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chr12:121,194,565-125,270,773

Best TWAS P=2.03e-19 · Best GWAS P=1.93e-25 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	HIP1R	0.06	0.02	lasso	6	0.04	1.9e-05	-7.3	-6.2	7.4e-10	0.09	0.18	0.02	FALSE
2	GTEx	Adipose Subcutaneous	ZCCHC8	0.04	0.00	lasso	7	0.00	1.4e-01	6.7	6.4	1.6e-10	-0.31	0.17	0.10	TRUE
3	GTEx	Adipose Subcutaneous	CCDC92	0.23	0.04	enet	27	0.16	6.9e-13	-4.7	6.7	2.5e-11	-0.09	0.10	0.90	FALSE
4	GTEx	Adipose Subcutaneous	RP11-380L11.3	0.09	0.03	lasso	3	0.03	1.4e-03	5.7	7.2	5.9e-13	-0.07	0.03	0.96	FALSE
5	GTEx	Adipose Visceral Omentum	CCDC92	0.19	0.02	lasso	8	0.09	3.3e-05	5.7	7.2	7.0e-13	-0.12	0.03	0.97	TRUE
6	GTEx	Adipose Visceral Omentum	RP11-380L11.3	0.15	0.03	lasso	5	0.01	1.4e-01	4.5	7.2	5.7e-13	-0.08	0.03	0.79	TRUE
7	GTEx	Artery Coronary	DDX55	0.32	0.15	lasso	3	0.23	2.9e-08	-4.0	5.2	1.6e-07	-0.08	0.92	0.02	FALSE
8	GTEx	Artery Tibial	RP11-380L11.4	0.14	0.12	lasso	4	0.12	2.2e-09	5.7	5.6	2.3e-08	-0.04	0.02	0.98	FALSE
9	GTEx	Brain Cerebellar Hemisphere	WDR66	0.28	0.05	lasso	8	0.04	3.6e-02	-3.2	-5.3	1.5e-07	0.10	0.08	0.17	TRUE
10	GTEx	Brain Hippocampus	CLIP1	0.27	0.14	lasso	4	0.12	1.0e-03	-4.3	-6.3	3.6e-10	0.24	0.05	0.48	FALSE
11	GTEx	Brain Putamen basal ganglia	WDR66	0.25	0.01	enet	16	-0.01	5.6e-01	6.7	-5.9	3.1e-09	0.15	0.06	0.26	TRUE
12	GTEx	Breast Mammary Tissue	DDX55	0.21	0.08	lasso	5	0.12	9.5e-07	-4.6	5.3	1.2e-07	-0.12	0.90	0.07	FALSE
13	GTEx	Breast Mammary Tissue (Male)	CCDC92	0.06	-0.01	lasso	3	0.00	4.3e-01	4.8	5.2	2.1e-07	-0.07	0.04	0.14	FALSE
14	GTEx	Breast Mammary Tissue (Female)	KDM2B	0.13	0.00	lasso	3	0.01	1.2e-01	-4.6	5.2	1.5e-07	-0.12	0.04	0.19	TRUE
15	GTEx	Breast Mammary Tissue (Female)	C12orf65	0.06	0.00	enet	13	-0.01	6.5e-01	-4.5	-6.3	2.3e-10	0.27	0.05	0.06	FALSE
16	GTEx	Cells Transformed fibroblasts	BCL7A	0.06	0.01	lasso	4	0.01	3.1e-02	3.7	-7.6	2.5e-14	0.24	0.09	0.05	TRUE
17	GTEx	Colon Sigmoid	RP11-380L11.4	0.21	0.12	lasso	3	0.08	1.1e-03	5.8	6.1	8.3e-10	-0.06	0.03	0.93	FALSE
18	GTEx	Colon Transverse	MLXIP	0.20	0.18	enet	23	0.14	5.8e-07	7.3	6.9	5.5e-12	-0.17	1.00	0.00	TRUE
19	GTEx	Colon Transverse	SNRNP35	0.18	0.02	lasso	8	0.04	6.5e-03	-5.4	7.7	1.9e-14	-0.16	0.06	0.25	TRUE
20	GTEx	Esophagus Mucosa	KDM2B	0.11	0.04	enet	22	0.10	4.1e-07	4.1	7.6	3.5e-14	-0.10	0.92	0.01	TRUE
21	GTEx	Esophagus Mucosa	HIP1R	0.21	0.05	lasso	5	0.07	1.5e-05	3.9	8.4	5.3e-17	-0.21	0.47	0.26	FALSE
22	GTEx	Esophagus Muscularis	RP11-380L11.4	0.27	0.29	lasso	8	0.27	1.0e-16	5.9	5.8	6.2e-09	-0.05	0.02	0.98	TRUE
23	GTEx	Heart Atrial Appendage	CCDC92	0.12	0.11	enet	9	0.11	1.1e-05	4.3	5.3	1.1e-07	-0.05	0.04	0.94	FALSE
24	GTEx	Heart Atrial Appendage	RP11-380L11.4	0.18	0.11	lasso	7	0.12	6.5e-06	5.7	6.6	3.8e-11	-0.07	0.02	0.97	FALSE
25	GTEx	Heart Left Ventricle	CCDC92	0.26	0.19	lasso	4	0.21	1.9e-11	4.8	5.8	8.5e-09	-0.06	0.05	0.95	TRUE
26	GTEx	Lung	DDX55	0.12	0.07	enet	10	0.11	1.3e-08	-4.6	5.1	3.1e-07	-0.11	0.87	0.11	FALSE
27	GTEx	Lung	CCDC92	0.14	0.00	enet	10	0.01	1.1e-01	5.2	6.2	5.1e-10	-0.08	0.15	0.26	FALSE
28	GTEx	Lung	RP11-380L11.4	0.07	0.07	lasso	3	0.07	8.2e-06	5.6	5.4	6.8e-08	-0.06	0.03	0.96	FALSE
29	GTEx	Muscle Skeletal	RSRC2	0.06	0.03	enet	7	0.04	9.6e-05	-4.1	-7.8	6.5e-15	0.43	0.25	0.48	FALSE
30	GTEx	Muscle Skeletal	DDX55	0.04	0.01	lasso	5	0.00	1.4e-01	-3.8	5.3	1.3e-07	-0.11	0.34	0.08	FALSE
31	GTEx	Nerve Tibial	CCDC92	0.16	0.01	enet	6	0.04	6.7e-04	4.3	5.7	1.3e-08	-0.10	0.08	0.62	FALSE
32	GTEx	Nerve Tibial	KNTC1	0.12	0.05	lasso	5	0.05	1.9e-04	-7.4	-7.8	5.7e-15	0.31	0.53	0.03	TRUE
33	GTEx	Skin Not Sun Exposed Suprapubic	DDX55	0.25	0.09	lasso	10	0.18	5.2e-10	-3.9	5.6	1.8e-08	-0.11	0.95	0.04	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	KNTC1	0.11	0.04	lasso	4	0.03	7.1e-03	5.4	-5.4	6.0e-08	0.14	0.22	0.04	FALSE
35	GTEx	Skin Sun Exposed Lower leg	DDX55	0.13	0.05	enet	13	0.10	1.6e-08	-4.6	6.0	2.1e-09	-0.13	0.90	0.09	TRUE
36	GTEx	Skin Sun Exposed Lower leg	RP11-380L11.4	0.04	0.02	enet	15	0.02	1.9e-02	5.7	5.1	3.0e-07	-0.04	0.03	0.94	FALSE
37	GTEx	Stomach	DDX55	0.10	0.04	enet	9	0.04	5.6e-03	-3.9	5.5	4.4e-08	-0.13	0.29	0.05	FALSE
38	GTEx	Thyroid	DDX55	0.24	0.18	enet	27	0.18	1.5e-13	-4.6	5.7	1.2e-08	-0.14	0.91	0.09	FALSE
39	GTEx	Thyroid	CCDC92	0.06	0.03	lasso	3	0.02	1.1e-02	5.7	6.9	5.9e-12	-0.08	0.03	0.94	FALSE
40	GTEx	Thyroid	ZNF664	0.13	0.06	lasso	11	0.08	6.7e-07	4.8	-5.5	3.9e-08	0.04	0.03	0.97	FALSE
41	GTEx	Whole Blood	DDX55	0.13	0.04	enet	13	0.06	3.3e-06	-4.6	5.4	7.4e-08	-0.17	0.32	0.08	TRUE
42	METSIM	Adipose	ABCB9	0.04	0.03	enet	19	0.03	7.7e-05	-7.3	-9.0	2.0e-19	0.38	0.08	0.65	TRUE
43	METSIM	Adipose	CCDC92	0.10	0.01	bslmm	435	0.06	5.5e-10	-3.0	6.1	8.4e-10	-0.08	0.19	0.81	FALSE
44	METSIM	Adipose	CLIP1	0.03	0.01	bslmm	372	0.01	3.3e-03	-6.5	6.0	2.1e-09	-0.31	0.60	0.04	FALSE
45	METSIM	Adipose	RP11-214K3.24	0.05	0.03	bslmm	444	0.02	2.7e-04	4.8	6.7	2.7e-11	-0.07	0.03	0.95	FALSE
46	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LRRC43	0.06	0.03	enet	6	0.03	8.7e-04	-4.4	-5.7	1.1e-08	0.10	0.08	0.49	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	DNAH10	0.11	0.03	blup	99	0.05	8.2e-11	5.2	6.6	5.6e-11	-0.05	0.02	0.98	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	VPS33A	0.01	0.02	lasso	2	0.02	2.7e-04	6.8	-6.8	9.5e-12	0.14	0.07	0.85	FALSE
49	The Cancer Genome Atlas	Colon Adenocarcinoma	MLXIP	0.06	0.04	lasso	7	0.02	2.7e-02	7.2	7.0	2.3e-12	-0.17	0.02	0.93	TRUE
50	The Cancer Genome Atlas	Glioblastoma Multiforme	CCDC92	0.07	0.02	blup	52	0.04	1.8e-02	4.8	5.3	1.3e-07	-0.05	0.02	0.72	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DNAH10	0.07	0.03	lasso	3	0.05	7.4e-06	5.8	5.9	3.4e-09	-0.06	0.02	0.98	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRRC43	0.03	0.03	enet	8	0.02	1.5e-03	-4.4	-6.4	1.6e-10	0.15	0.08	0.21	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	VPS33A	0.03	0.05	lasso	1	0.05	4.4e-06	6.7	-6.7	2.3e-11	0.13	0.08	0.91	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	GPR109A	0.03	0.01	blup	21	0.01	1.3e-02	-5.1	-6.1	8.3e-10	0.29	0.05	0.03	TRUE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	GPR81	0.07	0.02	blup	54	0.02	4.4e-03	5.5	5.6	1.8e-08	-0.13	0.04	0.20	TRUE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	LRRC43	0.04	0.00	blup	58	0.01	6.9e-02	6.7	-6.2	4.5e-10	0.12	0.02	0.22	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	VPS33A	0.04	0.05	lasso	1	0.04	3.0e-05	6.8	-6.8	1.4e-11	0.13	0.08	0.92	FALSE
58	The Cancer Genome Atlas	Rectum Adenocarcinoma	MLXIP	0.18	0.14	lasso	4	0.13	5.1e-04	6.0	6.5	9.6e-11	-0.16	0.02	0.87	TRUE
59	The Cancer Genome Atlas	Soft Tissue Sarcoma	DDX55	0.06	0.02	enet	6	0.04	3.2e-03	-3.7	5.3	1.2e-07	-0.09	0.02	0.56	FALSE
60	The Cancer Genome Atlas	Stomach Adenocarcinoma	MLXIP	0.06	0.02	blup	68	0.04	1.2e-03	7.2	8.3	9.8e-17	-0.23	0.02	0.87	TRUE
61	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TMED2	0.10	0.03	enet	14	0.06	3.1e-03	-4.9	-5.2	1.8e-07	0.13	0.01	0.45	FALSE
62	The Cancer Genome Atlas	Thyroid Carcinoma	VPS33A	0.06	0.00	enet	8	0.03	9.6e-04	6.6	-7.6	3.9e-14	0.20	0.10	0.89	TRUE
63	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF664	0.06	0.05	enet	9	0.05	2.8e-05	5.7	-5.7	1.1e-08	0.08	0.02	0.98	FALSE