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chr17:4,041,725-6,093,417

Best TWAS P=1.44e-13 · Best GWAS P=1.05e-12 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	NUP88	0.14	0.15	lasso	6	0.17	4.3e-20	5.5	-5.1	2.9e-07	-0.86	0.98	0.02	FALSE
2	GTEx	Adipose Subcutaneous	RPAIN	0.10	0.08	lasso	5	0.04	2.2e-04	4.3	-5.4	8.0e-08	-0.82	0.46	0.54	TRUE
3	GTEx	Adipose Visceral Omentum	CHRNE	0.29	0.27	lasso	3	0.22	7.0e-12	4.9	5.1	3.1e-07	0.28	1.00	0.00	FALSE
4	GTEx	Adrenal Gland	RABEP1	0.13	0.03	lasso	13	0.02	7.2e-02	-5.2	-6.5	6.4e-11	-0.81	0.03	0.85	FALSE
5	GTEx	Artery Coronary	CHRNE	0.50	0.38	lasso	6	0.37	3.0e-13	4.9	5.5	4.5e-08	0.29	1.00	0.00	FALSE
6	GTEx	Artery Tibial	CHRNE	0.40	0.38	lasso	4	0.45	2.8e-38	4.9	5.2	2.2e-07	0.28	1.00	0.00	FALSE
7	GTEx	Artery Tibial	NUP88	0.10	0.05	lasso	3	0.04	2.5e-04	5.6	-5.5	4.5e-08	-0.83	0.72	0.21	FALSE
8	GTEx	Brain Cerebellum	ZNF232	0.18	0.02	enet	15	0.05	1.4e-02	4.2	-5.5	3.7e-08	-0.57	0.07	0.60	FALSE
9	GTEx	Brain Frontal Cortex BA9	CHRNE	0.29	0.03	lasso	6	0.03	4.6e-02	5.5	6.0	2.7e-09	0.33	0.12	0.07	FALSE
10	GTEx	Brain Hypothalamus	C1QBP	0.30	0.21	lasso	8	0.17	7.2e-05	5.1	5.2	2.1e-07	0.70	0.20	0.10	FALSE
11	GTEx	Brain Putamen basal ganglia	AC012146.7	0.30	0.03	enet	23	0.03	7.6e-02	5.1	-6.9	4.3e-12	-0.45	0.08	0.26	FALSE
12	GTEx	Breast Mammary Tissue	CHRNE	0.36	0.31	lasso	4	0.29	1.6e-15	5.3	5.8	8.8e-09	0.34	1.00	0.00	FALSE
13	GTEx	Breast Mammary Tissue (Female)	CHRNE	0.41	0.30	lasso	9	0.30	1.7e-09	5.5	5.6	1.8e-08	0.27	0.93	0.02	FALSE
14	GTEx	Cells Transformed fibroblasts	CHRNE	0.43	0.42	enet	23	0.49	2.9e-41	4.8	5.1	2.9e-07	0.27	1.00	0.00	FALSE
15	GTEx	Cells Transformed fibroblasts	NUP88	0.09	0.10	enet	15	0.10	8.8e-08	5.5	-5.6	2.1e-08	-0.83	0.96	0.04	FALSE
16	GTEx	Cells Transformed fibroblasts	GP1BA	0.22	0.10	enet	9	0.18	3.1e-13	6.4	5.2	2.0e-07	0.26	0.62	0.38	FALSE
17	GTEx	Colon Sigmoid	CHRNE	0.32	0.26	lasso	4	0.26	1.0e-09	4.9	5.2	2.4e-07	0.28	1.00	0.00	FALSE
18	GTEx	Colon Sigmoid	GP1BA	0.25	0.17	lasso	4	0.12	3.6e-05	5.1	5.5	5.1e-08	0.29	0.26	0.04	FALSE
19	GTEx	Colon Transverse	RABEP1	0.13	0.11	lasso	4	0.08	8.7e-05	5.5	-5.5	3.0e-08	-0.83	0.35	0.64	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	DHX33	0.12	0.08	lasso	5	0.07	1.8e-03	7.1	-6.9	6.4e-12	-0.96	0.02	0.96	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	RABEP1	0.19	-0.01	lasso	13	0.00	4.2e-01	5.6	-6.7	1.7e-11	-0.82	0.03	0.81	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	GP1BA	0.35	0.16	lasso	11	0.18	5.9e-07	4.6	6.5	9.3e-11	0.56	0.25	0.61	FALSE
23	GTEx	Esophagus Mucosa	CHRNE	0.11	0.07	enet	19	0.07	2.5e-05	4.7	5.3	8.7e-08	0.31	0.95	0.01	FALSE
24	GTEx	Esophagus Muscularis	RABEP1	0.13	0.09	lasso	10	0.10	2.1e-06	7.1	-6.7	2.5e-11	-0.95	0.02	0.98	FALSE
25	GTEx	Heart Atrial Appendage	RABEP1	0.13	0.10	enet	11	0.12	7.2e-06	5.6	-5.7	9.8e-09	-0.86	0.06	0.92	FALSE
26	GTEx	Lung	RABEP1	0.11	0.12	lasso	6	0.10	3.4e-08	5.6	-5.7	1.1e-08	-0.83	0.20	0.80	FALSE
27	GTEx	Lung	CAMTA2	0.10	0.02	lasso	3	0.02	1.2e-02	4.5	6.1	9.2e-10	0.37	0.36	0.05	FALSE
28	GTEx	Muscle Skeletal	RABEP1	0.06	0.05	lasso	2	0.04	1.0e-04	5.1	-5.2	2.5e-07	-0.76	0.89	0.04	FALSE
29	GTEx	Muscle Skeletal	NUP88	0.05	0.01	enet	7	0.00	1.0e-01	3.7	5.4	7.4e-08	0.72	0.10	0.76	FALSE
30	GTEx	Nerve Tibial	RABEP1	0.15	0.15	lasso	10	0.14	5.9e-10	5.5	-5.1	3.0e-07	-0.76	0.97	0.03	FALSE
31	GTEx	Nerve Tibial	NUP88	0.08	0.07	lasso	3	0.09	5.0e-07	5.5	-5.3	1.3e-07	-0.88	0.10	0.89	TRUE
32	GTEx	Ovary	RABEP1	0.28	0.30	lasso	9	0.26	4.6e-07	5.5	-5.5	2.8e-08	-0.83	0.35	0.56	FALSE
33	GTEx	Pancreas	MIS12	0.18	0.12	lasso	4	0.09	8.5e-05	4.3	-5.2	1.6e-07	-0.79	0.03	0.92	FALSE
34	GTEx	Skin Sun Exposed Lower leg	CAMTA2	0.12	0.01	lasso	5	0.02	3.7e-03	5.7	5.3	1.5e-07	0.32	0.80	0.03	FALSE
35	GTEx	Skin Sun Exposed Lower leg	AC012146.7	0.21	0.07	enet	17	0.18	1.3e-14	2.8	-5.2	1.7e-07	-0.45	1.00	0.00	FALSE
36	GTEx	Spleen	RABEP1	0.26	0.26	lasso	13	0.24	6.1e-07	5.6	-5.2	1.6e-07	-0.79	0.11	0.87	FALSE
37	GTEx	Spleen	CHRNE	0.26	0.26	lasso	2	0.22	2.9e-06	5.3	5.4	6.3e-08	0.27	0.23	0.06	FALSE
38	GTEx	Stomach	CHRNE	0.20	0.16	enet	12	0.14	2.0e-07	5.0	5.2	1.8e-07	0.24	0.98	0.00	FALSE
39	GTEx	Testis	RABEP1	0.69	0.60	lasso	12	0.68	4.9e-40	5.5	-5.6	2.1e-08	-0.81	0.99	0.01	FALSE
40	GTEx	Testis	INCA1	0.15	0.03	lasso	5	0.02	5.9e-02	5.1	5.3	1.4e-07	0.33	0.13	0.10	FALSE
41	GTEx	Thyroid	DHX33	0.09	0.09	enet	13	0.06	1.5e-05	5.8	-5.8	4.9e-09	-0.86	0.19	0.80	FALSE
42	GTEx	Thyroid	RABEP1	0.21	0.27	lasso	7	0.26	1.4e-19	5.5	-5.6	2.2e-08	-0.81	0.99	0.01	FALSE
43	GTEx	Thyroid	SLC25A11	0.08	0.05	lasso	5	0.02	6.4e-03	5.7	5.8	5.8e-09	0.31	0.12	0.05	FALSE
44	GTEx	Thyroid	CHRNE	0.36	0.39	lasso	10	0.40	8.4e-33	5.3	5.3	9.9e-08	0.28	1.00	0.00	FALSE
45	GTEx	Whole Blood	CAMTA2	0.10	0.07	lasso	8	0.08	1.3e-07	4.2	5.2	2.7e-07	0.35	0.99	0.00	FALSE
46	GTEx	Whole Blood	RP5-1050D4.2	0.05	0.02	enet	11	0.04	3.1e-04	5.3	6.1	1.1e-09	0.37	0.72	0.06	FALSE
47	METSIM	Adipose	SLC52A1	0.07	0.02	lasso	7	0.05	1.8e-07	4.2	-6.0	2.7e-09	-0.20	0.95	0.03	FALSE
48	NTR	Blood	CHRNE	0.05	0.07	lasso	5	0.06	2.1e-18	4.4	5.2	1.6e-07	0.25	0.91	0.09	FALSE
49	NTR	Blood	MINK1	0.11	0.15	lasso	3	0.15	2.1e-46	6.4	5.9	4.3e-09	0.25	0.31	0.69	FALSE
50	NTR	Blood	NUP88	0.05	0.03	lasso	4	0.03	4.8e-10	5.1	-5.2	2.2e-07	-0.79	0.18	0.82	FALSE
51	ROSMAP	Brain Pre-frontal Cortex	RABEP1	0.20	0.22	bslmm	546	0.20	7.4e-25	5.6	-6.8	1.5e-11	-0.77	0.99	0.01	FALSE
52	ROSMAP	Brain Pre-frontal Cortex	RPAIN	0.06	0.06	lasso	3	0.06	3.1e-08	7.1	-7.4	1.4e-13	-0.99	0.00	1.00	TRUE
53	ROSMAP	Brain Pre-frontal Cortex	MINK1	0.08	0.06	lasso	3	0.05	4.0e-07	5.5	5.5	4.4e-08	0.31	0.96	0.04	FALSE
54	YFS	Blood	MINK1	0.18	0.11	enet	24	0.16	4.3e-50	6.4	5.3	1.2e-07	0.17	0.32	0.68	FALSE
55	The Cancer Genome Atlas	Breast Invasive Carcinoma	C17orf107	0.05	0.02	blup	41	0.04	7.0e-09	5.3	5.7	1.2e-08	0.21	0.00	1.00	TRUE
56	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHRNE	0.15	0.28	enet	9	0.29	1.3e-60	4.7	5.2	1.7e-07	0.28	0.87	0.13	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	GP1BA	0.03	0.03	enet	5	0.04	1.3e-08	5.1	5.1	2.9e-07	0.27	0.43	0.57	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	NUP88	0.03	0.02	lasso	2	0.02	6.7e-06	3.7	-5.3	1.1e-07	-0.90	0.01	0.98	FALSE
59	The Cancer Genome Atlas	Colon Adenocarcinoma	C17orf107	0.05	0.03	lasso	3	0.04	3.9e-03	5.0	6.0	1.9e-09	0.23	0.06	0.54	FALSE
60	The Cancer Genome Atlas	Colon Adenocarcinoma	CHRNE	0.25	0.29	lasso	6	0.30	5.4e-18	5.0	5.2	1.6e-07	0.25	0.75	0.25	FALSE
61	The Cancer Genome Atlas	Glioblastoma Multiforme	NUP88	0.12	0.07	enet	12	0.09	1.2e-03	5.6	-6.2	4.7e-10	-0.80	0.02	0.68	FALSE
62	The Cancer Genome Atlas	Glioblastoma Multiforme	RABEP1	0.23	0.13	blup	79	0.15	3.4e-05	5.5	-6.8	1.0e-11	-0.78	0.05	0.86	FALSE
63	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CHRNE	0.19	0.15	blup	41	0.19	6.2e-21	5.0	5.2	1.6e-07	0.27	0.75	0.25	FALSE
64	The Cancer Genome Atlas	Brain Lower Grade Glioma	C17orf107	0.03	0.01	blup	40	0.01	1.3e-02	5.5	5.8	7.1e-09	0.37	0.01	0.69	FALSE
65	The Cancer Genome Atlas	Brain Lower Grade Glioma	NUP88	0.11	0.11	lasso	4	0.10	1.4e-11	5.5	-5.4	6.4e-08	-0.83	0.98	0.02	FALSE
66	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C17orf107	0.03	0.01	enet	8	0.03	5.1e-04	3.4	6.5	1.1e-10	0.19	0.01	0.80	TRUE
67	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NUP88	0.02	0.03	lasso	3	0.02	1.9e-03	-5.3	-5.3	1.3e-07	-0.75	0.12	0.36	FALSE
68	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C17orf107	0.10	0.03	blup	40	0.05	3.9e-03	5.0	6.1	8.5e-10	0.32	0.03	0.87	FALSE
69	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RABEP1	0.06	0.00	blup	79	0.00	2.1e-01	5.0	-5.2	1.8e-07	-0.90	0.02	0.53	FALSE
70	The Cancer Genome Atlas	Prostate Adenocarcinoma	GP1BA	0.02	0.02	blup	49	0.02	9.3e-03	5.1	6.4	1.2e-10	0.33	0.01	0.77	FALSE
71	The Cancer Genome Atlas	Soft Tissue Sarcoma	INCA1	0.06	0.00	enet	11	0.00	1.7e-01	4.6	5.9	3.9e-09	0.30	0.02	0.53	FALSE
72	The Cancer Genome Atlas	Stomach Adenocarcinoma	C17orf107	0.05	0.01	blup	40	0.03	2.0e-03	6.4	6.2	4.7e-10	0.31	0.00	0.96	TRUE
73	The Cancer Genome Atlas	Testicular Germ Cell Tumors	GP1BA	0.11	0.13	lasso	3	0.13	3.2e-05	5.1	5.2	2.2e-07	0.32	0.01	0.96	FALSE
74	The Cancer Genome Atlas	Thyroid Carcinoma	C1QBP	0.03	0.03	blup	57	0.04	4.8e-05	4.9	5.5	2.9e-08	0.88	0.28	0.67	FALSE
75	The Cancer Genome Atlas	Thyroid Carcinoma	CHRNE	0.11	0.15	enet	9	0.15	1.0e-14	4.8	5.4	7.0e-08	0.31	0.86	0.14	FALSE
76	The Cancer Genome Atlas	Thyroid Carcinoma	RABEP1	0.04	0.03	enet	5	0.03	1.5e-03	-5.3	-6.7	2.7e-11	-0.68	0.09	0.82	FALSE