Hub : Genes

RTF1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cortex 0.3510 0.114 3.7e-03 0.117 NA 0.065 NA 0.000 4.1e-04 NA 7.2e-03 NA 3.2e-01
2 GTEx Heart Atrial Appendage 0.1390 0.066 9.0e-04 0.066 NA 0.016 NA 0.077 6.8e-04 NA 6.3e-02 NA 2.4e-04
3 GTEx Thyroid 0.2790 0.065 8.8e-12 0.266 NA 0.207 NA 0.258 2.0e-20 NA 8.9e-16 NA 8.4e-20
4 NTR Blood 0.0377 0.014 5.9e-08 0.020 0.026 0.024 0.025 0.015 2.8e-07 6.9e-09 3.1e-08 1.1e-08 1.2e-05
5 TCGA Thyroid Carcinoma 0.0380 0.026 6.4e-03 0.020 0.007 0.015 NA 0.020 4.3e-03 6.0e-02 1.2e-02 NA 4.0e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 4.1 6.5 11.2 0.8 2.4 3.3 -2.0 3.4
Bipolar Disorder or Schizophrenia 1.2 2.9 4.0 1.9 1.1 2.0 -1.5 1.9
Depressed Affect (Nagel 2018) 0.6 1.4 1.8 -0.9 -1.3 -1.0 1.3 -1.2
Depression (Nagel 2018) 0.2 0.3 0.6 -0.1 0.0 -0.8 0.4 -0.7
Intelligence (Savage-Jansen 2018) 0.8 2.4 4.3 -1.7 0.1 -2.1 1.1 -2.0
Neuroticism (Nagel 2018) 0.3 0.7 1.5 -0.0 -1.2 -0.8 0.7 -1.0
Schizophrenia (2018) 0.3 0.7 3.1 1.8 -0.5 -0.1 -0.2 -0.2
Schizophrenia vs Biploar Disorder 0.3 0.4 1.1 0.9 -1.1 0.2 -0.2 -0.4
Worry (Nagel 2018) 0.2 0.3 0.9 0.1 -0.9 -0.6 -0.1 -0.7
Alzheimer’s Disease (in mother) 0.5 0.6 2.2 -0.5 0.5 0.1 -1.5 0.2
Alzheimer’s Disease (in father) 2.1 2.3 5.0 0.0 2.2 1.5 -1.0 1.8
Alzheimer’s Disease (including proxy) 1.4 2.0 4.8 -0.2 1.4 1.1 -2.2 1.3
Crohns Disease (2017) 0.1 0.3 0.7 -0.6 -0.3 0.8 -0.2 0.5
Irritable Bowel Disease (IBD) 2.6 6.2 12.1 0.6 3.5 2.5 -2.3 2.7
Ulcerative Colitis (UC) 5.8 10.8 27.0 0.8 5.2 2.6 -2.8 3.4
Major Depression (MDD) 1.3 1.6 4.3 2.1 -1.7 0.6 -0.6 -0.2
Reaction Time 1.2 2.4 6.7 2.6 -0.8 1.7 -0.7 1.1
Verbal and Numeric Reasoning (VNR) 1.2 2.9 5.7 -2.4 0.9 -2.1 0.9 -1.7
Breast Cancer 0.4 0.9 2.2 0.3 1.2 0.9 -1.5 0.6
Ovarian Cancer 2.9 3.9 5.6 -0.5 -2.3 -1.7 2.2 -2.4
Prostate Cancer 0.5 0.8 1.4 -1.1 1.2 -0.5 0.9 -0.1
Age at First Birth 2.0 2.9 6.4 -2.5 0.2 -1.1 2.4 -0.8
Bipolar Disorder (2011) 0.4 0.4 2.0 1.4 0.1 0.0 -0.2 0.0
Body Mass Index (BMI) (2010) 1.5 2.1 4.2 0.6 -1.6 -1.7 0.9 -2.0
Coronary Artery Disease (CAD) 0.8 1.0 2.7 -0.6 -0.0 -1.6 1.4 0.0
Crohns Disease (2012) 0.6 1.0 2.0 -0.6 0.5 1.2 -1.4 0.9
Mean Putamen Volume 0.9 1.1 1.6 -1.0 -0.8 -1.3 0.8 -1.2
Fasting Glucose 0.3 0.3 0.6 0.4 -0.5 -0.7 0.4 -0.6
HbA1C 0.2 0.3 0.5 0.7 0.7 0.4 0.2 0.4
HDL Cholesterol 0.4 0.6 1.2 -0.0 0.8 0.9 -0.6 1.1
LDL Cholesterol 0.4 0.6 0.9 0.6 -1.0 0.9 -0.1 0.8
Lupus 2.3 3.5 7.4 -0.7 -0.5 -2.7 1.7 -2.5
Neuroticism (2016) 0.9 1.3 2.6 0.0 -0.4 -1.4 1.4 -1.6
Primary Biliary Cirrhosis 0.3 0.5 1.0 -0.0 0.1 -1.0 0.8 -0.9
Rheumatoid Arthritis 1.3 1.8 5.5 0.3 2.3 0.7 -1.4 1.1
Schizophrenia (2014) 0.3 0.8 3.2 1.8 -0.6 0.3 -0.3 0.1
Triglycerides 2.0 3.3 5.3 -0.4 -1.3 -2.3 2.1 -2.3
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.7 1.3 0.6 -0.1 -0.7 0.0
Ulcerative Colitis 6.0 8.6 17.2 0.4 4.2 2.7 -2.9 3.2
Blood Eosinophil Count 3.1 23.6 43.6 0.7 -4.2 -6.2 4.3 -6.6
Blood Platelet Count 0.2 2.3 7.1 -2.7 -1.9 0.1 0.4 -0.4
Blood Red Count 3.1 29.5 47.5 6.9 -0.1 6.3 -5.1 5.8
Blood White Count 3.2 23.6 40.7 1.4 2.8 6.4 -5.5 6.1
Heel T-Score 0.4 3.2 7.2 -2.7 -1.3 -1.1 1.9 -1.5
BMI 1.2 7.0 27.0 0.5 -5.2 -0.8 1.7 -2.1
Height 2.5 47.4 79.0 3.0 7.2 6.9 -7.0 8.9
Waist Hip Ratio (WHR) 2.3 10.3 13.7 3.7 1.9 3.4 -3.6 3.1
Systolic Blood Pressure 4.9 24.3 36.0 -3.9 -2.9 -6.0 5.4 -5.7
Smoking Status 0.9 2.1 6.6 2.6 1.1 0.9 -1.1 0.8
Allergy or Eczema 20.3 53.4 77.0 -4.1 -5.5 -8.6 8.4 -8.8
Cardiovascular Disease 6.0 19.7 28.4 -2.9 -3.8 -5.1 4.6 -5.3
Hypothyroidism (self reported) 1.5 3.5 5.4 -0.6 -2.2 -2.3 1.3 -2.3
Respiratory disease 7.6 17.0 29.3 -0.9 -2.4 -5.1 4.8 -5.4
Type 2 Diabetes (T2D) (2018) 1.6 2.9 9.4 3.1 -1.9 -0.0 -0.8 -0.8
Lung FEV1/FVC ratio 2.9 14.9 47.3 6.9 -4.2 1.2 -2.8 0.0
Lung FVC 3.7 18.7 24.2 -4.8 -2.4 -4.9 4.5 -4.6
Neuroticism 0.4 1.0 2.1 -0.2 -0.7 -1.4 0.6 -1.4
Chronotype (morning person) 0.5 1.2 2.5 -0.7 -0.5 1.6 -0.6 1.5
Hair Pigment 0.3 9.1 10.2 3.1 2.4 3.1 -3.2 3.2
Tanning 0.0 0.1 0.2 -0.5 -0.0 -0.0 -0.4 -0.1
Hand grip strength (left) 0.5 1.4 3.5 1.1 1.9 0.5 -0.7 1.2
Number of treatments/medications taken 2.7 4.8 9.2 -1.0 -3.0 -1.9 2.0 -2.5
Average weekly spirits intake 3.7 4.5 8.9 3.0 1.4 1.9 -2.4 1.7
Sensitivity / hurt feelings 0.7 1.2 2.2 0.4 -1.3 -1.3 0.3 -1.5
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.9 1.4 -0.2 -0.8 -0.0 -0.9
Hearing difficulty/problems: Yes 0.7 1.1 2.0 -1.4 1.2 -1.2 -0.4 -0.7
Relative age of first facial hair 0.1 0.3 0.6 -0.6 0.0 -0.8 0.7 -0.1
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 2.8 1.5 1.5 0.7 -1.7 0.8
Ever used hormone-replacement therapy (HRT) 3.5 4.5 7.3 -0.6 -2.0 -2.4 2.3 -2.7
Ever had hysterectomy (womb removed) 0.3 0.3 0.5 0.4 -0.5 -0.7 0.7 -0.6
Systolic blood pressure, automated reading 5.0 14.6 23.0 -3.0 -3.2 -3.8 4.8 -4.1
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 1.2 0.2 0.3 -0.8 1.1 -0.5
Angina 3.7 4.9 5.6 -2.1 -2.3 -1.9 2.4 -2.3
Medication for hormone replacement therapy 1.4 1.5 3.2 -0.3 -0.3 -1.8 1.4 -1.5
Vitamin and mineral supplements 1.7 2.3 4.7 -0.7 -2.2 -1.5 1.1 -1.6
Supplements: Zinc 1.2 1.3 3.4 1.8 0.4 1.0 -1.0 1.0
Medication: Co-codamol 0.7 0.8 1.3 0.9 -1.1 -0.9 -0.1 -1.1
Medication: Metformin 1.9 2.6 6.1 2.5 -1.9 -1.1 0.1 -1.6
Diabetes (father) 0.8 1.0 2.9 1.7 -0.6 -0.9 0.1 -1.0
Diabetes (mother) 0.8 1.0 3.8 1.9 0.3 0.1 -1.1 0.0
Severe depression (siblings) 0.7 0.8 1.3 0.9 0.7 1.0 -0.7 1.1
Pack years adult smoking proportion 1.6 2.5 4.1 0.7 -2.0 -1.5 1.7 -1.7
Impedance of leg (right) 0.4 1.8 2.4 -0.1 -1.6 -1.2 1.6 -1.6
Leg fat-free mass (left) 0.6 3.3 5.5 1.8 -0.1 2.1 -1.8 2.3
Trunk fat percentage 2.5 10.0 29.7 1.1 -5.5 -1.6 2.9 -2.8
Hand grip strength (right) 1.3 3.7 5.6 0.9 2.3 1.4 -2.4 2.1
Townsend deprivation index at recruitment 1.4 1.9 3.0 1.3 -1.7 -1.4 -0.3 -1.7
Current tobacco smoking 0.6 1.0 2.3 1.5 1.2 -0.5 -0.8 -0.2
Average weekly fortified wine intake 0.2 0.2 0.3 -0.2 0.4 0.5 0.6 0.3
Maternal smoking around birth 0.4 0.6 0.9 0.2 0.4 1.0 -1.0 0.9
Fed-up feelings 1.6 2.9 5.3 -0.6 -2.3 -1.7 1.5 -1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.6 0.6 0.2 -0.8 -0.2 -0.6
Relative age voice broke 0.2 0.3 0.7 0.4 0.7 -0.9 -0.4 -0.4
Taking other prescription medications 3.1 4.7 7.6 -1.1 -1.8 -2.3 2.5 -2.8
Age when periods started (menarche) 5.1 12.2 17.0 4.1 2.5 3.6 -2.8 4.1
Bilateral oophorectomy (both ovaries removed) 1.7 2.0 5.0 2.2 0.5 1.1 -1.5 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.7 -1.3 -1.2 0.1 0.5 -0.2
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.9 -0.6 -0.9 -0.1 0.5 -0.1
Qualifications: CSEs or equivalent 0.7 1.0 2.1 0.9 1.4 -0.5 -1.3 0.0
Serious illness, injury or assault to yourself 1.1 1.4 4.6 2.2 0.0 0.8 -1.1 0.6
High blood pressure 5.3 14.8 21.0 -1.8 -3.8 -4.4 4.0 -4.6
Hayfever, allergic rhinitis or eczema 13.9 30.2 43.3 -3.5 -3.6 -6.6 6.3 -6.5
Multivitamins +/- minerals 2.3 3.0 6.4 2.5 1.6 1.6 -1.2 1.4
Stomach or abdominal pain in last month 0.5 0.6 2.1 0.6 -1.4 -0.5 0.1 -0.5
Supplements: Glucosamine 1.5 1.9 3.4 1.4 0.5 1.7 -0.9 1.9
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 2.8 1.3 -1.2 0.0 1.7 -0.3
Medication: Atenolol 1.3 1.6 6.2 0.2 -2.5 -0.4 0.7 -1.0
Medication: Levothyroxine sodium 1.2 2.1 4.1 0.1 -2.0 -1.4 1.1 -1.8
Sitting height 1.8 12.7 21.3 1.4 2.8 3.9 -4.1 4.6
Chronic bronchitis/emphysema (father) 0.5 0.6 1.7 0.0 0.2 1.3 -0.2 1.1
High blood pressure (mother) 0.4 0.6 1.2 1.1 -0.3 -0.9 0.2 -0.9
Body mass index (BMI) 1.5 6.3 21.5 0.5 -4.6 -1.2 1.9 -2.1
Impedance of leg (left) 0.2 1.0 1.8 0.1 -0.8 -1.2 1.0 -1.4
Leg predicted mass (left) 0.6 3.3 5.5 1.8 -0.0 2.1 -1.8 2.3
Trunk fat mass 1.3 5.5 20.1 1.6 -4.5 -0.5 1.6 -1.4
Waist circumference 0.9 3.4 7.3 2.7 -2.7 1.4 -0.5 0.7
Number of incorrect matches in round 0.6 1.0 1.8 0.3 0.8 1.1 -1.3 1.2
Past tobacco smoking 1.9 3.5 4.9 -2.2 -1.8 -1.6 2.0 -1.6
Alcohol usually taken with meals 0.6 1.0 3.9 -2.0 -0.3 0.4 0.7 0.4
Nervous feelings 0.2 0.4 1.2 -0.2 1.1 -0.5 -0.7 -0.4
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.0 -0.3 0.3 -1.0 0.5 -0.9
Hearing difficulty/problems with background noise 1.5 2.4 4.7 -2.2 -0.1 -2.0 0.6 -1.7
Hair/balding pattern: Pattern 2 0.8 1.1 1.7 0.7 1.2 0.8 -1.0 1.3
Had menopause 7.2 9.0 13.0 -2.5 -3.5 -2.3 3.6 -2.9
Had other major operations 2.5 3.1 7.3 -1.4 -2.7 -0.8 1.9 -1.4
Forced vital capacity (FVC) 0.3 1.0 2.2 -1.5 0.1 -1.5 0.5 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.8 -1.3 -1.2 -0.1 0.3 -0.3
Ever unenthusiastic/disinterested for a whole week 2.2 2.7 6.3 2.5 -0.3 1.2 -2.1 1.0
Qualifications: None of the above 0.2 0.5 1.8 -0.4 -1.3 0.5 0.5 -0.1
Financial difficulties in last 2 years 0.6 0.8 1.9 1.2 -1.4 -0.1 0.6 -0.4
Mouth/teeth dental problems 0.1 0.1 0.4 -0.2 -0.2 -0.3 0.6 -0.2
Heart attack 0.3 0.3 1.4 -1.2 -0.5 0.3 -0.2 0.1
Allergy 12.0 27.6 44.2 2.9 2.8 6.6 -5.9 6.7
Pain all over the body in last month 1.8 1.9 2.7 -0.8 -1.3 -1.6 1.5 -1.6
Diabetes (self-reported) 0.9 1.3 4.3 2.1 -1.3 0.2 -0.6 -0.5
Hayfever/allergic rhinitis (self-reported) 5.7 7.6 11.6 -1.4 -2.0 -3.1 3.4 -3.3
Medication: Ramipril 3.3 4.2 7.9 -0.3 -1.6 -2.8 1.7 -2.8
Medication: Simvastatin 1.8 2.6 5.8 -0.3 -1.5 -2.0 1.0 -2.4
Fluid intelligence score 0.8 1.7 4.2 -1.1 2.1 -1.4 0.1 -1.0
Illnesses of siblings 5.4 7.6 11.4 2.0 1.1 3.1 -3.4 3.3
Neuroticism score 0.2 0.5 1.0 0.2 -0.6 -1.0 0.1 -1.0
Weight 0.4 1.9 5.7 1.6 -2.4 0.9 -0.4 0.6
Impedance of arm (right) 0.7 3.2 5.8 0.6 -0.4 -2.2 2.4 -2.2
Arm fat percentage (right) 2.9 11.5 30.0 1.1 -5.5 -2.2 3.2 -3.4
Trunk fat-free mass 1.9 10.9 17.9 2.3 1.5 3.6 -4.0 4.2
Hip circumference 0.4 1.7 6.6 0.9 -2.6 -0.1 0.9 -0.3
Time employed in main current job 5.1 5.8 7.2 2.2 2.7 2.1 -2.6 2.4
Alcohol intake versus 10 years previously 0.2 0.4 0.9 0.9 -0.6 0.1 -0.7 0.2
Father’s age at death 3.1 4.1 10.0 0.1 0.7 3.2 -1.7 2.7
Worrier / anxious feelings 1.2 2.2 3.8 0.1 -1.9 -1.7 1.0 -1.8
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 3.6 0.6 -1.9 -0.7 0.2 -1.4
Falls in the last year 0.3 0.5 1.6 0.7 -1.3 0.3 -0.2 -0.1
Hair/balding pattern: Pattern 3 0.2 0.3 1.3 -0.6 -1.1 0.2 0.1 0.0
Number of live births 2.1 2.9 5.3 0.5 -2.3 -1.2 2.3 -1.6
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 1.8 0.1 -1.1 -1.3 0.1 -0.8
Pulse rate 0.3 0.4 1.1 0.5 0.8 0.3 -1.0 0.4
Happiness 1.3 1.6 2.2 0.6 1.3 1.4 -1.5 1.3
Noisy workplace 0.3 0.4 0.9 0.6 -0.9 -0.7 0.0 -0.3
Qualifications: A levels/AS levels or equivalent 0.7 1.5 3.1 -0.8 -0.0 -1.8 1.0 -1.6
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.4 -0.1 1.2 -0.8 -0.6 -0.5
Mouth/teeth dental problems: Dentures 0.1 0.2 0.6 0.8 0.1 -0.1 0.0 -0.4
Asthma 6.8 13.3 25.9 -0.1 -1.9 -4.8 3.8 -5.1
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 1.6 1.2 1.0 0.7 -1.3 0.9
Medication: Cholesterol lowering 5.1 7.9 10.0 -2.0 -3.0 -2.6 3.2 -3.1
Depression (self-reported) 0.1 0.1 0.3 -0.3 -0.5 0.2 0.3 0.1
Medication: Lansoprazole 1.0 1.1 2.9 -0.0 -0.6 -1.0 1.7 -1.2
Prospective memory result 0.9 1.1 2.3 1.5 -1.4 0.8 0.6 0.3
Lung cancer (father) 2.0 2.3 4.4 0.0 0.8 2.0 -1.6 2.1
Illnesses of mother 1.1 1.4 2.8 1.0 0.0 1.7 -0.9 1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.4 2.9 0.4 -1.6 -1.7 -0.0 -1.2
Pulse wave Arterial Stiffness index 0.8 0.9 1.6 -1.0 -1.3 -0.4 1.2 -0.7
Impedance of arm (left) 0.8 3.5 7.6 0.1 -0.2 -2.2 2.8 -2.2
Arm fat mass (right) 1.5 6.2 20.9 1.4 -4.6 -1.1 1.8 -1.9
Trunk predicted mass 1.8 10.6 17.2 2.3 1.4 3.6 -4.0 4.2
Standing height 2.1 20.5 32.6 2.8 4.4 4.3 -4.9 5.7
Length of working week for main job 0.4 0.4 1.4 1.2 -0.1 0.4 -0.5 0.7
Exposure to tobacco smoke at home 3.2 3.5 5.7 -1.6 -1.9 -1.5 2.4 -1.8
Breastfed as a baby 0.2 0.2 0.6 0.2 0.8 0.3 -0.5 0.5
Tense / ‘highly strung’ 0.3 0.5 1.1 -0.2 -1.0 -0.3 1.0 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 1.4 1.1 -0.9 -1.0 1.0 -1.2
Hair/balding pattern: Pattern 4 0.3 0.8 1.8 -0.4 0.8 1.3 0.1 1.1
Birth weight of first child 4.8 8.8 11.3 3.0 2.2 2.9 -3.4 3.2
Peak expiratory flow (PEF) 0.2 0.6 1.4 0.9 0.6 -0.5 -1.2 -0.0
Pulse wave reflection index 4.2 5.2 7.3 -0.7 -2.4 -2.5 2.7 -2.6
Ever highly irritable/argumentative for 2 days 2.2 2.6 8.9 0.5 -3.0 -1.1 1.0 -1.4
Loud music exposure frequency 0.1 0.2 0.5 0.0 -0.3 -0.7 0.1 -0.4
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 2.1 -0.8 -0.5 -1.5 0.5 -1.3
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.9 -1.7 -0.6 -0.6 0.2 -0.5
Blood clot in the leg (DVT) 0.3 0.4 0.8 -0.6 -0.9 -0.5 -0.2 -0.7
Medication: Paracetamol 0.7 1.1 4.9 2.2 -0.5 -0.3 -0.4 -0.5
Headache pain in last month 2.4 4.1 10.4 1.8 -3.2 -1.3 1.5 -1.7
Medication for cholesterol, blood pressure or diabetes 4.7 7.7 10.4 2.4 2.1 3.1 -3.0 3.2
Glaucoma (self-reported) 0.9 1.0 4.1 -2.0 0.6 -0.4 0.6 0.1
Gout (self-reported) 1.0 1.3 2.4 1.6 1.0 0.8 -1.4 0.8
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 5.2 0.2 -2.3 -1.1 0.9 -1.5
Medication: Amlodipine 2.5 3.4 4.6 -1.2 -1.5 -2.1 2.1 -2.2
Medication: Ventolin 100micrograms inhaler 3.7 4.7 8.0 -1.4 -1.9 -2.2 2.8 -2.3
Birth weight 2.7 5.9 8.7 2.6 -0.6 2.7 -2.9 2.6
Chronic bronchitis/emphysema (mother) 1.0 1.2 3.7 -0.7 -1.9 -0.6 0.9 -0.7
High blood pressure (siblings) 5.9 8.4 12.1 -1.6 -2.7 -3.3 3.0 -3.5
Forced vital capacity (FVC), Best measure 0.5 1.8 4.8 -1.3 -0.5 -2.2 0.4 -1.4
Body fat percentage 3.0 11.8 33.8 0.9 -5.8 -1.9 3.2 -3.2
Leg fat percentage (right) 3.3 12.0 35.1 0.3 -5.9 -1.8 3.4 -3.2
Arm fat-free mass (right) 1.4 7.3 12.9 1.4 0.6 3.3 -3.3 3.6
Exposure to tobacco smoke outside home 0.4 0.5 1.2 -1.1 1.0 -0.2 -0.6 0.2
Comparative body size at age 10 1.8 4.8 12.7 -0.1 -3.6 -1.4 2.1 -2.3
Number of full brothers 0.5 0.6 1.5 -0.4 -0.4 -1.1 0.3 -1.2
Worry too long after embarrassment 0.2 0.3 0.3 0.5 -0.4 -0.6 0.5 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.3 0.3 0.9 1.0 -1.1 1.0
Wheeze or whistling in the chest in last year 1.4 2.5 4.3 -0.2 -0.5 -2.0 1.9 -2.1
Number of children fathered 0.5 0.6 1.9 1.4 0.1 -0.3 -0.9 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.2 -0.5 0.8 0.7 0.9 1.1
Age at first live birth 0.6 1.1 1.8 0.4 1.1 1.1 -0.9 1.3
Pulse wave peak to peak time 1.4 1.6 3.0 1.2 1.7 0.7 -1.5 1.0
Health satisfaction 1.1 1.4 2.1 -0.8 -1.1 -1.3 1.1 -1.5
Shortness of breath walking on level ground 2.7 3.2 6.6 -1.3 -2.6 -1.7 1.4 -1.6
Qualifications: College or University degree 0.2 0.7 1.2 -0.2 0.9 -1.0 1.1 -0.7
Eye problems/disorders: None of the above 0.1 0.1 0.3 0.2 0.1 0.2 -0.6 -0.0
Mouth/teeth dental problems: Loose teeth 3.0 3.6 7.1 1.8 1.2 1.7 -2.7 1.8
Emphysema/chronic bronchitis 0.4 0.5 1.0 -0.6 0.7 1.0 -0.4 0.6
Medication for pain relief, constipation, heartburn 1.2 2.1 5.3 -0.8 2.3 0.9 -1.2 1.5
Neck or shoulder pain in last month 1.3 1.9 3.2 -0.5 -1.5 -1.3 1.8 -1.4
Medication: Blood pressure 2.1 3.7 7.3 -1.2 -1.0 -2.6 1.4 -2.7
Angina (self-reported) 3.8 5.0 5.7 -2.1 -2.3 -1.9 2.4 -2.4
Migraine (self-reported) 0.4 0.5 1.6 1.3 0.4 0.4 -0.4 0.5
Medication: Ibuprofen 0.6 0.7 1.2 0.5 0.5 0.8 -1.0 1.1
Medication: Allopurinol 0.3 0.4 1.3 1.2 0.2 -0.1 -0.8 -0.2
Medication: Omeprazole 1.8 2.1 5.3 -1.3 -2.3 -0.7 1.3 -1.1
Medication: Seretide 50 evohaler 1.7 1.9 3.5 0.1 -0.5 -1.8 1.6 -1.9
Mean time to correctly identify matches 1.0 1.8 3.7 1.9 -1.2 1.7 -0.3 1.0
Heart disease (mother) 1.1 1.4 2.0 -0.5 -1.3 -1.3 1.1 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.4 0.6 -0.3 0.6 -0.3 0.4
Whole body fat mass 1.5 6.2 22.4 1.5 -4.7 -0.6 1.9 -1.6
Leg fat mass (right) 1.7 6.5 24.0 0.9 -4.9 -0.7 2.1 -1.7
Arm predicted mass (right) 1.7 8.7 14.5 2.0 0.5 3.5 -3.5 3.8
Pulse rate, automated reading 0.7 2.4 5.0 0.5 1.0 2.2 -1.2 2.1
Alcohol intake frequency. 2.3 5.2 11.3 -0.3 -3.4 -2.0 2.1 -2.5
Comparative height size at age 10 0.8 4.2 5.4 2.3 1.8 1.7 -2.2 2.1
Number of full sisters 0.4 0.5 2.0 1.4 -0.4 -0.5 -0.1 -0.6
Suffer from ‘nerves’ 0.0 0.1 0.2 -0.2 0.2 -0.4 0.0 -0.4
Overall health rating 1.0 2.1 5.6 0.6 -2.4 -1.2 0.2 -1.8
Chest pain or discomfort 1.2 1.7 2.0 -1.0 -1.4 -1.4 1.3 -1.4
Had major operations 1.2 1.4 2.4 -1.2 -1.1 -1.4 0.2 -1.6
Age at last live birth 1.4 2.0 3.0 1.6 0.9 1.6 -0.9 1.7
Family relationship satisfaction 0.4 0.4 0.9 -1.0 -0.8 -0.5 -0.1 -0.6
Leg pain on walking 2.4 2.9 7.8 1.4 -2.8 -1.4 0.5 -1.6
Qualifications: NVQ or HND or HNC or equivalent 3.8 4.5 8.9 3.0 2.1 0.7 -2.8 1.1
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.6 -1.3 -0.6 -0.4 0.9 -0.4
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 2.3 -1.5 0.0 0.4 0.2 0.3
Medication: Aspirin 1.3 1.7 3.0 -0.6 -1.7 -1.2 1.0 -1.7
Supplements: Vitamin C 0.3 0.4 1.3 -1.2 0.7 -0.3 0.1 0.1
Knee pain experienced in last month 0.6 0.9 2.6 1.6 -1.3 -0.1 0.3 -0.6
Hypertension (Self-reported) 5.4 15.1 22.2 -2.0 -3.6 -4.6 4.0 -4.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.5 -0.4 0.7 -0.5 -0.6 -0.3
Illnesses of father: Heart disease 4.6 6.4 9.5 -1.3 -2.4 -2.5 3.1 -2.9
Illnesses of siblings: Diabetes 0.2 0.2 0.4 0.5 -0.2 -0.4 0.6 -0.5
Smoking status: Previous 1.6 2.4 3.3 1.8 0.8 1.8 -1.3 1.7
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 2.6 -0.0 0.5 0.7 -1.6 1.4
Whole body fat-free mass 1.5 8.7 14.3 2.2 1.1 3.3 -3.5 3.8
Leg fat-free mass (right) 0.8 4.5 7.6 1.8 0.9 2.3 -2.4 2.8
Arm fat percentage (left) 2.8 11.0 28.1 0.8 -5.3 -2.2 3.2 -3.3
Average weekly red wine intake 0.4 0.6 2.7 -0.1 1.6 -0.3 0.6 0.2
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.2 -1.1 -1.1 0.9 -0.2 0.7
Mood swings 0.1 0.1 0.3 0.5 -0.1 0.0 -0.4 -0.1
Loneliness, isolation 0.2 0.3 0.4 -0.7 -0.2 0.7 -0.4 0.6
Long-standing illness, disability or infirmity 2.8 4.2 8.3 -0.5 -2.0 -2.4 1.7 -2.9
Ever had bowel cancer screening 1.6 1.9 5.2 0.4 0.0 2.3 -0.8 1.8
Diabetes diagnosed by doctor 1.2 2.0 5.0 2.2 -2.0 -0.2 0.2 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 2.4 2.6 4.5 0.4 -0.7 -2.1 1.8 -2.1
Friendships satisfaction 0.8 1.0 1.8 -1.0 -1.0 -1.1 0.5 -1.4
Qualifications: nursing, teaching 0.2 0.4 1.1 0.5 1.1 -0.2 -0.6 0.1
Commuting to job workplace: Walk 1.4 1.5 4.1 2.0 0.9 0.8 -1.1 0.8
Eye problems/disorders: Cataract 0.1 0.1 0.4 0.6 -0.2 -0.2 0.4 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.1 1.1 0.6 0.3 -0.1 0.4
Medication for cholesterol 3.0 4.6 9.0 0.7 1.7 2.8 -1.6 3.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 5.8 6.8 14.2 -0.1 -3.8 -1.9 3.0 -2.7
Back pain experienced in last month 0.8 1.1 2.6 1.6 -1.4 0.9 -0.1 0.6
Mineral and other dietary supplements 0.9 1.2 2.9 -1.7 -0.9 -1.0 0.2 -1.2
Breast cancer (self-reported) 1.1 1.3 3.0 -1.7 -0.8 -0.0 1.6 0.0
Asthma (self-reported) 6.7 13.4 25.6 -0.2 -1.8 -4.8 3.9 -5.1
Osteoporosis (self-reported) 2.2 2.8 7.3 -2.7 -1.5 -0.3 2.0 -0.5
Osteoarthritis (self-reported) 0.5 0.6 2.6 0.7 -1.6 0.2 -0.1 -0.3
Medication: Aspirin 1.2 1.6 3.0 -1.3 -1.7 -0.9 0.9 -1.4
Medication: Gliclazide 0.7 0.8 2.0 1.4 -1.2 0.7 -0.4 0.2
Illnesses of father: None of the above (group 1) 4.4 5.5 8.6 1.4 2.1 2.5 -2.5 2.9
Smoking status: Current 0.8 1.3 3.1 1.8 1.1 -1.0 -0.6 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.2 4.6 8.5 -0.1 -2.9 -2.4 1.5 -2.5
Whole body water mass 1.4 8.1 13.5 2.2 1.1 3.2 -3.3 3.7
Leg predicted mass (right) 0.9 4.6 7.5 1.9 0.9 2.3 -2.4 2.7
Arm fat mass (left) 1.4 5.8 19.8 1.2 -4.5 -1.0 1.8 -1.8
Number of self-reported non-cancer illnesses 3.6 6.3 12.0 -0.2 -1.9 -3.2 2.3 -3.5
Average weekly champagne plus white wine intake 2.4 3.3 5.5 0.6 1.0 2.3 -2.3 2.1
Miserableness 0.1 0.2 0.5 0.0 -0.4 -0.7 -0.0 -0.6
Guilty feelings 0.1 0.1 0.3 0.6 -0.2 0.1 -0.4 -0.0
Wears glasses or contact lenses 1.0 1.2 2.3 -1.5 -1.5 0.2 1.1 -0.0
Ever taken oral contraceptive pill 0.5 0.5 1.9 0.1 1.4 -0.2 -0.8 0.2
Hearing aid user 0.5 0.5 1.4 0.5 -1.2 -0.4 0.5 -0.8
Mother’s age at death 0.4 0.5 1.8 -0.6 0.5 0.1 1.4 0.4
Financial situation satisfaction 0.3 0.4 1.3 0.1 -1.1 -0.4 0.2 -0.7
Tinnitus: Yes, now most or all of the time 1.9 2.3 4.0 0.4 -1.4 -2.0 1.1 -2.0
Commuting to job workplace: Public transport 1.4 1.7 3.4 0.2 -1.5 -1.5 0.8 -1.9
Eye problems/disorders: Glaucoma 1.0 1.2 2.2 -1.5 -0.4 -1.2 1.4 -0.6
Medication: Blood pressure 4.2 8.0 11.9 -1.5 -2.9 -3.2 2.7 -3.5
Pain type(s) experienced in last month: Hip pain 3.0 3.8 8.7 -0.7 -3.0 -1.6 1.6 -2.1
Supplements: Fish oil (including cod liver oil) 0.5 0.7 1.4 1.2 1.2 0.4 -0.0 0.7
High cholesterol (Self-reported) 2.5 4.5 6.8 -1.5 -2.0 -2.2 2.1 -2.6
Medication: Bendroflumethiazide 0.8 1.2 2.5 -0.2 -1.1 -1.4 0.5 -1.6
Medication: Paracetamol 0.8 1.3 5.0 2.2 -0.7 0.4 -0.8 0.2
Medication: Lisinopril 1.7 2.2 6.0 -2.5 0.0 -1.5 0.8 -1.5
Medication: Atorvastatin 3.8 4.7 9.0 -2.1 -3.0 -1.2 2.4 -1.8
Illnesses of father: High blood pressure 3.0 3.7 4.8 -1.7 -2.2 -1.9 1.8 -1.9
Alcohol drinker status: Never 2.0 2.4 8.1 -1.2 -2.8 -0.6 1.1 -0.9
Ever smoked 2.3 4.0 8.2 1.4 2.9 1.5 -2.1 1.8
Basal metabolic rate 1.0 5.5 8.9 2.1 0.2 2.7 -2.7 3.0
Leg fat percentage (left) 3.1 11.1 30.8 0.5 -5.5 -2.0 3.2 -3.2
Arm fat-free mass (left) 1.2 6.3 10.1 2.1 -0.0 2.9 -2.9 3.2
Number of operations (self-reported) 2.3 3.3 10.3 0.1 -3.2 -1.1 1.5 -1.7
Average weekly beer plus cider intake 0.5 0.7 1.9 1.4 0.7 -0.5 -0.7 -0.3
Irritability 0.1 0.2 0.4 -0.4 0.6 0.1 -0.4 0.3
Risk taking 1.5 2.2 3.5 0.4 1.9 1.5 -1.4 1.7
Ever had prostate specific antigen (PSA) test 2.9 3.4 7.0 0.2 1.9 2.4 -0.8 2.6
Fractured/broken bones in last 5 years 0.1 0.1 0.2 0.3 0.0 0.5 -0.4 0.4
Age started oral contraceptive pill 0.4 0.5 0.7 -0.8 -0.5 0.7 0.8 0.5
Diastolic blood pressure, automated reading 5.0 15.5 22.3 -1.7 -4.4 -3.8 4.7 -4.3
Ever depressed for a whole week 0.2 0.2 1.0 1.0 -0.2 0.0 -0.2 -0.1
Unable to work because of sickness or disability 0.3 0.4 0.7 0.6 -0.3 0.8 -0.5 0.6
Commuting to job workplace: Cycle 3.8 4.5 8.2 1.0 2.9 2.0 -2.2 2.1
Myopia 0.2 0.3 0.9 -0.6 1.0 0.0 0.4 0.3
Vascular/heart problems diagnosed by doctor 5.7 15.4 21.6 2.3 4.0 4.5 -3.9 4.7
Cholesterol lowering medication 0.9 1.4 2.8 -0.1 -1.6 -1.2 0.3 -1.7
Medication: Omeprazole (e.g. Zanprol) 2.4 3.0 4.9 -1.1 -2.2 -1.4 2.0 -1.7
Pain experienced in last month 1.7 2.8 8.0 -0.9 2.8 1.1 -1.2 1.5
Supplements: Calcium 0.9 1.0 1.5 -0.1 1.1 1.2 -1.1 1.2
Basal cell carcinoma (self-reported) 2.0 2.4 4.6 2.1 -1.9 1.1 -1.4 0.8
Heart attack/myocardial infarction (self-reported) 0.2 0.3 1.2 -1.1 -0.5 0.2 -0.1 0.0
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.7 -0.7 -0.8 -0.4 -0.2 -0.7
Heart disease (siblings) 5.2 6.4 10.7 -1.1 -0.9 -3.0 3.2 -3.3
Alcohol drinker status: Previous 0.4 0.4 0.8 -0.1 0.7 -0.9 -0.3 -0.9
Pack years of smoking 1.8 2.7 4.6 0.6 -2.1 -1.4 1.8 -1.7
Impedance of whole body 0.5 2.3 3.9 0.3 -0.6 -1.9 1.9 -2.0
Leg fat mass (left) 1.6 6.1 22.4 0.9 -4.7 -0.8 2.0 -1.7
Arm predicted mass (left) 1.2 5.9 9.3 2.0 -0.3 2.8 -2.9 3.0