Best TWAS P=6.89e-09 · Best GWAS P=7.94e-09 conditioned to 0.00195
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PSMB7 | 0.08 | 0.04 | lasso | 6 | 0.04 | 3.4e-04 | 4.3 | -5.5 | 5.2e-08 | -0.84 | 0.02 | 0.97 | FALSE |
| 2 | GTEx | Artery Aorta | PSMB7 | 0.15 | 0.03 | enet | 16 | 0.05 | 1.4e-03 | -4.9 | -5.8 | 6.9e-09 | -0.55 | 0.07 | 0.66 | TRUE |
| 3 | GTEx | Breast Mammary Tissue | PSMB7 | 0.11 | 0.03 | lasso | 7 | 0.04 | 4.7e-03 | 5.8 | -5.8 | 7.7e-09 | -0.98 | 0.01 | 0.96 | FALSE |
| 4 | GTEx | Colon Transverse | PSMB7 | 0.13 | 0.02 | lasso | 3 | 0.03 | 1.8e-02 | 5.8 | -5.1 | 2.9e-07 | -0.90 | 0.01 | 0.93 | FALSE |
| 5 | GTEx | Thyroid | NEK6 | 0.20 | 0.21 | lasso | 4 | 0.20 | 1.3e-15 | 4.7 | -5.2 | 2.1e-07 | -0.78 | 0.23 | 0.76 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PSMB7 | 0.03 | 0.04 | lasso | 4 | 0.04 | 1.2e-04 | 5.3 | -5.2 | 2.0e-07 | -0.78 | 0.03 | 0.94 | FALSE |