Best TWAS P=5.11e-09 · Best GWAS P=1.17e-08 conditioned to 0.261
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | CHRNB1 | 0.29 | 0.14 | lasso | 5 | 0.14 | 1.0e-07 | -4.6 | -5.2 | 1.5e-07 | -0.02 | 0.35 | 0.61 | FALSE |
| 2 | GTEx | Brain Putamen basal ganglia | ELP5 | 0.67 | 0.38 | lasso | 11 | 0.39 | 2.6e-10 | -3.8 | -5.3 | 1.1e-07 | -0.68 | 0.30 | 0.64 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | CHRNB1 | 0.23 | 0.07 | enet | 19 | 0.14 | 1.6e-07 | 2.2 | -5.8 | 5.1e-09 | -0.15 | 0.34 | 0.51 | TRUE |
| 4 | YFS | Blood | KDM6B | 0.07 | 0.04 | enet | 34 | 0.04 | 1.1e-13 | 3.6 | -5.7 | 1.5e-08 | -0.09 | 0.54 | 0.24 | TRUE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C17orf81 | 0.04 | 0.05 | enet | 8 | 0.04 | 1.2e-05 | -3.2 | -5.2 | 1.7e-07 | -0.67 | 0.03 | 0.29 | TRUE |