Hub : Genes

KDM6B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1389	0.0496	1.3e-03	0.015	NA	0.032	NA	0.028	2.0e-02	NA	1.4e-03	NA	2.6e-03
2	NTR	Blood	0.0509	0.0155	3.0e-06	0.046	0.020	0.039	0.047	0.044	1.4e-14	4.3e-07	1.7e-12	8.8e-15	5.0e-14
3	ROSMAP	Brain Pre-frontal Cortex	0.0743	0.0247	7.3e-05	0.054	0.027	0.041	0.036	0.043	1.6e-07	1.7e-04	4.2e-06	1.8e-05	2.7e-06
4	YFS	Blood	0.0654	0.0194	9.8e-07	0.038	0.022	0.042	0.041	0.041	1.5e-12	7.1e-08	1.1e-13	1.9e-13	2.3e-13

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.9	1.4	3.1	-1.8	-0.0	-1.3	-0.8
Bipolar Disorder or Schizophrenia	0.1	0.3	0.9	-0.4	-0.9	0.1	0.0
Depressed Affect (Nagel 2018)	1.8	3.7	6.5	-2.3	-0.5	-1.7	-2.5
Depression (Nagel 2018)	5.2	7.8	13.1	-2.9	-0.7	-3.0	-3.6
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.3	-0.0	0.9	-0.9	-1.1
Neuroticism (Nagel 2018)	2.0	4.6	9.2	-3.0	-1.3	-1.6	-2.2
Schizophrenia (2018)	0.5	1.0	1.4	0.9	-1.2	1.1	0.7
Schizophrenia vs Biploar Disorder	2.1	2.8	5.6	2.4	-1.7	1.6	0.5
Worry (Nagel 2018)	1.8	3.8	11.3	-3.4	-0.1	-0.9	-1.7
Alzheimer’s Disease (in mother)	0.2	0.3	0.9	-0.0	-0.0	1.0	0.4
Alzheimer’s Disease (in father)	0.6	0.7	1.0	0.8	-0.7	1.0	0.7
Alzheimer’s Disease (including proxy)	0.5	0.7	1.2	0.7	-1.1	0.9	0.7
Crohns Disease (2017)	0.6	1.4	5.5	0.1	-2.3	-0.1	-0.2
Irritable Bowel Disease (IBD)	0.4	1.0	2.3	-1.2	-1.5	-0.1	-0.7
Ulcerative Colitis (UC)	0.8	1.5	5.0	-2.2	0.0	-0.3	-1.0
Major Depression (MDD)	2.5	3.1	6.0	-2.4	-0.1	-1.2	-2.2
Reaction Time	1.6	3.0	5.8	2.4	-1.8	1.5	1.0
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.6	-1.0	1.9	-1.1	-1.3
Breast Cancer	0.7	1.6	5.3	0.4	1.0	2.3	0.1
Ovarian Cancer	0.9	1.2	2.4	1.4	-0.5	1.5	0.3
Prostate Cancer	2.6	3.7	8.2	-1.3	2.9	-1.1	-1.9
Age at First Birth	1.2	1.7	2.9	0.6	-1.1	1.7	1.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	3.3	4.5	7.4	-2.7	0.9	-2.2	-2.3
Coronary Artery Disease (CAD)	0.6	0.7	1.3	1.1	-0.7	0.1	1.0
Crohns Disease (2012)	0.7	1.1	3.5	-0.3	-1.9	-0.7	-0.4
Mean Putamen Volume	0.1	0.1	0.3	0.6	0.2	0.5	-0.0
Fasting Glucose	0.5	0.6	1.3	1.0	-1.1	-0.1	0.5
HbA1C	0.1	0.1	0.2	0.0	-0.3	-0.4	0.4
HDL Cholesterol	0.6	1.0	2.1	-1.2	0.3	-0.7	-1.5
LDL Cholesterol	0.3	0.5	0.9	0.7	-0.9	-0.5	0.6
Lupus	0.5	0.7	2.7	1.6	-0.3	-0.4	-0.1
Neuroticism (2016)	1.2	1.7	3.4	-1.8	-0.4	-1.1	-1.5
Primary Biliary Cirrhosis	2.1	3.0	8.6	-1.2	-1.4	-2.9	-0.4
Rheumatoid Arthritis	0.3	0.4	0.9	-0.5	-0.4	-0.9	-0.6
Schizophrenia (2014)	1.1	2.3	4.6	1.8	-2.1	1.0	0.7
Triglycerides	1.0	1.6	3.5	0.4	-1.5	-1.9	0.7
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.8	0.3	1.4	-0.3	0.9
Ulcerative Colitis	0.3	0.5	0.9	-0.6	0.3	1.0	0.7
Blood Eosinophil Count	0.3	2.3	6.5	0.0	2.5	0.3	1.6
Blood Platelet Count	0.6	7.1	27.4	-0.1	5.2	0.7	0.6
Blood Red Count	4.6	44.6	73.6	-6.5	4.1	-8.6	-6.7
Blood White Count	1.1	8.1	24.8	-0.7	2.1	-5.0	-1.5
Heel T-Score	7.9	62.8	146.4	2.9	-0.7	12.1	9.8
BMI	3.6	20.6	32.0	-4.7	3.6	-4.0	-5.7
Height	1.8	35.1	121.0	11.0	-3.0	2.4	2.1
Waist Hip Ratio (WHR)	2.9	13.1	30.5	5.5	-1.3	3.4	2.9
Systolic Blood Pressure	4.1	20.6	39.3	-6.2	-0.7	-6.3	-2.0
Smoking Status	0.8	2.0	6.1	-0.4	-2.5	1.2	0.3
Allergy or Eczema	0.6	1.5	2.6	1.1	-0.2	1.4	1.6
Cardiovascular Disease	3.8	12.4	27.5	-3.9	-0.9	-5.2	-2.5
Hypothyroidism (self reported)	0.6	1.5	2.7	-0.3	0.9	-1.6	-1.6
Respiratory disease	0.9	2.0	4.7	2.2	0.6	0.8	1.6
Type 2 Diabetes (T2D) (2018)	1.0	1.8	3.7	1.9	-1.5	0.1	1.2
Lung FEV1/FVC ratio	1.4	7.1	16.2	1.9	2.1	4.0	2.1
Lung FVC	2.5	12.8	22.7	-4.8	-0.5	-4.3	-3.2
Neuroticism	1.0	2.4	4.9	-2.2	-0.3	-1.4	-1.6
Chronotype (morning person)	1.1	2.5	3.9	-1.8	2.0	-0.8	-1.5
Hair Pigment	0.0	1.2	3.1	-0.4	0.1	-1.3	-1.8
Tanning	0.2	2.7	6.6	-0.0	-0.7	2.6	2.0
Hand grip strength (left)	0.3	0.8	2.0	1.4	-0.2	0.7	0.9
Number of treatments/medications taken	1.0	1.8	3.8	-1.6	-0.3	-1.9	-0.8
Average weekly spirits intake	0.6	0.8	1.7	-1.3	0.7	1.0	0.3
Sensitivity / hurt feelings	1.8	3.1	5.1	-1.6	-1.3	-2.3	-1.8
Frequency of depressed mood in last 2 weeks	4.3	6.0	9.0	-3.0	-0.6	-2.6	-2.8
Hearing difficulty/problems: Yes	0.3	0.4	0.9	-0.7	0.4	-0.9	-0.4
Relative age of first facial hair	1.3	2.7	5.2	-2.3	0.2	-1.5	-1.8
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	2.6	-0.2	1.4	-1.6	-1.1
Ever used hormone-replacement therapy (HRT)	0.7	0.8	2.0	1.4	-0.6	-1.0	-0.2
Ever had hysterectomy (womb removed)	0.6	0.7	1.4	-0.0	0.4	-1.2	-1.1
Systolic blood pressure, automated reading	2.6	7.7	16.9	-4.1	-0.2	-3.5	-1.3
Eye problems/disorders: Diabetes related eye disease	3.4	3.8	7.2	0.6	0.5	2.7	2.7
Angina	0.4	0.5	1.4	1.2	-0.7	-0.1	0.3
Medication for hormone replacement therapy	0.4	0.4	1.5	-0.3	-0.4	-0.1	-1.2
Vitamin and mineral supplements	0.5	0.7	1.2	1.1	-0.7	0.7	0.7
Supplements: Zinc	0.7	0.7	1.7	0.2	-1.3	0.8	0.8
Medication: Co-codamol	3.5	4.1	6.4	-2.2	-0.3	-2.3	-2.5
Medication: Metformin	0.2	0.3	0.5	0.4	-0.4	-0.7	0.5
Diabetes (father)	1.6	2.0	5.1	1.7	-0.3	0.0	2.3
Diabetes (mother)	1.1	1.4	2.0	-1.1	1.0	-1.4	-1.1
Severe depression (siblings)	0.1	0.1	0.4	-0.2	0.1	0.1	0.6
Pack years adult smoking proportion	3.7	5.7	7.6	-2.4	2.1	-2.3	-2.8
Impedance of leg (right)	0.5	2.5	9.0	0.3	-3.0	0.3	1.0
Leg fat-free mass (left)	0.4	2.3	4.3	1.1	1.7	-1.0	-2.1
Trunk fat percentage	1.8	7.2	14.7	-2.4	-1.2	-2.6	-3.8
Hand grip strength (right)	0.6	1.6	3.5	1.9	-1.0	1.3	0.3
Townsend deprivation index at recruitment	1.1	1.5	3.4	-0.7	0.2	-1.4	-1.8
Current tobacco smoking	1.1	1.7	6.2	-0.4	-2.5	0.7	0.4
Average weekly fortified wine intake	3.5	4.0	5.5	2.0	-1.3	2.3	2.4
Maternal smoking around birth	1.5	2.1	3.6	1.4	-0.9	1.5	1.9
Fed-up feelings	2.2	4.0	9.0	-3.0	1.4	-1.4	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	2.7	3.6	7.0	-1.6	0.1	-2.1	-2.6
Relative age voice broke	0.1	0.1	0.2	0.1	0.4	-0.3	-0.4
Taking other prescription medications	1.6	2.5	7.2	-0.3	-0.4	-2.7	-1.6
Age when periods started (menarche)	1.1	2.8	8.6	-0.2	0.3	-2.9	-1.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.1	0.9	1.1	-0.5	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	3.9	8.8	19.8	0.1	1.0	4.4	3.8
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.1	0.9	-1.1	0.4	-0.1
Qualifications: CSEs or equivalent	1.2	1.6	5.2	-2.3	-0.3	-0.9	-0.3
Serious illness, injury or assault to yourself	1.4	1.7	3.7	-0.8	1.5	-0.3	-1.9
High blood pressure	6.3	17.5	38.1	-3.9	-1.8	-6.2	-3.6
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.6	0.9	-0.1	1.3	1.2
Multivitamins +/- minerals	0.3	0.3	0.5	-0.6	0.7	-0.7	-0.3
Stomach or abdominal pain in last month	2.1	2.6	8.5	-1.2	-2.9	-0.3	0.4
Supplements: Glucosamine	0.1	0.2	0.5	-0.0	0.3	-0.1	-0.7
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.6	-1.0	-1.3	-0.2	-0.1
Medication: Atenolol	0.8	1.0	2.9	-0.9	0.3	-1.7	-0.7
Medication: Levothyroxine sodium	0.7	1.2	2.4	-0.9	0.1	-1.3	-1.5
Sitting height	0.9	6.6	24.3	4.9	-0.2	0.7	1.3
Chronic bronchitis/emphysema (father)	0.5	0.6	1.6	1.3	-0.9	0.1	0.1
High blood pressure (mother)	2.3	3.3	6.2	-2.3	0.4	-2.5	-1.2
Body mass index (BMI)	2.2	9.3	14.6	-3.1	1.7	-3.2	-3.8
Impedance of leg (left)	0.6	2.8	9.5	0.5	-3.1	-0.5	1.0
Leg predicted mass (left)	0.4	2.2	4.2	1.1	1.6	-0.9	-2.0
Trunk fat mass	1.2	5.2	13.7	-1.2	-0.4	-2.4	-3.7
Waist circumference	0.5	2.0	5.0	0.7	0.4	-1.5	-2.2
Number of incorrect matches in round	1.4	2.3	8.9	0.0	-3.0	-0.4	0.4
Past tobacco smoking	0.6	1.1	3.5	-0.8	1.9	0.0	-0.4
Alcohol usually taken with meals	3.6	5.8	9.0	2.2	-1.4	2.7	3.0
Nervous feelings	0.7	1.3	3.2	-1.8	-0.3	-0.9	-1.1
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	3.8	-2.0	0.7	-1.7	-1.4
Hearing difficulty/problems with background noise	1.6	2.5	4.3	2.1	-1.5	0.6	1.7
Hair/balding pattern: Pattern 2	0.3	0.4	1.1	0.2	-0.1	1.1	0.8
Had menopause	0.3	0.4	1.0	0.4	1.0	0.4	0.6
Had other major operations	1.2	1.5	3.2	-0.8	-1.8	-1.0	-1.1
Forced vital capacity (FVC)	0.5	1.9	2.9	0.0	-1.7	-1.7	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	3.4	7.7	16.2	0.2	1.3	4.0	3.6
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	0.1	0.2	0.3	-0.5
Qualifications: None of the above	1.3	2.7	6.4	0.3	-1.8	-2.5	-1.1
Financial difficulties in last 2 years	1.3	1.8	3.6	0.4	-1.2	-1.9	-1.4
Mouth/teeth dental problems	2.3	3.5	6.8	0.4	-2.6	-1.4	-2.2
Heart attack	0.6	0.7	1.2	0.1	-1.1	-1.0	-0.8
Allergy	0.4	1.0	3.4	-1.8	0.7	-0.4	-0.1
Pain all over the body in last month	1.3	1.4	3.4	-0.6	-0.9	-1.9	-0.9
Diabetes (self-reported)	0.3	0.4	1.3	1.2	-0.3	-0.4	0.3
Hayfever/allergic rhinitis (self-reported)	2.2	3.0	4.6	2.1	-0.2	1.9	1.9
Medication: Ramipril	1.3	1.7	3.8	-1.2	-0.2	-1.9	-1.2
Medication: Simvastatin	0.3	0.4	0.7	-0.5	-0.6	-0.6	0.9
Fluid intelligence score	0.7	1.4	2.9	-0.8	1.7	-0.5	-1.3
Illnesses of siblings	1.0	1.4	2.4	0.7	-1.2	1.6	1.0
Neuroticism score	1.5	3.1	4.8	-2.2	0.6	-1.9	-1.9
Weight	0.9	4.3	10.2	-0.1	1.2	-2.4	-3.2
Impedance of arm (right)	1.8	8.5	23.1	1.0	-4.8	3.0	0.7
Arm fat percentage (right)	1.6	6.3	14.4	-2.7	-0.7	-1.7	-3.8
Trunk fat-free mass	0.7	4.1	10.8	3.3	2.3	-0.3	-0.4
Hip circumference	1.9	8.3	17.4	-2.1	1.2	-3.1	-4.2
Time employed in main current job	1.8	2.0	7.2	-0.9	2.7	0.2	0.2
Alcohol intake versus 10 years previously	0.5	0.8	1.8	1.4	-1.1	-0.1	0.2
Father’s age at death	0.7	0.9	2.9	1.7	-0.1	0.8	-0.3
Worrier / anxious feelings	0.7	1.2	4.5	-2.1	-0.5	0.3	-0.4
Frequency of tiredness / lethargy in last 2 weeks	4.9	7.9	11.2	-3.2	-1.3	-3.4	-3.0
Falls in the last year	1.7	2.4	6.6	1.3	-0.3	1.0	2.6
Hair/balding pattern: Pattern 3	0.7	1.0	2.6	-0.0	-0.4	-1.6	-1.1
Number of live births	1.8	2.5	5.4	-1.6	-0.8	-2.3	-1.2
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.2	-0.3	-0.7	-1.3	-1.5
Pulse rate	0.4	0.6	1.9	-0.2	1.4	-0.8	0.3
Happiness	1.6	2.0	3.5	-1.5	-0.4	-1.4	-1.9
Noisy workplace	0.9	1.1	2.0	-0.5	1.4	-1.4	-0.6
Qualifications: A levels/AS levels or equivalent	0.8	1.7	2.9	1.1	1.7	1.6	0.3
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.7	5.2	-2.3	1.2	-0.4	-0.0
Mouth/teeth dental problems: Dentures	0.2	0.3	0.8	-0.5	0.9	-0.4	-0.3
Asthma	1.8	3.6	9.7	3.1	-0.4	1.2	1.7
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	5.2	0.7	-0.1	1.7	2.3
Medication: Cholesterol lowering	0.7	1.0	1.7	1.3	-0.7	0.5	1.3
Depression (self-reported)	1.0	1.2	3.6	0.2	0.1	-1.0	-1.9
Medication: Lansoprazole	0.8	1.0	2.3	-0.5	0.9	0.7	1.5
Prospective memory result	0.6	0.7	2.1	-0.2	-1.4	-0.7	0.3
Lung cancer (father)	2.7	3.1	4.9	-1.9	0.8	-1.8	-2.2
Illnesses of mother	0.7	0.9	2.1	1.4	0.4	1.1	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.5	1.3	-0.1	-0.4	-1.2	-0.6
Pulse wave Arterial Stiffness index	0.9	1.0	1.8	1.4	1.1	0.8	0.6
Impedance of arm (left)	1.4	6.6	21.3	0.3	-4.6	2.2	0.2
Arm fat mass (right)	1.2	4.7	12.6	-1.6	0.2	-2.0	-3.5
Trunk predicted mass	0.7	4.1	11.0	3.3	2.2	-0.3	-0.4
Standing height	1.1	10.7	38.9	6.2	-1.1	1.4	0.9
Length of working week for main job	0.3	0.3	0.4	0.4	0.5	-0.7	-0.6
Exposure to tobacco smoke at home	0.5	0.6	1.8	-0.3	-0.5	-0.3	-1.3
Breastfed as a baby	1.3	1.6	3.1	-0.4	1.8	1.3	1.1
Tense / ‘highly strung’	0.9	1.6	2.7	-1.0	0.4	-1.5	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.5	3.8	7.1	-1.5	-0.5	-2.4	-2.7
Hair/balding pattern: Pattern 4	0.6	1.5	3.5	0.6	1.4	-0.1	1.9
Birth weight of first child	0.8	1.4	2.0	1.2	1.0	-1.4	-1.1
Peak expiratory flow (PEF)	0.0	0.1	0.2	-0.1	-0.4	-0.3	-0.3
Pulse wave reflection index	0.4	0.5	1.5	-0.6	0.2	-0.4	-1.2
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.2	-0.0	0.4	0.9	1.8
Loud music exposure frequency	2.7	3.0	7.3	-2.7	1.2	-1.5	-1.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.6	-0.6	0.3	1.3	0.0
Mouth/teeth dental problems: Bleeding gums	2.4	3.1	8.2	0.6	2.9	1.3	1.5
Blood clot in the leg (DVT)	6.7	8.7	19.1	-2.1	-0.1	-3.3	-4.4
Medication: Paracetamol	1.5	2.5	7.1	-2.7	0.7	-1.3	-0.7
Headache pain in last month	0.4	0.7	1.6	-0.1	0.2	1.3	1.0
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	4.0	1.1	0.8	2.0	1.4
Glaucoma (self-reported)	1.5	1.8	2.9	-0.9	1.4	-1.1	-1.7
Gout (self-reported)	3.3	4.5	9.0	-1.8	1.1	-3.0	-2.2
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.5	-0.3	0.8	-1.2	-1.2
Medication: Amlodipine	5.7	8.0	12.8	-3.6	-0.4	-3.3	-2.8
Medication: Ventolin 100micrograms inhaler	1.0	1.2	3.1	1.8	0.4	1.1	0.7
Birth weight	0.2	0.3	0.6	0.4	0.7	-0.8	-0.4
Chronic bronchitis/emphysema (mother)	1.3	1.5	4.5	1.2	-2.1	-0.0	0.4
High blood pressure (siblings)	2.0	2.9	4.8	-1.2	2.2	-1.8	-1.3
Forced vital capacity (FVC), Best measure	0.3	1.1	2.2	0.2	-1.2	-1.5	-0.7
Body fat percentage	2.0	8.0	15.7	-2.7	-0.9	-2.9	-4.0
Leg fat percentage (right)	2.4	8.6	13.2	-3.2	0.1	-3.3	-3.6
Arm fat-free mass (right)	0.9	4.5	8.3	1.4	2.9	-2.2	-1.7
Exposure to tobacco smoke outside home	0.5	0.7	1.6	1.3	0.1	1.0	0.2
Comparative body size at age 10	0.8	2.2	4.0	-1.2	2.0	0.7	-1.7
Number of full brothers	0.4	0.5	1.2	-0.7	-0.3	-1.1	0.1
Worry too long after embarrassment	0.1	0.1	0.3	0.1	0.1	-0.5	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.2	-0.0	-1.5	-1.0	-0.9
Wheeze or whistling in the chest in last year	0.5	0.9	2.8	0.4	0.3	-0.9	-1.7
Number of children fathered	2.0	2.3	3.9	1.0	0.7	2.0	1.9
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.0	0.9	-1.0	-1.4	-1.3
Age at first live birth	0.4	0.7	1.4	-1.2	-0.4	-0.1	-1.2
Pulse wave peak to peak time	0.6	0.7	1.5	-0.8	-1.2	-0.7	-0.5
Health satisfaction	0.6	0.8	1.3	1.2	-0.8	0.2	1.1
Shortness of breath walking on level ground	0.2	0.3	0.4	0.6	-0.2	-0.6	-0.5
Qualifications: College or University degree	0.7	2.1	4.1	1.1	2.0	1.3	-1.1
Eye problems/disorders: None of the above	0.3	0.4	1.3	1.1	-0.3	0.3	-0.1
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.4	0.1	0.4	0.6	0.3
Emphysema/chronic bronchitis	1.3	1.5	2.7	-1.6	0.4	-1.2	-1.3
Medication for pain relief, constipation, heartburn	0.5	0.9	1.6	1.1	0.9	1.3	0.1
Neck or shoulder pain in last month	1.2	1.7	2.7	-1.1	-1.1	-1.6	-1.4
Medication: Blood pressure	4.6	8.1	13.3	-2.9	-1.0	-3.6	-3.2
Angina (self-reported)	0.3	0.5	1.1	1.0	-0.8	-0.2	-0.1
Migraine (self-reported)	0.3	0.4	0.6	-0.8	0.6	0.4	0.5
Medication: Ibuprofen	1.6	1.9	3.8	0.5	0.4	1.9	2.0
Medication: Allopurinol	6.8	9.1	19.6	-2.6	0.4	-4.4	-3.1
Medication: Omeprazole	1.2	1.4	4.1	2.0	-0.9	-0.7	0.6
Medication: Seretide 50 evohaler	0.2	0.3	0.5	0.7	-0.2	0.1	-0.7
Mean time to correctly identify matches	2.5	4.7	10.6	3.3	-1.5	2.0	1.5
Heart disease (mother)	2.2	2.6	4.9	-1.1	0.4	-2.1	-2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	3.1	0.3	0.1	0.4	1.8
Whole body fat mass	1.2	5.1	12.5	-1.4	-0.2	-2.5	-3.5
Leg fat mass (right)	1.7	6.6	13.1	-1.8	0.5	-3.1	-3.6
Arm predicted mass (right)	0.8	4.2	7.3	1.4	2.7	-2.2	-1.6
Pulse rate, automated reading	0.7	2.4	4.5	0.8	1.9	-2.1	-0.7
Alcohol intake frequency.	2.2	5.1	18.1	-0.4	4.2	-0.7	-1.3
Comparative height size at age 10	0.6	3.3	5.7	2.4	-0.7	2.1	1.6
Number of full sisters	0.4	0.5	1.5	-0.3	-0.4	-1.2	0.5
Suffer from ‘nerves’	1.1	1.8	3.0	-1.5	-0.1	-1.7	-1.4
Overall health rating	0.8	1.7	3.0	-0.2	-1.3	-1.7	-1.5
Chest pain or discomfort	0.7	1.0	2.8	0.7	0.1	-1.0	-1.7
Had major operations	2.2	2.6	4.0	-1.0	1.2	-1.9	-2.0
Age at last live birth	0.3	0.4	1.2	-0.5	-1.1	0.0	-0.5
Family relationship satisfaction	1.4	1.7	4.2	0.2	-2.1	-0.5	-1.5
Leg pain on walking	0.1	0.1	0.3	0.2	0.4	-0.5	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.8	-1.3	0.1	-0.7	0.0
Commuting to job workplace: Car/motor vehicle	1.2	1.3	2.9	-1.0	-0.2	-1.3	1.7
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	3.5	1.0	-1.9	0.9	0.8
Medication: Aspirin	2.7	3.6	8.1	-1.1	-1.3	-2.8	-1.9
Supplements: Vitamin C	0.2	0.2	0.7	-0.2	-0.9	-0.1	-0.2
Knee pain experienced in last month	0.2	0.2	0.6	-0.5	-0.4	-0.2	0.7
Hypertension (Self-reported)	7.3	20.2	42.4	-4.4	-1.4	-6.5	-4.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	3.3	-0.2	0.1	-0.4	1.8
Illnesses of father: Heart disease	0.6	0.8	2.4	-1.5	0.5	0.5	0.7
Illnesses of siblings: Diabetes	0.3	0.4	1.2	-0.1	1.1	-0.4	0.6
Smoking status: Previous	0.2	0.3	0.8	0.7	-0.9	-0.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.6	1.9	-0.3	-1.0	-0.3
Whole body fat-free mass	0.6	3.2	6.4	2.5	2.2	-0.6	-1.0
Leg fat-free mass (right)	0.4	2.2	3.0	1.5	1.7	-1.0	-1.6
Arm fat percentage (left)	2.2	8.9	18.1	-3.4	-0.6	-2.3	-4.3
Average weekly red wine intake	2.9	4.2	7.2	2.7	-2.5	1.3	1.4
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.4	-0.7	-0.4	-1.2	-1.0
Mood swings	0.7	1.2	2.5	-1.6	1.1	-0.8	-0.7
Loneliness, isolation	0.2	0.3	0.8	-0.3	-0.9	-0.4	-0.2
Long-standing illness, disability or infirmity	1.7	2.7	4.1	-1.9	1.2	-2.0	-1.2
Ever had bowel cancer screening	0.2	0.2	0.7	0.3	-0.1	-0.9	-0.2
Diabetes diagnosed by doctor	0.4	0.6	1.7	1.3	-0.3	-0.1	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.8	-0.9	-1.3	0.3	0.1
Friendships satisfaction	0.5	0.7	1.5	-0.8	-1.2	-0.4	-0.6
Qualifications: nursing, teaching	0.8	1.2	2.5	0.9	1.6	1.0	-0.8
Commuting to job workplace: Walk	0.6	0.7	2.2	0.2	0.7	0.3	-1.5
Eye problems/disorders: Cataract	0.5	0.6	1.2	-0.5	-0.9	-1.1	-0.4
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	4.1	-1.3	1.1	1.7	2.0
Medication for cholesterol	2.8	4.2	9.5	1.7	1.0	3.1	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.2	1.5	0.1	0.1	0.4
Back pain experienced in last month	0.1	0.1	0.4	0.6	-0.2	-0.1	0.1
Mineral and other dietary supplements	0.5	0.7	1.4	1.1	-1.2	0.1	0.4
Breast cancer (self-reported)	0.4	0.5	1.8	0.5	0.1	-0.1	1.3
Asthma (self-reported)	2.0	3.9	11.1	3.3	-0.2	1.3	1.7
Osteoporosis (self-reported)	2.2	2.7	6.5	-2.6	1.3	-1.2	-1.2
Osteoarthritis (self-reported)	1.1	1.5	2.8	-0.8	0.1	-1.7	-1.6
Medication: Aspirin	3.7	4.8	9.1	-1.5	-1.5	-3.0	-2.3
Medication: Gliclazide	1.0	1.2	1.8	-1.3	-1.0	-1.4	0.2
Illnesses of father: None of the above (group 1)	1.2	1.5	3.9	-0.3	1.3	-0.5	-2.0
Smoking status: Current	1.0	1.6	5.7	-0.3	-2.4	0.7	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	5.3	-2.0	0.1	-2.3	-1.5
Whole body water mass	0.5	3.1	5.8	2.4	2.2	-0.7	-1.1
Leg predicted mass (right)	0.4	2.3	3.1	1.5	1.8	-1.0	-1.7
Arm fat mass (left)	1.4	5.7	14.0	-2.0	0.3	-2.2	-3.7
Number of self-reported non-cancer illnesses	3.5	6.0	16.2	-1.4	-0.4	-4.0	-2.4
Average weekly champagne plus white wine intake	0.6	0.9	2.3	0.4	0.7	1.5	0.7
Miserableness	3.7	6.4	10.2	-2.5	-0.1	-3.0	-3.2
Guilty feelings	2.6	3.9	6.1	-2.0	-1.2	-2.0	-2.5
Wears glasses or contact lenses	1.9	2.2	3.7	1.1	0.7	1.9	1.9
Ever taken oral contraceptive pill	2.9	3.2	7.3	1.2	-0.3	2.0	2.7
Hearing aid user	0.5	0.5	1.4	-1.2	0.1	-0.3	0.8
Mother’s age at death	3.7	4.6	9.7	2.7	0.2	3.1	1.1
Financial situation satisfaction	3.0	3.7	7.5	-1.4	-1.2	-2.7	-2.0
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.1	-0.7	0.4	1.1	0.1
Commuting to job workplace: Public transport	0.5	0.6	1.4	0.9	-0.2	1.2	-0.0
Eye problems/disorders: Glaucoma	0.6	0.7	1.0	-0.9	0.8	-0.7	-1.0
Medication: Blood pressure	5.1	9.7	24.7	-2.9	-0.3	-5.0	-2.4
Pain type(s) experienced in last month: Hip pain	0.9	1.2	2.6	1.6	-1.1	0.2	0.9
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	-0.7	0.9	-0.1	-0.6
High cholesterol (Self-reported)	0.5	0.8	2.6	0.7	-0.4	-0.0	1.6
Medication: Bendroflumethiazide	6.5	9.9	13.9	-3.4	2.5	-3.7	-2.8
Medication: Paracetamol	1.9	2.9	5.9	-2.4	1.3	-1.8	-0.9
Medication: Lisinopril	2.5	3.2	8.6	-0.9	-2.9	-1.7	-0.7
Medication: Atorvastatin	0.7	0.8	2.8	1.7	-0.8	0.1	0.2
Illnesses of father: High blood pressure	1.9	2.3	3.8	-1.6	-1.5	-1.9	-0.9
Alcohol drinker status: Never	0.3	0.4	1.0	-0.0	1.0	-0.7	-0.1
Ever smoked	1.2	2.1	4.7	1.1	-2.2	0.9	1.3
Basal metabolic rate	0.5	2.8	3.6	1.8	1.9	-1.3	-1.7
Leg fat percentage (left)	2.5	9.1	13.1	-3.2	0.3	-3.6	-3.6
Arm fat-free mass (left)	0.7	3.7	5.7	2.0	2.4	-1.6	-1.5
Number of operations (self-reported)	0.2	0.3	0.7	-0.4	-0.1	-0.7	-0.9
Average weekly beer plus cider intake	0.6	0.8	2.7	-0.3	0.1	-1.6	-0.7
Irritability	0.2	0.3	0.8	0.2	0.5	0.9	0.5
Risk taking	1.0	1.5	4.4	1.0	-2.1	0.4	0.7
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.2	-0.3	0.6	-1.1	-0.7
Fractured/broken bones in last 5 years	0.2	0.3	0.7	0.2	0.6	0.0	-0.8
Age started oral contraceptive pill	0.7	0.9	2.1	-0.3	1.4	0.3	1.1
Diastolic blood pressure, automated reading	4.6	14.4	28.7	-3.3	0.0	-5.4	-4.2
Ever depressed for a whole week	0.4	0.5	1.2	-0.3	0.9	1.1	-0.2
Unable to work because of sickness or disability	1.5	1.9	5.6	0.6	-2.4	-1.3	-0.3
Commuting to job workplace: Cycle	2.3	2.8	8.4	2.9	-0.1	1.6	0.5
Myopia	0.5	0.7	2.7	-0.3	1.6	-0.4	0.1
Vascular/heart problems diagnosed by doctor	4.5	12.2	28.0	3.2	1.8	5.3	2.8
Cholesterol lowering medication	0.4	0.6	2.1	-0.3	-0.6	-1.4	-0.2
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	5.7	2.4	-0.9	-1.1	0.4
Pain experienced in last month	0.3	0.5	1.7	-0.0	1.3	0.2	-0.5
Supplements: Calcium	0.4	0.5	0.9	-0.1	0.6	0.9	0.9
Basal cell carcinoma (self-reported)	0.3	0.3	0.6	-0.3	0.8	0.6	0.4
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.2	0.3	-1.1	-0.9	-0.6
Deep venous thrombosis (DVT) (self-reported)	7.5	9.7	20.9	-2.3	0.1	-3.5	-4.6
Heart disease (siblings)	1.4	1.7	2.6	1.4	-1.6	-1.3	0.9
Alcohol drinker status: Previous	1.6	1.9	4.3	-0.6	1.3	-1.0	-2.1
Pack years of smoking	3.3	4.8	5.6	-2.3	2.2	-1.9	-2.4
Impedance of whole body	1.0	5.2	17.8	0.5	-4.2	1.4	0.9
Leg fat mass (left)	1.9	7.3	13.6	-1.9	0.5	-3.4	-3.7
Arm predicted mass (left)	0.7	3.5	4.9	2.1	2.2	-1.5	-1.6