Best TWAS P=2.45e-10 · Best GWAS P=8.66e-10 conditioned to 0.126
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | RP11-23P13.7 | 0.18 | 0.08 | lasso | 3 | 0.08 | 1.0e-06 | 5.7 | 6.3 | 4.0e-10 | 0.81 | 0.06 | 0.94 | TRUE |
| 2 | GTEx | Brain Cortex | OIP5-AS1 | 0.25 | 0.01 | enet | 11 | 0.03 | 6.1e-02 | 4.9 | 6.3 | 2.4e-10 | 0.22 | 0.04 | 0.07 | TRUE |
| 3 | GTEx | Heart Atrial Appendage | RTF1 | 0.14 | 0.07 | lasso | 4 | 0.08 | 2.4e-04 | 5.1 | -5.2 | 2.0e-07 | -0.11 | 0.44 | 0.10 | FALSE |
| 4 | GTEx | Pancreas | NDUFAF1 | 0.41 | 0.39 | enet | 20 | 0.42 | 2.7e-19 | 4.8 | 5.2 | 2.4e-07 | 0.08 | 0.92 | 0.08 | FALSE |
| 5 | GTEx | Prostate | NDUFAF1 | 0.30 | 0.12 | lasso | 2 | 0.14 | 2.7e-04 | 4.9 | 5.3 | 1.3e-07 | 0.10 | 0.28 | 0.06 | FALSE |
| 6 | GTEx | Thyroid | NDUFAF1 | 0.25 | 0.21 | lasso | 6 | 0.22 | 9.3e-17 | 4.8 | 5.1 | 2.9e-07 | 0.12 | 0.92 | 0.08 | FALSE |