Best TWAS P=9.49e-14 · Best GWAS P=6.02e-13 conditioned to 0.206
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | URM1 | 0.14 | 0.08 | lasso | 3 | 0.10 | 9.7e-06 | 4.0 | -5.5 | 4.9e-08 | -0.63 | 0.02 | 0.97 | FALSE |
2 | GTEx | Artery Coronary | URM1 | 0.28 | 0.06 | lasso | 3 | 0.07 | 2.2e-03 | 3.9 | -5.4 | 5.4e-08 | -0.67 | 0.01 | 0.91 | FALSE |
3 | GTEx | Artery Coronary | RP11-339B21.14 | 0.14 | 0.05 | lasso | 6 | 0.07 | 3.0e-03 | 6.7 | -6.8 | 1.0e-11 | -0.93 | 0.01 | 0.93 | FALSE |
4 | GTEx | Brain Caudate basal ganglia | PKN3 | 0.26 | 0.00 | lasso | 10 | 0.04 | 2.4e-02 | 4.4 | -5.4 | 8.2e-08 | -0.41 | 0.06 | 0.16 | FALSE |
5 | GTEx | Brain Caudate basal ganglia | RP11-339B21.15 | 0.30 | 0.02 | lasso | 6 | 0.01 | 1.7e-01 | -3.0 | -5.6 | 2.4e-08 | -0.36 | 0.03 | 0.17 | TRUE |
6 | GTEx | Brain Cerebellar Hemisphere | RP11-395P17.3 | 0.32 | 0.03 | lasso | 4 | 0.06 | 1.1e-02 | 4.1 | 5.5 | 4.2e-08 | 0.46 | 0.05 | 0.12 | TRUE |
7 | GTEx | Brain Cerebellum | URM1 | 0.34 | 0.09 | lasso | 5 | 0.13 | 1.3e-04 | 3.9 | -5.9 | 4.0e-09 | -0.79 | 0.01 | 0.94 | TRUE |
8 | GTEx | Cells EBV-transformed lymphocytes | URM1 | 0.35 | 0.19 | lasso | 6 | 0.22 | 8.0e-08 | 5.5 | -6.0 | 2.4e-09 | -0.62 | 0.07 | 0.84 | FALSE |
9 | GTEx | Cells Transformed fibroblasts | URM1 | 0.23 | 0.07 | lasso | 4 | 0.10 | 2.8e-08 | 5.5 | -5.3 | 1.1e-07 | -0.63 | 0.16 | 0.84 | FALSE |
10 | GTEx | Cells Transformed fibroblasts | RP11-339B21.14 | 0.19 | 0.12 | lasso | 8 | 0.12 | 6.3e-09 | 7.0 | -6.9 | 4.1e-12 | -0.88 | 0.00 | 1.00 | FALSE |
11 | GTEx | Esophagus Mucosa | TRUB2 | 0.12 | 0.05 | lasso | 3 | 0.03 | 2.7e-03 | 5.9 | -6.1 | 1.1e-09 | -0.76 | 0.15 | 0.79 | FALSE |
12 | GTEx | Esophagus Mucosa | URM1 | 0.12 | 0.04 | lasso | 2 | 0.05 | 2.8e-04 | 6.7 | -6.3 | 2.2e-10 | -0.87 | 0.01 | 0.98 | FALSE |
13 | GTEx | Esophagus Mucosa | RP11-339B21.15 | 0.09 | 0.02 | enet | 4 | 0.02 | 2.9e-02 | 2.3 | -5.2 | 2.3e-07 | -0.55 | 0.02 | 0.83 | FALSE |
14 | GTEx | Esophagus Mucosa | RP11-339B21.14 | 0.16 | 0.03 | lasso | 7 | 0.01 | 4.1e-02 | 7.0 | -7.0 | 3.1e-12 | -0.85 | 0.00 | 1.00 | FALSE |
15 | GTEx | Esophagus Muscularis | URM1 | 0.20 | 0.09 | lasso | 7 | 0.10 | 2.2e-06 | 3.2 | -5.7 | 9.6e-09 | -0.60 | 0.07 | 0.92 | FALSE |
16 | GTEx | Heart Left Ventricle | RP11-339B21.15 | 0.21 | 0.11 | lasso | 8 | 0.10 | 4.9e-06 | 5.9 | -5.9 | 2.9e-09 | -0.73 | 0.28 | 0.70 | FALSE |
17 | GTEx | Muscle Skeletal | RP11-339B21.15 | 0.05 | 0.03 | lasso | 2 | 0.04 | 3.1e-05 | 5.9 | -5.3 | 1.0e-07 | -0.66 | 0.05 | 0.83 | FALSE |
18 | GTEx | Muscle Skeletal | RP11-339B21.14 | 0.06 | 0.04 | lasso | 3 | 0.03 | 7.1e-04 | 5.5 | -6.0 | 2.7e-09 | -0.72 | 0.03 | 0.92 | FALSE |
19 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-339B21.15 | 0.13 | 0.04 | lasso | 5 | 0.07 | 1.8e-04 | 7.0 | -6.6 | 5.3e-11 | -0.82 | 0.00 | 0.99 | FALSE |
20 | GTEx | Skin Sun Exposed Lower leg | URM1 | 0.15 | 0.05 | enet | 9 | 0.11 | 1.7e-09 | 3.2 | -6.0 | 2.3e-09 | -0.71 | 0.00 | 1.00 | FALSE |
21 | GTEx | Spleen | URM1 | 0.39 | 0.17 | lasso | 6 | 0.16 | 8.2e-05 | 3.2 | -5.3 | 1.4e-07 | -0.60 | 0.14 | 0.32 | FALSE |
22 | GTEx | Stomach | RP11-339B21.14 | 0.11 | 0.04 | lasso | 6 | 0.05 | 1.7e-03 | 5.8 | -6.2 | 4.3e-10 | -0.73 | 0.01 | 0.91 | FALSE |
23 | GTEx | Testis | SLC27A4 | 0.60 | 0.39 | enet | 27 | 0.45 | 4.1e-22 | 5.9 | -5.7 | 1.6e-08 | -0.74 | 0.55 | 0.45 | FALSE |
24 | GTEx | Thyroid | CERCAM | 0.37 | 0.05 | lasso | 9 | 0.08 | 9.0e-07 | 7.0 | 6.5 | 9.3e-11 | 0.71 | 0.00 | 1.00 | FALSE |
25 | GTEx | Thyroid | RP11-339B21.13 | 0.11 | 0.00 | enet | 17 | 0.00 | 1.7e-01 | 4.1 | 7.5 | 9.5e-14 | 0.59 | 0.07 | 0.59 | TRUE |
26 | GTEx | Thyroid | RP11-339B21.15 | 0.12 | 0.08 | lasso | 4 | 0.06 | 1.7e-05 | 5.9 | -6.1 | 9.4e-10 | -0.76 | 0.02 | 0.97 | FALSE |
27 | METSIM | Adipose | CERCAM | 0.02 | 0.00 | blup | 288 | 0.02 | 1.2e-03 | 4.1 | 6.0 | 2.0e-09 | 0.57 | 0.13 | 0.37 | FALSE |
28 | METSIM | Adipose | RP11-339B21.14 | 0.05 | 0.05 | enet | 6 | 0.04 | 8.0e-07 | 6.7 | -6.5 | 6.1e-11 | -0.92 | 0.00 | 1.00 | FALSE |
29 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | URM1 | 0.08 | 0.05 | blup | 34 | 0.05 | 2.9e-06 | 4.1 | -5.2 | 2.1e-07 | -0.63 | 0.72 | 0.13 | FALSE |
30 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SLC27A4 | 0.02 | 0.02 | lasso | 2 | 0.02 | 5.2e-03 | 5.9 | 5.6 | 1.8e-08 | 0.71 | 0.02 | 0.61 | FALSE |
31 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | URM1 | 0.10 | 0.03 | blup | 31 | 0.04 | 1.3e-02 | 5.9 | -5.5 | 4.0e-08 | -0.67 | 0.00 | 0.72 | FALSE |