Best TWAS P=4.52e-13 · Best GWAS P=1.89e-12 conditioned to 0.0439
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | RPS6KA5 | 0.08 | 0.07 | lasso | 2 | 0.06 | 5.3e-05 | -6.7 | 6.9 | 5.0e-12 | -0.89 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Colon Sigmoid | RPS6KA5 | 0.16 | 0.09 | lasso | 5 | 0.08 | 7.1e-04 | -6.5 | -6.6 | 5.1e-11 | 0.81 | 0.05 | 0.88 | FALSE |
| 3 | GTEx | Spleen | C14orf159 | 0.30 | 0.21 | lasso | 5 | 0.21 | 3.6e-06 | -6.4 | 7.2 | 4.5e-13 | -0.81 | 0.08 | 0.42 | TRUE |
| 4 | METSIM | Adipose | C14orf159 | 0.04 | 0.00 | blup | 464 | 0.01 | 4.0e-03 | -5.1 | 5.6 | 2.7e-08 | -0.70 | 0.08 | 0.76 | FALSE |