5.2 | 1.8e-07 | -0.46 | 1.00 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | UBE2R2 | 0.04 | 0.01 | blup | 57 | 0.02 | 1.3e-03 | -4.6 | 5.6 | 1.8e-08 | 0.48 | 0.04 | 0.69 | FALSE |