Best TWAS P=4.74e-10 · Best GWAS P=4.24e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | ZNF605 | 0.23 | 0.07 | lasso | 9 | 0.06 | 4.5e-03 | 6.2 | 6.2 | 4.7e-10 | 0.95 | 0.01 | 0.96 | TRUE |
| 2 | GTEx | Artery Tibial | ZNF605 | 0.20 | 0.14 | enet | 22 | 0.17 | 1.3e-13 | 4.0 | 5.3 | 1.2e-07 | 0.79 | 0.05 | 0.95 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | ANKLE2 | 0.11 | 0.01 | enet | 17 | 0.06 | 7.4e-03 | 4.9 | 5.3 | 1.4e-07 | 0.67 | 0.02 | 0.50 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | POLE | 0.38 | 0.17 | lasso | 5 | 0.28 | 6.9e-10 | 4.0 | -5.3 | 8.8e-08 | -0.26 | 0.64 | 0.15 | TRUE |
| 5 | GTEx | Colon Sigmoid | ZNF605 | 0.14 | -0.01 | lasso | 4 | 0.01 | 1.8e-01 | 4.9 | 5.2 | 2.2e-07 | 0.75 | 0.02 | 0.63 | FALSE |
| 6 | GTEx | Muscle Skeletal | ANKLE2 | 0.06 | 0.01 | enet | 17 | 0.03 | 8.8e-04 | 6.2 | 5.8 | 5.2e-09 | 0.74 | 0.00 | 0.96 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ANKLE2 | 0.04 | 0.02 | lasso | 2 | 0.02 | 5.8e-06 | 6.0 | 5.8 | 5.6e-09 | 0.96 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | ANKLE2 | 0.20 | 0.02 | blup | 49 | 0.08 | 6.2e-05 | 4.9 | 5.2 | 2.3e-07 | 0.73 | 0.01 | 0.83 | FALSE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ANKLE2 | 0.15 | 0.05 | enet | 12 | 0.06 | 1.6e-07 | 4.9 | 5.3 | 1.3e-07 | 0.66 | 0.00 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Lung Adenocarcinoma | ANKLE2 | 0.13 | 0.02 | blup | 49 | 0.06 | 7.2e-08 | -2.6 | 5.2 | 2.4e-07 | 0.64 | 0.13 | 0.82 | FALSE |