Best TWAS P=1.67e-13 · Best GWAS P=1.67e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | HMGB1 | 0.26 | 0.02 | lasso | 6 | 0.03 | 9.1e-03 | -7.4 | 6.9 | 4.2e-12 | -0.83 | 0.00 | 0.97 | FALSE |
| 2 | GTEx | Muscle Skeletal | HMGB1 | 0.21 | 0.05 | lasso | 6 | 0.08 | 7.1e-08 | -6.5 | 6.7 | 1.8e-11 | -0.86 | 0.01 | 0.99 | FALSE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HMGB1 | 0.08 | 0.04 | lasso | 1 | 0.04 | 6.9e-05 | -7.4 | 7.4 | 1.7e-13 | -1.00 | 0.00 | 1.00 | TRUE |
| 4 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HMGB1 | 0.10 | 0.07 | lasso | 4 | 0.06 | 1.4e-06 | -6.5 | 6.7 | 2.2e-11 | -0.92 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | HMGB1 | 0.07 | 0.06 | lasso | 1 | 0.05 | 1.2e-05 | -6.5 | 6.5 | 8.7e-11 | -0.90 | 0.02 | 0.98 | FALSE |