Best TWAS P=1.5e-17 · Best GWAS P=2.32e-17 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RP11-298P3.4 | 0.09 | 0.01 | lasso | 7 | 0.00 | 1.9e-01 | -7.9 | -8.1 | 4.2e-16 | 0.84 | 0.08 | 0.82 | FALSE |
| 2 | GTEx | Artery Aorta | N4BP2L2 | 0.13 | 0.10 | lasso | 3 | 0.09 | 1.1e-05 | -8.2 | -8.1 | 6.9e-16 | 0.98 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Nerve Tibial | RP11-298P3.4 | 0.06 | 0.01 | enet | 19 | 0.01 | 7.8e-02 | -7.6 | -5.7 | 1.1e-08 | 0.66 | 0.12 | 0.57 | FALSE |
| 4 | GTEx | Whole Blood | KL | 0.12 | 0.00 | lasso | 7 | 0.00 | 4.9e-01 | -2.2 | 7.2 | 4.2e-13 | -0.58 | 0.12 | 0.22 | FALSE |
| 5 | YFS | Blood | PDS5B | 0.03 | 0.04 | lasso | 1 | 0.03 | 1.4e-11 | -7.7 | -7.7 | 1.5e-14 | 0.81 | 0.23 | 0.77 | FALSE |
| 6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CG030 | 0.06 | 0.01 | blup | 38 | 0.03 | 6.0e-04 | 3.3 | 6.0 | 2.3e-09 | -0.83 | 0.01 | 0.79 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CG030 | 0.04 | 0.01 | lasso | 3 | 0.02 | 2.1e-04 | -8.2 | 8.0 | 1.4e-15 | -0.97 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | N4BP2L2 | 0.02 | 0.02 | lasso | 2 | 0.01 | 1.4e-03 | -8.4 | -8.3 | 1.1e-16 | 1.00 | 0.00 | 0.97 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CG030 | 0.07 | 0.02 | lasso | 4 | 0.03 | 2.4e-04 | -7.9 | 7.4 | 1.1e-13 | -0.83 | 0.01 | 0.67 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | N4BP2L2 | 0.04 | 0.03 | blup | 69 | 0.02 | 9.4e-04 | -8.2 | -7.8 | 7.0e-15 | 0.97 | 0.01 | 0.98 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CG030 | 0.06 | 0.01 | blup | 38 | 0.02 | 1.9e-03 | 4.4 | 6.8 | 9.6e-12 | -0.82 | 0.02 | 0.87 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | N4BP2L2 | 0.10 | 0.10 | lasso | 4 | 0.11 | 5.2e-12 | -8.2 | -7.7 | 1.3e-14 | 0.97 | 0.01 | 0.99 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Adenocarcinoma | N4BP2L2 | 0.03 | 0.02 | lasso | 4 | 0.02 | 2.8e-03 | -8.5 | -6.6 | 5.6e-11 | 0.89 | 0.01 | 0.96 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | N4BP2L2 | 0.04 | 0.04 | lasso | 2 | 0.03 | 1.5e-04 | -8.4 | -8.5 | 1.5e-17 | 0.99 | 0.00 | 0.99 | TRUE |
| 15 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CG030 | 0.08 | 0.04 | blup | 38 | 0.04 | 1.4e-03 | -7.9 | 7.7 | 1.2e-14 | -0.92 | 0.00 | 0.92 | FALSE |
| 16 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CG030 | 0.12 | 0.02 | blup | 38 | 0.03 | 3.1e-02 | -7.9 | 7.5 | 6.5e-14 | -0.82 | 0.00 | 0.60 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | N4BP2L2 | 0.06 | 0.03 | lasso | 3 | 0.05 | 1.0e-05 | 5.5 | -7.2 | 6.3e-13 | 0.79 | 0.03 | 0.96 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | N4BP2L2 | 0.12 | 0.14 | enet | 7 | 0.16 | 1.1e-15 | -7.0 | -8.0 | 1.5e-15 | 0.98 | 0.01 | 0.99 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | PDS5B | 0.02 | 0.01 | blup | 78 | 0.02 | 1.2e-02 | -8.2 | 8.1 | 4.2e-16 | -0.92 | 0.02 | 0.78 | FALSE |