TWAS hub - POLE

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3030	0.0380	0.0e+00	0.572	0.548	0.574	0.576	0.582	3.5e-85	6.3e-80	1.3e-85	4e-86	1.6e-87
2	GTEx	Brain Caudate basal ganglia	0.2730	0.0800	3.2e-06	0.118	NA	0.101	NA	0.207	2.9e-04	NA	7.7e-04	NA	1.3e-06
3	GTEx	Brain Cerebellar Hemisphere	0.3710	0.0750	5.9e-11	0.475	NA	0.461	NA	0.490	6.8e-14	NA	2.1e-13	NA	1.9e-14
4	GTEx	Brain Cortex	0.3550	0.0700	4.3e-11	0.467	NA	0.443	NA	0.469	1.5e-14	NA	1.1e-13	NA	1.2e-14
5	GTEx	Brain Frontal Cortex BA9	0.2928	0.0880	1.0e-06	0.275	NA	0.150	NA	0.220	5.7e-08	NA	9.0e-05	NA	1.7e-06
6	GTEx	Brain Nucleus accumbens basal ganglia	0.3060	0.0800	2.3e-06	0.289	NA	0.241	NA	0.277	1.9e-08	NA	4.0e-07	NA	4.2e-08
7	GTEx	Cells EBV-transformed lymphocytes	0.3800	0.0920	5.6e-06	0.169	NA	0.252	NA	0.285	3.6e-06	NA	8.6e-09	NA	6.9e-10
8	GTEx	Muscle Skeletal	0.0891	0.0246	5.8e-10	0.100	NA	0.106	NA	0.090	5.5e-10	NA	1.4e-10	NA	4.2e-09
9	GTEx	Nerve Tibial	0.1943	0.0529	5.7e-10	0.105	NA	0.154	NA	0.153	7.0e-08	NA	5.2e-11	NA	6.1e-11
10	GTEx	Skin Not Sun Exposed Suprapubic	0.0870	0.0430	8.9e-03	0.120	NA	0.111	NA	0.116	4.4e-07	NA	1.2e-06	NA	6.5e-07
11	GTEx	Skin Sun Exposed Lower leg	0.0670	0.0290	2.1e-03	0.030	NA	0.050	NA	0.047	1.4e-03	NA	5.1e-05	NA	8.7e-05
12	GTEx	Spleen	0.2200	0.0940	4.3e-03	0.000	NA	0.009	NA	0.029	3.2e-01	NA	1.8e-01	NA	6.2e-02
13	GTEx	Thyroid	0.0360	0.0180	9.5e-03	0.038	NA	0.040	NA	0.038	6.4e-04	NA	5.0e-04	NA	6.7e-04
14	TCGA	Breast Invasive Carcinoma	0.0429	0.0182	8.1e-05	0.003	0.019	0.021	NA	0.021	6.4e-02	6.6e-05	2.9e-05	NA	2.9e-05
15	TCGA	Head and Neck Squamous Cell Carcinoma	0.0508	0.0265	1.1e-04	0.019	0.035	0.040	NA	0.036	2.6e-03	7.6e-05	2.5e-05	NA	5.4e-05
16	TCGA	Ovarian Serous Cystadenocarcinoma	0.0790	0.0410	1.8e-04	0.071	0.060	0.066	NA	0.076	1.5e-05	6.5e-05	3.0e-05	NA	7.3e-06
17	TCGA	Stomach Adenocarcinoma	0.1550	0.0590	3.0e-05	0.081	0.050	0.050	NA	0.066	1.9e-06	1.6e-04	1.6e-04	NA	1.5e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17
Migraine (self-reported)	5.0	6.2	8.6	-2.8	-2.6	-2.7	-2.6	-2.6	-2.7	-1.4	-2.6	2.6	2.5	2.5	1.8	2.7	-2.3	-2.9	-2.6	-2.2
Mineral and other dietary supplements	4.6	6.2	10.3	-2.1	-2.1	-2.2	-2.2	-1.9	-2.2	-1.7	-2.3	2.6	3.2	2.7	2.5	2.1	-2.8	-3.1	-3.0	-2.7
Pain experienced in last month	4.1	6.8	10.6	2.3	2.6	2.4	2.5	2.7	2.4	2.4	2.8	-2.9	-2.8	-3.0	-3.3	-2.8	1.2	3.0	2.7	2.1
Supplements: Calcium	4.0	4.4	7.7	1.9	1.5	1.8	1.8	1.6	1.7	1.7	2.0	-2.5	-2.7	-2.2	-1.4	-1.9	2.5	2.8	2.4	2.6
Chest pain or discomfort	3.8	5.5	8.8	-2.5	-2.4	-2.7	-2.6	-3.0	-2.5	-2.9	-2.5	2.5	2.2	1.6	1.3	2.7	-1.6	-2.7	-1.8	-1.7
Impedance of arm (left)	3.7	17.2	24.3	3.9	3.8	4.2	4.4	4.2	3.9	4.9	4.7	-4.8	-4.6	-3.6	-3.7	-4.5	2.2	4.5	4.6	3.1
Supplements: Fish oil (including cod liver oil)	3.6	4.6	6.8	2.2	2.2	2.2	2.3	1.9	2.2	1.2	2.2	-2.1	-2.4	-1.9	-1.9	-2.1	2.5	2.6	2.2	2.1
Ovarian Cancer	3.4	4.6	9.9	-1.9	-1.6	-2.0	-2.2	-2.1	-1.8	-3.1	-1.8	2.5	2.4	1.6	1.6	1.9	-2.4	-2.6	-1.7	-2.4
Age at First Birth	3.2	4.7	10.3	1.4	1.0	1.6	1.5	1.6	1.4	2.5	2.2	-2.4	-2.8	-2.8	-3.2	-1.9	1.6	2.1	2.8	2.5
Impedance of arm (right)	3.2	15.1	22.3	3.6	3.6	3.8	4.1	3.9	3.6	4.7	4.2	-4.6	-4.3	-3.5	-3.2	-4.1	2.4	4.3	4.2	3.2
Angina	3.1	4.1	7.7	-2.5	-2.4	-2.5	-2.5	-2.8	-2.4	-1.5	-2.1	2.0	1.3	1.1	2.1	2.3	-1.6	-2.1	-1.0	-0.6
Angina (self-reported)	3.1	4.1	7.8	-2.6	-2.4	-2.5	-2.5	-2.8	-2.5	-1.3	-2.1	2.0	1.2	1.0	2.1	2.3	-1.6	-2.1	-1.0	-0.5
Medication: Paracetamol	3.1	4.8	14.2	-0.6	-0.5	-0.9	-0.9	-1.1	-0.6	-3.3	-2.0	2.5	3.1	3.5	3.8	1.5	-0.2	-2.0	-3.1	-2.3
Impedance of whole body	3.1	15.8	30.2	3.6	3.7	3.8	4.1	4.1	3.6	5.5	3.9	-4.8	-4.4	-3.1	-3.0	-4.0	2.8	4.5	4.0	3.7
Age when periods started (menarche)	3.0	7.3	11.4	2.6	2.2	2.7	2.9	3.0	2.7	3.3	3.4	-2.9	-2.6	-2.1	-3.4	-3.1	0.7	2.9	2.5	1.5
Qualifications: NVQ or HND or HNC or equivalent	3.0	3.6	6.6	-2.3	-2.0	-2.4	-2.5	-2.4	-2.4	-0.8	-2.6	1.6	1.2	1.0	1.8	2.6	-0.5	-1.8	-1.2	-0.1
Frequency of tiredness / lethargy in last 2 weeks	2.9	4.8	9.9	-1.6	-1.6	-1.7	-1.9	-1.6	-1.5	-3.1	-2.1	2.4	2.8	2.7	1.4	2.1	-1.8	-2.5	-2.6	-2.7
Pulse wave Arterial Stiffness index	2.9	3.4	6.2	-2.3	-2.2	-2.4	-2.1	-2.5	-2.2	-1.3	-1.8	2.2	1.4	0.6	1.7	2.3	-1.1	-2.1	-1.1	-0.5
Number of full brothers	2.9	3.7	6.7	-2.1	-2.2	-2.2	-2.6	-2.3	-2.3	-1.6	-2.3	1.8	1.2	1.2	2.3	2.3	-0.1	-1.9	-1.4	-0.1
Eye problems/disorders: None of the above	2.9	3.3	6.8	2.0	1.8	1.8	1.9	1.7	1.9	1.5	1.5	-2.0	-1.8	-1.2	-1.1	-1.8	2.6	2.3	1.1	2.1
Heart attack/myocardial infarction (self-reported)	2.9	3.7	6.8	-2.5	-2.6	-2.4	-2.5	-2.3	-2.4	-0.8	-2.3	1.9	1.2	0.9	1.5	2.2	-1.4	-2.2	-1.5	-0.3
Body Mass Index (BMI) (2010)	2.8	3.8	9.8	-1.2	-1.1	-1.4	-1.3	-1.3	-1.2	-3.1	-1.9	2.6	2.6	2.5	2.0	1.7	-0.9	-2.1	-2.4	-2.0
Loud music exposure frequency	2.8	3.1	6.7	-1.0	-0.8	-1.1	-1.1	-1.1	-0.9	-2.6	-1.9	2.1	2.3	2.5	1.6	1.7	-0.3	-1.6	-2.6	-2.4
Headache pain in last month	2.8	4.8	9.4	-1.8	-1.9	-2.0	-2.2	-2.1	-1.8	-3.1	-2.6	2.4	2.4	2.6	1.9	2.4	-0.6	-2.3	-2.3	-2.0
Risk taking	2.8	4.0	7.0	2.4	2.2	2.3	2.3	2.3	2.3	1.2	2.3	-2.3	-1.8	-1.2	-1.2	-2.7	1.3	2.2	1.5	1.4
Leg fat mass (right)	2.7	10.4	21.8	-2.2	-2.1	-2.4	-2.6	-2.4	-2.2	-4.7	-3.1	4.2	4.3	3.8	2.9	2.8	-2.3	-3.9	-3.8	-3.4
Waist circumference	2.6	9.7	18.6	-2.5	-2.4	-2.5	-2.7	-2.8	-2.4	-4.3	-2.9	4.0	3.9	3.2	2.6	2.8	-2.5	-3.6	-3.3	-3.3
Fluid intelligence score	2.6	5.5	8.2	2.3	2.4	2.5	2.6	2.5	2.4	1.8	2.9	-2.6	-2.2	-1.6	-2.8	-2.6	1.2	2.8	2.6	1.2
Medication: Paracetamol	2.6	4.2	12.5	-0.4	-0.1	-0.7	-0.7	-1.0	-0.4	-3.0	-2.0	2.0	2.9	3.5	3.4	1.4	-0.0	-1.7	-3.2	-2.3
Time employed in main current job	2.5	2.9	6.4	2.4	2.0	2.5	2.5	2.5	2.4	1.2	1.9	-1.3	-0.4	0.0	-0.2	-2.1	0.8	1.4	0.3	0.3
Leg fat mass (left)	2.5	9.7	20.4	-2.2	-2.1	-2.3	-2.5	-2.4	-2.2	-4.5	-3.0	4.1	4.1	3.6	2.7	2.8	-2.1	-3.7	-3.7	-3.2
Arm predicted mass (left)	2.5	12.8	17.6	-3.6	-3.6	-3.7	-4.0	-3.8	-3.6	-4.2	-3.7	4.1	3.8	3.0	2.4	3.8	-2.8	-4.0	-3.4	-3.0
Frequency of depressed mood in last 2 weeks	2.4	3.4	6.3	-1.4	-1.3	-1.6	-1.4	-1.4	-1.3	-1.9	-1.8	1.9	2.4	2.2	1.0	1.8	-2.0	-2.1	-2.3	-2.5
Arm fat-free mass (right)	2.4	12.4	16.8	-3.6	-3.5	-3.6	-3.9	-3.7	-3.5	-4.0	-3.5	4.1	3.7	3.0	2.3	3.6	-3.0	-4.1	-3.2	-3.1
Arm predicted mass (right)	2.4	12.4	17.1	-3.6	-3.5	-3.6	-3.9	-3.7	-3.5	-4.1	-3.5	4.1	3.7	2.9	2.2	3.6	-3.0	-4.0	-3.2	-3.0
Length of working week for main job	2.3	2.5	4.2	2.0	1.9	2.0	1.9	1.9	2.0	1.0	1.6	-1.6	-1.0	-0.6	-0.7	-1.9	1.8	1.8	0.6	1.1
Arm fat-free mass (left)	2.3	11.5	16.1	-3.4	-3.3	-3.4	-3.7	-3.5	-3.3	-4.0	-3.5	4.0	3.6	2.9	2.4	3.5	-2.6	-3.8	-3.2	-2.9
Ulcerative Colitis (UC)	2.2	4.1	7.6	1.4	1.5	1.6	1.5	1.6	1.5	2.1	1.9	-2.7	-2.7	-2.8	-1.5	-1.8	1.7	2.2	2.5	2.4
Trunk fat-free mass	2.2	12.4	16.6	-3.8	-3.8	-3.8	-4.1	-4.0	-3.8	-3.7	-3.5	3.9	3.5	2.6	2.0	3.7	-3.2	-4.0	-3.0	-3.0
Pulse wave peak to peak time	2.2	2.6	4.6	1.9	1.9	2.0	1.7	2.1	1.9	1.2	1.6	-2.0	-1.2	-0.4	-1.6	-2.0	0.8	1.8	1.0	0.4
Eye problems/disorders: Cataract	2.2	2.5	3.9	-1.9	-1.9	-1.7	-1.7	-1.9	-1.9	-0.9	-1.3	1.7	1.4	0.9	0.6	1.7	-1.9	-2.0	-1.1	-1.6
Basal metabolic rate	2.2	12.1	18.6	-3.5	-3.4	-3.5	-3.8	-3.7	-3.4	-4.3	-3.3	4.0	3.7	2.8	2.1	3.5	-3.0	-4.1	-3.0	-3.1
Body mass index (BMI)	2.1	8.9	23.4	-1.8	-1.9	-2.0	-2.2	-2.2	-1.8	-4.8	-2.7	3.9	4.1	3.4	2.6	2.4	-1.9	-3.5	-3.6	-3.4
Heart attack	2.1	2.7	5.2	-2.2	-2.3	-2.0	-2.2	-2.0	-2.1	-0.5	-1.9	1.5	1.0	0.5	1.2	1.8	-1.2	-1.9	-1.2	-0.1
Whole body fat-free mass	2.1	12.0	16.4	-3.6	-3.6	-3.6	-3.9	-3.8	-3.6	-4.0	-3.3	3.9	3.5	2.6	2.0	3.5	-3.1	-4.0	-2.9	-3.0
Average weekly champagne plus white wine intake	2.1	2.8	7.2	2.5	2.7	2.4	2.3	2.5	2.4	0.0	1.7	-1.5	-0.1	0.6	-1.0	-2.0	0.7	0.9	-0.2	-0.5
Medication: Metformin	2.0	2.9	4.8	-1.5	-1.7	-1.5	-1.7	-1.6	-1.5	-2.2	-1.4	2.0	2.1	1.3	1.3	1.5	-2.0	-1.9	-1.3	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	4.5	-1.4	-1.3	-1.4	-1.3	-1.4	-1.4	-1.7	-1.6	1.9	2.1	1.8	1.0	1.6	-1.5	-1.9	-1.9	-2.1
Trunk predicted mass	2.0	11.6	15.7	-3.7	-3.6	-3.7	-4.0	-3.8	-3.7	-3.6	-3.4	3.7	3.4	2.5	1.9	3.6	-3.1	-3.8	-2.9	-2.9
Qualifications: O levels/GCSEs or equivalent	2.0	3.1	6.6	1.2	1.5	1.3	1.3	1.0	1.1	2.0	1.7	-2.3	-2.4	-2.0	-2.0	-1.7	1.3	1.9	2.6	1.8
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	4.8	-1.2	-0.9	-1.4	-1.3	-1.1	-1.2	-1.3	-1.6	1.3	1.8	2.0	2.2	1.3	-1.3	-1.4	-1.9	-1.1
Whole body water mass	2.0	11.4	16.3	-3.5	-3.5	-3.5	-3.8	-3.7	-3.5	-4.0	-3.2	3.8	3.4	2.5	1.9	3.5	-3.1	-3.9	-2.8	-3.0
Depression (Nagel 2018)	1.9	2.9	8.0	-1.4	-1.3	-1.4	-1.3	-1.2	-1.3	-1.6	-1.4	1.6	2.2	1.8	0.3	1.4	-2.4	-1.8	-1.9	-2.8
Had other major operations	1.9	2.3	4.5	-1.3	-1.4	-1.4	-1.4	-1.8	-1.4	-2.1	-1.1	1.5	1.7	1.3	1.1	1.3	-2.1	-1.6	-0.9	-1.6
Mouth/teeth dental problems	1.9	2.9	5.8	-2.4	-2.3	-2.3	-2.3	-2.2	-2.3	-0.7	-1.8	1.5	0.9	0.4	0.7	1.9	-1.6	-2.0	-0.7	-0.4
Weight	1.9	9.2	18.2	-2.4	-2.4	-2.4	-2.6	-2.7	-2.4	-4.3	-2.6	3.8	3.9	3.2	2.1	2.7	-2.8	-3.7	-3.2	-3.4
Leg fat percentage (right)	1.9	6.7	15.7	-1.4	-1.3	-1.5	-1.7	-1.5	-1.4	-4.0	-2.5	3.5	3.8	3.4	2.7	2.1	-1.4	-2.9	-3.4	-2.8
Medication for pain relief, constipation, heartburn	1.9	3.2	9.4	0.1	0.1	0.2	0.4	0.7	-0.0	3.0	1.5	-1.8	-2.6	-3.1	-3.0	-1.1	-0.3	1.3	2.8	1.7
Knee pain experienced in last month	1.9	2.9	5.6	-1.8	-2.1	-2.0	-1.8	-1.8	-1.8	0.0	-2.4	2.1	1.4	1.4	1.9	2.0	-0.4	-1.6	-1.8	-0.6
Fasting Glucose	1.8	2.1	10.6	-0.4	-0.3	-0.5	-0.4	-0.6	-0.5	-1.0	-1.5	1.3	2.3	2.1	3.3	0.9	-0.4	-1.3	-2.4	-1.0
Ulcerative Colitis	1.8	2.6	5.0	1.2	0.0	1.3	1.2	1.4	1.2	1.7	1.5	-2.0	-2.2	-2.2	-1.3	-1.3	1.3	1.8	2.1	2.1
BMI	1.8	10.2	28.6	-2.4	-2.4	-2.5	-2.7	-2.8	-2.3	-5.3	-2.5	4.0	4.0	3.0	2.2	2.7	-2.9	-3.9	-3.2	-3.8
Leg fat-free mass (left)	1.8	9.7	18.8	-3.0	-2.9	-3.0	-3.3	-3.3	-3.0	-4.3	-2.7	3.7	3.3	2.4	1.8	3.0	-2.8	-3.8	-2.6	-3.0
Leg predicted mass (left)	1.8	9.7	18.4	-3.1	-3.0	-3.1	-3.3	-3.4	-3.0	-4.3	-2.7	3.7	3.3	2.4	1.8	3.0	-2.8	-3.8	-2.5	-3.0
Comparative body size at age 10	1.8	4.9	12.3	-1.6	-1.3	-1.9	-1.9	-1.9	-1.6	-3.5	-2.3	2.6	2.8	2.3	1.8	2.1	-1.7	-2.3	-2.4	-2.3
Neck or shoulder pain in last month	1.8	2.5	8.9	0.7	0.7	0.6	0.7	0.3	0.7	-1.9	-0.1	1.0	2.5	3.0	1.7	-0.1	-1.1	-1.4	-2.5	-2.9
Neuroticism score	1.7	3.5	6.7	-1.7	-1.8	-1.8	-1.7	-1.8	-1.8	-2.1	-1.6	1.9	2.1	1.6	0.3	2.0	-2.4	-2.6	-1.7	-2.3
Hip circumference	1.7	7.4	14.5	-2.3	-2.4	-2.3	-2.5	-2.6	-2.3	-3.8	-2.4	3.6	3.3	2.7	2.0	2.5	-2.1	-3.4	-2.6	-2.7
Pulse wave reflection index	1.7	2.1	3.2	-1.8	-1.6	-1.6	-1.7	-1.8	-1.7	-1.1	-1.4	1.3	1.4	0.6	1.2	1.6	-1.4	-1.7	-1.1	-0.9
Gout (self-reported)	1.7	2.4	4.0	1.5	1.4	1.5	1.8	1.4	1.6	1.1	1.5	-1.4	-1.7	-1.4	-0.6	-1.5	1.8	2.0	1.4	1.9
Mood swings	1.7	3.0	5.7	-1.5	-1.7	-1.7	-1.8	-1.6	-1.5	-2.4	-2.1	1.9	1.9	1.7	1.9	2.0	-0.2	-1.8	-2.0	-1.1
Qualifications: nursing, teaching	1.7	2.6	5.1	2.1	2.0	2.1	2.3	2.2	1.9	1.8	2.0	-1.4	-0.6	0.0	-1.5	-1.9	0.0	1.1	0.6	-0.2
Pain type(s) experienced in last month: Hip pain	1.7	2.1	4.1	-1.9	-1.9	-1.7	-1.8	-1.7	-1.8	-0.4	-1.3	1.5	1.2	0.6	0.3	1.7	-2.0	-1.5	-0.7	-1.1
Neuroticism (2016)	1.6	2.3	7.6	-2.2	-2.8	-1.9	-2.1	-1.8	-2.1	0.1	-1.5	1.2	0.0	-0.5	0.0	1.8	-1.0	-1.4	-0.0	0.3
Average weekly spirits intake	1.6	2.0	4.5	1.0	0.9	1.2	1.3	0.7	1.0	0.9	1.7	-1.3	-1.7	-1.9	-1.6	-1.3	1.3	1.9	2.1	1.5
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	3.2	1.3	1.3	1.3	1.3	1.2	1.3	1.3	1.2	-1.5	-1.6	-1.3	-0.1	-1.3	1.5	1.8	1.6	1.6
Impedance of leg (left)	1.6	8.0	21.5	2.5	2.5	2.5	2.7	2.9	2.4	4.6	2.2	-3.4	-3.1	-1.9	-1.7	-2.6	2.6	3.4	2.4	3.2
Diabetes (self-reported)	1.6	2.5	5.5	-1.4	-1.3	-1.3	-1.5	-1.3	-1.3	-2.4	-1.3	1.7	2.2	1.5	1.0	1.2	-2.0	-1.8	-1.6	-1.6
Medication: Ramipril	1.6	2.0	3.2	1.4	1.2	1.4	1.4	1.0	1.4	0.9	1.8	-1.5	-1.6	-1.4	0.3	-1.5	1.3	1.8	1.8	1.7
Noisy workplace	1.6	2.0	7.8	-0.9	-1.0	-1.1	-1.4	-1.2	-0.8	-2.8	-1.5	1.5	1.5	1.3	1.4	1.4	0.0	-1.8	-1.6	-0.5
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	5.8	-0.6	-0.9	-0.6	-0.8	-0.7	-0.7	-2.0	-1.4	1.8	2.0	2.4	1.1	1.3	-0.8	-1.5	-2.0	-2.0
Arm fat mass (right)	1.6	6.6	16.1	-1.7	-1.7	-1.8	-1.9	-2.0	-1.7	-4.0	-2.2	3.3	3.5	2.9	2.2	2.1	-2.0	-3.1	-2.9	-2.9
Qualifications: College or University degree	1.6	5.1	12.6	2.2	2.3	2.3	2.5	2.5	2.2	2.1	2.9	-2.4	-1.8	-1.9	-3.5	-2.6	-0.1	1.8	2.1	0.5
Overall health rating	1.6	3.4	11.2	-0.4	-0.7	-0.5	-0.5	-0.7	-0.5	-2.3	-1.3	1.9	3.0	3.0	3.3	1.0	-1.2	-1.8	-2.7	-2.0
Average weekly beer plus cider intake	1.6	2.3	7.7	-1.1	-1.1	-1.1	-1.2	-1.0	-1.0	-1.1	-1.6	1.7	1.8	1.9	2.8	1.4	-0.8	-1.4	-2.2	-1.0
Blood Eosinophil Count	1.5	11.7	20.5	4.5	4.3	4.5	4.5	3.9	4.2	1.4	4.4	-3.2	-2.2	-1.6	-1.5	-4.3	2.1	3.9	2.5	1.2
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	3.8	-1.3	-1.4	-1.2	-1.3	-1.0	-1.3	-0.8	-1.2	1.3	1.4	1.1	1.2	1.2	-1.9	-1.4	-0.8	-1.2
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	4.3	-1.1	-0.8	-1.3	-1.2	-1.0	-1.1	-1.7	-1.6	1.2	2.1	1.9	0.7	1.5	-1.7	-2.0	-2.0	-2.0
Happiness	1.5	1.8	3.9	1.8	2.0	1.8	2.0	1.8	1.9	-0.4	1.6	-0.7	0.6	0.8	-0.3	-1.8	-0.8	0.7	-0.3	-1.2
Tense / ‘highly strung’	1.5	2.5	7.6	-1.0	-1.2	-1.2	-1.3	-1.3	-1.0	-2.8	-1.4	1.7	2.1	1.8	1.4	1.4	-1.0	-1.9	-1.9	-1.6
Exposure to tobacco smoke outside home	1.5	2.0	4.3	1.9	1.5	1.9	2.1	1.9	1.9	0.6	1.9	-1.3	-0.5	-0.2	-1.2	-1.7	0.2	1.1	0.5	-0.3
Whole body fat mass	1.5	6.3	13.5	-1.6	-1.6	-1.7	-1.9	-1.8	-1.6	-3.7	-2.1	3.3	3.5	3.0	2.0	2.0	-2.2	-3.1	-2.9	-2.9
Leg fat-free mass (right)	1.5	8.2	15.6	-2.9	-2.9	-2.9	-3.2	-3.2	-2.8	-4.0	-2.6	3.4	2.9	2.1	1.7	2.9	-2.3	-3.4	-2.3	-2.5
Leg predicted mass (right)	1.5	7.8	15.2	-2.8	-2.8	-2.8	-3.1	-3.1	-2.8	-3.9	-2.5	3.3	2.8	2.0	1.7	2.8	-2.2	-3.4	-2.2	-2.4
Leg fat percentage (left)	1.5	5.4	13.2	-1.2	-1.2	-1.3	-1.6	-1.3	-1.2	-3.6	-2.3	3.2	3.4	3.1	2.4	1.9	-1.0	-2.6	-3.1	-2.4
Qualifications: None of the above	1.4	3.1	5.2	-1.5	-1.8	-1.6	-1.6	-1.7	-1.5	-2.3	-1.5	2.2	2.0	1.7	1.8	1.6	-1.4	-1.8	-1.9	-1.7
Medication: Ibuprofen	1.4	1.7	4.1	-0.8	-1.0	-0.8	-0.9	-0.8	-0.8	-1.8	-1.4	1.8	1.6	2.0	1.2	1.3	-0.6	-1.2	-1.5	-1.4
Medication: Omeprazole	1.4	1.7	3.2	1.5	1.6	1.6	1.8	1.5	1.6	1.0	1.5	-1.4	-0.8	-0.9	-0.7	-1.3	1.1	1.5	0.8	1.0
Diabetes diagnosed by doctor	1.4	2.3	6.5	-0.9	-0.6	-0.8	-1.0	-0.7	-0.8	-2.5	-1.0	1.6	2.4	1.7	0.8	0.8	-2.1	-1.6	-1.7	-2.1
Osteoporosis (self-reported)	1.4	1.7	4.3	1.3	1.0	1.2	1.3	1.4	1.1	2.1	1.0	-1.4	-1.5	-1.2	-0.3	-1.3	1.2	1.4	1.1	1.7
Reaction Time	1.3	2.4	9.2	1.9	1.9	1.7	1.5	1.6	2.1	-1.1	1.1	-0.8	-1.0	-0.3	-0.1	-1.6	3.0	1.5	0.5	1.6
Neuroticism	1.3	3.2	5.8	-1.5	-1.5	-1.6	-1.4	-1.5	-1.5	-2.4	-1.4	1.9	2.0	1.7	0.1	1.7	-2.2	-2.4	-1.7	-2.3
Fed-up feelings	1.3	2.3	6.0	-1.0	-1.2	-1.0	-1.1	-1.2	-1.0	-2.5	-1.1	1.5	2.3	1.6	0.5	1.3	-1.6	-1.7	-1.8	-2.2
Alcohol usually taken with meals	1.3	2.1	3.9	1.4	1.3	1.4	1.2	1.2	1.3	1.0	1.3	-1.7	-1.6	-1.9	-2.0	-1.4	1.0	1.6	1.6	1.1
Heart disease (mother)	1.3	1.6	3.1	-1.4	-1.6	-1.4	-1.4	-1.7	-1.6	-0.1	-1.2	0.9	0.8	0.6	1.8	1.4	-1.0	-1.7	-0.9	-0.2
Medication: Gliclazide	1.3	1.5	2.5	-1.2	-1.4	-1.3	-1.1	-1.5	-1.3	-1.2	-0.9	1.5	1.1	0.4	0.6	1.3	-1.4	-1.6	-0.8	-1.4
Number of operations (self-reported)	1.3	1.9	6.7	-1.1	-1.3	-1.2	-1.3	-1.7	-1.2	-2.6	-1.0	1.5	1.3	1.2	1.8	1.3	-0.9	-1.4	-0.7	-1.1
Allergy or Eczema	1.2	3.3	11.2	0.5	0.8	0.6	1.0	0.4	0.5	2.0	1.9	-1.4	-2.9	-3.0	-2.2	-1.1	0.6	1.8	3.3	2.1
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	4.1	1.5	1.1	1.6	1.7	1.0	1.4	0.7	2.0	-1.2	-0.8	-1.0	-1.0	-1.7	-0.3	1.1	1.3	0.5
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.9	-1.5	-1.4	-1.4	-1.3	-1.7	-1.7	1.3	-1.3	0.7	-0.0	0.2	0.7	1.4	-0.5	-0.9	-0.5	0.4
Hayfever, allergic rhinitis or eczema	1.2	2.6	9.8	0.1	0.4	0.2	0.6	-0.1	0.2	1.8	1.5	-1.3	-2.8	-3.0	-1.4	-0.8	0.7	1.6	3.1	2.2
Medication: Lansoprazole	1.2	1.4	4.6	-1.1	-1.1	-1.1	-1.3	-1.0	-1.1	-0.6	-1.5	1.3	1.0	0.9	2.2	1.3	-0.5	-1.1	-1.2	-0.3
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	3.8	1.8	1.8	1.8	1.7	1.9	1.9	-0.6	1.4	-0.9	-0.2	0.1	-0.6	-1.5	0.7	1.0	0.2	-0.2
Age at last live birth	1.2	1.7	4.8	1.0	1.2	1.1	1.4	1.2	1.0	2.2	1.3	-1.6	-1.4	-1.3	-1.6	-1.3	0.5	1.0	1.1	1.3
Medication for cholesterol	1.2	1.9	6.7	0.8	0.7	1.0	0.9	1.0	0.7	1.5	1.7	-1.8	-1.6	-1.6	-2.6	-1.4	-0.2	1.3	1.8	0.8
Arm fat mass (left)	1.2	5.0	13.4	-1.4	-1.4	-1.5	-1.6	-1.7	-1.4	-3.7	-1.8	3.0	3.1	2.6	1.9	1.8	-1.9	-2.7	-2.4	-2.7
Miserableness	1.2	2.1	4.5	-1.3	-1.3	-1.5	-1.4	-1.6	-1.4	-2.1	-1.7	1.6	1.4	1.6	1.1	1.8	-0.3	-1.7	-1.4	-1.0
Intelligence (Savage-Jansen 2018)	1.1	3.2	6.2	1.6	1.8	1.8	1.9	1.9	1.7	1.7	2.0	-2.0	-1.8	-1.0	-2.5	-2.0	0.9	2.2	2.2	0.7
Alzheimer’s Disease (in father)	1.1	1.2	2.7	-0.9	-1.0	-0.9	-1.0	-1.1	-1.0	-0.9	-1.1	1.1	1.2	0.9	1.1	1.1	-0.7	-1.6	-1.6	-1.2
Verbal and Numeric Reasoning (VNR)	1.1	2.8	5.5	1.3	1.4	1.5	1.8	1.7	1.5	1.8	2.0	-1.8	-1.7	-1.1	-2.3	-1.7	0.6	2.1	2.1	0.7
Type 2 Diabetes (T2D) (2018)	1.1	2.1	4.3	-1.2	-1.1	-1.3	-1.4	-1.2	-1.2	-2.1	-1.4	1.6	1.8	1.4	1.7	1.3	-1.3	-1.5	-1.6	-1.4
Number of incorrect matches in round	1.1	1.9	3.9	-1.7	-1.9	-1.7	-1.7	-2.0	-1.7	-1.4	-1.2	1.6	0.6	0.2	0.6	1.6	-0.9	-1.5	-0.5	-0.5
Illnesses of mother	1.1	1.3	3.6	0.9	0.5	0.7	0.6	0.9	0.9	0.5	1.0	-0.8	-1.6	-1.2	-1.3	-0.9	1.9	1.4	1.6	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	3.7	-1.9	-1.9	-1.8	-1.6	-1.8	-1.9	1.4	-1.2	0.4	-0.7	-1.0	-0.3	1.6	-0.9	-0.9	0.6	0.6
Worry too long after embarrassment	1.1	1.8	3.8	1.8	1.8	1.7	1.8	2.0	1.7	-0.2	1.6	-1.3	-0.1	-0.0	-1.5	-1.5	-0.5	0.6	0.4	-1.1
Comparative height size at age 10	1.1	6.0	10.1	-3.2	-3.0	-3.0	-3.0	-3.0	-3.0	-0.7	-2.8	2.1	1.6	1.8	2.4	2.7	-2.3	-2.5	-1.6	-1.0
Medication: Bendroflumethiazide	1.1	1.6	3.2	1.8	1.7	1.5	1.6	1.3	1.8	-1.1	0.5	0.2	0.7	1.3	1.4	-1.1	1.5	0.5	-1.3	-0.5
Illnesses of father: High blood pressure	1.1	1.4	4.5	-0.8	-0.9	-0.9	-1.0	-1.1	-0.8	-1.4	-1.4	1.3	1.2	1.4	2.1	1.3	0.3	-1.1	-1.2	-0.4
Commuting to job workplace: Cycle	1.1	1.4	3.2	-1.6	-1.8	-1.6	-1.6	-1.6	-1.8	1.0	-1.2	0.6	-0.4	-0.3	1.1	1.4	-0.0	-0.7	0.1	0.4
Schizophrenia (2018)	1.0	2.0	5.6	-2.2	0.0	-2.1	-2.4	-1.9	-2.3	0.6	-1.8	1.0	0.1	-0.2	0.5	2.0	-0.5	-1.4	-0.3	0.0
Systolic Blood Pressure	1.0	5.1	8.5	2.7	1.9	2.9	2.9	2.2	2.5	2.1	2.7	-2.4	-1.9	-1.7	-0.6	-2.6	1.8	2.5	1.6	2.1
Impedance of leg (right)	1.0	4.8	15.4	1.9	2.0	2.0	2.2	2.4	1.9	3.9	1.7	-2.7	-2.2	-1.2	-1.4	-2.0	1.6	2.6	1.8	2.2
Average weekly fortified wine intake	1.0	1.2	4.5	0.9	0.6	1.1	1.2	1.2	1.0	2.1	1.1	-1.1	-1.1	-1.2	-1.3	-1.2	0.1	0.9	0.7	0.6
High blood pressure (mother)	1.0	1.4	2.3	-1.1	-0.9	-1.1	-1.2	-1.4	-1.2	-1.1	-1.3	0.9	1.2	1.0	1.5	1.3	-0.7	-1.4	-1.2	-0.8
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	5.4	-0.4	-0.5	-0.3	-0.3	-0.1	-0.4	2.3	0.1	-0.7	-1.7	-2.1	-0.3	-0.0	0.8	0.5	1.2	2.3
Qualifications: A levels/AS levels or equivalent	1.0	2.2	5.2	1.6	1.7	1.6	1.7	1.8	1.4	1.8	1.6	-1.8	-1.1	-0.6	-2.3	-1.7	0.1	1.2	1.2	0.3
Birth weight	1.0	2.2	3.7	1.5	1.6	1.5	1.7	1.4	1.5	1.2	1.8	-1.7	-1.6	-1.2	-0.7	-1.7	0.8	1.9	1.6	1.3
Friendships satisfaction	1.0	1.3	2.6	1.1	1.5	1.3	1.1	1.5	1.2	0.1	1.4	-1.4	-0.3	-0.4	-1.6	-1.6	-0.8	0.8	0.8	-0.4
Irritable Bowel Disease (IBD)	0.9	2.1	5.4	1.0	1.1	1.0	0.8	0.9	0.9	1.2	0.9	-2.1	-2.1	-1.9	-0.3	-1.0	2.1	1.3	1.6	2.3
Hand grip strength (right)	0.9	2.3	7.8	-1.2	-1.1	-1.3	-1.2	-1.1	-1.2	0.3	-2.1	1.2	1.7	1.9	1.9	1.7	-0.4	-1.5	-2.8	-1.2
Multivitamins +/- minerals	0.9	1.1	6.1	0.8	0.7	0.9	0.7	0.7	0.9	-0.3	1.4	-1.0	-1.1	-1.1	-2.5	-0.9	0.2	0.9	1.3	0.2
Medication: Levothyroxine sodium	0.9	1.4	3.4	1.4	1.7	1.6	1.7	1.4	1.5	0.0	1.8	-0.9	-0.2	-0.2	-1.0	-1.6	-0.6	0.9	0.7	-0.7
Trunk fat mass	0.9	3.8	9.3	-1.1	-1.1	-1.1	-1.3	-1.3	-1.1	-3.0	-1.4	2.5	2.8	2.5	1.5	1.4	-2.0	-2.5	-2.1	-2.5
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	3.5	0.3	0.6	0.4	0.9	0.2	0.4	1.3	1.2	-1.0	-1.8	-1.7	-1.2	-0.7	0.5	1.0	1.9	1.2
Hair/balding pattern: Pattern 3	0.9	1.3	7.0	-0.4	-0.3	-0.2	-0.2	-0.4	-0.3	0.9	0.9	-0.6	-2.0	-1.9	-1.5	-0.3	-0.0	1.0	2.6	1.6
Number of live births	0.9	1.2	3.2	-0.7	-0.5	-0.8	-0.7	-1.0	-0.8	-1.5	-0.9	1.2	1.5	1.8	1.6	0.8	-0.8	-1.1	-1.3	-1.0
Medication: Ventolin 100micrograms inhaler	0.9	1.1	5.3	-0.2	-0.3	-0.3	-0.1	-0.1	-0.2	1.6	0.2	-0.9	-1.8	-1.6	-0.2	-0.1	1.1	1.1	1.3	2.3
Health satisfaction	0.9	1.2	3.8	-0.4	-0.2	-0.4	-0.3	-0.3	-0.4	-1.1	-0.8	1.2	1.8	1.9	1.4	0.6	-1.5	-1.2	-1.5	-1.3
Shortness of breath walking on level ground	0.9	1.1	2.3	-0.9	-0.8	-1.1	-1.0	-1.0	-0.9	-1.2	-0.9	1.5	1.0	1.0	1.4	1.1	-0.9	-1.2	-0.9	-0.5
Medication: Blood pressure	0.9	1.6	6.9	0.3	0.1	0.3	0.2	-0.0	0.3	-2.6	-0.2	1.3	1.9	2.1	1.3	0.1	-0.8	-1.1	-1.8	-1.7
Mean time to correctly identify matches	0.9	1.8	4.2	1.9	1.7	1.7	1.7	1.7	2.0	-0.6	1.2	-0.5	-0.6	0.1	-0.1	-1.6	1.9	1.2	0.1	0.8
Leg pain on walking	0.9	1.1	3.8	-0.2	-0.1	-0.2	-0.3	-0.2	-0.2	-2.0	-0.3	1.2	1.7	1.0	0.8	0.3	-1.7	-1.3	-1.2	-1.6
Long-standing illness, disability or infirmity	0.9	1.3	2.7	-0.7	-1.0	-0.8	-0.7	-1.0	-0.8	-1.2	-0.7	1.2	1.5	1.6	1.6	0.9	-1.6	-1.2	-1.1	-1.2
Breast cancer (self-reported)	0.9	1.1	2.7	-1.2	-1.4	-1.3	-1.2	-1.2	-1.3	-0.2	-1.1	1.1	0.5	0.3	1.6	1.2	-0.7	-1.2	-0.4	0.1
Vascular/heart problems diagnosed by doctor	0.9	2.3	6.6	-0.1	0.2	-0.1	-0.1	0.4	-0.1	2.0	0.6	-1.6	-2.5	-2.4	-2.3	-0.4	1.2	1.5	2.6	2.1
Alzheimer’s Disease (including proxy)	0.8	1.2	4.2	-0.3	-0.4	-0.3	-0.4	-0.3	-0.4	-1.1	-0.6	0.9	1.9	1.5	0.4	0.6	-1.5	-1.5	-1.8	-2.0
Primary Biliary Cirrhosis	0.8	1.1	2.5	1.6	1.3	1.5	1.3	1.4	1.4	-0.4	1.1	-0.8	-0.3	-0.1	-0.9	-1.3	0.9	0.8	0.1	0.4
Respiratory disease	0.8	1.8	3.9	1.0	0.7	0.9	1.0	1.0	0.9	1.9	1.2	-1.5	-2.0	-1.8	-0.4	-1.1	1.1	1.7	1.5	1.7
Sensitivity / hurt feelings	0.8	1.4	3.4	-1.6	-1.8	-1.5	-1.6	-1.8	-1.7	-0.6	-0.6	0.8	-0.1	-0.6	-0.0	1.5	-1.0	-1.3	0.7	-0.0
Medication for hormone replacement therapy	0.8	0.9	1.9	-1.1	-1.0	-1.3	-1.2	-1.1	-1.0	-1.2	-1.1	1.3	0.5	0.5	0.6	1.4	-0.1	-0.9	-0.3	-0.2
Medication: Co-codamol	0.8	0.9	3.9	0.1	0.1	-0.1	0.2	-0.2	0.0	-1.4	-0.3	0.8	1.5	1.4	2.0	0.2	-0.9	-1.0	-1.3	-1.1
Qualifications: CSEs or equivalent	0.8	1.1	5.2	-0.5	-0.8	-0.8	-0.8	-1.0	-0.7	-0.5	-1.3	0.4	-0.4	0.3	2.1	1.0	2.3	0.1	-0.1	1.4
Hearing difficulty/problems with background noise	0.8	1.2	2.3	-1.2	-1.2	-1.1	-1.1	-1.2	-1.2	0.0	-1.0	1.1	1.2	0.5	0.5	1.3	-1.5	-1.4	-0.8	-1.4
Had menopause	0.8	1.0	2.1	1.2	1.1	1.3	1.4	1.2	1.2	0.6	1.5	-0.6	-0.2	-0.3	-1.2	-1.3	-0.8	0.9	0.6	-0.4
Allergy	0.8	1.8	6.1	0.1	-0.1	0.1	-0.3	0.1	0.1	-2.1	-0.7	1.1	2.5	2.4	0.7	0.3	-0.8	-1.2	-2.3	-2.1
Arm fat percentage (right)	0.8	3.0	10.3	-0.5	-0.6	-0.6	-0.8	-0.8	-0.6	-3.2	-1.2	2.3	2.7	2.3	1.7	1.0	-1.2	-2.0	-2.1	-2.4
Number of children fathered	0.8	0.9	2.2	-0.8	-1.0	-0.9	-1.1	-0.6	-0.7	-1.5	-1.1	1.3	0.9	0.9	0.4	1.2	-0.1	-1.0	-1.1	-0.6
Cholesterol lowering medication	0.8	1.2	4.3	-0.7	-0.7	-0.8	-0.8	-0.8	-0.7	-1.0	-1.6	1.4	1.3	1.1	2.1	1.1	0.3	-0.9	-1.6	-0.5
Worry (Nagel 2018)	0.7	1.5	2.6	-1.5	-1.5	-1.6	-1.3	-1.4	-1.5	-0.7	-1.3	1.3	0.8	0.3	-0.0	1.5	-1.4	-1.6	-0.7	-0.8
Number of treatments/medications taken	0.7	1.3	3.5	1.1	0.8	0.9	1.1	0.8	1.1	-1.5	0.4	0.7	1.5	1.9	1.8	-0.5	-0.6	-0.1	-1.4	-1.4
Relative age of first facial hair	0.7	1.5	3.0	1.7	1.5	1.7	1.7	1.7	1.7	-0.1	1.6	-1.0	0.3	0.4	-1.4	-1.4	0.1	0.8	-0.1	-0.9
Supplements: Zinc	0.7	0.8	4.1	-0.5	-0.7	-0.2	-0.4	-0.7	-0.4	-0.2	1.1	-0.7	-1.1	-1.4	-1.1	-0.2	-0.9	0.2	2.0	0.7
Severe depression (siblings)	0.7	0.7	2.0	0.8	0.8	0.8	0.9	0.8	0.7	0.8	0.9	-0.9	-0.1	0.4	-1.4	-1.0	-1.2	0.7	0.4	-1.3
Relative age voice broke	0.7	1.1	2.2	1.4	1.4	1.5	1.4	1.3	1.4	0.0	1.2	-0.7	0.4	0.5	-1.5	-1.1	0.0	0.5	-0.3	-1.0
Taking other prescription medications	0.7	1.1	3.4	0.9	0.8	0.7	1.0	0.6	0.8	-1.1	0.1	0.6	1.5	1.9	1.8	-0.2	-0.3	-0.6	-1.6	-1.2
Stomach or abdominal pain in last month	0.7	0.9	4.0	-0.2	-0.3	-0.5	-0.5	-0.6	-0.3	-1.1	-1.2	0.6	0.8	1.2	2.0	0.8	1.4	-0.4	-1.3	0.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.2	1.5	1.1	1.4	1.4	1.4	1.4	-0.1	0.8	-0.4	0.0	0.3	0.3	-1.1	0.3	0.7	-0.3	-0.3
Pain all over the body in last month	0.7	0.7	2.7	-0.4	-0.7	-0.4	-0.6	-0.8	-0.5	-1.6	-0.7	1.2	1.2	0.8	0.6	0.6	-0.4	-1.1	-1.0	-0.7
Exposure to tobacco smoke at home	0.7	0.8	2.1	1.3	1.1	1.1	1.1	1.0	1.3	-1.5	0.6	-0.1	0.6	0.9	-0.2	-1.0	0.2	0.4	-0.5	-0.6
Breastfed as a baby	0.7	0.8	3.7	-0.3	-0.4	-0.1	-0.2	0.1	-0.3	1.9	0.2	-0.7	-1.4	-1.4	-1.4	-0.1	0.2	0.7	1.0	1.3
Body fat percentage	0.7	2.8	7.9	-0.5	-0.5	-0.5	-0.6	-0.6	-0.5	-2.8	-1.1	2.3	2.7	2.5	1.4	0.9	-1.4	-2.0	-2.1	-2.3
Age at first live birth	0.7	1.3	3.5	1.0	1.2	1.2	1.4	1.4	1.0	1.9	1.2	-1.3	-0.6	-0.5	-1.8	-1.2	-0.3	0.5	0.5	0.0
Medication: Allopurinol	0.7	0.9	2.8	0.7	0.4	0.7	1.0	0.6	0.7	1.0	0.8	-0.6	-1.3	-1.2	0.1	-0.7	1.3	1.2	1.1	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	3.5	0.5	0.7	0.3	0.2	0.3	0.5	-1.8	-0.5	0.4	1.1	1.2	1.9	0.2	0.4	-0.4	-1.3	-0.7
Arm fat percentage (left)	0.7	2.7	10.1	-0.4	-0.4	-0.4	-0.6	-0.6	-0.4	-3.2	-0.9	2.2	2.5	2.2	1.4	0.8	-1.3	-1.9	-1.9	-2.3
Guilty feelings	0.7	1.0	4.0	-0.6	-0.7	-0.6	-0.5	-0.7	-0.6	-1.6	-0.3	1.3	1.2	0.8	-0.8	0.7	-1.5	-1.0	-0.7	-2.0
Financial situation satisfaction	0.7	0.8	1.6	-0.9	-0.9	-0.9	-0.9	-0.8	-0.8	-1.1	-0.8	1.1	0.7	0.8	1.3	1.0	-1.0	-1.0	-0.5	-0.6
Fractured/broken bones in last 5 years	0.7	0.9	2.3	1.3	1.0	1.4	1.3	1.3	1.3	-0.3	1.5	-0.7	0.1	-0.1	-0.5	-1.4	-0.8	0.5	0.2	-0.6
Basal cell carcinoma (self-reported)	0.7	0.9	2.5	-0.7	-0.5	-0.8	-0.6	-0.7	-0.6	-1.6	-0.9	1.2	1.1	1.1	0.6	0.9	-0.7	-1.0	-1.0	-1.2
Heart disease (siblings)	0.7	0.8	1.8	-1.3	-1.0	-1.1	-0.9	-1.1	-1.2	0.4	-0.8	0.8	0.5	0.7	0.9	1.0	-1.3	-0.8	-0.4	-0.5
Depressed Affect (Nagel 2018)	0.6	1.3	3.1	-1.0	-1.3	-1.1	-1.1	-1.2	-1.0	-1.8	-1.1	1.2	1.2	0.9	0.3	1.3	-0.5	-1.2	-1.1	-1.1
Major Depression (MDD)	0.6	0.7	1.7	-1.3	0.0	-1.2	-1.1	-1.0	-1.1	0.3	-0.9	0.9	0.4	0.2	0.4	1.1	0.0	-1.3	-0.4	0.0
Schizophrenia (2014)	0.6	1.3	3.2	-1.8	0.0	-1.6	-1.6	-1.5	-1.8	0.5	-1.2	0.7	0.3	-0.2	-0.1	1.6	-1.4	-1.3	-0.2	0.0
Chronotype (morning person)	0.6	1.3	2.3	1.4	1.1	1.4	1.3	1.5	1.4	0.9	1.1	-1.5	-0.7	-0.8	-0.5	-1.3	1.2	1.3	0.6	0.6
Systolic blood pressure, automated reading	0.6	1.7	3.6	1.6	1.1	1.9	1.9	1.4	1.5	1.5	1.9	-1.3	-0.7	-1.0	-1.0	-1.6	-0.1	1.2	0.7	0.4
Medication: Atenolol	0.6	0.7	4.3	0.9	0.6	0.8	0.6	0.6	0.8	-0.0	0.1	-0.6	-0.7	-0.8	0.6	-0.5	2.1	0.8	-0.0	1.6
Father’s age at death	0.6	0.9	3.2	-0.6	-0.6	-0.6	-0.7	-0.4	-0.7	1.4	-0.5	-0.4	-1.2	-1.8	-0.3	0.7	1.4	0.4	0.8	1.5
Lung cancer (father)	0.6	0.7	1.8	-1.0	-1.1	-1.0	-0.7	-1.2	-1.2	0.4	-0.5	0.8	0.2	-0.1	0.3	0.9	-1.3	-0.9	-0.1	-0.6
Chronic bronchitis/emphysema (mother)	0.6	0.6	3.2	0.5	0.3	0.4	0.3	0.3	0.6	-1.8	-0.1	0.6	1.2	1.5	0.7	-0.2	-0.5	-0.4	-0.9	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.9	0.1	0.1	0.2	0.1	-0.1	0.2	0.6	0.2	-0.6	-1.1	-0.8	-1.4	-0.3	1.7	1.1	0.8	1.4
Mouth/teeth dental problems: Loose teeth	0.6	0.7	3.0	0.1	0.1	0.1	0.2	-0.1	0.1	-1.2	0.0	0.9	1.3	1.7	0.7	0.1	-1.1	-0.8	-0.9	-1.5
Pulse rate, automated reading	0.6	2.1	4.3	-2.0	-1.9	-2.1	-2.0	-1.9	-2.0	0.3	-1.6	1.0	-0.2	-0.4	1.3	1.8	0.8	-0.9	0.2	1.0
Number of self-reported non-cancer illnesses	0.6	1.0	2.2	1.5	1.1	1.4	1.5	0.9	1.4	-1.4	0.9	0.0	0.7	1.0	1.2	-0.9	0.4	0.2	-0.6	-0.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.5	1.1	0.7	0.9	0.7	1.0	1.0	-0.0	0.7	-0.5	-0.7	-0.9	-0.3	-0.8	1.2	1.0	0.8	0.9
Alcohol drinker status: Previous	0.6	0.6	1.3	0.8	0.8	0.9	0.7	1.0	0.9	0.5	0.9	-1.0	-0.7	-0.9	-0.3	-1.1	-0.2	0.9	0.9	0.7
Bipolar Disorder or Schizophrenia	0.5	1.2	3.4	-1.9	0.0	-1.6	-1.7	-1.5	-1.8	1.0	-1.2	0.6	-0.0	-0.2	-0.3	1.5	-0.7	-1.0	-0.0	0.0
HbA1C	0.5	0.6	1.6	0.9	0.9	0.9	1.3	0.9	1.1	1.1	0.4	-0.1	-0.2	-0.2	0.3	-0.4	1.3	0.6	-0.7	0.0
Hypothyroidism (self reported)	0.5	1.0	2.1	1.3	1.4	1.4	1.5	1.2	1.3	0.5	1.4	-0.7	-0.6	-0.5	-0.6	-1.3	0.5	0.9	0.8	0.2
Hand grip strength (left)	0.5	1.2	6.8	0.0	0.1	-0.1	-0.1	-0.0	0.0	-0.2	-1.2	0.7	1.7	2.0	1.3	0.6	0.1	-0.8	-2.6	-1.4
High blood pressure	0.5	1.5	3.9	1.0	0.6	0.9	1.0	0.4	0.9	-1.5	0.2	0.9	1.9	2.0	1.5	-0.3	-0.7	-0.8	-2.0	-1.8
Hair/balding pattern: Pattern 2	0.5	0.7	3.4	0.6	0.4	0.5	0.5	0.7	0.7	-0.9	-0.3	0.5	1.2	1.3	0.4	-0.3	0.2	-0.4	-1.8	-1.2
Falls in the last year	0.5	0.7	3.6	-0.4	-0.7	-0.4	-0.4	-0.2	-0.5	-0.2	-0.4	0.9	1.3	0.7	0.4	0.5	-1.9	-1.2	-0.7	-1.1
Birth weight of first child	0.5	0.9	5.0	0.2	0.2	0.5	0.5	0.3	0.2	0.9	1.3	-0.7	0.4	0.2	-2.2	-0.7	-2.2	0.0	0.5	-1.1
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.8	1.0	1.2	1.2	1.3	0.9	1.0	0.4	1.7	-0.8	-0.8	-0.8	-1.3	-1.2	-0.3	0.9	1.2	0.0
Medication: Amlodipine	0.5	0.7	1.8	1.1	0.9	1.2	1.3	1.1	1.2	0.7	0.8	-0.7	0.1	0.3	0.4	-1.0	0.3	0.7	-0.2	-0.2
Alcohol intake frequency.	0.5	1.1	2.7	-1.3	-1.4	-1.3	-1.6	-1.2	-1.3	0.2	-1.5	0.4	-0.0	-0.2	1.6	1.2	0.3	-0.2	-0.2	0.7
Suffer from ‘nerves’	0.5	0.7	1.4	-0.9	-0.7	-1.0	-0.9	-0.8	-0.9	-1.0	-1.1	1.1	0.6	0.3	0.3	1.2	-0.9	-1.2	-0.6	-0.6
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.5	1.1	1.2	0.8	1.0	0.9	1.1	-0.4	0.3	-0.3	0.2	0.4	0.8	-0.7	1.2	0.6	-0.5	-0.0
Medication: Blood pressure	0.5	0.9	5.2	0.6	0.8	0.5	0.6	0.4	0.6	-0.3	-0.6	0.4	1.0	1.4	2.3	0.0	0.8	-0.1	-1.6	-0.5
Medication: Lisinopril	0.5	0.7	2.8	0.2	0.3	0.3	0.4	0.0	0.3	-1.1	0.2	0.8	1.3	1.4	0.3	-0.1	-0.8	-0.8	-1.1	-1.7
Ever depressed for a whole week	0.5	0.6	2.5	-0.9	-0.9	-0.9	-0.6	-0.7	-1.0	1.6	-0.3	0.1	-0.5	-1.0	-0.0	0.6	-0.8	-0.9	0.3	0.7
Pack years of smoking	0.5	0.7	1.6	0.5	0.2	0.6	0.7	0.6	0.6	1.0	1.1	-0.9	-1.1	-1.2	-0.7	-1.0	-0.3	0.8	1.3	0.7
Neuroticism (Nagel 2018)	0.4	1.0	2.2	-0.9	-1.1	-1.0	-0.9	-1.0	-1.0	-1.5	-0.8	1.1	1.0	0.6	-0.3	1.1	-1.0	-1.3	-0.8	-1.2
Schizophrenia vs Biploar Disorder	0.4	0.6	1.3	-1.1	0.0	-1.0	-1.1	-1.0	-1.1	-0.2	-0.7	0.5	0.4	-0.0	-0.0	1.0	-1.0	-1.0	-0.3	0.0
Triglycerides	0.4	0.6	3.2	-0.7	-1.0	-0.7	-0.6	-0.5	-0.8	0.8	-0.8	0.5	0.5	0.4	1.8	0.8	0.1	-0.7	-0.6	0.5
Blood Red Count	0.4	3.4	8.7	-1.8	-2.0	-1.8	-1.8	-1.9	-2.0	3.0	-2.3	0.6	-1.2	-0.5	2.7	1.6	1.6	-0.2	0.0	2.8
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.9	-0.5	-0.3	-0.5	-0.4	-0.3	-0.4	-0.6	-0.7	0.7	1.0	0.9	0.8	0.7	-0.7	-0.7	-0.9	-0.8
Diabetes (mother)	0.4	0.6	1.2	-0.9	-1.0	-0.8	-0.7	-0.9	-1.0	0.2	-0.5	0.5	0.7	0.5	0.4	0.8	-1.1	-0.9	-0.3	-0.6
Pack years adult smoking proportion	0.4	0.6	1.5	0.4	0.0	0.4	0.5	0.4	0.5	0.7	0.8	-0.8	-1.2	-1.1	-0.3	-0.8	0.4	0.8	1.2	1.0
Current tobacco smoking	0.4	0.7	1.4	-0.7	-0.8	-0.6	-0.6	-0.8	-0.6	-1.1	-0.5	0.9	0.9	1.1	1.2	0.5	-0.5	-0.6	-1.2	-0.7
Supplements: Glucosamine	0.4	0.6	1.1	0.6	0.9	0.7	0.7	0.8	0.7	0.9	0.5	-0.8	-0.7	-0.8	-1.1	-0.5	0.7	0.8	0.6	0.7
Past tobacco smoking	0.4	0.7	1.6	0.8	0.7	0.8	0.8	1.2	0.9	1.0	0.5	-0.6	-0.8	-1.3	-1.2	-0.8	0.6	1.0	0.5	0.3
Illnesses of siblings	0.4	0.6	1.6	-0.9	-0.8	-1.0	-1.0	-0.8	-0.8	-0.2	-1.3	0.5	0.3	0.4	0.4	1.1	0.6	-0.7	-0.8	0.0
Alcohol intake versus 10 years previously	0.4	0.6	3.4	-0.6	-0.8	-0.6	-0.6	-0.6	-0.5	0.7	-0.5	-0.2	-1.0	-0.7	0.8	0.5	1.2	0.3	0.6	1.8
Mouth/teeth dental problems: Dentures	0.4	0.7	1.5	1.2	1.1	1.1	1.2	1.0	1.2	0.2	0.8	-0.4	-0.4	0.1	0.7	-0.9	1.2	0.9	0.1	0.4
Asthma	0.4	0.8	2.9	-0.2	-0.1	-0.2	0.1	-0.1	-0.2	1.7	0.3	-0.7	-1.6	-1.4	-0.0	0.0	0.4	0.9	1.3	1.5
Depression (self-reported)	0.4	0.5	2.7	-0.5	-0.2	-0.6	-0.6	-0.5	-0.4	0.5	-0.9	0.2	-0.6	-0.5	0.7	0.7	1.6	0.0	-0.2	1.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	3.8	-0.5	-0.4	-0.5	-0.4	-0.2	-0.6	2.0	-0.4	-0.6	-1.3	-1.3	-0.7	0.4	1.0	0.4	0.8	1.2
High blood pressure (siblings)	0.4	0.6	2.3	0.1	-0.1	0.2	0.1	-0.3	0.0	-1.5	0.2	0.8	1.1	0.8	0.5	-0.1	-1.3	-0.8	-0.6	-1.4
Wheeze or whistling in the chest in last year	0.4	0.8	1.4	1.0	0.8	1.0	0.9	0.8	0.9	0.8	0.9	-1.1	-1.0	-0.7	-0.5	-1.0	1.0	1.2	0.4	0.7
Hypertension (Self-reported)	0.4	1.1	3.0	0.9	0.6	0.8	0.8	0.4	0.8	-1.4	0.1	0.7	1.6	1.6	1.5	-0.3	-0.5	-0.6	-1.7	-1.5
Smoking status: Previous	0.4	0.6	2.2	-0.5	-0.5	-0.6	-0.6	-0.8	-0.6	-1.0	-0.4	0.6	0.9	1.3	1.5	0.7	-0.7	-0.9	-0.4	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.6	0.8	1.0	0.8	0.7	0.5	0.9	-1.6	0.7	-0.1	0.0	0.3	0.5	-0.9	0.1	0.6	0.4	0.1
Back pain experienced in last month	0.4	0.7	3.1	-0.2	-0.6	-0.4	-0.3	-0.6	-0.2	-0.9	-0.5	1.0	1.0	1.3	1.8	0.6	0.2	-0.7	-1.1	-0.5
Asthma (self-reported)	0.4	0.8	3.0	-0.1	-0.1	-0.2	0.1	-0.1	-0.1	1.7	0.4	-0.8	-1.6	-1.4	-0.0	-0.1	0.4	0.9	1.3	1.5
Medication: Aspirin	0.4	0.5	1.5	-0.0	0.0	-0.1	-0.1	-0.3	0.0	-1.2	-0.5	0.8	1.1	1.0	1.2	0.4	-0.2	-0.4	-1.1	-0.7
Wears glasses or contact lenses	0.4	0.5	2.2	0.3	0.5	0.3	0.6	0.5	0.3	-0.1	0.3	0.5	0.9	1.2	-0.5	-0.2	-1.2	-0.6	-0.8	-1.5
Hearing aid user	0.4	0.4	2.6	0.5	-0.0	0.5	0.4	0.6	0.3	0.4	0.7	-0.2	0.3	0.3	-0.8	-0.5	-1.6	-0.4	-0.1	-1.1
Mother’s age at death	0.4	0.5	1.2	0.7	1.1	0.8	0.8	0.6	0.6	0.6	0.9	-1.0	-0.7	-0.8	-0.5	-0.6	0.2	0.8	0.7	0.1
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	0.9	0.7	0.9	0.9	1.0	0.9	0.3	0.8	-0.6	-0.6	-1.0	-0.6	-0.9	0.3	0.7	0.6	0.2
High cholesterol (Self-reported)	0.4	0.6	2.0	-0.5	-0.4	-0.6	-0.6	-0.6	-0.5	-1.1	-0.5	0.9	1.1	0.6	1.0	0.4	-1.4	-0.8	-0.5	-0.9
HDL Cholesterol	0.3	0.6	1.7	0.2	0.1	0.3	0.1	0.4	0.2	1.2	0.1	-0.9	-1.2	-1.1	-0.6	-0.4	1.0	0.9	0.8	1.3
Lupus	0.3	0.4	1.7	0.6	0.7	0.7	0.8	0.8	0.7	0.1	0.8	-0.6	0.1	0.2	-0.8	-0.6	-1.3	-0.0	0.2	-0.8
Rheumatoid Arthritis	0.3	0.5	1.3	0.4	0.0	0.2	0.0	0.2	0.2	0.3	0.5	-1.0	-1.2	-0.9	0.0	-0.4	0.8	0.8	1.1	1.1
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.8	-0.4	0.0	-0.2	-0.3	-0.1	-0.3	-0.4	-0.4	0.9	1.2	1.3	0.9	0.2	0.0	-0.9	-0.8	0.0
Blood Platelet Count	0.3	4.1	10.0	-2.2	-1.8	-2.3	-2.3	-1.9	-2.2	-0.7	-3.2	2.0	1.7	1.7	2.3	2.7	-0.7	-1.6	-2.3	-0.8
Height	0.3	5.0	20.5	-3.0	-3.0	-2.5	-2.4	-2.9	-2.9	0.6	-1.1	1.1	1.2	0.8	-0.2	2.0	-4.5	-2.2	-0.2	-2.0
Lung FEV1/FVC ratio	0.3	1.5	7.2	0.5	0.7	0.8	0.6	0.9	0.7	-0.3	1.2	-0.4	0.8	-0.1	-2.7	-1.3	-2.6	0.1	0.2	-2.0
Hearing difficulty/problems: Yes	0.3	0.4	0.9	0.6	0.7	0.7	0.6	0.8	0.7	0.5	0.8	-0.6	-0.4	-1.0	-1.0	-0.8	-0.1	0.5	0.7	0.1
Vitamin and mineral supplements	0.3	0.4	2.3	-0.3	-0.2	-0.4	-0.4	-0.2	-0.4	-0.5	-0.7	0.6	0.8	0.5	1.5	0.3	-0.3	-0.7	-0.6	-0.4
Trunk fat percentage	0.3	1.1	3.9	0.2	0.1	0.2	0.1	0.1	0.2	-2.0	-0.2	1.4	1.8	1.8	0.8	0.1	-1.0	-1.2	-1.2	-1.6
Chronic bronchitis/emphysema (father)	0.3	0.4	1.0	0.7	0.3	0.5	0.5	0.8	0.6	0.1	0.6	-0.3	-0.6	-0.8	-0.2	-0.5	0.9	0.7	0.6	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	3.0	-0.1	-0.4	-0.0	-0.2	-0.2	-0.0	0.3	0.5	-0.5	-1.4	-1.7	-0.9	-0.2	0.7	0.6	1.5	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.4	-0.2	-0.2	-0.1	-0.1	-0.5	-0.2	0.7	0.2	-0.6	-1.0	-1.1	-0.4	0.1	0.7	0.5	0.8	1.2
Prospective memory result	0.3	0.4	1.0	0.9	1.0	0.8	1.0	0.9	1.0	0.2	0.6	-0.6	-0.3	0.1	-0.2	-0.8	0.4	0.4	-0.4	0.0
Medication: Seretide 50 evohaler	0.3	0.3	1.0	0.7	0.9	0.7	1.0	0.6	0.7	0.4	0.7	-0.6	-0.1	0.2	-0.1	-0.6	0.2	0.3	0.1	-0.0
Family relationship satisfaction	0.3	0.3	1.7	-0.4	-0.2	-0.3	-0.5	-0.2	-0.3	-0.8	0.3	-0.3	0.2	-0.3	-0.9	-0.0	-1.3	-0.4	0.6	-0.8
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	2.0	-0.4	-0.5	-0.3	-0.2	-0.1	-0.3	-0.5	-0.3	0.8	0.9	0.6	-0.3	0.3	-1.2	-0.6	-0.4	-1.4
Illnesses of father: Heart disease	0.3	0.4	1.6	0.1	0.1	0.1	0.2	-0.1	0.1	0.6	0.3	-0.5	-0.9	-0.5	0.7	-0.2	0.9	0.8	1.1	1.3
Illnesses of siblings: Diabetes	0.3	0.4	1.0	0.8	1.0	0.9	0.8	0.8	0.9	0.2	0.5	-0.5	0.2	0.2	0.4	-0.7	0.2	0.6	-0.2	-0.2
Average weekly red wine intake	0.3	0.4	2.9	0.0	0.2	0.2	0.1	0.0	0.1	0.1	0.7	-0.7	-0.3	-0.7	-1.7	-0.5	-1.3	0.3	0.8	-0.4
Loneliness, isolation	0.3	0.4	1.2	0.8	0.6	0.8	0.9	0.7	0.7	-0.3	0.8	-0.1	0.7	0.3	0.3	-0.5	-0.7	0.2	-0.3	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.2	0.7	0.7	0.8	0.6	1.1	0.7	0.7	0.5	-1.1	-0.6	-0.5	-1.1	-0.9	0.5	0.9	0.7	0.3
Alcohol drinker status: Never	0.3	0.4	1.2	0.4	0.6	0.4	0.3	0.9	0.6	1.0	0.3	-1.0	-0.5	-0.5	-0.0	-0.7	0.2	1.1	0.4	0.4
Unable to work because of sickness or disability	0.3	0.4	1.8	0.2	0.2	-0.0	0.1	0.2	0.1	-1.3	-0.1	0.6	1.1	0.8	0.4	0.1	-0.6	-0.7	-0.9	-0.9
Mean Putamen Volume	0.2	0.2	0.6	0.5	0.6	0.4	0.6	0.3	0.3	0.8	0.5	-0.6	-0.2	-0.5	0.0	-0.6	0.2	0.3	0.1	0.2
Cardiovascular Disease	0.2	0.8	3.2	0.2	0.1	0.1	0.2	-0.4	0.2	-1.7	-0.4	0.7	1.1	1.4	1.8	0.2	-0.2	-0.6	-1.2	-0.8
Townsend deprivation index at recruitment	0.2	0.3	1.8	-0.1	-0.5	-0.2	-0.0	-0.2	-0.1	-0.9	-0.3	1.0	0.4	0.8	1.3	0.3	0.2	-0.0	-0.5	-0.3
Maternal smoking around birth	0.2	0.3	1.1	-0.0	0.1	-0.1	-0.1	0.0	0.1	-0.9	-0.2	0.1	0.7	1.1	0.8	-0.0	-0.8	-0.3	-0.5	-0.6
Financial difficulties in last 2 years	0.2	0.2	1.6	-0.2	-0.1	-0.4	-0.2	-0.3	-0.2	-0.4	-0.5	0.2	-0.3	0.3	1.3	0.3	0.8	-0.3	-0.4	0.5
Worrier / anxious feelings	0.2	0.5	1.9	-0.1	-0.2	0.0	-0.1	0.2	-0.1	0.8	0.2	-0.6	-1.1	-1.4	-1.3	0.1	0.3	0.3	1.1	0.8
Pulse rate	0.2	0.3	1.4	-0.2	-0.2	-0.3	-0.3	-0.2	-0.2	0.0	0.0	-0.0	-1.0	-0.4	0.0	0.2	1.2	0.6	1.0	1.0
Medication: Cholesterol lowering	0.2	0.3	4.0	-0.4	-0.2	-0.1	-0.1	-0.3	-0.3	-0.0	0.5	-0.2	0.3	-0.0	-0.2	-0.2	-2.0	-0.3	0.5	-0.5
Hair/balding pattern: Pattern 4	0.2	0.5	2.2	0.0	0.1	0.1	0.1	-0.1	-0.0	0.9	0.6	-0.8	-1.1	-1.5	-0.3	-0.3	0.3	0.5	1.1	1.1
Glaucoma (self-reported)	0.2	0.2	1.3	0.2	0.1	0.2	0.2	0.4	0.2	-0.8	0.2	0.4	0.6	-0.0	-0.2	-0.3	-1.1	-0.3	-0.2	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	0.4	0.1	0.3	0.1	0.2	0.3	0.1	0.5	-0.4	-0.6	-0.6	-0.8	-0.3	0.2	0.7	0.6	0.4
Number of full sisters	0.2	0.3	0.8	-0.7	-0.7	-0.6	-0.8	-0.5	-0.8	0.9	-0.8	0.1	0.1	0.1	-0.0	0.6	-0.2	0.2	-0.4	0.1
Medication: Aspirin	0.2	0.2	0.9	0.2	0.3	0.3	0.2	0.1	0.3	-0.6	-0.2	0.4	0.8	0.8	1.0	-0.0	-0.2	-0.0	-0.9	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	0.8	0.9	0.7	0.6	0.5	0.7	-0.6	0.5	-0.5	0.3	0.0	-0.6	-0.4	0.2	0.4	0.1	-0.6
Illnesses of father: None of the above (group 1)	0.2	0.2	1.5	0.3	0.4	0.3	0.4	0.4	0.3	0.1	0.4	-0.0	0.5	0.5	-0.5	-0.3	-0.7	-0.3	-0.6	-1.2
Smoking status: Current	0.2	0.3	1.0	-0.3	-0.3	-0.2	-0.2	-0.4	-0.2	-0.8	-0.2	0.4	0.6	0.8	0.8	0.1	-0.2	-0.3	-1.0	-0.5
Ever taken oral contraceptive pill	0.2	0.2	2.2	0.0	-0.1	-0.0	-0.1	-0.0	-0.0	-0.3	0.3	-0.5	-0.2	-0.2	-1.5	-0.2	-0.2	-0.1	0.4	0.1
Irritability	0.2	0.4	1.7	0.3	0.2	0.0	0.1	0.1	0.2	-1.3	-0.0	0.4	0.9	1.0	-0.2	0.2	-0.2	-0.8	-0.8	-0.9
Ever had prostate specific antigen (PSA) test	0.2	0.2	2.0	0.1	-0.1	-0.1	-0.3	-0.2	-0.0	-0.4	-0.2	0.1	-0.5	-0.3	0.4	0.1	1.4	0.0	0.1	0.8
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	0.6	0.7	0.7	0.7	0.6	0.8	0.3	0.2	-0.2	0.2	0.1	0.3	-0.2	0.5	0.3	-0.5	0.4
Bipolar Disorder (2018)	0.1	0.2	1.3	-0.2	0.0	0.0	0.2	-0.1	-0.1	0.8	0.3	-0.4	-0.2	0.1	-1.1	-0.0	-0.6	0.0	0.3	-0.0
Alzheimer’s Disease (in mother)	0.1	0.1	0.6	0.3	0.4	0.3	0.3	0.5	0.3	-0.1	0.2	-0.2	0.4	0.3	-0.2	-0.2	-0.7	-0.1	-0.3	-0.6
Crohns Disease (2017)	0.1	0.2	1.3	-0.0	0.1	-0.0	-0.2	-0.3	-0.1	-0.2	-0.4	-0.6	-0.3	0.1	0.8	0.2	1.2	-0.4	-0.3	0.8
Coronary Artery Disease (CAD)	0.1	0.2	0.8	-0.6	0.0	-0.5	-0.4	-0.7	-0.7	0.9	-0.3	-0.1	-0.2	-0.0	-0.1	0.4	0.0	-0.1	0.1	0.0
Crohns Disease (2012)	0.1	0.1	0.6	0.3	0.0	0.3	0.3	0.1	0.3	-0.1	0.0	-0.4	-0.0	0.1	0.8	-0.3	0.0	-0.0	0.0	0.4
LDL Cholesterol	0.1	0.1	1.0	-0.4	-0.3	-0.2	-0.1	-0.2	-0.3	0.0	0.1	0.3	0.4	0.0	0.1	0.1	-1.0	-0.3	0.1	-0.4
Blood White Count	0.1	0.7	4.4	0.0	-0.0	0.0	-0.2	-0.2	0.0	-2.1	-0.4	0.8	1.3	1.2	1.0	0.1	-0.1	-0.7	-1.1	-1.0
Heel T-Score	0.1	0.7	2.6	-1.0	-1.2	-0.6	-0.6	-0.6	-0.8	1.6	0.1	0.0	-0.5	-1.0	-1.0	0.3	-1.6	-0.2	0.8	0.5
Waist Hip Ratio (WHR)	0.1	0.6	1.5	0.9	1.2	0.9	1.1	0.8	1.1	0.7	0.5	-1.1	-0.3	0.1	0.6	-0.9	0.6	1.1	-0.1	0.2
Smoking Status	0.1	0.2	0.6	0.5	0.6	0.5	0.7	0.1	0.5	-0.6	0.7	-0.2	0.1	0.8	0.3	-0.5	0.3	0.4	-0.2	0.2
Lung FVC	0.1	0.4	1.6	0.6	0.7	0.6	0.3	1.1	0.7	0.3	-0.4	-0.5	-0.1	0.2	0.5	-0.4	1.3	0.8	-0.3	0.7
Tanning	0.1	0.6	1.9	-0.2	-0.0	-0.3	-0.1	-0.4	-0.0	-1.4	-0.6	0.9	1.2	1.2	1.1	0.4	-0.1	-0.9	-1.4	-0.9
Ever had hysterectomy (womb removed)	0.1	0.1	0.8	0.3	0.1	0.3	0.2	0.0	0.3	-0.2	0.1	0.1	-0.2	0.2	0.9	-0.2	0.5	0.3	0.2	0.4
Diabetes (father)	0.1	0.1	0.3	0.3	0.2	0.5	0.3	0.2	0.4	-0.5	0.4	-0.2	0.4	0.4	0.3	-0.3	-0.5	0.0	0.0	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.1	-0.3	-0.5	-0.3	-0.5	-0.3	-0.2	-0.2	-0.1	-0.1	-0.7	-1.0	-0.3	0.2	0.5	0.2	0.8	1.1
Serious illness, injury or assault to yourself	0.1	0.1	1.0	0.3	0.1	0.2	0.2	-0.1	0.2	-0.5	0.4	-0.1	0.1	0.2	1.0	-0.2	0.2	0.2	0.2	0.2
Sitting height	0.1	0.7	1.8	-1.0	-1.3	-0.9	-1.0	-0.9	-1.1	1.3	-0.2	-0.2	-0.8	-0.8	0.3	0.5	-0.5	-0.1	1.0	0.8
Nervous feelings	0.1	0.2	0.6	-0.2	-0.3	-0.1	0.0	-0.1	-0.2	0.8	0.1	-0.3	-0.6	-0.6	-0.0	-0.0	-0.4	-0.1	0.5	0.7
Medication: Simvastatin	0.1	0.1	0.6	-0.2	0.1	-0.2	-0.1	-0.3	-0.1	-0.6	-0.2	0.3	0.1	-0.0	0.8	0.1	0.2	-0.1	0.1	0.4
Standing height	0.1	1.4	4.8	-1.7	-1.7	-1.5	-1.4	-1.6	-1.6	0.9	-0.5	0.3	0.0	0.0	-0.5	0.9	-2.2	-0.9	0.5	-0.4
Peak expiratory flow (PEF)	0.1	0.2	0.9	-0.2	-0.1	-0.0	-0.3	0.0	-0.2	0.8	-0.0	-0.8	-0.6	-0.8	-0.9	-0.1	-0.1	0.5	0.8	0.3
Blood clot in the leg (DVT)	0.1	0.1	0.3	-0.4	-0.2	-0.4	-0.1	-0.3	-0.3	0.5	-0.1	-0.2	-0.2	0.2	0.5	0.3	-0.4	-0.2	0.1	-0.1
Forced vital capacity (FVC), Best measure	0.1	0.3	1.0	-0.6	-0.3	-0.6	-0.7	-0.4	-0.5	-0.4	-1.0	-0.0	0.1	0.7	0.5	0.5	0.5	-0.1	-0.4	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.7	-0.1	-0.1	-0.1	0.1	0.1	-0.0	0.2	0.1	0.2	-0.5	-0.4	-0.9	0.0	-0.5	-0.0	0.5	-0.0
Emphysema/chronic bronchitis	0.1	0.1	0.4	-0.3	-0.4	-0.2	-0.3	0.1	-0.2	0.6	-0.2	-0.0	-0.0	0.3	-0.5	0.1	-0.6	-0.2	-0.1	0.1
Had major operations	0.1	0.2	0.5	-0.3	-0.7	-0.3	-0.4	-0.6	-0.5	-0.3	-0.2	0.1	0.1	-0.1	-0.5	0.4	-0.5	-0.5	0.1	-0.3
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	-0.5	-0.3	-0.3	-0.2	-0.3	-0.3	0.5	-0.2	-0.1	-0.0	-0.3	-0.2	0.3	-0.5	-0.5	-0.1	0.3
Supplements: Vitamin C	0.1	0.2	0.4	-0.4	-0.3	-0.3	-0.3	-0.6	-0.3	-0.5	-0.4	0.5	0.2	0.6	0.5	0.5	0.5	-0.1	-0.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	2.0	-0.0	-0.2	-0.0	-0.1	-0.3	-0.1	0.2	0.4	-0.6	-0.9	-0.6	0.2	-0.3	0.2	0.5	1.4	0.9
Ever had bowel cancer screening	0.1	0.1	0.6	0.2	0.2	0.2	0.0	-0.0	0.3	-0.7	0.2	0.0	-0.4	-0.3	0.3	-0.0	0.8	0.5	0.4	0.5
Commuting to job workplace: Walk	0.1	0.2	0.7	-0.3	-0.4	-0.1	-0.3	-0.4	-0.2	-0.8	-0.0	0.5	0.4	0.4	-0.3	-0.0	-0.4	0.0	-0.1	-0.7
Osteoarthritis (self-reported)	0.1	0.1	0.7	-0.4	-0.3	-0.4	-0.2	-0.3	-0.3	-0.1	-0.1	0.2	0.2	-0.2	-0.1	0.3	-0.9	-0.4	0.1	-0.1
Commuting to job workplace: Public transport	0.1	0.1	0.3	0.4	0.3	0.4	0.4	0.3	0.3	-0.1	0.3	0.1	0.1	0.6	0.5	-0.3	0.4	-0.0	-0.2	-0.2
Ever smoked	0.1	0.1	0.4	0.0	0.2	0.1	0.1	-0.4	0.1	-0.6	0.5	-0.4	-0.2	0.4	0.1	-0.1	0.4	0.3	0.3	0.4
Age started oral contraceptive pill	0.1	0.1	0.4	0.0	-0.3	0.1	-0.1	0.2	-0.0	0.6	-0.2	0.2	0.2	0.3	-0.5	0.1	-0.3	-0.4	-0.4	-0.3
Diastolic blood pressure, automated reading	0.1	0.3	1.2	0.3	-0.0	0.4	0.4	0.0	0.1	1.1	0.3	-0.4	-0.7	-0.7	0.7	-0.3	0.8	0.5	0.5	1.0
Myopia	0.1	0.1	0.9	-0.2	0.1	-0.2	-0.2	-0.3	-0.2	-0.2	-0.2	0.1	0.4	0.9	0.6	0.3	0.0	-0.2	-0.5	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.7	-0.2	0.0	-0.1	0.1	-0.2	-0.1	0.8	0.2	-0.5	-0.6	-0.2	0.2	-0.0	-0.3	0.1	0.5	0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.2	1.4	0.2	0.1	0.2	0.2	0.0	0.1	-1.2	0.6	-0.5	-0.2	-0.3	-0.8	-0.4	-0.3	0.3	0.9	-0.3
Forced vital capacity (FVC)	0.0	0.2	0.5	-0.4	-0.2	-0.4	-0.6	-0.1	-0.3	0.3	-0.6	-0.5	-0.5	-0.1	-0.1	0.3	0.7	0.3	0.2	0.6
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.6	-0.4	-0.1	-0.3	-0.6	-0.0	-0.2	-0.2	-0.7	-0.3	0.1	0.3	-0.5	0.2	0.2	0.1	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.2	0.8	-0.4	-0.1	-0.3	-0.6	-0.1	-0.2	-0.5	-0.9	-0.1	0.3	0.7	0.0	0.3	0.3	-0.0	-0.4	-0.2
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.2	0.1	0.1	0.1	-0.0	-0.0	0.1	-0.0	-0.1	0.0	-0.2	-0.1	0.4	-0.1	0.4	-0.3	-0.1	0.4
Medication: Atorvastatin	0.0	0.0	0.3	0.0	-0.3	0.1	-0.1	0.1	0.1	-0.0	0.2	-0.0	0.1	-0.3	0.1	-0.2	-0.2	-0.1	0.4	0.5

Hub : Genes

POLE

Models

Trait associations